JP2004517098A5 - - Google Patents
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- Publication number
- JP2004517098A5 JP2004517098A5 JP2002551528A JP2002551528A JP2004517098A5 JP 2004517098 A5 JP2004517098 A5 JP 2004517098A5 JP 2002551528 A JP2002551528 A JP 2002551528A JP 2002551528 A JP2002551528 A JP 2002551528A JP 2004517098 A5 JP2004517098 A5 JP 2004517098A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- solvate
- salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- -1 2 - cyclopropyl Chemical group 0.000 claims 2
- 101710011551 PTGER4 Proteins 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000005418 aryl aryl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 230000001268 conjugating Effects 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000005529 alkyleneoxy group Chemical group 0.000 claims 1
- 230000003042 antagnostic Effects 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated Effects 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000035479 physiological effects, processes and functions Effects 0.000 claims 1
- 230000004977 physiological function Effects 0.000 claims 1
- 230000035790 physiological processes and functions Effects 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0031315.5A GB0031315D0 (en) | 2000-12-21 | 2000-12-21 | Indole derivatives |
| PCT/GB2001/005701 WO2002050031A1 (en) | 2000-12-21 | 2001-12-20 | Indole derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004517098A JP2004517098A (ja) | 2004-06-10 |
| JP2004517098A5 true JP2004517098A5 (ru) | 2005-12-22 |
| JP4460830B2 JP4460830B2 (ja) | 2010-05-12 |
Family
ID=9905643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002551528A Expired - Fee Related JP4460830B2 (ja) | 2000-12-21 | 2001-12-20 | インドール誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7288564B2 (ru) |
| EP (1) | EP1343757B1 (ru) |
| JP (1) | JP4460830B2 (ru) |
| AT (1) | ATE353875T1 (ru) |
| AU (1) | AU2002217286A1 (ru) |
| DE (1) | DE60126652T2 (ru) |
| ES (1) | ES2282195T3 (ru) |
| GB (1) | GB0031315D0 (ru) |
| WO (1) | WO2002050031A1 (ru) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN2001000224A (es) | 2000-10-19 | 2002-06-13 | Pfizer | Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos. |
| SE0301446D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
| SE0402284D0 (sv) * | 2004-09-21 | 2004-09-21 | Astrazeneca Ab | New heterocyclic amides |
| CA2586156A1 (en) * | 2004-11-04 | 2006-05-18 | Merck & Co., Inc. | Niacin receptor agonists, compositions containing such compounds and methods of treatment |
| CA2623759A1 (en) * | 2005-10-06 | 2007-04-19 | Exelixis, Inc. | Pyridopyrimidinone inhibitors of pim 1 and/or pim-3 |
| UY30048A1 (es) * | 2005-12-23 | 2007-07-31 | Astrazeneca Ab | Derivados sustituidos de la n,2-(1h-benzimidazol-1-il) acetamida, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones |
| UY30121A1 (es) | 2006-02-03 | 2007-08-31 | Glaxo Group Ltd | Nuevos compuestos |
| JP5244091B2 (ja) * | 2006-04-24 | 2013-07-24 | メルク カナダ インコーポレイテッド | Ｅｐ４受容体アンタゴニストとしてのインドールアミド誘導体 |
| TWI433839B (zh) * | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
| US20100074896A1 (en) * | 2006-11-30 | 2010-03-25 | The Johns Hopkins University | Antagonists of pge2 ep3 receptors |
| JP5069752B2 (ja) | 2006-12-15 | 2012-11-07 | グラクソ グループ リミテッド | Ｅｐ４受容体アゴニストとしてのベンズアミド誘導体 |
| GB0701970D0 (en) * | 2007-02-01 | 2007-03-14 | Wilson Stuart | Treatment of protein aggregation diseases |
| EP2172447A4 (en) * | 2007-07-03 | 2011-08-24 | Astellas Pharma Inc | amide |
| GB0721611D0 (en) | 2007-11-02 | 2007-12-12 | Glaxo Group Ltd | Novel compounds |
| DK2565191T3 (da) * | 2008-05-14 | 2014-11-10 | Astellas Pharma Inc | 4-(Indol-7-ylcarbonylaminomethyl)cyclohexancarboxylsyrederivater som EP4-receptorantagonister der er anvendelige til behandlingen af kronisk nyresvigt eller diabetisk nephropati |
| WO2010087425A1 (ja) | 2009-01-30 | 2010-08-05 | 国立大学法人京都大学 | 前立腺癌の進行抑制剤および進行抑制方法 |
| CA2777782C (en) | 2009-10-15 | 2016-06-28 | Children's Medical Center Corporation | Sepiapterin reductase inhibitors for the treatment of pain |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| PL2970265T3 (pl) * | 2013-03-15 | 2018-11-30 | Plexxikon Inc. | Heterocykliczne związki i ich zastosowania |
| ES2954717T3 (es) * | 2017-05-22 | 2023-11-23 | Ono Pharmaceutical Co | Antagonista de EP4 |
| US10717735B2 (en) | 2017-10-13 | 2020-07-21 | Plexxikon Inc. | Solid forms of a compound for modulating kinases |
| KR20230107228A (ko) | 2020-11-13 | 2023-07-14 | 오노 야꾸힝 고교 가부시키가이샤 | Ep4 길항약과 면역 체크포인트 저해 물질의 병용에 의한 암 치료 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4251446A (en) * | 1977-03-01 | 1981-02-17 | Sterling Drug Inc. | Phthalide compounds, processes and marking systems |
| US4322352A (en) * | 1979-04-04 | 1982-03-30 | Sterling Drug Inc. | Indolyl phthalide compounds |
| JPS62138469A (ja) * | 1985-12-11 | 1987-06-22 | Yoshitomi Pharmaceut Ind Ltd | インド−ル誘導体 |
| US5075313A (en) * | 1990-09-13 | 1991-12-24 | Eli Lilly And Company | 3-aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof |
| GB9022785D0 (en) * | 1990-10-19 | 1990-12-05 | Merck Sharp & Dohme | Therapeutic agents |
| JP3092947B2 (ja) * | 1995-12-14 | 2000-09-25 | メルク エンド カンパニー インコーポレーテッド | ゴナドトロピン放出ホルモン拮抗剤 |
| AU717430B2 (en) * | 1996-08-26 | 2000-03-23 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| JPH1171336A (ja) * | 1997-06-25 | 1999-03-16 | Mitsubishi Chem Corp | アミド誘導体 |
| AU753360B2 (en) * | 1998-07-31 | 2002-10-17 | Nippon Soda Co., Ltd. | Phenylazole compounds, process for producing the same and drugs for hyperlipemia |
| US6437146B1 (en) * | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
| AU1444200A (en) * | 1998-10-15 | 2000-05-01 | Merck & Co., Inc. | Methods for inhibiting bone resorption |
| GB9902455D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| AU2001278771A1 (en) * | 2000-08-22 | 2002-03-04 | Ono Pharmaceutical Co. Ltd. | Carboxylic acid derivatives, process for producing the same and drugs containingthe same as the active ingredient |
| CA2430978C (en) * | 2000-12-28 | 2012-05-15 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitors |
-
2000
- 2000-12-21 GB GBGB0031315.5A patent/GB0031315D0/en not_active Ceased
-
2001
- 2001-12-20 AT AT01271354T patent/ATE353875T1/de not_active IP Right Cessation
- 2001-12-20 WO PCT/GB2001/005701 patent/WO2002050031A1/en active IP Right Grant
- 2001-12-20 US US10/450,894 patent/US7288564B2/en not_active Expired - Fee Related
- 2001-12-20 ES ES01271354T patent/ES2282195T3/es not_active Expired - Lifetime
- 2001-12-20 DE DE60126652T patent/DE60126652T2/de not_active Expired - Lifetime
- 2001-12-20 JP JP2002551528A patent/JP4460830B2/ja not_active Expired - Fee Related
- 2001-12-20 AU AU2002217286A patent/AU2002217286A1/en not_active Abandoned
- 2001-12-20 EP EP01271354A patent/EP1343757B1/en not_active Expired - Lifetime
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