JP2004505986A5 - - Google Patents

Info

Publication number

JP2004505986A5

JP2004505986A5 JP2002518232A JP2002518232A JP2004505986A5 JP 2004505986 A5 JP2004505986 A5 JP 2004505986A5 JP 2002518232 A JP2002518232 A JP 2002518232A JP 2002518232 A JP2002518232 A JP 2002518232A JP 2004505986 A5 JP2004505986 A5 JP 2004505986A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

compound

group

composition according

antigen

Prior art date

2001-08-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 239000008194 pharmaceutical composition Substances 0.000 claims description 27
• 150000001875 compounds Chemical class 0.000 claims description 24
• 239000000427 antigen Substances 0.000 claims description 12
• 102000036639 antigens Human genes 0.000 claims description 12
• 108091007433 antigens Proteins 0.000 claims description 12
• 238000000034 method Methods 0.000 claims description 9
• 239000000203 mixture Substances 0.000 claims description 8
• 239000004094 surface-active agent Substances 0.000 claims description 8
• PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims description 5
• 239000013011 aqueous formulation Substances 0.000 claims description 5
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 4
• KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 4
• SLKDGVPOSSLUAI-PGUFJCEWSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCCCC SLKDGVPOSSLUAI-PGUFJCEWSA-N 0.000 claims description 4
• YFWHNAWEOZTIPI-DIPNUNPCSA-N 1,2-dioctadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCCCC YFWHNAWEOZTIPI-DIPNUNPCSA-N 0.000 claims description 4
• BIABMEZBCHDPBV-MPQUPPDSSA-N 1,2-palmitoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-MPQUPPDSSA-N 0.000 claims description 4
• NEZDNQCXEZDCBI-UHFFFAOYSA-N 2-azaniumylethyl 2,3-di(tetradecanoyloxy)propyl phosphate Chemical compound CCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCC NEZDNQCXEZDCBI-UHFFFAOYSA-N 0.000 claims description 4
• FVJZSBGHRPJMMA-IOLBBIBUSA-N PG(18:0/18:0) Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-IOLBBIBUSA-N 0.000 claims description 4
• NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims description 3
• 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
• BUHVIAUBTBOHAG-FOYDDCNASA-N (2r,3r,4s,5r)-2-[6-[[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound COC1=CC(OC)=CC(C(CNC=2C=3N=CN(C=3N=CN=2)[C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)C=2C(=CC=CC=2)C)=C1 BUHVIAUBTBOHAG-FOYDDCNASA-N 0.000 claims description 2
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 2
• CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 claims description 2
• OZSITQMWYBNPMW-GDLZYMKVSA-N 1,2-ditetradecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCC OZSITQMWYBNPMW-GDLZYMKVSA-N 0.000 claims description 2
• JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims description 2
• 125000002252 acyl group Chemical group 0.000 claims description 2
• 125000000217 alkyl group Chemical group 0.000 claims description 2
• 229960003724 dimyristoylphosphatidylcholine Drugs 0.000 claims description 2
• 229960005160 dimyristoylphosphatidylglycerol Drugs 0.000 claims description 2
• BPHQZTVXXXJVHI-AJQTZOPKSA-N ditetradecanoyl phosphatidylglycerol Chemical group CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-AJQTZOPKSA-N 0.000 claims description 2
• 239000000839 emulsion Substances 0.000 claims description 2
• 230000028993 immune response Effects 0.000 claims description 2
• 230000001939 inductive effect Effects 0.000 claims description 2
• WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 2
• 150000008104 phosphatidylethanolamines Chemical class 0.000 claims description 2
• 150000003904 phospholipids Chemical class 0.000 claims description 2
• 150000003839 salts Chemical class 0.000 claims description 2
• 208000028867 ischemia Diseases 0.000 claims 5
• 208000023275 Autoimmune disease Diseases 0.000 claims 3
• 241001465754 Metazoa Species 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 3
• LVNGJLRDBYCPGB-UHFFFAOYSA-N 1,2-distearoylphosphatidylethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)OCC[NH3+])OC(=O)CCCCCCCCCCCCCCCCC LVNGJLRDBYCPGB-UHFFFAOYSA-N 0.000 claims 2
• 241000124008 Mammalia Species 0.000 claims 2
• MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 2
• PCLFEHAPITXKJL-UHFFFAOYSA-N 5,8-dihydroxy-2-[2-(4-methoxyphenyl)ethyl]chromen-4-one Chemical compound C1=CC(OC)=CC=C1CCC1=CC(=O)C2=C(O)C=CC(O)=C2O1 PCLFEHAPITXKJL-UHFFFAOYSA-N 0.000 claims 1
• 241000588807 Bordetella Species 0.000 claims 1
• 241000589968 Borrelia Species 0.000 claims 1
• 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
• 241000606161 Chlamydia Species 0.000 claims 1
• 241000605314 Ehrlichia Species 0.000 claims 1
• 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 1
• 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 1
• 241000701024 Human betaherpesvirus 5 Species 0.000 claims 1
• 241000701806 Human papillomavirus Species 0.000 claims 1
• 208000004554 Leishmaniasis Diseases 0.000 claims 1
• 208000016604 Lyme disease Diseases 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
• 241000588653 Neisseria Species 0.000 claims 1
• 241000224016 Plasmodium Species 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 241000725643 Respiratory syncytial virus Species 0.000 claims 1
• 241000607142 Salmonella Species 0.000 claims 1
• 241000580858 Simian-Human immunodeficiency virus Species 0.000 claims 1
• 241000223996 Toxoplasma Species 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 1
• AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
• 230000001668 ameliorated effect Effects 0.000 claims 1
• 210000004556 brain Anatomy 0.000 claims 1
• 210000000481 breast Anatomy 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000000969 carrier Substances 0.000 claims 1
• 210000001072 colon Anatomy 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 210000003128 head Anatomy 0.000 claims 1
• 208000006454 hepatitis Diseases 0.000 claims 1
• 231100000283 hepatitis Toxicity 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 206010028417 myasthenia gravis Diseases 0.000 claims 1
• 210000003739 neck Anatomy 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 210000000496 pancreas Anatomy 0.000 claims 1
• 230000001717 pathogenic effect Effects 0.000 claims 1
• 210000002307 prostate Anatomy 0.000 claims 1
• 230000010410 reperfusion Effects 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 241000712461 unidentified influenza virus Species 0.000 claims 1
• LVNGJLRDBYCPGB-LDLOPFEMSA-N (R)-1,2-distearoylphosphatidylethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[NH3+])OC(=O)CCCCCCCCCCCCCCCCC LVNGJLRDBYCPGB-LDLOPFEMSA-N 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 239000000126 substance Substances 0.000 description 1