JP2004508292A5 - - Google Patents
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- JP2004508292A5 JP2004508292A5 JP2001586316A JP2001586316A JP2004508292A5 JP 2004508292 A5 JP2004508292 A5 JP 2004508292A5 JP 2001586316 A JP2001586316 A JP 2001586316A JP 2001586316 A JP2001586316 A JP 2001586316A JP 2004508292 A5 JP2004508292 A5 JP 2004508292A5
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- JP
- Japan
- Prior art keywords
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- independently selected
- twenty
- compounds
- acyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 description 34
- 150000001875 compounds Chemical class 0.000 description 18
- 125000002252 acyl group Chemical group 0.000 description 12
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- 239000004094 surface-active agent Substances 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 6
- -1 n-tetradecanoyl Chemical group 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- SLKDGVPOSSLUAI-PGUFJCEWSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCCCC SLKDGVPOSSLUAI-PGUFJCEWSA-N 0.000 description 4
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 4
- YFWHNAWEOZTIPI-DIPNUNPCSA-N 1,2-dioctadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCCCC YFWHNAWEOZTIPI-DIPNUNPCSA-N 0.000 description 4
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 description 4
- LVNGJLRDBYCPGB-UHFFFAOYSA-N 1,2-distearoylphosphatidylethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)OCC[NH3+])OC(=O)CCCCCCCCCCCCCCCCC LVNGJLRDBYCPGB-UHFFFAOYSA-N 0.000 description 4
- BIABMEZBCHDPBV-MPQUPPDSSA-N 1,2-palmitoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-MPQUPPDSSA-N 0.000 description 4
- NEZDNQCXEZDCBI-UHFFFAOYSA-N 2-azaniumylethyl 2,3-di(tetradecanoyloxy)propyl phosphate Chemical compound CCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCC NEZDNQCXEZDCBI-UHFFFAOYSA-N 0.000 description 4
- FVJZSBGHRPJMMA-IOLBBIBUSA-N PG(18:0/18:0) Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-IOLBBIBUSA-N 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 description 2
- OZSITQMWYBNPMW-GDLZYMKVSA-N 1,2-ditetradecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCC OZSITQMWYBNPMW-GDLZYMKVSA-N 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000016396 cytokine production Effects 0.000 description 2
- 229960003724 dimyristoylphosphatidylcholine Drugs 0.000 description 2
- 229960005160 dimyristoylphosphatidylglycerol Drugs 0.000 description 2
- BPHQZTVXXXJVHI-AJQTZOPKSA-N ditetradecanoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-AJQTZOPKSA-N 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 0 CCCCCCCCCCCC(*)CC(N(C)CC*)=O Chemical compound CCCCCCCCCCCC(*)CC(N(C)CC*)=O 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20582000P | 2000-05-19 | 2000-05-19 | |
| US60/205,820 | 2000-05-19 | ||
| US28156701P | 2001-04-04 | 2001-04-04 | |
| US60/281,567 | 2001-04-04 | ||
| PCT/US2001/016327 WO2001090129A2 (en) | 2000-05-19 | 2001-05-18 | Prophylactic and therapeutic treatment of infectious, autoimmune and allergic diseases with mono and disaccharide-base compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004508292A JP2004508292A (ja) | 2004-03-18 |
| JP2004508292A5 true JP2004508292A5 (https=) | 2008-07-10 |
| JP5004261B2 JP5004261B2 (ja) | 2012-08-22 |
Family
ID=26900794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001586316A Expired - Lifetime JP5004261B2 (ja) | 2000-05-19 | 2001-05-18 | 単糖類及び二糖類に基づく化合物を用いた感染症及び他の疾患の予防的並びに治療的な処置 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6800613B2 (https=) |
| EP (2) | EP2000144A1 (https=) |
| JP (1) | JP5004261B2 (https=) |
| KR (1) | KR100829674B1 (https=) |
| CN (1) | CN1606446A (https=) |
| AT (1) | ATE395923T1 (https=) |
| AU (3) | AU2001269695B2 (https=) |
| BR (1) | BR0110975A (https=) |
| CA (1) | CA2409221C (https=) |
| CY (1) | CY1108211T1 (https=) |
| DE (1) | DE60134134D1 (https=) |
| DK (1) | DK1284740T3 (https=) |
| ES (1) | ES2305086T3 (https=) |
| HU (1) | HU230847B1 (https=) |
| IL (3) | IL152935A0 (https=) |
| MX (1) | MXPA02011486A (https=) |
| NO (1) | NO331939B1 (https=) |
| NZ (1) | NZ522755A (https=) |
| PL (1) | PL206832B1 (https=) |
| PT (1) | PT1284740E (https=) |
| WO (1) | WO2001090129A2 (https=) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040006242A1 (en) * | 1999-02-01 | 2004-01-08 | Hawkins Lynn D. | Immunomodulatory compounds and method of use thereof |
| US7915238B2 (en) | 1999-02-01 | 2011-03-29 | Eisai R & D Management Co., Ltd. | Immunomodulatory compounds and methods of use thereof |
| US6835721B2 (en) | 1999-02-01 | 2004-12-28 | Eisai Co., Ltd. | Immunomodulatory compounds and methods of use thereof |
| US20030105032A1 (en) * | 2000-05-19 | 2003-06-05 | Persing David H. | Phophylactic and therapeutic treatment of infectious and other diseases with mono-and disaccharide-based compounds |
| US7709451B2 (en) * | 2001-09-07 | 2010-05-04 | Trustees Of Boston University | Method and composition for treating immune complex associated disorders |
| EP1302206A1 (en) * | 2001-10-11 | 2003-04-16 | Universitair Medisch Centrum Utrecht | Methods and means for the use of the adventitial toll-like receptor |
| US6911434B2 (en) | 2002-02-04 | 2005-06-28 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
| JP2005523902A (ja) | 2002-02-04 | 2005-08-11 | コリクサ コーポレイション | 感染症及び他の疾患の免疫効果化合物による予防及び治療処理 |
| RU2340621C2 (ru) | 2002-07-08 | 2008-12-10 | Корикса Корпорейшн | Способы получения аминоалкилглюкозаминидфосфатов и дисахаридных иммуноэффекторов и их промежуточных соединений |
| US7960522B2 (en) | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| CA2512108C (en) | 2003-01-06 | 2013-04-02 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| WO2005089122A2 (en) * | 2004-03-05 | 2005-09-29 | Mayo Foundation For Medical Education And Research | Animals with reduced body fat and increased bone density |
| AU2006207998A1 (en) | 2005-01-27 | 2006-08-03 | Novartis Vaccines And Diagnostics Inc. | A method for characterizing the efficacy of an agent targeting a primary cystic fibrosis defect |
| EP1874342B1 (en) | 2005-04-26 | 2018-06-06 | Eisai R&D Management Co., Ltd. | Compositions and methods for cancer immunotherapy |
| GB0510463D0 (en) * | 2005-05-23 | 2005-06-29 | Britania Pharmaceuticals Ltd | Improvements in or relating to organic materials |
| US7622128B2 (en) * | 2005-12-13 | 2009-11-24 | University Of Washington | Porphyromonas gingivalis 1435/1449 LPS as an immune modulator |
| PT2468300T (pt) | 2006-09-26 | 2018-01-30 | Infectious Disease Res Inst | Composição para vacina contendo adjuvante sintético |
| US20090181078A1 (en) * | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| US20090215710A1 (en) * | 2007-09-24 | 2009-08-27 | Reliance Life Sciences Pvt. Ltd. | Carbohydrate based toll-like receptor (tlr) antagonists |
| US20090136509A1 (en) * | 2007-10-31 | 2009-05-28 | Simon Blake | Use of Toll-Like Receptor 4 Antagonists for the Treatment or Prevention of Osteoarthritic Conditions |
| CN102481312B (zh) | 2009-06-05 | 2015-07-15 | 传染性疾病研究院 | 合成的吡喃葡萄糖脂佐剂 |
| EP2550362B1 (en) | 2010-03-25 | 2017-01-04 | Oregon Health&Science University | Cmv glycoproteins and recombinant vectors |
| DK2618842T3 (da) | 2010-09-22 | 2019-07-01 | Ena Therapeutics Pty Ltd | Hidtil ukendt immunstimulerende fremgangsmåde |
| GB201101331D0 (en) | 2011-01-26 | 2011-03-09 | Glaxosmithkline Biolog Sa | Compositions and uses |
| CA2832109C (en) | 2011-06-10 | 2021-07-06 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| EP2568289A3 (en) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| US9241988B2 (en) * | 2012-04-12 | 2016-01-26 | Avanti Polar Lipids, Inc. | Disaccharide synthetic lipid compounds and uses thereof |
| KR102136433B1 (ko) | 2012-05-16 | 2020-07-22 | 이뮨 디자인 코포레이션 | Hsv-2 백신 |
| EP2679596B1 (en) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 env glycoprotein variant |
| ES2743465T3 (es) | 2013-03-15 | 2020-02-19 | Glaxosmithkline Biologicals Sa | Composición que contiene derivados fosfato de aminoalquil glucosaminida tamponados y su uso para potenciar una respuesta inmunitaria |
| EP2986303B1 (en) | 2013-04-18 | 2020-02-26 | Immune Design Corp. | Gla monotherapy for use in cancer treatment |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| KR20160127828A (ko) | 2014-03-12 | 2016-11-04 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 면역원성 리포솜 제형 |
| KR20160132088A (ko) | 2014-03-12 | 2016-11-16 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 점막 전달용 리포솜 조성물 |
| MA41414A (fr) | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | Protéines de liaison agonistes d' icos |
| EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| WO2017013603A1 (en) | 2015-07-21 | 2017-01-26 | Glaxosmithkline Biologicals Sa | Adjuntive immunotherapy for the prevention or treatment of infectious disease |
| WO2017021912A1 (en) | 2015-08-06 | 2017-02-09 | Glaxosmithkline Intellectual Property Development Limited | Combined tlrs modulators with anti ox40 antibodies |
| EP3331565A1 (en) | 2015-08-06 | 2018-06-13 | GlaxoSmithKline Intellectual Property Development Ltd | Tlr4 agonists and compositions thereof and their use in the treatment of cancer |
| TW201716084A (zh) | 2015-08-06 | 2017-05-16 | 葛蘭素史克智慧財產發展有限公司 | 組合物及其用途與治療 |
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| JP2019510802A (ja) | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | タンパク質調節物質として有用な複素環アミド |
| HRP20220936T1 (hr) | 2016-04-07 | 2022-10-28 | Glaxosmithkline Intellectual Property Development Limited | Heterociklički amidi korisni kao modulatori proteina |
| CA3023157A1 (en) | 2016-05-05 | 2017-11-09 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
| JP2019521166A (ja) | 2016-07-20 | 2019-07-25 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｐｅｒｋ阻害剤としてのイソキノリン誘導体 |
| KR20190090824A (ko) | 2016-12-01 | 2019-08-02 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 암을 치료하는 방법 |
| US11389465B2 (en) | 2017-05-01 | 2022-07-19 | Vanderbilt University | Phosphorylated hexaacyl disaccharides (PHADs) for treating or preventing infections |
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| US20210238172A1 (en) | 2017-10-05 | 2021-08-05 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators and methods of using the same |
| EP3728289B1 (en) | 2017-12-21 | 2025-09-10 | Axelia Oncology Pty Ltd | Optimised compounds |
| ES2985591T3 (es) | 2018-02-12 | 2024-11-06 | Inimmune Corp | Ligandos de receptores tipo Toll |
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-
2001
- 2001-05-18 EP EP08153476A patent/EP2000144A1/en not_active Withdrawn
- 2001-05-18 PL PL365169A patent/PL206832B1/pl not_active IP Right Cessation
- 2001-05-18 CN CNA018114881A patent/CN1606446A/zh active Pending
- 2001-05-18 DE DE60134134T patent/DE60134134D1/de not_active Expired - Lifetime
- 2001-05-18 HU HU0301815A patent/HU230847B1/hu unknown
- 2001-05-18 WO PCT/US2001/016327 patent/WO2001090129A2/en not_active Ceased
- 2001-05-18 PT PT01948222T patent/PT1284740E/pt unknown
- 2001-05-18 KR KR1020027015626A patent/KR100829674B1/ko not_active Expired - Lifetime
- 2001-05-18 JP JP2001586316A patent/JP5004261B2/ja not_active Expired - Lifetime
- 2001-05-18 AT AT01948222T patent/ATE395923T1/de active
- 2001-05-18 MX MXPA02011486A patent/MXPA02011486A/es active IP Right Grant
- 2001-05-18 BR BR0110975-8A patent/BR0110975A/pt not_active IP Right Cessation
- 2001-05-18 CA CA2409221A patent/CA2409221C/en not_active Expired - Lifetime
- 2001-05-18 AU AU2001269695A patent/AU2001269695B2/en not_active Expired
- 2001-05-18 NZ NZ522755A patent/NZ522755A/en not_active IP Right Cessation
- 2001-05-18 DK DK01948222T patent/DK1284740T3/da active
- 2001-05-18 IL IL15293501A patent/IL152935A0/xx unknown
- 2001-05-18 ES ES01948222T patent/ES2305086T3/es not_active Expired - Lifetime
- 2001-05-18 EP EP01948222A patent/EP1284740B1/en not_active Expired - Lifetime
- 2001-05-18 US US09/861,466 patent/US6800613B2/en not_active Expired - Lifetime
- 2001-05-18 AU AU6969501A patent/AU6969501A/xx active Pending
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2002
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2007
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