HUP0301824A2 - Eljárás ciánvegyületek képzésére aldehidekbżl - Google Patents

Eljárás ciánvegyületek képzésére aldehidekbżl

Info

Publication number
HUP0301824A2
HUP0301824A2 HU0301824A HUP0301824A HUP0301824A2 HU P0301824 A2 HUP0301824 A2 HU P0301824A2 HU 0301824 A HU0301824 A HU 0301824A HU P0301824 A HUP0301824 A HU P0301824A HU P0301824 A2 HUP0301824 A2 HU P0301824A2
Authority
HU
Hungary
Prior art keywords
aldehydes
contain
cyano compounds
cyanation
group
Prior art date
Application number
HU0301824A
Other languages
English (en)
Inventor
Yuri Belokon
Michael North
Original Assignee
King's College London, An Institution Incorporated By Royal Charter
Nesmeyanov Institute Of Organoelement Compounds
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by King's College London, An Institution Incorporated By Royal Charter, Nesmeyanov Institute Of Organoelement Compounds filed Critical King's College London, An Institution Incorporated By Royal Charter
Publication of HUP0301824A2 publication Critical patent/HUP0301824A2/hu
Publication of HUP0301824A3 publication Critical patent/HUP0301824A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/08—Formation or introduction of functional groups containing nitrogen of cyano groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
    • B01J31/2208—Oxygen, e.g. acetylacetonates
    • B01J31/2226—Anionic ligands, i.e. the overall ligand carries at least one formal negative charge
    • B01J31/2243—At least one oxygen and one nitrogen atom present as complexing atoms in an at least bidentate or bridging ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
    • B01J2231/34—Other additions, e.g. Monsanto-type carbonylations, addition to 1,2-C=X or 1,2-C-X triplebonds, additions to 1,4-C=C-C=X or 1,4-C=-C-X triple bonds with X, e.g. O, S, NH/N
    • B01J2231/341—1,2-additions, e.g. aldol or Knoevenagel condensations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0202—Polynuclearity
    • B01J2531/0205—Bi- or polynuclear complexes, i.e. comprising two or more metal coordination centres, without metal-metal bonds, e.g. Cp(Lx)Zr-imidazole-Zr(Lx)Cp
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0238—Complexes comprising multidentate ligands, i.e. more than 2 ionic or coordinative bonds from the central metal to the ligand, the latter having at least two donor atoms, e.g. N, O, S, P
    • B01J2531/0241—Rigid ligands, e.g. extended sp2-carbon frameworks or geminal di- or trisubstitution
    • B01J2531/0252—Salen ligands or analogues, e.g. derived from ethylenediamine and salicylaldehyde
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/40—Complexes comprising metals of Group IV (IVA or IVB) as the central metal
    • B01J2531/46—Titanium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/50—Complexes comprising metals of Group V (VA or VB) as the central metal
    • B01J2531/56—Vanadium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Manufacture And Refinement Of Metals (AREA)

Abstract

A találmány tárgya eljárás ciánvegyületek kialakítására aldehidekbőloly módon, hogy az aldehidet királis katalizátor jelenlétében (i) egy Si-CN csoportot vagy C-(C=O)-CN molekularészt nemtartalmazó cianidforrással, és (ii) egy halogén kilépőcsoportot nemtartalmazó, nukleofil támadásra érzékeny szubsztrátummal reagáltatják.Ezzel az eljárással egyszerűen és igen jó optikai tisztasággalállíthatók elő aszimmetrikus ciánvegyületek, például O-acil-ciánhidrinek. Ó
HU0301824A 2000-08-02 2001-08-01 Process for the cyanation of aldehydes HUP0301824A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0018973.8A GB0018973D0 (en) 2000-08-02 2000-08-02 Synthesis of chiral cyanohydrins
PCT/GB2001/003456 WO2002010095A2 (en) 2000-08-02 2001-08-01 Process for the cyanation of aldehydes

Publications (2)

Publication Number Publication Date
HUP0301824A2 true HUP0301824A2 (hu) 2003-09-29
HUP0301824A3 HUP0301824A3 (en) 2005-11-28

Family

ID=9896847

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301824A HUP0301824A3 (en) 2000-08-02 2001-08-01 Process for the cyanation of aldehydes

Country Status (17)

Country Link
EP (1) EP1307427B3 (hu)
JP (1) JP2004505097A (hu)
KR (1) KR100820273B1 (hu)
CN (1) CN100406433C (hu)
AT (1) ATE323069T1 (hu)
AU (1) AU2001275740A1 (hu)
CA (1) CA2418116A1 (hu)
CZ (1) CZ2003276A3 (hu)
DE (2) DE60118752D1 (hu)
DK (1) DK1307427T5 (hu)
ES (1) ES2262665T7 (hu)
GB (1) GB0018973D0 (hu)
HK (1) HK1062008A1 (hu)
HU (1) HUP0301824A3 (hu)
MX (1) MXPA03000903A (hu)
PT (1) PT1307427E (hu)
WO (1) WO2002010095A2 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0212017D0 (en) * 2002-05-24 2002-07-03 King S College London Catalyst and process
GB0103857D0 (en) 2001-02-16 2001-04-04 Avecia Ltd Preparation of chloromandelic acid
DE10131811A1 (de) * 2001-06-30 2003-04-03 Clariant Gmbh Optisch aktive Katalysatoren
DE10131810A1 (de) * 2001-06-30 2003-02-27 Clariant Gmbh Verfahren zur Herstellung von optisch aktiven Cyanhydrinen und deren korrespondierenden Säuren
EP1409125B1 (en) 2001-07-12 2016-04-20 Reaxa Limited Microencapsulated catalyst, methods of preparation and methods of use thereof
DE10259162A1 (de) * 2002-12-18 2004-07-08 Clariant Gmbh Optisch aktive Komplexe enthaltende Mischungen
CN101039898B (zh) 2004-10-15 2012-01-11 三井化学株式会社 钛化合物及光学活性羟腈类的制备方法
AU2007225765B2 (en) 2006-03-10 2012-05-24 Nissan Chemical Industries, Ltd. Process for producing optically active chromene oxide compound
UA94449C2 (ru) * 2006-03-10 2011-05-10 Ниссан Кэмикал Индастриз, Лтд. Способ получения оптически активного соединения оксида хромена
JP5275335B2 (ja) * 2007-03-29 2013-08-28 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 光学活性シアノヒドリン誘導体の製造方法
CN102234291B (zh) * 2010-04-23 2014-10-15 中国科学院上海有机化学研究所 桥连双希夫碱钛络合物、合成方法及其应用
CN106552671A (zh) * 2015-09-25 2017-04-05 沈阳中化农药化工研发有限公司 一种多相催化剂及其制备和应用
CN116987004B (zh) * 2023-09-27 2023-12-12 新华制药（寿光）有限公司 一种3-(3,4-二甲氧基苯基)-2-氨基-2-甲基丙腈的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2919974A1 (de) * 1979-05-17 1980-11-27 Hoechst Ag Verfahren zur herstellung von cyanhydrinacylaten von aldehyden
JPH0429965A (ja) * 1990-05-28 1992-01-31 Katakura Chitsukarin Kk α―Ｎ―アルキルアミノニトリル誘導体鏡像異性体の製造方法
JP3303327B2 (ja) * 1992-03-18 2002-07-22 住友化学工業株式会社 不斉誘起触媒
US5349079A (en) * 1992-12-14 1994-09-20 Akzo Nobel Nv Process for forming α-aminonitriles from carbonyl compound and fatty amine hydrohalide
JPH06271522A (ja) * 1993-01-21 1994-09-27 Sumitomo Chem Co Ltd 光学活性シアノヒドリンエステルの製造方法
JPH0770040A (ja) * 1993-06-22 1995-03-14 Sumitomo Chem Co Ltd 光学活性シアノヒドリンエステルの製造法

Also Published As

Publication number Publication date
MXPA03000903A (es) 2004-08-02
CN1468212A (zh) 2004-01-14
DK1307427T5 (da) 2009-06-15
HUP0301824A3 (en) 2005-11-28
WO2002010095A2 (en) 2002-02-07
JP2004505097A (ja) 2004-02-19
ES2262665T7 (es) 2009-11-05
CN100406433C (zh) 2008-07-30
AU2001275740A1 (en) 2002-02-13
ES2262665T3 (es) 2006-12-01
ATE323069T1 (de) 2006-04-15
DE60118752T4 (de) 2009-10-22
CA2418116A1 (en) 2002-02-07
CZ2003276A3 (cs) 2003-05-14
PT1307427E (pt) 2006-07-31
GB0018973D0 (en) 2000-09-20
DE60118752T2 (de) 2007-03-15
HK1062008A1 (en) 2004-10-15
EP1307427B3 (en) 2009-04-29
KR20030022339A (ko) 2003-03-15
WO2002010095A3 (en) 2002-04-18
KR100820273B1 (ko) 2008-04-07
DK1307427T3 (da) 2006-07-31
DE60118752D1 (de) 2006-05-24
EP1307427A2 (en) 2003-05-07
EP1307427B1 (en) 2006-04-12

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees