JP2004507540A5 - - Google Patents
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- Publication number
- JP2004507540A5 JP2004507540A5 JP2002523894A JP2002523894A JP2004507540A5 JP 2004507540 A5 JP2004507540 A5 JP 2004507540A5 JP 2002523894 A JP2002523894 A JP 2002523894A JP 2002523894 A JP2002523894 A JP 2002523894A JP 2004507540 A5 JP2004507540 A5 JP 2004507540A5
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- JP
- Japan
- Prior art keywords
- formula
- alkyl
- compound
- contacting
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- -1 (1,1-dimethyl-2-hydroxy) ethyl Chemical group 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- BWESROVQGZSBRX-UHFFFAOYSA-N pyrido[3,2-d]pyrimidine Chemical compound C1=NC=NC2=CC=CN=C21 BWESROVQGZSBRX-UHFFFAOYSA-N 0.000 claims 4
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 3
- 229940100198 alkylating agent Drugs 0.000 claims 3
- 239000002168 alkylating agent Substances 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical class NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical class [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 230000002152 alkylating effect Effects 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 239000007859 condensation product Substances 0.000 claims 2
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical class [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 2
- XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims 1
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
- SDTMFDGELKWGFT-UHFFFAOYSA-N 2-methylpropan-2-olate Chemical group CC(C)(C)[O-] SDTMFDGELKWGFT-UHFFFAOYSA-N 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 150000004703 alkoxides Chemical class 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 1
- 230000000414 obstructive effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 150000003230 pyrimidines Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22957700P | 2000-08-31 | 2000-08-31 | |
| PCT/EP2001/009688 WO2002018379A2 (en) | 2000-08-31 | 2001-08-22 | 7-oxo pyridopyrimidines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004507540A JP2004507540A (ja) | 2004-03-11 |
| JP2004507540A5 true JP2004507540A5 (https=) | 2005-03-17 |
| JP4146721B2 JP4146721B2 (ja) | 2008-09-10 |
Family
ID=22861834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002523894A Expired - Fee Related JP4146721B2 (ja) | 2000-08-31 | 2001-08-22 | ７−オキソ−ピリドピリミジン類 |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1315727B1 (https=) |
| JP (1) | JP4146721B2 (https=) |
| KR (1) | KR100582325B1 (https=) |
| CN (2) | CN100358892C (https=) |
| AR (1) | AR033996A1 (https=) |
| AT (1) | ATE298751T1 (https=) |
| AU (2) | AU2002212147B2 (https=) |
| BR (1) | BR0113590A (https=) |
| CA (1) | CA2420122A1 (https=) |
| DE (1) | DE60111752T2 (https=) |
| ES (1) | ES2243568T3 (https=) |
| GT (1) | GT200100190A (https=) |
| MX (1) | MXPA03001733A (https=) |
| PA (1) | PA8527401A1 (https=) |
| PE (1) | PE20020524A1 (https=) |
| UY (1) | UY26920A1 (https=) |
| WO (1) | WO2002018379A2 (https=) |
| ZA (1) | ZA200301078B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040103972A (ko) * | 2002-04-19 | 2004-12-09 | 스미스클라인 비참 코포레이션 | 신규 화합물 |
| AU2003300076C1 (en) | 2002-12-30 | 2010-03-04 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| WO2005007193A2 (en) * | 2003-07-07 | 2005-01-27 | Vande Woude, George, F. | Inhibition of tumor angiogenesis by combination of thrombospondin-1 and inhibitors of vascular endothelial growth factor |
| WO2005105097A2 (en) * | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Pyridopyrimidines for treating inflammatory and other diseases |
| CA2569654C (en) * | 2004-06-15 | 2010-12-21 | Pfizer Inc. | Benzimidazolone carboxylic acid derivatives |
| US20090306380A1 (en) * | 2005-04-25 | 2009-12-10 | Shigeyoshi Nishino | Process for preparing 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde |
| JP2006321749A (ja) * | 2005-05-19 | 2006-11-30 | Ube Ind Ltd | ２−シアノマロンアルデヒドのアルカリ金属塩の製法 |
| ES2329419T3 (es) | 2006-01-31 | 2009-11-25 | F. Hoffmann-La Roche Ag | 7h-pirido(3,4-d)pirimidin-8-onas, su preparacion y uso como inhibidores de proteinas cinasas. |
| WO2008055842A1 (en) * | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Substituted 6-phenyl-pyrido [2,3-d] pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same |
| WO2008151992A2 (en) | 2007-06-15 | 2008-12-18 | F. Hoffmann-La Roche Ag | A novel process for the preparation of 3-amino-pentan-1,5-diol |
| US8372970B2 (en) * | 2009-10-09 | 2013-02-12 | Afraxis, Inc. | 8-ethyl-6-(aryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders |
| US20120184542A1 (en) | 2011-01-19 | 2012-07-19 | Kevin Anderson | Pyrido pyrimidines |
| US8877763B2 (en) * | 2012-03-22 | 2014-11-04 | Genosco | Substituted pyridopyrimidine compounds and their use as FLT3 inhibitors |
| US9321786B2 (en) | 2013-03-15 | 2016-04-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| EP3943087A1 (en) | 2013-03-15 | 2022-01-26 | Celgene CAR LLC | Heteroaryl compounds and uses thereof |
| CN105307657B (zh) | 2013-03-15 | 2020-07-10 | 西建卡尔有限责任公司 | 杂芳基化合物和其用途 |
| BR112020006677A2 (pt) | 2017-10-05 | 2020-10-06 | Fulcrum Therapeutics, Inc. | uso de inibidores p38 para reduzir a expressão de dux4 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| US12351576B2 (en) | 2018-09-14 | 2025-07-08 | Abbisko Therapeutics Co., Ltd. | FGFR inhibitor, preparation method therefor and application thereof |
| CN115960098B (zh) * | 2020-09-11 | 2026-04-10 | 上海凌达生物医药有限公司 | 一类含氮稠环类化合物的制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6183168A (ja) * | 1984-09-28 | 1986-04-26 | Ube Ind Ltd | ２−メルカプト−４−アミノ−５−ホルミルピリミジンおよびその製法 |
| IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| JP2000511533A (ja) * | 1996-05-20 | 2000-09-05 | メルク エンド カンパニー インコーポレーテッド | ゴナドトロピン放出ホルモン拮抗薬 |
| US5945422A (en) * | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
| US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| CA2420286A1 (en) * | 2000-08-31 | 2002-03-07 | F. Hoffmann-La Roche Ag | 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation |
-
2001
- 2001-08-22 CA CA002420122A patent/CA2420122A1/en not_active Abandoned
- 2001-08-22 CN CNB018150276A patent/CN100358892C/zh not_active Expired - Fee Related
- 2001-08-22 MX MXPA03001733A patent/MXPA03001733A/es active IP Right Grant
- 2001-08-22 DE DE60111752T patent/DE60111752T2/de not_active Expired - Fee Related
- 2001-08-22 KR KR1020037002955A patent/KR100582325B1/ko not_active Expired - Fee Related
- 2001-08-22 AU AU2002212147A patent/AU2002212147B2/en not_active Ceased
- 2001-08-22 CN CNB2005100835295A patent/CN1303072C/zh not_active Expired - Fee Related
- 2001-08-22 JP JP2002523894A patent/JP4146721B2/ja not_active Expired - Fee Related
- 2001-08-22 WO PCT/EP2001/009688 patent/WO2002018379A2/en not_active Ceased
- 2001-08-22 ES ES01980258T patent/ES2243568T3/es not_active Expired - Lifetime
- 2001-08-22 EP EP01980258A patent/EP1315727B1/en not_active Expired - Lifetime
- 2001-08-22 AU AU1214702A patent/AU1214702A/xx active Pending
- 2001-08-22 BR BR0113590-2A patent/BR0113590A/pt not_active Application Discontinuation
- 2001-08-22 AT AT01980258T patent/ATE298751T1/de not_active IP Right Cessation
- 2001-08-28 PA PA20018527401A patent/PA8527401A1/es unknown
- 2001-08-28 PE PE2001000861A patent/PE20020524A1/es not_active Application Discontinuation
- 2001-08-30 AR ARP010104131A patent/AR033996A1/es unknown
- 2001-08-30 UY UY26920A patent/UY26920A1/es not_active Application Discontinuation
- 2001-09-18 GT GT200100190A patent/GT200100190A/es unknown
-
2003
- 2003-02-07 ZA ZA200301078A patent/ZA200301078B/xx unknown
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