JP2004508357A5 - - Google Patents
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- Publication number
- JP2004508357A5 JP2004508357A5 JP2002525110A JP2002525110A JP2004508357A5 JP 2004508357 A5 JP2004508357 A5 JP 2004508357A5 JP 2002525110 A JP2002525110 A JP 2002525110A JP 2002525110 A JP2002525110 A JP 2002525110A JP 2004508357 A5 JP2004508357 A5 JP 2004508357A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- pyrrolidin
- compound according
- quinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 208000008589 Obesity Diseases 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- -1 methylenedioxy Chemical group 0.000 claims 4
- 235000020824 obesity Nutrition 0.000 claims 4
- 125000001544 thienyl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 229940086609 Lipase inhibitor Drugs 0.000 claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000030814 Eating disease Diseases 0.000 claims 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 208000001647 Renal Insufficiency Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 235000014632 disordered eating Nutrition 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical group CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 claims 2
- 229960001243 orlistat Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000004950 trifluoroalkyl group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- PBTSUCHVZHEYFX-UHFFFAOYSA-N 1-[3-(2-methyl-4-pyrrolidin-1-ylquinazolin-7-yl)phenyl]ethanone Chemical compound CC(=O)C1=CC=CC(C=2C=C3N=C(C)N=C(C3=CC=2)N2CCCC2)=C1 PBTSUCHVZHEYFX-UHFFFAOYSA-N 0.000 claims 1
- WLHTVHLJGMWRLP-UHFFFAOYSA-N 1-[4-(2-methyl-4-pyrrolidin-1-ylquinolin-7-yl)phenyl]ethanone Chemical compound C1=CC(C(=O)C)=CC=C1C1=CC=C(C(=CC(C)=N2)N3CCCC3)C2=C1 WLHTVHLJGMWRLP-UHFFFAOYSA-N 0.000 claims 1
- SVQUONYNVYWPAQ-UHFFFAOYSA-N 1-[5-(2-methyl-4-pyrrolidin-1-ylquinolin-7-yl)thiophen-2-yl]ethanone Chemical compound S1C(C(=O)C)=CC=C1C1=CC=C(C(=CC(C)=N2)N3CCCC3)C2=C1 SVQUONYNVYWPAQ-UHFFFAOYSA-N 0.000 claims 1
- ZEHYSJACCJZZFU-UHFFFAOYSA-N 2-methoxy-4-(2-methyl-4-pyrrolidin-1-ylquinolin-7-yl)phenol Chemical compound C1=C(O)C(OC)=CC(C=2C=C3N=C(C)C=C(C3=CC=2)N2CCCC2)=C1 ZEHYSJACCJZZFU-UHFFFAOYSA-N 0.000 claims 1
- ZKDKANVEYYIOHT-UHFFFAOYSA-N 2-methyl-4-piperidin-1-yl-7-[3-(trifluoromethyl)phenyl]quinoline Chemical compound C=12C=CC(C=3C=C(C=CC=3)C(F)(F)F)=CC2=NC(C)=CC=1N1CCCCC1 ZKDKANVEYYIOHT-UHFFFAOYSA-N 0.000 claims 1
- YHOOHRCDOSVZAJ-UHFFFAOYSA-N 2-methyl-4-pyrrolidin-1-yl-7-[3-(trifluoromethyl)phenyl]quinazoline Chemical compound C=12C=CC(C=3C=C(C=CC=3)C(F)(F)F)=CC2=NC(C)=NC=1N1CCCC1 YHOOHRCDOSVZAJ-UHFFFAOYSA-N 0.000 claims 1
- GWRLSUAPTXQGQZ-UHFFFAOYSA-N 2-methyl-4-pyrrolidin-1-yl-7-[3-(trifluoromethyl)phenyl]quinoline Chemical compound C=12C=CC(C=3C=C(C=CC=3)C(F)(F)F)=CC2=NC(C)=CC=1N1CCCC1 GWRLSUAPTXQGQZ-UHFFFAOYSA-N 0.000 claims 1
- QHMXVJPBDHKSNO-UHFFFAOYSA-N 2-methyl-4-pyrrolidin-1-yl-7-thiophen-2-ylquinoline Chemical compound C=12C=CC(C=3SC=CC=3)=CC2=NC(C)=CC=1N1CCCC1 QHMXVJPBDHKSNO-UHFFFAOYSA-N 0.000 claims 1
- DVUXOKQEIGQWDI-UHFFFAOYSA-N 2-methyl-7-naphthalen-2-yl-4-pyrrolidin-1-ylquinoline Chemical compound C=12C=CC(C=3C=C4C=CC=CC4=CC=3)=CC2=NC(C)=CC=1N1CCCC1 DVUXOKQEIGQWDI-UHFFFAOYSA-N 0.000 claims 1
- OXHZRYAWIMZYBS-UHFFFAOYSA-N 2-methyl-7-pyridin-3-yl-4-pyrrolidin-1-ylquinoline Chemical compound C=12C=CC(C=3C=NC=CC=3)=CC2=NC(C)=CC=1N1CCCC1 OXHZRYAWIMZYBS-UHFFFAOYSA-N 0.000 claims 1
- VHRDDHZYCJGTHE-UHFFFAOYSA-N 3-(2-methyl-4-pyrrolidin-1-ylquinazolin-7-yl)benzonitrile Chemical compound C=12C=CC(C=3C=C(C=CC=3)C#N)=CC2=NC(C)=NC=1N1CCCC1 VHRDDHZYCJGTHE-UHFFFAOYSA-N 0.000 claims 1
- IBDGJNBACMWLOR-UHFFFAOYSA-N 4-(azepan-1-yl)-2-methyl-7-[3-(trifluoromethyl)phenyl]quinazoline Chemical compound C=12C=CC(C=3C=C(C=CC=3)C(F)(F)F)=CC2=NC(C)=NC=1N1CCCCCC1 IBDGJNBACMWLOR-UHFFFAOYSA-N 0.000 claims 1
- HNZFUPVFLZIPGY-UHFFFAOYSA-N 4-(azepan-1-yl)-2-methyl-7-[3-(trifluoromethyl)phenyl]quinoline Chemical compound C=12C=CC(C=3C=C(C=CC=3)C(F)(F)F)=CC2=NC(C)=CC=1N1CCCCCC1 HNZFUPVFLZIPGY-UHFFFAOYSA-N 0.000 claims 1
- DEHDCLRPFIWCER-UHFFFAOYSA-N 5-(3-chlorophenyl)-2-methyl-4-piperidin-1-ylquinoline Chemical compound C=12C(C=3C=C(Cl)C=CC=3)=CC=CC2=NC(C)=CC=1N1CCCCC1 DEHDCLRPFIWCER-UHFFFAOYSA-N 0.000 claims 1
- WKPACHADPWHREV-UHFFFAOYSA-N 7-(3,4-dichlorophenyl)-2-methyl-4-pyrrolidin-1-ylquinoline Chemical compound C=12C=CC(C=3C=C(Cl)C(Cl)=CC=3)=CC2=NC(C)=CC=1N1CCCC1 WKPACHADPWHREV-UHFFFAOYSA-N 0.000 claims 1
- GGSPYNHXXJFFLS-UHFFFAOYSA-N 7-(3,5-dichlorophenyl)-2-methyl-4-pyrrolidin-1-ylquinoline Chemical compound C=12C=CC(C=3C=C(Cl)C=C(Cl)C=3)=CC2=NC(C)=CC=1N1CCCC1 GGSPYNHXXJFFLS-UHFFFAOYSA-N 0.000 claims 1
- DTYNDESCRADOCW-UHFFFAOYSA-N 7-(3-chloro-4-fluorophenyl)-2-methyl-4-pyrrolidin-1-ylquinoline Chemical compound C=12C=CC(C=3C=C(Cl)C(F)=CC=3)=CC2=NC(C)=CC=1N1CCCC1 DTYNDESCRADOCW-UHFFFAOYSA-N 0.000 claims 1
- FIQCWGFEPZLCIE-UHFFFAOYSA-N 7-(3-chlorophenyl)-2-methyl-4-pyrrolidin-1-ylquinazoline Chemical compound C=12C=CC(C=3C=C(Cl)C=CC=3)=CC2=NC(C)=NC=1N1CCCC1 FIQCWGFEPZLCIE-UHFFFAOYSA-N 0.000 claims 1
- MPAWSOPNRWJEAL-UHFFFAOYSA-N 7-(3-chlorophenyl)-2-methyl-4-pyrrolidin-1-ylquinoline Chemical compound C=12C=CC(C=3C=C(Cl)C=CC=3)=CC2=NC(C)=CC=1N1CCCC1 MPAWSOPNRWJEAL-UHFFFAOYSA-N 0.000 claims 1
- ASAMDAHECQCGAB-UHFFFAOYSA-N 7-(4-methoxyphenyl)-2-methyl-4-pyrrolidin-1-ylquinoline Chemical compound C1=CC(OC)=CC=C1C1=CC=C(C(=CC(C)=N2)N3CCCC3)C2=C1 ASAMDAHECQCGAB-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 229940127470 Lipase Inhibitors Drugs 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000003725 azepanyl group Chemical group 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 238000006880 cross-coupling reaction Methods 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00119262 | 2000-09-06 | ||
| PCT/EP2001/010014 WO2002020488A2 (en) | 2000-09-06 | 2001-08-30 | Quinoline and quinazoline derivatives as ligands for the neuropeptide y receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004508357A JP2004508357A (ja) | 2004-03-18 |
| JP2004508357A5 true JP2004508357A5 (enExample) | 2005-03-17 |
Family
ID=8169763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002525110A Pending JP2004508357A (ja) | 2000-09-06 | 2001-08-30 | キノリンおよびキナゾリン誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6900226B2 (enExample) |
| EP (1) | EP1318981A2 (enExample) |
| JP (1) | JP2004508357A (enExample) |
| KR (1) | KR100621272B1 (enExample) |
| CN (1) | CN1274676C (enExample) |
| AR (1) | AR030596A1 (enExample) |
| AU (2) | AU1047402A (enExample) |
| BR (1) | BR0113710A (enExample) |
| CA (1) | CA2420703A1 (enExample) |
| GT (1) | GT200100183A (enExample) |
| MX (1) | MXPA03001928A (enExample) |
| PA (1) | PA8528401A1 (enExample) |
| PE (1) | PE20020485A1 (enExample) |
| UY (1) | UY26926A1 (enExample) |
| WO (1) | WO2002020488A2 (enExample) |
| ZA (1) | ZA200301719B (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002338896B2 (en) * | 2001-05-21 | 2006-04-27 | F.Hoffman-La Roche Ag | Quinoline derivatives as ligands for the neuropeptide Y receptor |
| GB0121709D0 (en) * | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
| HU228621B1 (en) * | 2001-09-24 | 2013-04-29 | Univ Oregon Health & Science | Modification of feeding behavior |
| US6787558B2 (en) | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
| US8058233B2 (en) * | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
| BR0307441A (pt) * | 2002-02-04 | 2005-01-04 | Hoffmann La Roche | Compostos, processo para a preparação de um composto, composição farmacêutica, utilização desses compostos, método para o tratamento e profilaxia de enfermidades e método para o tratamento de obesidade |
| WO2003077847A2 (en) | 2002-03-12 | 2003-09-25 | Merck & Co., Inc. | Substituted amides |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| EP1560816A1 (en) | 2002-07-05 | 2005-08-10 | F. Hoffmann-La Roche Ag | Quinazoline derivatives |
| CA2493712A1 (en) | 2002-08-07 | 2004-02-19 | F. Hoffmann-La Roche Ag | Aminothiazole derivatives as npy5 receptor inhibitors |
| EP1571146A4 (en) * | 2002-12-10 | 2010-09-01 | Ono Pharmaceutical Co | NITROGENIC HETEROCYCLIC COMPOUNDS AND THEIR MEDICAL USE |
| US7166575B2 (en) * | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
| GB0300571D0 (en) * | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EP1601357A4 (en) * | 2003-03-10 | 2007-10-03 | Schering Corp | HETEROCYCLIC KINASE INHIBITORS: METHOD OF USE AND SYNTHESIS |
| KR20050122220A (ko) | 2003-03-25 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 디펩티딜 펩티다제 억제제 |
| CA2535619A1 (en) | 2003-08-13 | 2005-02-24 | Takeda Pharmaceutical Company Limited | 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors |
| US7790734B2 (en) | 2003-09-08 | 2010-09-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2005028438A1 (ja) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | 新規ピペリジン誘導体 |
| JP2007510745A (ja) | 2003-11-10 | 2007-04-26 | シンタ ファーマシューティカルズ コーポレーション | 縮合複素環式化合物 |
| CA2559302C (en) | 2004-03-15 | 2012-06-19 | Takeda Pharmaceutical Company Limited | 6-amino-1h-pyrimidine-2,4-dione derivatives as dipeptidyl peptidase inhibitors |
| EP2305352A1 (en) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
| US7718658B2 (en) * | 2004-09-02 | 2010-05-18 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US8283354B2 (en) * | 2004-09-02 | 2012-10-09 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| EP1812409A1 (en) * | 2004-11-09 | 2007-08-01 | F. Hoffmann-Roche AG | Aminoquinazolines compounds |
| WO2006068978A2 (en) | 2004-12-21 | 2006-06-29 | Takeda Pharmaceutial Company Limited | Dipeptidyl peptidase inhibitors |
| WO2006129826A1 (ja) | 2005-05-30 | 2006-12-07 | Banyu Pharmaceutical Co., Ltd. | 新規ピペリジン誘導体 |
| GB0511986D0 (en) * | 2005-06-13 | 2005-07-20 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| CA2618112A1 (en) | 2005-08-10 | 2007-02-15 | Banyu Pharmaceutical Co., Ltd. | Pyridone compound |
| EP1921065B1 (en) | 2005-08-24 | 2010-10-20 | Banyu Pharmaceutical Co., Ltd. | Phenylpyridone derivative |
| WO2007029847A1 (ja) | 2005-09-07 | 2007-03-15 | Banyu Pharmaceutical Co., Ltd. | 二環性芳香族置換ピリドン誘導体 |
| ES2376351T5 (es) | 2005-09-14 | 2014-07-15 | Takeda Pharmaceutical Company Limited | Inhibidores de la dipeptidil-peptidasa para el tratamiento de la diabetes |
| CN102675221A (zh) | 2005-09-16 | 2012-09-19 | 武田药品工业株式会社 | 用于制备嘧啶二酮衍生物的方法中的中间体 |
| BRPI0617621A2 (pt) | 2005-10-21 | 2011-08-02 | Novartis Ag | combinação de compostos orgánicos |
| AU2006307046A1 (en) | 2005-10-27 | 2007-05-03 | Msd K.K. | Novel benzoxathiin derivative |
| CA2629018C (en) | 2005-11-10 | 2013-12-31 | Banyu Pharmaceutical Co., Ltd. | Aza-substituted spiro derivative |
| US7678803B2 (en) * | 2006-08-24 | 2010-03-16 | Serenex, Inc. | Quinazoline derivatives for the treatment of cancer |
| US8027888B2 (en) * | 2006-08-31 | 2011-09-27 | Experian Interactive Innovation Center, Llc | Online credit card prescreen systems and methods |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| CA2664358A1 (en) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diarylketimine derivative |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| TWI428346B (zh) * | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| CA2682727C (en) | 2007-04-02 | 2016-03-22 | Banyu Pharmaceutical Co., Ltd. | Indoledione derivative |
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| ES2559319T3 (es) | 2007-06-04 | 2016-02-11 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| JPWO2009110510A1 (ja) | 2008-03-06 | 2011-07-14 | Ｍｓｄ株式会社 | アルキルアミノピリジン誘導体 |
| US20110015198A1 (en) | 2008-03-28 | 2011-01-20 | Banyu Pharmaceutical Co., Inc. | Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US20110071129A1 (en) | 2008-06-19 | 2011-03-24 | Makoto Ando | Spirodiamine-diaryl ketoxime derivative |
| WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| EP2319841A1 (en) | 2008-07-30 | 2011-05-11 | Msd K.K. | (5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative |
| US20110178041A1 (en) * | 2008-09-25 | 2011-07-21 | Yasushi Kohno | Heterocyclic biaryl derivative and pde inhibitor comprising same as active ingredient |
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-
2001
- 2001-08-27 US US09/939,883 patent/US6900226B2/en not_active Expired - Fee Related
- 2001-08-30 AU AU1047402A patent/AU1047402A/xx active Pending
- 2001-08-30 CN CNB018134610A patent/CN1274676C/zh not_active Expired - Fee Related
- 2001-08-30 BR BR0113710-7A patent/BR0113710A/pt not_active IP Right Cessation
- 2001-08-30 EP EP01978324A patent/EP1318981A2/en not_active Withdrawn
- 2001-08-30 CA CA002420703A patent/CA2420703A1/en not_active Abandoned
- 2001-08-30 KR KR1020037003252A patent/KR100621272B1/ko not_active Expired - Fee Related
- 2001-08-30 JP JP2002525110A patent/JP2004508357A/ja active Pending
- 2001-08-30 MX MXPA03001928A patent/MXPA03001928A/es not_active Application Discontinuation
- 2001-08-30 AU AU2002210474A patent/AU2002210474B2/en not_active Ceased
- 2001-08-30 WO PCT/EP2001/010014 patent/WO2002020488A2/en not_active Ceased
- 2001-09-04 PA PA20018528401A patent/PA8528401A1/es unknown
- 2001-09-04 AR ARP010104191A patent/AR030596A1/es unknown
- 2001-09-05 UY UY26926A patent/UY26926A1/es not_active Application Discontinuation
- 2001-09-05 GT GT200100183A patent/GT200100183A/es unknown
- 2001-09-05 PE PE2001000891A patent/PE20020485A1/es not_active Application Discontinuation
-
2003
- 2003-02-28 ZA ZA200301719A patent/ZA200301719B/en unknown
-
2005
- 2005-04-07 US US11/100,938 patent/US7265125B2/en not_active Expired - Fee Related
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