JP2004516017A5 - - Google Patents

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Publication number
JP2004516017A5
JP2004516017A5 JP2002530710A JP2002530710A JP2004516017A5 JP 2004516017 A5 JP2004516017 A5 JP 2004516017A5 JP 2002530710 A JP2002530710 A JP 2002530710A JP 2002530710 A JP2002530710 A JP 2002530710A JP 2004516017 A5 JP2004516017 A5 JP 2004516017A5
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Japan
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acid molecule
fatty acid
unsaturated fatty
polypeptide
amino acid
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JP2002530710A
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English (en)
Japanese (ja)
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JP4071622B2 (ja
JP2004516017A (ja
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Priority claimed from PCT/IB2001/002346 external-priority patent/WO2002026946A2/en
Publication of JP2004516017A publication Critical patent/JP2004516017A/ja
Publication of JP2004516017A5 publication Critical patent/JP2004516017A5/ja
Application granted granted Critical
Publication of JP4071622B2 publication Critical patent/JP4071622B2/ja
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JP2002530710A 2000-09-28 2001-09-28 脂肪酸不飽和化酵素ファミリーのメンバーであるfad4、fad5、fad5−2およびfad6、ならびにそれらの使用方法 Expired - Fee Related JP4071622B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23630300P 2000-09-28 2000-09-28
US29756201P 2001-06-12 2001-06-12
PCT/IB2001/002346 WO2002026946A2 (en) 2000-09-28 2001-09-28 Fad4, fad5, fad5-2, and fad6, fatty acid desaturase family members and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006151242A Division JP4365387B2 (ja) 2000-09-28 2006-05-31 脂肪酸不飽和化酵素ファミリーのメンバーであるfad4、fad5、fad5−2およびfad6、ならびにそれらの使用方法

Publications (3)

Publication Number Publication Date
JP2004516017A JP2004516017A (ja) 2004-06-03
JP2004516017A5 true JP2004516017A5 (enExample) 2006-08-17
JP4071622B2 JP4071622B2 (ja) 2008-04-02

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ID=26929655

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2002530710A Expired - Fee Related JP4071622B2 (ja) 2000-09-28 2001-09-28 脂肪酸不飽和化酵素ファミリーのメンバーであるfad4、fad5、fad5−2およびfad6、ならびにそれらの使用方法
JP2006151242A Expired - Fee Related JP4365387B2 (ja) 2000-09-28 2006-05-31 脂肪酸不飽和化酵素ファミリーのメンバーであるfad4、fad5、fad5−2およびfad6、ならびにそれらの使用方法
JP2009076067A Expired - Fee Related JP4456172B2 (ja) 2000-09-28 2009-03-26 脂肪酸不飽和化酵素ファミリーのメンバーであるfad4、fad5、fad5−2およびfad6、ならびにそれらの使用方法

Family Applications After (2)

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JP2006151242A Expired - Fee Related JP4365387B2 (ja) 2000-09-28 2006-05-31 脂肪酸不飽和化酵素ファミリーのメンバーであるfad4、fad5、fad5−2およびfad6、ならびにそれらの使用方法
JP2009076067A Expired - Fee Related JP4456172B2 (ja) 2000-09-28 2009-03-26 脂肪酸不飽和化酵素ファミリーのメンバーであるfad4、fad5、fad5−2およびfad6、ならびにそれらの使用方法

Country Status (13)

Country Link
US (7) US7087432B2 (enExample)
EP (3) EP1322752B2 (enExample)
JP (3) JP4071622B2 (enExample)
CN (3) CN100567483C (enExample)
AT (2) ATE510908T1 (enExample)
AU (3) AU2002218447C9 (enExample)
CA (1) CA2421267C (enExample)
DE (1) DE60141760D1 (enExample)
DK (2) DK1322752T3 (enExample)
ES (2) ES2343106T3 (enExample)
NO (2) NO331104B1 (enExample)
PT (2) PT1911837E (enExample)
WO (1) WO2002026946A2 (enExample)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US7211418B2 (en) * 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US20070244192A1 (en) * 1999-01-14 2007-10-18 Martek Biosciences Corporation Plant seed oils containing polyunsaturated fatty acids
US8003772B2 (en) 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
US7217856B2 (en) * 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
EP1392823B1 (en) * 2001-01-25 2011-11-30 Abbott Laboratories Desaturase genes and uses thereof
US6635451B2 (en) 2001-01-25 2003-10-21 Abbott Laboratories Desaturase genes and uses thereof
TWI324181B (en) 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
US7045683B2 (en) 2001-05-04 2006-05-16 Abbott Laboratories Δ4-desaturase genes and uses thereof
DE10137374A1 (de) * 2001-07-31 2003-02-27 Ipk Inst Fuer Pflanzengenetik Verfahren zur Herstellung von Arachidonsäure in transgenen Organismen
EP2261312A1 (en) 2001-12-12 2010-12-15 Martek Biosciences Corporation Extraction and Winterization of Lipids from Oilseed and Microbial Sources
CA2883729C (en) 2002-05-22 2017-03-07 Virginia M. Ursin Fatty acid desaturases from fungi
US7485414B2 (en) * 2002-08-30 2009-02-03 Rigel Pharmaceuticals, Inc. Modulators of angiogenesis
US20040172682A1 (en) 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
US8084074B2 (en) 2003-02-12 2011-12-27 E. I. Du Pont De Nemours And Company Production of very long chain polyunsaturated fatty acids in oil seed plants
ES2516641T3 (es) * 2003-03-26 2014-10-31 Dsm Ip Assets B.V. Sistemas de policétido sintasa de AGPI y usos de los mismos
JP4732333B2 (ja) * 2003-04-08 2011-07-27 ビーエーエスエフ プラント サイエンス ゲーエムベーハー ミドリムシ(Euglenagracilis)由来のΔ−4−デサチュラーゼを発現する植物およびPUFA含有油
PT2172536T (pt) 2003-08-01 2016-08-17 Basf Plant Science Gmbh Processo para a produção de ácidos gordos poli-insaturados em organismos transgénicos
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
AU2004268196B2 (en) * 2003-08-21 2010-03-04 Monsanto Technology Llc Fatty acid desaturases from primula
US20050132441A1 (en) 2003-11-12 2005-06-16 Damude Howard G. Delta15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast
CA2558726C (en) 2004-02-27 2017-11-07 Basf Plant Science Gmbh Method for producing unsaturated .omega.-3-fatty acids in transgenic organisms
CN1930277B (zh) 2004-02-27 2011-02-02 巴斯福植物科学有限公司 在转基因植物中产生多不饱和脂肪酸的方法
JP2007533310A (ja) * 2004-04-16 2007-11-22 モンサント テクノロジー エルエルシー トウモロコシにおける脂肪酸デサチュラーゼの発現
ES2529572T3 (es) 2004-04-22 2015-02-23 Commonwealth Scientific And Industrial Research Organisation Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes
PL1756280T3 (pl) * 2004-04-22 2015-04-30 Commw Scient Ind Res Org Synteza długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach rekombinowanych
AU2005250074B2 (en) 2004-06-04 2011-04-14 Fluxome Sciences A/S Metabolically engineered cells for the production of polyunsaturated fatty acids
US7550651B2 (en) 2004-06-25 2009-06-23 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
DK1780275T3 (da) 2004-07-12 2011-02-21 Suntory Holdings Ltd Polypeptid med en delta5-fedtsyre-desaturationsaktivitet, polynukleotid kodende for polypeptidet og anvendelse deraf
US7138391B2 (en) * 2004-08-09 2006-11-21 Silverbrook Research Pty Ltd Hydrophilizable and hydrophilic cyanine dyes
AU2006219823A1 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
DE102005013779A1 (de) 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
MX338235B (es) 2005-06-07 2016-04-08 Dsm Nutritional Products Ag Microorganismos eucarioticos para producir lipidos y antioxidantes.
DE102005038036A1 (de) * 2005-08-09 2007-02-15 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen
WO2007061742A1 (en) 2005-11-23 2007-05-31 E. I. Du Pont De Nemours And Company Delta-9 elongases and their use in making polyunsaturated fatty acids
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
BRPI0708535A2 (pt) * 2006-03-03 2011-05-31 Monsanto Technology Llc meios para melhora da saúde cardiovascular
MX340759B (es) * 2006-03-15 2015-03-11 Dsm Ip Assets B V * Aceites de semillas vegetales que contienen ácidos grasos poli-insaturados.
US7943823B2 (en) 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
EP2082053B1 (en) 2006-08-01 2016-04-13 DSM Nutritional Products AG Process for producing microbial oil comprising polyunsaturated fatty acids
BRPI0716075A2 (pt) 2006-08-29 2013-08-06 Commw Scient Ind Res Org sÍntese de Ácidos graxos
EP2062574B1 (en) * 2006-09-08 2015-03-25 Kaneka Corporation Composition comprising reduced coenzyme q10 and lysolecithin
JP5101894B2 (ja) * 2007-01-15 2012-12-19 サントリーホールディングス株式会社 高度不飽和脂肪酸及びこれを含有する脂質の製造方法
DK2129777T3 (en) * 2007-04-03 2016-01-25 Du Pont MULTIZYMER AND USE THEREOF FOR THE PRODUCTION OF polyunsaturated fatty acids
US7943365B2 (en) 2007-05-03 2011-05-17 E.I. Du Pont De Nemours And Company Δ-5 desaturases and their use in making polyunsaturated fatty acids
CA2695161C (en) * 2007-07-13 2018-05-22 Ocean Nutrition Canada Limited D4 desaturases and d5 elongases
BRPI0821508B1 (pt) 2007-12-11 2018-12-26 Synthetic Genomics Inc cultura celular compreendendo uma cianobactéria recombinante da espécie synechococcus elongatus e método para converter carbono inorgânico em ácidos graxos.
US8119784B2 (en) * 2008-04-02 2012-02-21 E. I. Du Pont De Nemours And Company Delta-4 desaturase and its use in making polyunsaturated fatty acids
WO2010000708A2 (en) 2008-07-01 2010-01-07 Basf Plant Science Gmbh Promoters from brassica napus for seed specific gene expression
JP2011529689A (ja) * 2008-08-01 2011-12-15 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Δ6デサチュラーゼおよび多価不飽和脂肪酸生成におけるそれらの使用
CA3015426C (en) * 2008-11-18 2020-01-14 Commonwealth Scientific And Industrial Research Organisation Recombinant cells comprising exogenous .delta.5 and .delta.6 desaturases, .delta.5 and .delta.6 elongases, and .delta.4 desaturases
ES2752196T3 (es) 2009-03-16 2020-04-03 Dsm Ip Assets Bv Producción de proteínas en microorganismos del filo Labyrinthulomycota
ES2717102T3 (es) * 2009-03-19 2019-06-19 Dsm Ip Assets Bv Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos
US20100272875A1 (en) * 2009-04-24 2010-10-28 Monsanto Technology Llc Omega-3 enriched cereal, granola, and snack bars
CA2760326A1 (en) 2009-05-13 2010-11-18 Basf Plant Science Company Gmbh Acyltransferases and uses thereof in fatty acid production
JP2012529277A (ja) 2009-06-08 2012-11-22 ロザムステッド リサーチ リミテッド 新規の脂肪酸伸長成分およびその使用
WO2011008565A1 (en) 2009-06-29 2011-01-20 Synthetic Genomics, Inc. Acyl-acp thioesterase genes and uses therefor
US9493520B2 (en) 2009-07-17 2016-11-15 Basf Plant Science Company Gmbh Fatty acid desaturases and elongases and uses thereof
US9428757B2 (en) 2009-08-31 2016-08-30 Basf Plant Science Company Gmbh Regulatory nucleic acid molecules for enhancing seed-specific gene expression in plants promoting enhanced polyunsaturated fatty acid synthesis
EP2481799A4 (en) 2009-09-24 2013-08-07 Univ Kyushu Nat Univ Corp METHOD FOR THE TRANSFORMATION OF STRAMENOPILES
EP2504438A1 (en) 2009-11-24 2012-10-03 BASF Plant Science Company GmbH Novel fatty acid elongase and uses thereof
WO2011064181A1 (en) 2009-11-24 2011-06-03 Basf Plant Science Company Gmbh Novel fatty acid desaturase and uses thereof
US9388437B2 (en) 2010-06-25 2016-07-12 Basf Plant Science Company Gmbh Acyltransferases and uses thereof in fatty acid production
AU2011317632B2 (en) 2010-10-21 2016-08-18 Basf Plant Science Company Gmbh Novel fatty acid desaturases, elongases, elongation components and uses therof
JP2012096498A (ja) * 2010-11-05 2012-05-24 Tomoegawa Paper Co Ltd 両面印刷用熱転写受像シートおよびその製造方法
CN102559710B (zh) * 2011-06-27 2013-10-30 中国农业科学院油料作物研究所 等鞭金藻δ4-脂肪酸去饱和酶基因及其克隆方法
HUE033766T2 (en) 2012-06-15 2018-01-29 Commw Scient Ind Res Org Production of long chain polyunsaturated fatty acids in plant cells
AU2013298113A1 (en) 2012-08-03 2015-01-29 Basf Plant Science Company Gmbh Novel enzymes, enzyme components and uses thereof
EP2970926B1 (en) 2013-03-13 2018-01-31 DSM Nutritional Products AG Engineering microorganisms
US10731169B2 (en) 2013-07-05 2020-08-04 Basf Plant Science Company Gmbh Gene expression or activity enhancing elements
US10329541B2 (en) 2013-12-17 2019-06-25 Basf Plant Science Company Gmbh Methods for conversion of the substrate specificity of desaturases
EA037817B1 (ru) 2013-12-18 2021-05-25 Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн Экстрагированный растительный липид, содержащий длинноцепочечные полиненасыщенные жирные кислоты
CA2953008C (en) 2014-06-27 2024-03-19 Nuseed Pty Ltd Lipid comprising docosapentaenoic acid
US11484560B2 (en) 2014-11-14 2022-11-01 Basf Plant Science Company Gmbh Stabilising fatty acid compositions
CA3026079C (en) 2016-06-01 2024-10-01 Cargill Inc FISH FOOD PREPARED FROM OILSEED PLANTS PRODUCING OMEGA-3 FATTY ACIDS
CN107236679A (zh) * 2017-04-27 2017-10-10 广州弘宝元生物科技有限公司 一种高产不饱和脂肪酸重组工程菌株及其构建方法
CN112040766A (zh) * 2018-04-13 2020-12-04 嘉吉公司 栽培含lc-pufa的转基因芸苔属植物的方法
WO2020168277A1 (en) 2019-02-14 2020-08-20 Cargill, Incorporated Brassica plants producing elevated levels of polyunsaturated fatty acids
AU2021373697A1 (en) 2020-11-04 2023-06-08 Basf Plant Science Company Gmbh Harvest management
WO2022204454A1 (en) 2021-03-25 2022-09-29 Cargill, Incorporated Fertilizer management

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8025A (en) * 1851-04-08 Apparatus eor boltiitg flouk
US4873191A (en) * 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4656134A (en) * 1982-01-11 1987-04-07 Board Of Trustees Of Leland Stanford Jr. University Gene amplification in eukaryotic cells
NL8200523A (nl) * 1982-02-11 1983-09-01 Univ Leiden Werkwijze voor het in vitro transformeren van planteprotoplasten met plasmide-dna.
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4441972A (en) * 1983-04-08 1984-04-10 D.E.P. Systems, Inc. Apparatus for electrofusion of biological particles
US4476004A (en) * 1983-04-08 1984-10-09 D.E.P. Systems, Inc. Apparatus for electrofusion of biological particles
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
US4806476A (en) * 1983-09-08 1989-02-21 Lovelace Medical Foundation Efficient cell fusion process
US4608339A (en) * 1983-10-25 1986-08-26 Yoakum George H Protoplast fusion method for high-frequency DNA transfection in human cells
US4736866B1 (en) * 1984-06-22 1988-04-12 Transgenic non-human mammals
FR2569723B1 (fr) * 1984-08-31 1986-09-19 Centre Nat Rech Scient Application des antibiotiques de la famille des phleomycines a titre d'agent de selection dans le domaine du genie genetique
US4686186A (en) * 1984-09-26 1987-08-11 Wisconsin Alumni Research Foundation Recombinant vector and eukaryotic host transformed thereby
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
US4970162A (en) * 1985-11-13 1990-11-13 The United States Of America As Represented By The Department Of Health And Human Services Human-mouse hybrid cell line expressing monocyte-macrophage properties
US4935350A (en) * 1985-11-18 1990-06-19 Amgen Materials and methods for controlling plasmid copy number and stability
US4784737A (en) * 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US4923814A (en) * 1986-05-09 1990-05-08 Electropore, Inc. High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
US4906576A (en) * 1986-05-09 1990-03-06 Electropore, Inc. High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
US5215914A (en) * 1986-06-18 1993-06-01 American Registry Of Pathology Adherent and invasive mycoplasma
US5364761A (en) * 1986-07-24 1994-11-15 Daiichi Pharmaceutical Co., Ltd. Method for isolating a DNA encoding an autonomously replicating sequence
US4801540A (en) * 1986-10-17 1989-01-31 Calgene, Inc. PG gene and its use in plants
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US4997764A (en) * 1987-04-23 1991-03-05 New York University Transformation of human B-lympocytes with Epstein Barr virus and c-myc containing vectors
US5063162A (en) * 1987-04-24 1991-11-05 Hoffmann-La Roche Inc. Process for isolating nucleic acids utilizing protease digestion
CA1297431C (en) * 1987-04-24 1992-03-17 F. Hoffmann-La Roche Ag Process for the isolation of nucleic acids
US4873316A (en) * 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
DE3730246A1 (de) * 1987-09-09 1989-06-01 Boehringer Mannheim Gmbh Expressionsvektor und verfahren zur expression von heterologen proteinen in saeugerzellen
WO1989006555A1 (en) * 1988-01-21 1989-07-27 Massachusetts Institute Of Technology Transport of molecules across tissue using electroporation
US4955378A (en) * 1988-05-02 1990-09-11 University Of South Florida Apparatus and methods for performing electrofusion at specific anatomical sites
US5162215A (en) * 1988-09-22 1992-11-10 Amgen Inc. Method of gene transfer into chickens and other avian species
GB8823068D0 (en) * 1988-09-30 1988-11-09 Ici Plc Recombinant dna
US5175384A (en) * 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5272262A (en) * 1989-06-21 1993-12-21 City Of Hope Method for the production of catalytic RNA in bacteria
US5144019A (en) * 1989-06-21 1992-09-01 City Of Hope Ribozyme cleavage of HIV-I RNA
US5501967A (en) * 1989-07-26 1996-03-26 Mogen International, N.V./Rijksuniversiteit Te Leiden Process for the site-directed integration of DNA into the genome of plants
US5550318A (en) * 1990-04-17 1996-08-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
GB8918226D0 (en) * 1989-08-09 1989-09-20 Wellcome Found Dna assays
US5434086A (en) * 1989-08-22 1995-07-18 The Regents Of The University Of Michigan Method of testing potential cystic fibrosis treating compounds using cells in culture
US5240846A (en) * 1989-08-22 1993-08-31 The Regents Of The University Of Michigan Gene therapy vector for cystic fibrosis
US5149796A (en) * 1989-08-31 1992-09-22 City Of Hope Chimeric DNA-RNA catalytic sequences
ATE199398T1 (de) * 1989-10-24 2001-03-15 Chiron Corp Sekretion vom mit gamma-interferon signalpeptid gebundenen humänen protein
AU6882791A (en) * 1989-11-22 1991-06-13 Children's Hospital Of Los Angeles Bcr/abl transgenic animals as models for philadelphia chromosome positive chronic myelogenous and acute lymphoblastic leukemia
US5292658A (en) * 1989-12-29 1994-03-08 University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center Cloning and expressions of Renilla luciferase
US5436392A (en) * 1990-01-12 1995-07-25 Arizona Technology Development Corporation Transgenic plants expressing M. sexta protease inhibitor
CA2042093C (en) * 1990-05-09 2002-12-24 Gyula Hadlaczky Cell line carrying an excess of mammalian centromeres
US5387742A (en) * 1990-06-15 1995-02-07 Scios Nova Inc. Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease
JPH06506105A (ja) * 1990-08-29 1994-07-14 ファーミング ビーブイ 哺乳動物細胞における相同性組換え
US5470730A (en) * 1990-09-28 1995-11-28 Immunex Method for producing TH -independent cytotoxic T lymphocytes
US5382524A (en) * 1990-10-24 1995-01-17 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-n-acetylgalactosaminidase
DK0506945T3 (da) * 1990-10-25 1999-04-26 Clague Pitman Hodgson Fremgangsmåde til genoverførsel under anvendelse af retrotransposoner
US5300431A (en) * 1991-02-26 1994-04-05 E. I. Du Pont De Nemours And Company Positive selection vector for the bacteriophage P1 cloning system
US5461032A (en) * 1991-03-01 1995-10-24 Fmc Corporation Insecticidally effective peptides
ATE204328T1 (de) * 1991-03-11 2001-09-15 Syngenta Ltd Biozide proteine
US5240840A (en) * 1991-04-05 1993-08-31 Regents Of The University Of Michigan Dna superfragment cloning
US5468634A (en) * 1991-06-24 1995-11-21 The University Of North Carolina At Chapel Hill Axl oncogene
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
US5288625A (en) * 1991-09-13 1994-02-22 Biologic Research Center Of The Hungarian Academy Of Sciences Mammalian artificial chromosomes
PH31293A (en) * 1991-10-10 1998-07-06 Rhone Poulenc Agrochimie Production of y-linolenic acid by a delta6-desaturage.
US5614393A (en) * 1991-10-10 1997-03-25 Rhone-Poulenc Agrochimie Production of γ-linolenic acid by a Δ6-desaturase
WO1993008270A1 (en) * 1991-10-15 1993-04-29 Agracetus, Inc. Particle-mediated transformation of mammalian unattached cells
US5246842A (en) * 1991-10-30 1993-09-21 The United States Of America As Represented By The Secretary Of Agriculture Production of eicosapentaenoic acid from filamentous fungi utilizing lactose as a primary carbon source
US5260191A (en) * 1992-01-30 1993-11-09 Agracetus, Inc. Method for diagnosing tumors
US5266600A (en) * 1992-02-28 1993-11-30 Bristol-Myers Squibb Company BU-4641V, an antibacterial, antiviral and antitumor antibiotic
JP3314241B2 (ja) * 1992-04-06 2002-08-12 ヤマハ発動機株式会社 自動二輪車用エンジンの排気浄化装置
US5501662A (en) * 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
EP0578627A1 (en) * 1992-07-09 1994-01-12 Monsanto Company Virus resistant plants
US5453357A (en) * 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5449604A (en) * 1992-10-21 1995-09-12 University Of Washington Chromosome 14 and familial Alzheimers disease genetic markers and assays
US5496731A (en) * 1993-03-25 1996-03-05 Xu; Hong-Ji Broad-spectrum tumor suppressor genes, gene products and methods for tumor suppressor gene therapy
US5468615A (en) * 1993-07-01 1995-11-21 The Upjohn Company Binding assay employing a synthetic gene for D4 dopamine receptors
US5413914A (en) * 1993-07-07 1995-05-09 The Regents Of The University Of Colorado Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases
US5457182A (en) * 1994-02-15 1995-10-10 Merck & Co., Inc. FK-506 cytosolic binding protein, FKBP12.6
IT1274168B (it) 1994-04-15 1997-07-15 Eniricerche Spa Vettore plasmidico e suo impiego per la produzione di proteine eterologhe
US5625130A (en) * 1995-03-07 1997-04-29 Pioneer Hi-Bred International, Inc. Oilseed Brassica bearing an endogenous oil wherein the levels of oleic, alpha-linolenic, and saturated fatty acids are simultaneously provided in an atypical highly beneficial distribution via genetic control
US5543319A (en) * 1995-03-31 1996-08-06 Fred Hutchinson Cancer Research Center Recombination-proficient avian/mammalian microcell hybrids
WO1997016533A1 (en) * 1995-10-31 1997-05-09 The Regents Of The University Of California Mammalian artificial chromosomes and methods of using same
US6133503A (en) * 1995-10-31 2000-10-17 The Regents Of The University Of California Mammalian artificial chromosomes and methods of using same
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6077697A (en) * 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
DK0935667T3 (da) 1996-07-23 2007-04-10 Nagase Chemtex Corp Fremgangsmåde til fremstilling af docosahexaensyre og docosapentaensyre
US5968809A (en) * 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US6051754A (en) * 1997-04-11 2000-04-18 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
ATE297994T1 (de) * 1997-04-11 2005-07-15 Calgene Llc Verfahren und zusammensetzungen für die synthese von langkettigen, mehrfach ungesättigten fettsäuren in pflanzen.
US6432684B1 (en) 1997-04-11 2002-08-13 Abbott Laboratories Human desaturase gene and uses thereof
US5972664A (en) * 1997-04-11 1999-10-26 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
GB9724783D0 (en) * 1997-11-24 1998-01-21 Inst Arable Crops Research Novel polypeptides
EP1042485A2 (en) * 1997-12-23 2000-10-11 University Of Bristol Desaturase
EP1086236B1 (en) 1998-06-12 2007-09-05 Calgene LLC Polyunsaturated fatty acids in plants
US6403349B1 (en) 1998-09-02 2002-06-11 Abbott Laboratories Elongase gene and uses thereof
WO2000020603A1 (en) * 1998-10-05 2000-04-13 Abbott Laboratories Altered fatty acid biosynthesis in insect cells using delta five desaturase
AU1097900A (en) 1998-10-05 2000-04-26 Abbott Laboratories Delta 6 and delta 12 desaturases and modified fatty acid biosynthesis and products produced therefrom
JP2002527051A (ja) 1998-10-09 2002-08-27 メルク エンド カムパニー インコーポレーテッド デルタ6脂肪酸デサチュラーゼ
ES2284286T5 (es) 1998-10-15 2011-01-03 Dsm Ip Assets B.V. Suplementos de pufa.
CA2791961A1 (en) 1998-12-07 2000-06-15 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
ES2286999T5 (es) 1999-03-04 2016-11-17 Suntory Holdings Limited Utilización de un material que contiene ácido docosapentaenoico
IL146782A0 (en) 1999-06-07 2002-07-25 Basf Plant Science Gmbh 6-acetylenase and 6-desaturase from ceratodon purpureus
JP3520328B2 (ja) 2000-10-06 2004-04-19 奈良先端科学技術大学院大学長 コーヒー属植物のテオブロミン合成酵素ポリペプチド及び当該ポリペプチドをコードする遺伝子
EP1392823B1 (en) * 2001-01-25 2011-11-30 Abbott Laboratories Desaturase genes and uses thereof
DE10137374A1 (de) * 2001-07-31 2003-02-27 Ipk Inst Fuer Pflanzengenetik Verfahren zur Herstellung von Arachidonsäure in transgenen Organismen
EP2302060B1 (en) 2002-03-16 2012-07-25 The University of York Desaturases
JP4732333B2 (ja) 2003-04-08 2011-07-27 ビーエーエスエフ プラント サイエンス ゲーエムベーハー ミドリムシ(Euglenagracilis)由来のΔ−4−デサチュラーゼを発現する植物およびPUFA含有油

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