JP2004513108A5 - - Google Patents

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Publication number
JP2004513108A5
JP2004513108A5 JP2002539315A JP2002539315A JP2004513108A5 JP 2004513108 A5 JP2004513108 A5 JP 2004513108A5 JP 2002539315 A JP2002539315 A JP 2002539315A JP 2002539315 A JP2002539315 A JP 2002539315A JP 2004513108 A5 JP2004513108 A5 JP 2004513108A5
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JP
Japan
Prior art keywords
ring
oxadiazol
compound according
alkyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002539315A
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English (en)
Japanese (ja)
Other versions
JP2004513108A (ja
JP3880051B2 (ja
Filing date
Publication date
Priority claimed from GB0026827A external-priority patent/GB0026827D0/en
Priority claimed from GB0122685A external-priority patent/GB0122685D0/en
Application filed filed Critical
Priority claimed from PCT/GB2001/004817 external-priority patent/WO2002036555A1/en
Publication of JP2004513108A publication Critical patent/JP2004513108A/ja
Publication of JP2004513108A5 publication Critical patent/JP2004513108A5/ja
Application granted granted Critical
Publication of JP3880051B2 publication Critical patent/JP3880051B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2002539315A 2000-11-02 2001-10-29 γ−セクレターゼ阻害剤としてのスルファミド Expired - Fee Related JP3880051B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0026827A GB0026827D0 (en) 2000-11-02 2000-11-02 Therapeutic agents
GB0122685A GB0122685D0 (en) 2001-09-20 2001-09-20 Therapeutic agents
PCT/GB2001/004817 WO2002036555A1 (en) 2000-11-02 2001-10-29 Sulfamides as gamma-secretase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006078136A Division JP4495686B2 (ja) 2000-11-02 2006-03-22 γ−セクレターゼ阻害剤としてのスルファミド

Publications (3)

Publication Number Publication Date
JP2004513108A JP2004513108A (ja) 2004-04-30
JP2004513108A5 true JP2004513108A5 (https=) 2006-05-18
JP3880051B2 JP3880051B2 (ja) 2007-02-14

Family

ID=26245228

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002539315A Expired - Fee Related JP3880051B2 (ja) 2000-11-02 2001-10-29 γ−セクレターゼ阻害剤としてのスルファミド
JP2006078136A Expired - Fee Related JP4495686B2 (ja) 2000-11-02 2006-03-22 γ−セクレターゼ阻害剤としてのスルファミド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2006078136A Expired - Fee Related JP4495686B2 (ja) 2000-11-02 2006-03-22 γ−セクレターゼ阻害剤としてのスルファミド

Country Status (9)

Country Link
US (1) US7138400B2 (https=)
EP (1) EP1334085B1 (https=)
JP (2) JP3880051B2 (https=)
AT (1) ATE302753T1 (https=)
AU (2) AU2002210747B2 (https=)
CA (1) CA2427206C (https=)
DE (1) DE60112957T2 (https=)
ES (1) ES2248397T3 (https=)
WO (1) WO2002036555A1 (https=)

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WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
US8859776B2 (en) 2009-10-14 2014-10-14 Merck Sharp & Dohme Corp. Substituted piperidines that increase p53 activity and the uses thereof
WO2011046774A1 (en) * 2009-10-16 2011-04-21 Merck Sharp & Dohme Corp. Diaryl ether derivatives as notch sparing gamma secretase inhibitors
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ(qc、ec2.3.2.5)の複素環阻害剤
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
US8999957B2 (en) 2010-06-24 2015-04-07 Merck Sharp & Dohme Corp. Heterocyclic compounds as ERK inhibitors
CA2805265A1 (en) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
WO2012024170A2 (en) 2010-08-17 2012-02-23 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2012030685A2 (en) 2010-09-01 2012-03-08 Schering Corporation Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
EP2654748B1 (en) 2010-12-21 2016-07-27 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
ES2389416B1 (es) * 2011-03-30 2013-09-16 Fundación Instituto Mediterraneo Para El Avance De La Biotecnología Y La Investigación Sanitaria (Imabis) Uso de derivados de sulfamidas como neuroprotectores.
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EP2770987B1 (en) 2011-10-27 2018-04-04 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
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CA2883896C (en) 2012-09-07 2023-03-07 Massachusetts Eye & Ear Infirmary Treating hearing loss
CA2884309A1 (en) 2012-09-07 2014-03-13 Massachusetts Eye And Ear Infirmary Methods and compositions for regenerating hair cells and/or supporting cells from differentiated cochlear cells or differentiated utricular cells by modulation of notch and cmyc activity
WO2014052563A2 (en) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
ME02925B (me) 2012-11-28 2018-04-20 Merck Sharp & Dohme Kompozicije i postupci za liječenje kancera
TW201429969A (zh) 2012-12-20 2014-08-01 Merck Sharp & Dohme 作爲hdm2抑制劑之經取代咪唑吡啶
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
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JP6840774B2 (ja) 2016-05-16 2021-03-10 ザ ジェネラル ホスピタル コーポレイション 肺上皮エンジニアリングにおけるヒト気道幹細胞
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JP7589247B2 (ja) 2019-12-17 2024-11-25 メルク・シャープ・アンド・ドーム・エルエルシー Prmt5阻害剤
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GB0209995D0 (en) * 2002-05-01 2002-06-12 Merck Sharp & Dohme Therapeutic agents
GB0209997D0 (en) * 2002-05-01 2002-06-12 Merck Sharp & Dohme Therapeutic agents
GB0209991D0 (en) * 2002-05-01 2002-06-12 Merck Sharp & Dohme Therapeutic agents
DE60328182D1 (de) * 2002-05-01 2009-08-13 Merck Sharp & Dohme Heteroaryl substituierte spirocyclische sulfamide zur hemmung von gamma sekretase

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