JP2004505097A5 - - Google Patents
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- Publication number
- JP2004505097A5 JP2004505097A5 JP2002516228A JP2002516228A JP2004505097A5 JP 2004505097 A5 JP2004505097 A5 JP 2004505097A5 JP 2002516228 A JP2002516228 A JP 2002516228A JP 2002516228 A JP2002516228 A JP 2002516228A JP 2004505097 A5 JP2004505097 A5 JP 2004505097A5
- Authority
- JP
- Japan
- Prior art keywords
- catalyst
- chiral
- cyanide
- aldehyde
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003054 catalyst Substances 0.000 description 8
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 5
- 229910052736 halogen Inorganic materials 0.000 description 5
- 150000002367 halogens Chemical class 0.000 description 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 4
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 4
- 229910052719 titanium Inorganic materials 0.000 description 4
- 239000010936 titanium Substances 0.000 description 4
- 229910052720 vanadium Inorganic materials 0.000 description 4
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 4
- OISVCGZHLKNMSJ-UHFFFAOYSA-N 2,6-dimethylpyridine Chemical compound CC1=CC=CC(C)=N1 OISVCGZHLKNMSJ-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000000269 nucleophilic effect Effects 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000004104 aryloxy group Chemical group 0.000 description 2
- 125000001188 haloalkyl group Chemical group 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- XWKFPIODWVPXLX-UHFFFAOYSA-N 2-methyl-5-methylpyridine Natural products CC1=CC=C(C)N=C1 XWKFPIODWVPXLX-UHFFFAOYSA-N 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 125000003172 aldehyde group Chemical group 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- -1 alkali metal cyanide Chemical class 0.000 description 1
- 229960004424 carbon dioxide Drugs 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 239000003880 polar aprotic solvent Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0018973.8A GB0018973D0 (en) | 2000-08-02 | 2000-08-02 | Synthesis of chiral cyanohydrins |
| PCT/GB2001/003456 WO2002010095A2 (en) | 2000-08-02 | 2001-08-01 | Process for the cyanation of aldehydes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004505097A JP2004505097A (ja) | 2004-02-19 |
| JP2004505097A5 true JP2004505097A5 (cg-RX-API-DMAC7.html) | 2008-07-31 |
Family
ID=9896847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002516228A Pending JP2004505097A (ja) | 2000-08-02 | 2001-08-01 | アルデヒド類のシアン化方法 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1307427B3 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2004505097A (cg-RX-API-DMAC7.html) |
| KR (1) | KR100820273B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN100406433C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE323069T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2001275740A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2418116A1 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ2003276A3 (cg-RX-API-DMAC7.html) |
| DE (2) | DE60118752D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1307427T5 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2262665T7 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0018973D0 (cg-RX-API-DMAC7.html) |
| HU (1) | HUP0301824A3 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA03000903A (cg-RX-API-DMAC7.html) |
| PT (1) | PT1307427E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002010095A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0212017D0 (en) * | 2002-05-24 | 2002-07-03 | King S College London | Catalyst and process |
| GB0103857D0 (en) * | 2001-02-16 | 2001-04-04 | Avecia Ltd | Preparation of chloromandelic acid |
| DE10131811A1 (de) * | 2001-06-30 | 2003-04-03 | Clariant Gmbh | Optisch aktive Katalysatoren |
| DE10131810A1 (de) * | 2001-06-30 | 2003-02-27 | Clariant Gmbh | Verfahren zur Herstellung von optisch aktiven Cyanhydrinen und deren korrespondierenden Säuren |
| EP1409125B1 (en) | 2001-07-12 | 2016-04-20 | Reaxa Limited | Microencapsulated catalyst, methods of preparation and methods of use thereof |
| DE10259162A1 (de) * | 2002-12-18 | 2004-07-08 | Clariant Gmbh | Optisch aktive Komplexe enthaltende Mischungen |
| KR100884441B1 (ko) | 2004-10-15 | 2009-02-19 | 미쓰이 가가쿠 가부시키가이샤 | 티탄 화합물 및 광학 활성 시아노하이드린류의 제조 방법 |
| CA2645683A1 (en) * | 2006-03-10 | 2007-09-20 | Nissan Chemical Industries, Ltd. | Process for producing optically active chromene oxide compound |
| CN101437827B (zh) * | 2006-03-10 | 2012-08-29 | 日产化学工业株式会社 | 光学活性色烯氧化物化合物的制造方法 |
| EP2132155A4 (en) * | 2007-03-29 | 2010-05-05 | Agency Science Tech & Res | METHOD FOR PRODUCING AN OPTICALLY ACTIVE CYANOHYDRIN DERIVATIVE |
| CN102234291B (zh) * | 2010-04-23 | 2014-10-15 | 中国科学院上海有机化学研究所 | 桥连双希夫碱钛络合物、合成方法及其应用 |
| CN106552671A (zh) * | 2015-09-25 | 2017-04-05 | 沈阳中化农药化工研发有限公司 | 一种多相催化剂及其制备和应用 |
| CN116987004B (zh) * | 2023-09-27 | 2023-12-12 | 新华制药（寿光）有限公司 | 一种3-(3,4-二甲氧基苯基)-2-氨基-2-甲基丙腈的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2919974A1 (de) * | 1979-05-17 | 1980-11-27 | Hoechst Ag | Verfahren zur herstellung von cyanhydrinacylaten von aldehyden |
| JPH0429965A (ja) * | 1990-05-28 | 1992-01-31 | Katakura Chitsukarin Kk | α―Ｎ―アルキルアミノニトリル誘導体鏡像異性体の製造方法 |
| JP3303327B2 (ja) * | 1992-03-18 | 2002-07-22 | 住友化学工業株式会社 | 不斉誘起触媒 |
| US5349079A (en) * | 1992-12-14 | 1994-09-20 | Akzo Nobel Nv | Process for forming α-aminonitriles from carbonyl compound and fatty amine hydrohalide |
| JPH06271522A (ja) * | 1993-01-21 | 1994-09-27 | Sumitomo Chem Co Ltd | 光学活性シアノヒドリンエステルの製造方法 |
| JPH0770040A (ja) * | 1993-06-22 | 1995-03-14 | Sumitomo Chem Co Ltd | 光学活性シアノヒドリンエステルの製造法 |
-
2000
- 2000-08-02 GB GBGB0018973.8A patent/GB0018973D0/en not_active Ceased
-
2001
- 2001-08-01 CZ CZ2003276A patent/CZ2003276A3/cs unknown
- 2001-08-01 HU HU0301824A patent/HUP0301824A3/hu unknown
- 2001-08-01 DE DE60118752A patent/DE60118752D1/de not_active Expired - Lifetime
- 2001-08-01 PT PT01953252T patent/PT1307427E/pt unknown
- 2001-08-01 EP EP01953252A patent/EP1307427B3/en not_active Expired - Lifetime
- 2001-08-01 JP JP2002516228A patent/JP2004505097A/ja active Pending
- 2001-08-01 WO PCT/GB2001/003456 patent/WO2002010095A2/en not_active Ceased
- 2001-08-01 AU AU2001275740A patent/AU2001275740A1/en not_active Abandoned
- 2001-08-01 CA CA002418116A patent/CA2418116A1/en not_active Abandoned
- 2001-08-01 MX MXPA03000903A patent/MXPA03000903A/es active IP Right Grant
- 2001-08-01 CN CNB018167209A patent/CN100406433C/zh not_active Expired - Fee Related
- 2001-08-01 DK DK01953252T patent/DK1307427T5/da active
- 2001-08-01 KR KR1020037001417A patent/KR100820273B1/ko not_active Expired - Fee Related
- 2001-08-01 DE DE60118752T patent/DE60118752T4/de not_active Expired - Lifetime
- 2001-08-01 AT AT01953252T patent/ATE323069T1/de not_active IP Right Cessation
- 2001-08-01 ES ES01953252T patent/ES2262665T7/es active Active