|
CA2369502A1
(en)
*
|
2000-02-05 |
2001-08-09 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of erk
|
|
US6436915B1
(en)
|
2000-04-07 |
2002-08-20 |
Kinetek Pharmaceuticals, Inc. |
Pyrazole compounds
|
|
AU2002213467A8
(en)
*
|
2000-10-11 |
2009-07-30 |
Chemocentryx Inc |
Modulation of ccr4 function
|
|
EP1368349B1
(de)
*
|
2001-02-24 |
2007-02-14 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Xanthinderivate, deren herstellung und deren verwendung als arzneimittel
|
|
CA2445568A1
(en)
|
2001-04-27 |
2002-11-07 |
Vertex Pharmaceuticals Incorporated |
Triazole-derived kinase inhibitors and uses thereof
|
|
US7144903B2
(en)
*
|
2001-05-23 |
2006-12-05 |
Amgen Inc. |
CCR4 antagonists
|
|
EP1423380B1
(en)
|
2001-08-03 |
2010-12-15 |
Vertex Pharmaceuticals Incorporated |
Pyrazole-derived kinase inhibitors and uses thereof
|
|
US20040248950A1
(en)
|
2001-08-24 |
2004-12-09 |
Natsuki Ishizuka |
Apo ai expression accelerating agent
|
|
AU2002333114B2
(en)
|
2001-11-30 |
2008-09-04 |
Qlt Inc. |
Hydrazonopyrazole derivatives and their use as therapeutics
|
|
ES2316756T3
(es)
*
|
2002-01-10 |
2009-04-16 |
F. Hoffmann-La Roche Ag |
Uso de un inhibidor de gsk-3beta en la fabricacion de un medicamento para incrementar la formacion osea.
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
AU2003249597B2
(en)
|
2002-03-08 |
2007-06-28 |
Merck Sharp & Dohme Corp. |
Mitotic kinesin inhibitors
|
|
US7304061B2
(en)
|
2002-04-26 |
2007-12-04 |
Vertex Pharmaceuticals Incorporated |
Heterocyclic inhibitors of ERK2 and uses thereof
|
|
US7407955B2
(en)
|
2002-08-21 |
2008-08-05 |
Boehringer Ingelheim Pharma Gmbh & Co., Kg |
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
|
|
US7495005B2
(en)
*
|
2002-08-22 |
2009-02-24 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Xanthine derivatives, their preparation and their use in pharmaceutical compositions
|
|
US7569574B2
(en)
*
|
2002-08-22 |
2009-08-04 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Purine derivatives, the preparation thereof and their use as pharmaceutical compositions
|
|
US20040092568A1
(en)
*
|
2002-10-31 |
2004-05-13 |
Zeldis Jerome B. |
Methods for the treatment, prevention and management of macular degeneration
|
|
US7482337B2
(en)
*
|
2002-11-08 |
2009-01-27 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
|
|
TWI335913B
(en)
*
|
2002-11-15 |
2011-01-11 |
Vertex Pharma |
Diaminotriazoles useful as inhibitors of protein kinases
|
|
DE10254304A1
(de)
*
|
2002-11-21 |
2004-06-03 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel
|
|
US20040175384A1
(en)
*
|
2003-12-12 |
2004-09-09 |
Mohapatra Shyam S. |
Protein kinase C as a target for the treatment of respiratory syncytial virus
|
|
US20050019366A1
(en)
*
|
2002-12-31 |
2005-01-27 |
Zeldis Jerome B. |
Drug-coated stents and methods of use therefor
|
|
EA200501607A1
(ru)
*
|
2003-04-14 |
2006-06-30 |
ДЗЕ ИНСТИТЬЮТС ФОР ФАРМАСЬЮТИКАЛ ДИСКАВЕРИ, ЭлЭлСи |
Замещённые фенилалкановые кислоты
|
|
US7566707B2
(en)
*
|
2003-06-18 |
2009-07-28 |
Boehringer Ingelheim International Gmbh |
Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
|
|
WO2005012294A1
(en)
|
2003-07-30 |
2005-02-10 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
|
|
US7316822B2
(en)
*
|
2003-11-26 |
2008-01-08 |
Ethicon, Inc. |
Conformable tissue repair implant capable of injection delivery
|
|
DE10355304A1
(de)
*
|
2003-11-27 |
2005-06-23 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 8-(Piperazin-1-yl)-und 8-([1,4]Diazepan-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
|
EP1694686A1
(en)
|
2003-12-19 |
2006-08-30 |
Takeda San Diego, Inc. |
Kinase inhibitors
|
|
US8592368B2
(en)
*
|
2003-12-19 |
2013-11-26 |
University Of South Florida |
JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection
|
|
US7501426B2
(en)
*
|
2004-02-18 |
2009-03-10 |
Boehringer Ingelheim International Gmbh |
8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
|
|
DE102004009039A1
(de)
*
|
2004-02-23 |
2005-09-08 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel
|
|
US7179809B2
(en)
*
|
2004-04-10 |
2007-02-20 |
Boehringer Ingelheim International Gmbh |
2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions
|
|
US20050250829A1
(en)
*
|
2004-04-23 |
2005-11-10 |
Takeda San Diego, Inc. |
Kinase inhibitors
|
|
DE102004030502A1
(de)
*
|
2004-06-24 |
2006-01-12 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel
|
|
CA2571572A1
(en)
|
2004-07-01 |
2006-01-19 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
AU2005262383A1
(en)
|
2004-07-01 |
2006-01-19 |
Merck Sharp & Dohme Corp. |
Mitotic kinesin inhibitors
|
|
AU2005262379A1
(en)
|
2004-07-01 |
2006-01-19 |
Merck Sharp & Dohme Corp. |
Prodrugs of mitotic kinesin inhibitors
|
|
WO2006023931A2
(en)
|
2004-08-18 |
2006-03-02 |
Takeda San Diego, Inc. |
Kinase inhibitors
|
|
DE102004043944A1
(de)
*
|
2004-09-11 |
2006-03-30 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 8-(3-Amino-piperidin-1-yl)-7-(but-2-inyl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
|
DE102004044221A1
(de)
*
|
2004-09-14 |
2006-03-16 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 3-Methyl-7-butinyl-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
|
EP1812439B2
(en)
|
2004-10-15 |
2017-12-06 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
|
EP1805136A1
(en)
*
|
2004-10-28 |
2007-07-11 |
The Institutes for Pharmaceutical Discovery, LLC |
Substituted phenylalkanoic acids
|
|
DE102004054054A1
(de)
|
2004-11-05 |
2006-05-11 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
|
|
CN101084214A
(zh)
|
2004-11-17 |
2007-12-05 |
迈卡纳治疗股份有限公司 |
激酶抑制剂
|
|
TW200639163A
(en)
|
2005-02-04 |
2006-11-16 |
Genentech Inc |
RAF inhibitor compounds and methods
|
|
BRPI0610876B8
(pt)
|
2005-06-08 |
2021-05-25 |
Rigel Pharmaceuticals Inc |
composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
DE102005035891A1
(de)
|
2005-07-30 |
2007-02-08 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
|
KR101487027B1
(ko)
*
|
2005-09-30 |
2015-01-28 |
미카나 테라퓨틱스, 인크. |
치환된 피라졸 화합물
|
|
US8119655B2
(en)
|
2005-10-07 |
2012-02-21 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
|
CA2633980A1
(en)
|
2005-12-29 |
2007-07-12 |
Anthrogenesis Corporation |
Improved composition for collecting and preserving placental stem cells and methods of using the composition
|
|
ES2622493T3
(es)
|
2006-02-24 |
2017-07-06 |
Rigel Pharmaceuticals, Inc. |
Composiciones y métodos para la inhibición de la ruta de JAK
|
|
EP2540725A1
(de)
|
2006-05-04 |
2013-01-02 |
Boehringer Ingelheim International GmbH |
Polymorphe von 1-((4-Methyl-chinazolin-2-yl)methyl)-3-methyl-7-(2-butin-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthin
|
|
EP1852108A1
(en)
*
|
2006-05-04 |
2007-11-07 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
DPP IV inhibitor formulations
|
|
PE20080251A1
(es)
|
2006-05-04 |
2008-04-25 |
Boehringer Ingelheim Int |
Usos de inhibidores de dpp iv
|
|
JP2010500326A
(ja)
*
|
2006-08-08 |
2010-01-07 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
糖尿病の治療のためのｄｐｐ−ｉｖ阻害剤としてのピロロ［３，２−ｄ］ピリミジン
|
|
EP2223925A1
(en)
*
|
2006-10-09 |
2010-09-01 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
|
SG158147A1
(en)
|
2006-10-09 |
2010-01-29 |
Takeda Pharmaceutical |
Kinase inhibitors
|
|
UY30892A1
(es)
|
2007-02-07 |
2008-09-02 |
Smithkline Beckman Corp |
Inhibidores de la actividad akt
|
|
EP2166849A4
(en)
*
|
2007-06-11 |
2010-09-15 |
Miikana Therapeutics Inc |
SUBSTITUTED PYRAZOL COMPOUNDS
|
|
WO2009024542A2
(en)
*
|
2007-08-17 |
2009-02-26 |
Boehringer Ingelheim International Gmbh |
Purin derivatives for use in the treatment of fab-related diseases
|
|
HUE030912T2
(en)
|
2008-02-15 |
2017-06-28 |
Rigel Pharmaceuticals Inc |
Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases
|
|
PE20091730A1
(es)
|
2008-04-03 |
2009-12-10 |
Boehringer Ingelheim Int |
Formulaciones que comprenden un inhibidor de dpp4
|
|
US8063058B2
(en)
|
2008-04-16 |
2011-11-22 |
Portola Pharmaceuticals, Inc. |
Inhibitors of syk and JAK protein kinases
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
AU2009238590A1
(en)
|
2008-04-22 |
2009-10-29 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
PE20100156A1
(es)
*
|
2008-06-03 |
2010-02-23 |
Boehringer Ingelheim Int |
Tratamiento de nafld
|
|
BRPI0916997A2
(pt)
|
2008-08-06 |
2020-12-15 |
Boehringer Ingelheim International Gmbh |
Inibidor de dpp-4 e seu uso
|
|
UY32030A
(es)
|
2008-08-06 |
2010-03-26 |
Boehringer Ingelheim Int |
"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
|
|
NZ604091A
(en)
*
|
2008-08-15 |
2014-08-29 |
Boehringer Ingelheim Int |
Purin derivatives for use in the treatment of fab-related diseases
|
|
CN102149407A
(zh)
|
2008-09-10 |
2011-08-10 |
贝林格尔.英格海姆国际有限公司 |
治疗糖尿病和相关病症的组合疗法
|
|
US20200155558A1
(en)
|
2018-11-20 |
2020-05-21 |
Boehringer Ingelheim International Gmbh |
Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
|
|
CN102256976A
(zh)
|
2008-12-23 |
2011-11-23 |
贝林格尔.英格海姆国际有限公司 |
有机化合物的盐形式
|
|
AR074990A1
(es)
|
2009-01-07 |
2011-03-02 |
Boehringer Ingelheim Int |
Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
|
|
CN106420756A
(zh)
*
|
2009-07-28 |
2017-02-22 |
里格尔药品股份有限公司 |
抑制jak途径的组合物和方法
|
|
KR20240090632A
(ko)
|
2009-11-27 |
2024-06-21 |
베링거 인겔하임 인터내셔날 게엠베하 |
리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
|
|
CN102946875A
(zh)
|
2010-05-05 |
2013-02-27 |
贝林格尔.英格海姆国际有限公司 |
组合疗法
|
|
WO2011161161A1
(en)
|
2010-06-24 |
2011-12-29 |
Boehringer Ingelheim International Gmbh |
Diabetes therapy
|
|
CA2807510A1
(en)
|
2010-08-05 |
2012-02-09 |
Case Western Reserve University |
Inhibitors of erk for developmental disorders of neuronal connectivity
|
|
EP2975027A1
(en)
|
2010-11-01 |
2016-01-20 |
Portola Pharmaceuticals, Inc. |
Nicotinamides as jak kinase modulators
|
|
AR083878A1
(es)
|
2010-11-15 |
2013-03-27 |
Boehringer Ingelheim Int |
Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
|
|
EP2714037B1
(en)
|
2011-05-25 |
2016-07-13 |
Université Paris Descartes |
Erk inhibitors for use in treating spinal muscular atrophy
|
|
US8883800B2
(en)
|
2011-07-15 |
2014-11-11 |
Boehringer Ingelheim International Gmbh |
Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
|
|
MX363551B
(es)
|
2011-11-23 |
2019-03-27 |
Portola Pharmaceuticals Inc Star |
Compuestos derivados de pirazina como inhibidores de cinasa.
|
|
US9555001B2
(en)
|
2012-03-07 |
2017-01-31 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition and uses thereof
|
|
JP6224084B2
(ja)
|
2012-05-14 |
2017-11-01 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
|
|
JP6218811B2
(ja)
|
2012-05-14 |
2017-10-25 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Ｓｉｒｓ及び／又は敗血症の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
|
|
WO2013174767A1
(en)
|
2012-05-24 |
2013-11-28 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
|
|
CN104703604A
(zh)
*
|
2012-07-16 |
2015-06-10 |
神经孔疗法股份有限公司 |
作为蛋白质聚集抑制剂的二-和三-杂芳基衍生物
|
|
WO2014058921A2
(en)
|
2012-10-08 |
2014-04-17 |
Portola Pharmaceuticals, Inc. |
Substituted pyrimidinyl kinase inhibitors
|
|
CA2814923C
(en)
|
2013-02-11 |
2016-10-11 |
Alexandre Cloutier |
Gauge kits for sheet bending brakes
|
|
AU2014318614B2
(en)
|
2013-09-12 |
2021-01-07 |
Dana-Farber Cancer Institute Inc. |
Methods for evaluating and treating Waldenstrom's macroglobulinemia
|
|
EP3110449B1
(en)
|
2014-02-28 |
2023-06-28 |
Boehringer Ingelheim International GmbH |
Medical use of a dpp-4 inhibitor
|
|
LT3390390T
(lt)
*
|
2015-12-16 |
2021-11-25 |
Boehringer Ingelheim International Gmbh |
Bipirazolilo dariniai, tinkami naudoti autoimuninių ligų gydymui
|
|
CN109310697A
(zh)
|
2016-06-10 |
2019-02-05 |
勃林格殷格翰国际有限公司 |
利格列汀和二甲双胍的组合
|
|
BR112021017957A2
(pt)
|
2019-03-28 |
2021-11-23 |
Jiangsu Hengrui Medicine Co |
Derivado tienoeterocíclico, método de preparação do mesmo e uso médico do mesmo
|
|
BR112021018924A2
(pt)
|
2019-03-29 |
2022-02-01 |
Jiangsu Hengrui Medicine Co |
Derivado de heterocíclico pirrol, método de preparação do mesmo e aplicação do mesmo em medicamento
|
|
TW202110848A
(zh)
|
2019-05-24 |
2021-03-16 |
大陸商江蘇恆瑞醫藥股份有限公司 |
取代的稠合雙環類衍生物、其製備方法及其在醫藥上的應用
|
|
WO2022068860A1
(zh)
|
2020-09-29 |
2022-04-07 |
江苏恒瑞医药股份有限公司 |
一种吡咯并杂环类衍生物的晶型及其制备方法
|