|
WO2001056557A2
(en)
*
|
2000-02-05 |
2001-08-09 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of erk
|
|
US6436915B1
(en)
|
2000-04-07 |
2002-08-20 |
Kinetek Pharmaceuticals, Inc. |
Pyrazole compounds
|
|
EP1578341A2
(en)
*
|
2000-10-11 |
2005-09-28 |
Tularik Inc. |
Modulation of ccr4 function
|
|
KR100926247B1
(ko)
*
|
2001-02-24 |
2009-11-12 |
베링거 잉겔하임 파르마 게엠베하 운트 코 카게 |
크산틴 유도체를 포함하는 약제학적 조성물 및 이의제조방법
|
|
JP2004532234A
(ja)
*
|
2001-04-27 |
2004-10-21 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
トリアゾール由来キナーゼインヒビターおよびその使用
|
|
US7144903B2
(en)
*
|
2001-05-23 |
2006-12-05 |
Amgen Inc. |
CCR4 antagonists
|
|
ATE491701T1
(de)
*
|
2001-08-03 |
2011-01-15 |
Vertex Pharma |
Von pyrazol abgeleitete kinaseinhibitoren und deren verwendung
|
|
US20040248950A1
(en)
|
2001-08-24 |
2004-12-09 |
Natsuki Ishizuka |
Apo ai expression accelerating agent
|
|
RU2332996C2
(ru)
|
2001-11-30 |
2008-09-10 |
КьюЭлТи Инк. |
Производные гидразонпиразола и их применение в качестве лекарственного средства
|
|
AU2003235798A1
(en)
|
2002-01-10 |
2003-07-24 |
F. Hoffmann-La Roche Ag |
Use of a gsk-3beta inhibitor in the manufacture of a medicament for increasing bone formation
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
EP1492487B1
(en)
|
2002-03-08 |
2009-11-11 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
AU2003237121A1
(en)
*
|
2002-04-26 |
2003-11-10 |
Vertex Pharmaceuticals Incorporated |
Pyrrole derivatives as inhibitors of erk2 and uses thereof
|
|
US7407955B2
(en)
|
2002-08-21 |
2008-08-05 |
Boehringer Ingelheim Pharma Gmbh & Co., Kg |
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
|
|
US7495005B2
(en)
*
|
2002-08-22 |
2009-02-24 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Xanthine derivatives, their preparation and their use in pharmaceutical compositions
|
|
US7569574B2
(en)
*
|
2002-08-22 |
2009-08-04 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Purine derivatives, the preparation thereof and their use as pharmaceutical compositions
|
|
US20040092568A1
(en)
*
|
2002-10-31 |
2004-05-13 |
Zeldis Jerome B. |
Methods for the treatment, prevention and management of macular degeneration
|
|
US7482337B2
(en)
|
2002-11-08 |
2009-01-27 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
|
|
CL2003002353A1
(es)
*
|
2002-11-15 |
2005-02-04 |
Vertex Pharma |
Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic
|
|
DE10254304A1
(de)
*
|
2002-11-21 |
2004-06-03 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel
|
|
US20040175384A1
(en)
*
|
2003-12-12 |
2004-09-09 |
Mohapatra Shyam S. |
Protein kinase C as a target for the treatment of respiratory syncytial virus
|
|
US20050019366A1
(en)
*
|
2002-12-31 |
2005-01-27 |
Zeldis Jerome B. |
Drug-coated stents and methods of use therefor
|
|
BRPI0409447A
(pt)
*
|
2003-04-14 |
2006-04-18 |
Inst For Pharm Discovery Inc |
ácidos fenilalcanóicos substituìdos
|
|
US7566707B2
(en)
*
|
2003-06-18 |
2009-07-28 |
Boehringer Ingelheim International Gmbh |
Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
|
|
BRPI0413018B8
(pt)
|
2003-07-30 |
2021-05-25 |
Rigel Pharmaceuticals Inc |
composto, e, uso de um composto
|
|
US7316822B2
(en)
*
|
2003-11-26 |
2008-01-08 |
Ethicon, Inc. |
Conformable tissue repair implant capable of injection delivery
|
|
DE10355304A1
(de)
*
|
2003-11-27 |
2005-06-23 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 8-(Piperazin-1-yl)-und 8-([1,4]Diazepan-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
|
US8592368B2
(en)
*
|
2003-12-19 |
2013-11-26 |
University Of South Florida |
JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection
|
|
WO2005061519A1
(en)
|
2003-12-19 |
2005-07-07 |
Takeda San Diego, Inc. |
Kinase inhibitors
|
|
US7501426B2
(en)
*
|
2004-02-18 |
2009-03-10 |
Boehringer Ingelheim International Gmbh |
8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
|
|
DE102004009039A1
(de)
*
|
2004-02-23 |
2005-09-08 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel
|
|
US7179809B2
(en)
*
|
2004-04-10 |
2007-02-20 |
Boehringer Ingelheim International Gmbh |
2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions
|
|
WO2005105788A1
(en)
*
|
2004-04-23 |
2005-11-10 |
Takeda San Diego, Inc. |
Indole derivatives and use thereof as kinase inhibitors
|
|
DE102004030502A1
(de)
*
|
2004-06-24 |
2006-01-12 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel
|
|
EP1773326A4
(en)
|
2004-07-01 |
2009-07-22 |
Merck & Co Inc |
INHIBITORS OF MITOTIC KINESINE
|
|
CA2571824A1
(en)
|
2004-07-01 |
2006-01-19 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
JP2008505090A
(ja)
|
2004-07-01 |
2008-02-21 |
メルク エンド カムパニー インコーポレーテッド |
有糸分裂キネシン阻害剤のプロドラッグ
|
|
EP1778669A2
(en)
|
2004-08-18 |
2007-05-02 |
Takeda San Diego, Inc. |
Kinase inhibitors
|
|
DE102004043944A1
(de)
*
|
2004-09-11 |
2006-03-30 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 8-(3-Amino-piperidin-1-yl)-7-(but-2-inyl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
|
DE102004044221A1
(de)
*
|
2004-09-14 |
2006-03-16 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 3-Methyl-7-butinyl-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
|
ATE479687T1
(de)
|
2004-10-15 |
2010-09-15 |
Takeda Pharmaceutical |
Kinaseinhibitoren
|
|
TW200630327A
(en)
*
|
2004-10-28 |
2006-09-01 |
Inst For Pharm Discovery Inc |
Substituted phenylalkanoic acids
|
|
DE102004054054A1
(de)
|
2004-11-05 |
2006-05-11 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
|
|
JP2008520713A
(ja)
|
2004-11-17 |
2008-06-19 |
ミイカナ セラピューティクス インコーポレイテッド |
キナーゼ阻害剤
|
|
TW200639163A
(en)
*
|
2005-02-04 |
2006-11-16 |
Genentech Inc |
RAF inhibitor compounds and methods
|
|
US20070203161A1
(en)
*
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
WO2006133426A2
(en)
|
2005-06-08 |
2006-12-14 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
DE102005035891A1
(de)
*
|
2005-07-30 |
2007-02-08 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
|
CA2622352C
(en)
*
|
2005-09-30 |
2014-05-27 |
Miikana Therapeutics, Inc. |
Substituted pyrazole compounds
|
|
US8119655B2
(en)
|
2005-10-07 |
2012-02-21 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
|
ZA200804717B
(en)
|
2005-12-29 |
2010-02-24 |
Anthrogenesis Corp |
Improved composition for collecting and preserving a placental stem cells and methods of using the composition
|
|
CA2642229C
(en)
|
2006-02-24 |
2015-05-12 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
PE20110235A1
(es)
|
2006-05-04 |
2011-04-14 |
Boehringer Ingelheim Int |
Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
|
|
KR101452915B1
(ko)
*
|
2006-05-04 |
2014-10-21 |
베링거 인겔하임 인터내셔날 게엠베하 |
다형태
|
|
EP1852108A1
(en)
|
2006-05-04 |
2007-11-07 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
DPP IV inhibitor formulations
|
|
JP2010500326A
(ja)
*
|
2006-08-08 |
2010-01-07 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
糖尿病の治療のためのdpp−iv阻害剤としてのピロロ[3,2−d]ピリミジン
|
|
SG158147A1
(en)
|
2006-10-09 |
2010-01-29 |
Takeda Pharmaceutical |
Kinase inhibitors
|
|
EP2223925A1
(en)
*
|
2006-10-09 |
2010-09-01 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
|
UY30892A1
(es)
|
2007-02-07 |
2008-09-02 |
Smithkline Beckman Corp |
Inhibidores de la actividad akt
|
|
AU2008262291A1
(en)
*
|
2007-06-11 |
2008-12-18 |
Miikana Therapeutics, Inc. |
Substituted pyrazole compounds
|
|
BRPI0815405A2
(pt)
*
|
2007-08-17 |
2015-02-03 |
Boehringer Ingelheim Int |
Compostos derivados de purina, processo para a preparação de uma composição farmacêutica e uso dos mesmos
|
|
US8309566B2
(en)
|
2008-02-15 |
2012-11-13 |
Rigel Pharmaceuticals, Inc. |
Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases
|
|
PE20091730A1
(es)
|
2008-04-03 |
2009-12-10 |
Boehringer Ingelheim Int |
Formulaciones que comprenden un inhibidor de dpp4
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
MX2010011463A
(es)
|
2008-04-16 |
2011-06-03 |
Portola Pharm Inc |
2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas.
|
|
NZ588830A
(en)
|
2008-04-22 |
2012-11-30 |
Portola Pharm Inc |
Inhibitors of protein kinases
|
|
PE20100156A1
(es)
*
|
2008-06-03 |
2010-02-23 |
Boehringer Ingelheim Int |
Tratamiento de nafld
|
|
UY32030A
(es)
|
2008-08-06 |
2010-03-26 |
Boehringer Ingelheim Int |
"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
|
|
KR20190016601A
(ko)
|
2008-08-06 |
2019-02-18 |
베링거 인겔하임 인터내셔날 게엠베하 |
메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
|
|
UA119131C2
(uk)
*
|
2008-08-15 |
2019-05-10 |
Бьорінгер Інгельхайм Інтернаціональ Гмбх |
Похідні пурину для застосування при лікуванні пов'язаних із fab захворювань
|
|
CA2736421A1
(en)
|
2008-09-10 |
2010-03-18 |
Boehringer Ingelheim International Gmbh |
Combination therapy for the treatment of diabetes and related conditions
|
|
US20200155558A1
(en)
|
2018-11-20 |
2020-05-21 |
Boehringer Ingelheim International Gmbh |
Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
|
|
JP2012512848A
(ja)
|
2008-12-23 |
2012-06-07 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
有機化合物の塩の形態
|
|
TW201036975A
(en)
|
2009-01-07 |
2010-10-16 |
Boehringer Ingelheim Int |
Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
|
|
CN102470135A
(zh)
*
|
2009-07-28 |
2012-05-23 |
里格尔药品股份有限公司 |
抑制jak途径的组合物和方法
|
|
KR20240090632A
(ko)
|
2009-11-27 |
2024-06-21 |
베링거 인겔하임 인터내셔날 게엠베하 |
리나글립틴과 같은 dpp-iv 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
|
|
CA3070513C
(en)
|
2010-05-05 |
2023-01-03 |
Boehringer Ingelheim International Gmbh |
A dpp-4 inhibitor for use in treatment of skin-alterations or necrosis
|
|
KR20130093012A
(ko)
|
2010-06-24 |
2013-08-21 |
베링거 인겔하임 인터내셔날 게엠베하 |
당뇨병 요법
|
|
EP2600862B1
(en)
|
2010-08-05 |
2016-04-20 |
Case Western Reserve University |
Inhibitors of erk for developmental disorders of neuronal connectivity
|
|
US9102625B2
(en)
|
2010-11-01 |
2015-08-11 |
Portola Pharmaceuticals, Inc. |
Nicotinamides as JAK kinase modulators
|
|
AR083878A1
(es)
|
2010-11-15 |
2013-03-27 |
Boehringer Ingelheim Int |
Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
|
|
ES2597052T3
(es)
|
2011-05-25 |
2017-01-13 |
Université Paris Descartes |
Inhibidores de ERK para su uso en el tratamiento de atrofia muscular espinal
|
|
DK2731947T3
(en)
|
2011-07-15 |
2019-04-23 |
Boehringer Ingelheim Int |
SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES
|
|
CA3094793A1
(en)
|
2011-11-23 |
2013-05-30 |
Portola Pharmaceuticals, Inc. |
Pyrazine kinase inhibitors
|
|
US9555001B2
(en)
|
2012-03-07 |
2017-01-31 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition and uses thereof
|
|
WO2013171167A1
(en)
|
2012-05-14 |
2013-11-21 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
|
|
WO2013171166A1
(en)
|
2012-05-14 |
2013-11-21 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp-4 inhibitor for use in the treatment of sirs and/or sepsis
|
|
WO2013174767A1
(en)
|
2012-05-24 |
2013-11-28 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
|
|
ES2661394T3
(es)
|
2012-07-16 |
2018-03-28 |
Neuropore Therapies, Inc. |
Derivados de di- y tri-heteroarilo como inhibidores de la agregación de proteínas
|
|
US9676756B2
(en)
|
2012-10-08 |
2017-06-13 |
Portola Pharmaceuticals, Inc. |
Substituted pyrimidinyl kinase inhibitors
|
|
CA2814923C
(en)
|
2013-02-11 |
2016-10-11 |
Alexandre Cloutier |
Gauge kits for sheet bending brakes
|
|
CA3206628A1
(en)
|
2013-09-12 |
2015-03-19 |
Dana-Farber Cancer Institute, Inc. |
Methods for evaluating and treating waldenstrom's macroglobulinemia
|
|
EP3110449B1
(en)
|
2014-02-28 |
2023-06-28 |
Boehringer Ingelheim International GmbH |
Medical use of a dpp-4 inhibitor
|
|
US9975882B2
(en)
*
|
2015-12-16 |
2018-05-22 |
Boehringer Ingelheim International Gmbh |
Heteroaromatic compounds as BTK inhibitors
|
|
EP4233840A3
(en)
|
2016-06-10 |
2023-10-18 |
Boehringer Ingelheim International GmbH |
Combinations of linagliptin and metformin
|
|
BR112021017957A2
(pt)
|
2019-03-28 |
2021-11-23 |
Jiangsu Hengrui Medicine Co |
Derivado tienoeterocíclico, método de preparação do mesmo e uso médico do mesmo
|
|
TW202102505A
(zh)
|
2019-03-29 |
2021-01-16 |
大陸商江蘇恆瑞醫藥股份有限公司 |
吡咯并雜環類衍生物、其製備方法及其在醫藥上的應用
|
|
JP2022534224A
(ja)
|
2019-05-24 |
2022-07-28 |
江蘇恒瑞医薬股▲ふん▼有限公司 |
置換縮合二環式誘導体、その調製方法、および医薬におけるその適用
|
|
WO2022068860A1
(zh)
|
2020-09-29 |
2022-04-07 |
江苏恒瑞医药股份有限公司 |
一种吡咯并杂环类衍生物的晶型及其制备方法
|