JP2004522706A5 - - Google Patents
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- Publication number
- JP2004522706A5 JP2004522706A5 JP2002539332A JP2002539332A JP2004522706A5 JP 2004522706 A5 JP2004522706 A5 JP 2004522706A5 JP 2002539332 A JP2002539332 A JP 2002539332A JP 2002539332 A JP2002539332 A JP 2002539332A JP 2004522706 A5 JP2004522706 A5 JP 2004522706A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen
- alkyl
- substituted
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 59
- 239000001257 hydrogen Substances 0.000 claims 59
- 125000000217 alkyl group Chemical group 0.000 claims 35
- 150000002431 hydrogen Chemical class 0.000 claims 34
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 25
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical compound C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 claims 21
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 19
- 125000003545 alkoxy group Chemical group 0.000 claims 19
- 125000003118 aryl group Chemical group 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- 238000000034 method Methods 0.000 claims 17
- 150000003857 carboxamides Chemical class 0.000 claims 12
- -1 hydroxy, amino Chemical group 0.000 claims 12
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 11
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 10
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 9
- 239000003054 catalyst Substances 0.000 claims 8
- 125000003282 alkyl amino group Chemical group 0.000 claims 7
- 239000003153 chemical reaction reagent Substances 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000004663 dialkyl amino group Chemical group 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 6
- 150000002825 nitriles Chemical class 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 4
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000005392 carboxamide group Chemical group NC(=O)* 0.000 claims 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 125000003003 spiro group Chemical group 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 4
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims 3
- 125000004442 acylamino group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- 230000003796 beauty Effects 0.000 claims 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 3
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 3
- 229910002091 carbon monoxide Inorganic materials 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 3
- 125000001174 sulfone group Chemical group 0.000 claims 3
- 125000003375 sulfoxide group Chemical group 0.000 claims 3
- ZJFPQVBARDXZPX-UHFFFAOYSA-N 2,6-methano-3-benzazocine Chemical compound C1=CC=C2C(C3)=CC=NC3=CC2=C1 ZJFPQVBARDXZPX-UHFFFAOYSA-N 0.000 claims 2
- 229910021529 ammonia Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical compound C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 claims 2
- 230000003301 hydrolyzing effect Effects 0.000 claims 2
- CYEBJEDOHLIWNP-UHFFFAOYSA-N methanethioamide Chemical compound NC=S CYEBJEDOHLIWNP-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical group [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical group NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 1
- 102000003840 Opioid Receptors Human genes 0.000 claims 1
- 108090000137 Opioid Receptors Proteins 0.000 claims 1
- 101150003085 Pdcl gene Proteins 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- GCUVBACNBHGZRS-UHFFFAOYSA-N cyclopenta-1,3-diene cyclopenta-2,4-dien-1-yl(diphenyl)phosphane iron(2+) Chemical compound [Fe++].c1cc[cH-]c1.c1cc[c-](c1)P(c1ccccc1)c1ccccc1 GCUVBACNBHGZRS-UHFFFAOYSA-N 0.000 claims 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 1
- OTYNBGDFCPCPOU-UHFFFAOYSA-N phosphane sulfane Chemical compound S.P[H] OTYNBGDFCPCPOU-UHFFFAOYSA-N 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- WJKHJLXJJJATHN-UHFFFAOYSA-N triflic anhydride Chemical group FC(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F WJKHJLXJJJATHN-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24443800P | 2000-10-31 | 2000-10-31 | |
| PCT/US2001/045581 WO2002036573A2 (en) | 2000-10-31 | 2001-10-31 | 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003422779A Division JP2004137288A (ja) | 2000-10-31 | 2003-12-19 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004522706A JP2004522706A (ja) | 2004-07-29 |
| JP2004522706A5 true JP2004522706A5 (cg-RX-API-DMAC7.html) | 2005-02-24 |
| JP4340437B2 JP4340437B2 (ja) | 2009-10-07 |
Family
ID=22922766
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539332A Expired - Lifetime JP4340437B2 (ja) | 2000-10-31 | 2001-10-31 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
| JP2003422779A Pending JP2004137288A (ja) | 2000-10-31 | 2003-12-19 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003422779A Pending JP2004137288A (ja) | 2000-10-31 | 2003-12-19 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
Country Status (9)
| Country | Link |
|---|---|
| US (9) | US6784187B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP1353909B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4340437B2 (cg-RX-API-DMAC7.html) |
| AT (2) | ATE391712T1 (cg-RX-API-DMAC7.html) |
| AU (2) | AU2002227135B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2426942C (cg-RX-API-DMAC7.html) |
| DE (2) | DE60109960T2 (cg-RX-API-DMAC7.html) |
| ES (3) | ES2239170T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002036573A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60109960T2 (de) * | 2000-10-31 | 2006-02-16 | Rensselaer Polytechnic Institute | 8-substituierte 2,6-methano-3-benzazocine und 3-substituierte morphinane als opioidrezeptorbindende agenzien |
| US6974824B2 (en) * | 2001-01-08 | 2005-12-13 | Research Triangle Institute | Kappa opioid receptor ligands |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| AU2003234621A1 (en) * | 2002-05-17 | 2003-12-02 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EP1602374A4 (en) * | 2003-03-07 | 2007-03-07 | Toray Industries | MEANS FOR TREATMENT OF MEDICAMENT / SUBSTANCE DEPENDENCE |
| US7381721B2 (en) | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US6992090B2 (en) | 2003-06-16 | 2006-01-31 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| WO2005003131A1 (en) | 2003-06-27 | 2005-01-13 | Janssen Pharmaceutica N.V. | Tricyclic delta opioid modulators |
| EP1595541A1 (en) | 2004-05-12 | 2005-11-16 | Alcasynn Pharmaceuticals Gmbh | Use of opioid receptor antagonist compounds for the prevention and/or treatment of diseases associated with the target calcineurin |
| JP5420170B2 (ja) * | 2004-05-14 | 2014-02-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | カルボキサミド系オピオイド化合物 |
| EA200700403A1 (ru) | 2004-08-05 | 2007-08-31 | Янссен Фармацевтика Н.В. | ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ |
| TW200621785A (en) * | 2004-11-04 | 2006-07-01 | Toray Industries | Analgesic |
| EP1817291A1 (en) | 2004-11-05 | 2007-08-15 | Rensselaer Polytechnic Institute | 4-hydroxybenzomorphans |
| MX2007007627A (es) | 2004-12-22 | 2008-01-28 | Johnson & Johnson | Moduladores delta-opioides triciclicos. |
| AU2005319060A1 (en) | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
| EP1846400A2 (en) | 2005-01-06 | 2007-10-24 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
| WO2006126529A1 (ja) | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体 |
| ATE490251T1 (de) | 2005-06-16 | 2010-12-15 | Janssen Pharmaceutica Nv | Tricyclische opioidmodulatoren |
| ES2480390T3 (es) | 2005-07-21 | 2014-07-28 | Rensselaer Polytechnic Institute | 2,6-metano-3-benzazocinas 8-carboxamido sustituidas y morfanos 3-carboxamido sustituidos como ligandos de los receptores opioides |
| US7538110B2 (en) | 2005-10-27 | 2009-05-26 | Adolor Corporation | Opioid antagonists |
| TWI425945B (zh) * | 2007-05-28 | 2014-02-11 | Seldar Pharma Inc | 四氫異喹啉－１－酮衍生物或其鹽 |
| KR101519682B1 (ko) * | 2007-08-09 | 2015-05-19 | 렌슬러 폴리테크닉 인스티튜트 | 4급 오피오이드 카르복스아미드 |
| AU2009274147B2 (en) * | 2008-07-21 | 2014-09-04 | Rensselaer Polytechnic Institute | Large substituent, non-phenolic amine opioids |
| AU2009342654B2 (en) * | 2009-03-19 | 2013-09-05 | Alkermes Pharma Ireland Limited | Morphinan derivatives with high oral bioavailability |
| US8624040B2 (en) | 2009-06-22 | 2014-01-07 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2010151318A1 (en) | 2009-06-22 | 2010-12-29 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| WO2011035142A1 (en) * | 2009-09-18 | 2011-03-24 | Adolor Corporation | Use of opioid receptor antagonist for gastrointestinal tract disorders |
| WO2011068594A1 (en) | 2009-12-04 | 2011-06-09 | Alkermes, Inc. | Morphinan derivatives for the treatment of drug overdose |
| WO2011106627A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US20110212969A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8436175B2 (en) | 2010-03-22 | 2013-05-07 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
| WO2011130163A1 (en) | 2010-04-12 | 2011-10-20 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| EP2590649B1 (en) | 2010-07-08 | 2018-11-28 | Alkermes Pharma Ireland Limited | Process for the synthesis of substituted morphinans |
| PL2593095T3 (pl) | 2010-07-16 | 2019-12-31 | Mallinckrodt Llc | (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania |
| RS65091B1 (sr) | 2010-08-23 | 2024-02-29 | Alkermes Pharma Ireland Ltd | Postupci za lečenje povećanja telesne težine indukovanog antipsihoticima |
| US8471026B2 (en) | 2010-08-26 | 2013-06-25 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8765773B2 (en) | 2010-10-18 | 2014-07-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2012088015A2 (en) * | 2010-12-22 | 2012-06-28 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2012138888A1 (en) | 2011-04-05 | 2012-10-11 | Alkermes, Inc. | Process for the synthesis of quaternary amine compounds |
| EP2725908B1 (en) | 2011-06-29 | 2017-05-31 | Alkermes, Inc. | Peripherally acting opioid compounds |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| TR201815154T4 (tr) | 2011-12-15 | 2018-11-21 | Alkermes Pharma Ireland Ltd | Depresi̇f bozukluklarin tedavi̇si̇ne yöneli̇k buprenorfi̇n i̇le kombi̇nasyon hali̇nde sami̇dorfan (alks 33). |
| CA2890655A1 (en) * | 2012-11-09 | 2014-05-15 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| WO2014190271A2 (en) | 2013-05-24 | 2014-11-27 | Alkermes Pharma Ireland Limted | Methods for treating depressive symptoms |
| AU2014268361B2 (en) | 2013-05-24 | 2018-09-06 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
| EP3074379B1 (en) | 2013-11-27 | 2019-06-26 | Nektar Therapeutics (India) Pvt. Ltd. | Opioid agonists and uses thereof |
| EP3139921A4 (en) | 2014-05-06 | 2018-02-14 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
| US10183934B2 (en) | 2015-02-02 | 2019-01-22 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors |
| SG11201706146UA (en) | 2015-02-02 | 2017-08-30 | Forma Therapeutics Inc | 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors |
| WO2017218950A1 (en) | 2016-06-17 | 2017-12-21 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
| US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH581624A5 (cg-RX-API-DMAC7.html) | 1970-08-14 | 1976-11-15 | Sumitomo Chemical Co | |
| US3856795A (en) | 1972-04-25 | 1974-12-24 | American Home Prod | Process for preparation of secondary amines from tertiary amines |
| US3957793A (en) | 1974-09-20 | 1976-05-18 | Sterling Drug Inc. | Hydroxyiminobenzazocines |
| US4032529A (en) | 1974-09-20 | 1977-06-28 | Sterling Drug Inc. | Aminomethanobenzazocine intermediates |
| US4205171A (en) | 1976-01-12 | 1980-05-27 | Sterling Drug Inc. | Aminomethanobenzazocines and nitromethanobenzazocines |
| US4373139A (en) | 1979-04-30 | 1983-02-08 | Motorola, Inc. | Detectors |
| US4464378A (en) * | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
| US4374139A (en) * | 1981-11-09 | 1983-02-15 | Hoffmann-La Roche Inc. | Levorotatory N-substituted acylmorphinans useful as analgesic agents |
| US4649200A (en) * | 1986-05-08 | 1987-03-10 | Regents Of The University Of Minnesota | Substituted pyrroles with opioid receptor activity |
| US4939264A (en) | 1986-07-14 | 1990-07-03 | Abbott Laboratories | Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies |
| US5258386A (en) | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| US5607941A (en) | 1992-06-26 | 1997-03-04 | Boehringer Ingelheim Kg | Useful for treating neurodegenerative diseases |
| SE9103745D0 (sv) * | 1991-12-18 | 1991-12-18 | Wikstroem Haakan | Aryl-triflates and related compounds |
| JPH07502734A (ja) | 1991-12-31 | 1995-03-23 | ザイモジェネティクス，インコーポレイティド | 血液損失を減少する方法および組成物 |
| EP0632041A1 (en) * | 1993-07-01 | 1995-01-04 | Katholieke Universiteit Nijmegen | New morphine derivatives having improved analgesic and narcotic properties |
| NZ326331A (en) * | 1996-01-10 | 2000-01-28 | Smithkline Beecham Spa | Heterocycle-condensed morphinoid derivatives and medicaments |
| GB9709972D0 (en) * | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
| GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| DE60109960T2 (de) | 2000-10-31 | 2006-02-16 | Rensselaer Polytechnic Institute | 8-substituierte 2,6-methano-3-benzazocine und 3-substituierte morphinane als opioidrezeptorbindende agenzien |
| ES2249722T3 (es) | 2002-05-30 | 2006-04-01 | Eli Lilly And Company | Antagonistas de receptor de opioides. |
| EP1817291A1 (en) * | 2004-11-05 | 2007-08-15 | Rensselaer Polytechnic Institute | 4-hydroxybenzomorphans |
| ES2480390T3 (es) * | 2005-07-21 | 2014-07-28 | Rensselaer Polytechnic Institute | 2,6-metano-3-benzazocinas 8-carboxamido sustituidas y morfanos 3-carboxamido sustituidos como ligandos de los receptores opioides |
-
2001
- 2001-10-31 DE DE60109960T patent/DE60109960T2/de not_active Expired - Lifetime
- 2001-10-31 DE DE60133584T patent/DE60133584T2/de not_active Expired - Lifetime
- 2001-10-31 AT AT03013544T patent/ATE391712T1/de not_active IP Right Cessation
- 2001-10-31 JP JP2002539332A patent/JP4340437B2/ja not_active Expired - Lifetime
- 2001-10-31 AT AT01992702T patent/ATE292625T1/de not_active IP Right Cessation
- 2001-10-31 AU AU2002227135A patent/AU2002227135B2/en not_active Expired
- 2001-10-31 ES ES01992702T patent/ES2239170T3/es not_active Expired - Lifetime
- 2001-10-31 ES ES08004779T patent/ES2572332T3/es not_active Expired - Lifetime
- 2001-10-31 CA CA2426942A patent/CA2426942C/en not_active Expired - Lifetime
- 2001-10-31 EP EP01992702A patent/EP1353909B1/en not_active Expired - Lifetime
- 2001-10-31 AU AU2713502A patent/AU2713502A/xx active Pending
- 2001-10-31 EP EP08004779.8A patent/EP1944292B9/en not_active Expired - Lifetime
- 2001-10-31 WO PCT/US2001/045581 patent/WO2002036573A2/en not_active Ceased
- 2001-10-31 ES ES03013544T patent/ES2304477T3/es not_active Expired - Lifetime
- 2001-10-31 EP EP03013544A patent/EP1359146B1/en not_active Expired - Lifetime
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2002
- 2002-11-26 US US10/305,287 patent/US6784187B2/en not_active Expired - Lifetime
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2003
- 2003-04-09 US US10/409,803 patent/US6887998B2/en not_active Expired - Lifetime
- 2003-12-19 JP JP2003422779A patent/JP2004137288A/ja active Pending
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2004
- 2004-11-12 US US10/987,527 patent/US7265226B2/en not_active Expired - Lifetime
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2005
- 2005-08-17 US US11/205,354 patent/US20060030580A1/en not_active Abandoned
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2008
- 2008-10-10 US US12/249,238 patent/US7956187B2/en not_active Expired - Fee Related
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2011
- 2011-05-09 US US13/103,599 patent/US8252929B2/en not_active Expired - Fee Related
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2012
- 2012-07-24 US US13/556,650 patent/US8642615B2/en not_active Expired - Lifetime
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2013
- 2013-12-19 US US14/134,264 patent/US20140275545A1/en not_active Abandoned
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2016
- 2016-09-09 US US15/260,610 patent/US9932349B2/en not_active Expired - Lifetime