ATE323069T1 - Verfahren zur cyanierung von aldehyden - Google Patents

Verfahren zur cyanierung von aldehyden

Info

Publication number
ATE323069T1
ATE323069T1 AT01953252T AT01953252T ATE323069T1 AT E323069 T1 ATE323069 T1 AT E323069T1 AT 01953252 T AT01953252 T AT 01953252T AT 01953252 T AT01953252 T AT 01953252T AT E323069 T1 ATE323069 T1 AT E323069T1
Authority
AT
Austria
Prior art keywords
chiral
aldehyde
leaving group
catalyst
nucleophilic attack
Prior art date
Application number
AT01953252T
Other languages
English (en)
Inventor
Michael North
Yuri Belokon
Original Assignee
King S College London
Nesmeyanov Inst Of Organoeleme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by King S College London, Nesmeyanov Inst Of Organoeleme filed Critical King S College London
Application granted granted Critical
Publication of ATE323069T1 publication Critical patent/ATE323069T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/08—Formation or introduction of functional groups containing nitrogen of cyano groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
    • B01J31/2208—Oxygen, e.g. acetylacetonates
    • B01J31/2226—Anionic ligands, i.e. the overall ligand carries at least one formal negative charge
    • B01J31/2243—At least one oxygen and one nitrogen atom present as complexing atoms in an at least bidentate or bridging ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
    • B01J2231/34—Other additions, e.g. Monsanto-type carbonylations, addition to 1,2-C=X or 1,2-C-X triplebonds, additions to 1,4-C=C-C=X or 1,4-C=-C-X triple bonds with X, e.g. O, S, NH/N
    • B01J2231/341—1,2-additions, e.g. aldol or Knoevenagel condensations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0202—Polynuclearity
    • B01J2531/0205—Bi- or polynuclear complexes, i.e. comprising two or more metal coordination centres, without metal-metal bonds, e.g. Cp(Lx)Zr-imidazole-Zr(Lx)Cp
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0238—Complexes comprising multidentate ligands, i.e. more than 2 ionic or coordinative bonds from the central metal to the ligand, the latter having at least two donor atoms, e.g. N, O, S, P
    • B01J2531/0241—Rigid ligands, e.g. extended sp2-carbon frameworks or geminal di- or trisubstitution
    • B01J2531/0252—Salen ligands or analogues, e.g. derived from ethylenediamine and salicylaldehyde
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/40—Complexes comprising metals of Group IV (IVA or IVB) as the central metal
    • B01J2531/46—Titanium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/50—Complexes comprising metals of Group V (VA or VB) as the central metal
    • B01J2531/56—Vanadium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Manufacture And Refinement Of Metals (AREA)
AT01953252T 2000-08-02 2001-08-01 Verfahren zur cyanierung von aldehyden ATE323069T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0018973.8A GB0018973D0 (en) 2000-08-02 2000-08-02 Synthesis of chiral cyanohydrins

Publications (1)

Publication Number Publication Date
ATE323069T1 true ATE323069T1 (de) 2006-04-15

Family

ID=9896847

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01953252T ATE323069T1 (de) 2000-08-02 2001-08-01 Verfahren zur cyanierung von aldehyden

Country Status (17)

Country Link
EP (1) EP1307427B3 (de)
JP (1) JP2004505097A (de)
KR (1) KR100820273B1 (de)
CN (1) CN100406433C (de)
AT (1) ATE323069T1 (de)
AU (1) AU2001275740A1 (de)
CA (1) CA2418116A1 (de)
CZ (1) CZ2003276A3 (de)
DE (2) DE60118752T4 (de)
DK (1) DK1307427T5 (de)
ES (1) ES2262665T7 (de)
GB (1) GB0018973D0 (de)
HK (1) HK1062008A1 (de)
HU (1) HUP0301824A3 (de)
MX (1) MXPA03000903A (de)
PT (1) PT1307427E (de)
WO (1) WO2002010095A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0212017D0 (en) * 2002-05-24 2002-07-03 King S College London Catalyst and process
GB0103857D0 (en) 2001-02-16 2001-04-04 Avecia Ltd Preparation of chloromandelic acid
DE10131810A1 (de) * 2001-06-30 2003-02-27 Clariant Gmbh Verfahren zur Herstellung von optisch aktiven Cyanhydrinen und deren korrespondierenden Säuren
DE10131811A1 (de) * 2001-06-30 2003-04-03 Clariant Gmbh Optisch aktive Katalysatoren
US8828902B2 (en) 2001-07-12 2014-09-09 Reaxa Limited Microencapsulated catalyst methods of preparation and method of use thereof
DE10259162A1 (de) * 2002-12-18 2004-07-08 Clariant Gmbh Optisch aktive Komplexe enthaltende Mischungen
JP4758907B2 (ja) 2004-10-15 2011-08-31 三井化学株式会社 チタン化合物及び光学活性シアノヒドリン類の製造法
UA94449C2 (ru) * 2006-03-10 2011-05-10 Ниссан Кэмикал Индастриз, Лтд. Способ получения оптически активного соединения оксида хромена
EP2003135A4 (de) * 2006-03-10 2011-03-02 Nissan Chemical Ind Ltd Verfahren zur herstellung einer optisch aktiven chromenoxidverbindung
JP5275335B2 (ja) * 2007-03-29 2013-08-28 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 光学活性シアノヒドリン誘導体の製造方法
CN102234291B (zh) * 2010-04-23 2014-10-15 中国科学院上海有机化学研究所 桥连双希夫碱钛络合物、合成方法及其应用
CN106552671A (zh) * 2015-09-25 2017-04-05 沈阳中化农药化工研发有限公司 一种多相催化剂及其制备和应用
CN116987004B (zh) * 2023-09-27 2023-12-12 新华制药（寿光）有限公司 一种3-(3,4-二甲氧基苯基)-2-氨基-2-甲基丙腈的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2919974A1 (de) * 1979-05-17 1980-11-27 Hoechst Ag Verfahren zur herstellung von cyanhydrinacylaten von aldehyden
JPH0429965A (ja) * 1990-05-28 1992-01-31 Katakura Chitsukarin Kk α―Ｎ―アルキルアミノニトリル誘導体鏡像異性体の製造方法
JP3303327B2 (ja) * 1992-03-18 2002-07-22 住友化学工業株式会社 不斉誘起触媒
US5349079A (en) * 1992-12-14 1994-09-20 Akzo Nobel Nv Process for forming α-aminonitriles from carbonyl compound and fatty amine hydrohalide
JPH06271522A (ja) * 1993-01-21 1994-09-27 Sumitomo Chem Co Ltd 光学活性シアノヒドリンエステルの製造方法
JPH0770040A (ja) * 1993-06-22 1995-03-14 Sumitomo Chem Co Ltd 光学活性シアノヒドリンエステルの製造法

Also Published As

Publication number Publication date
GB0018973D0 (en) 2000-09-20
CN100406433C (zh) 2008-07-30
KR100820273B1 (ko) 2008-04-07
DE60118752T2 (de) 2007-03-15
CA2418116A1 (en) 2002-02-07
EP1307427B1 (de) 2006-04-12
HUP0301824A3 (en) 2005-11-28
PT1307427E (pt) 2006-07-31
WO2002010095A3 (en) 2002-04-18
CN1468212A (zh) 2004-01-14
WO2002010095A2 (en) 2002-02-07
CZ2003276A3 (cs) 2003-05-14
ES2262665T7 (es) 2009-11-05
EP1307427B3 (de) 2009-04-29
MXPA03000903A (es) 2004-08-02
DK1307427T3 (da) 2006-07-31
AU2001275740A1 (en) 2002-02-13
DE60118752T4 (de) 2009-10-22
ES2262665T3 (es) 2006-12-01
KR20030022339A (ko) 2003-03-15
HK1062008A1 (en) 2004-10-15
JP2004505097A (ja) 2004-02-19
HUP0301824A2 (hu) 2003-09-29
DE60118752D1 (de) 2006-05-24
DK1307427T5 (da) 2009-06-15
EP1307427A2 (de) 2003-05-07

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