JP2004502638A5 - - Google Patents
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- Publication number
- JP2004502638A5 JP2004502638A5 JP2001547043A JP2001547043A JP2004502638A5 JP 2004502638 A5 JP2004502638 A5 JP 2004502638A5 JP 2001547043 A JP2001547043 A JP 2001547043A JP 2001547043 A JP2001547043 A JP 2001547043A JP 2004502638 A5 JP2004502638 A5 JP 2004502638A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen
- alkyl
- oxa
- hydroxyalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229930003316 Vitamin D Natural products 0.000 description 5
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- 235000019166 vitamin D Nutrition 0.000 description 5
- 239000011710 vitamin D Substances 0.000 description 5
- 229940046008 vitamin d Drugs 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000003709 fluoroalkyl group Chemical group 0.000 description 4
- 150000002431 hydrogen Chemical group 0.000 description 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 4
- -1 vitamin D compound Chemical class 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 208000037147 Hypercalcaemia Diseases 0.000 description 2
- 102000003814 Interleukin-10 Human genes 0.000 description 2
- 108090000174 Interleukin-10 Proteins 0.000 description 2
- 230000000148 hypercalcaemia Effects 0.000 description 2
- 208000030915 hypercalcemia disease Diseases 0.000 description 2
- AQYSYJUIMQTRMV-UHFFFAOYSA-N hypofluorous acid Chemical compound FO AQYSYJUIMQTRMV-UHFFFAOYSA-N 0.000 description 2
- 229940076144 interleukin-10 Drugs 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 0 CCC(C)(C(*)CC1)C1=C Chemical compound CCC(C)(C(*)CC1)C1=C 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/469,985 US6358939B1 (en) | 1999-12-21 | 1999-12-21 | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| PCT/US2000/034913 WO2001046132A1 (en) | 1999-12-21 | 2000-12-21 | Use of biologically active vitamin d compounds for the prevention and treatment of inflammatory bowel disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004502638A JP2004502638A (ja) | 2004-01-29 |
| JP2004502638A5 true JP2004502638A5 (cg-RX-API-DMAC7.html) | 2008-01-31 |
Family
ID=23865828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001547043A Withdrawn JP2004502638A (ja) | 1999-12-21 | 2000-12-21 | 炎症性腸疾患の予防および治療のための生物学的活性ビタミンｄ化合物の使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6358939B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1240136A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2004502638A (cg-RX-API-DMAC7.html) |
| KR (1) | KR100660508B1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU781113B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2395200A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA02006257A (cg-RX-API-DMAC7.html) |
| NO (1) | NO326517B1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001046132A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087350A (en) | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| CA2390859A1 (en) * | 1999-12-02 | 2001-06-14 | The Penn State Research Foundation | Treatment of inflammatory bowel disease with vitamin d compounds |
| US6989377B2 (en) * | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| EP1340078B1 (en) * | 2000-11-14 | 2009-05-27 | Techlab, Inc. | Method for differentiating irritable bowel syndrome from inflammatory bowel disease (ibd) and for monitoring persons with ibd using total endogenous lactoferrin as a marker |
| US7582670B2 (en) * | 2001-12-13 | 2009-09-01 | Natrogen Therapeutics, Inc. | Methods of treating an inflammatory-related disease |
| US20060094778A1 (en) * | 2003-01-10 | 2006-05-04 | Eli Lilly And Company, An Indiana Corporation | Vesicant treatment with phenyl-phenyl type vitamin d receptor modulators |
| CA2518079A1 (en) * | 2003-03-04 | 2004-10-28 | Teva Pharmaceutical Industries, Ltd. | Combination therapy with glatiramer acetate and alphacalcidol for the treatment of multiple sclerosis |
| GB0307865D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
| US20050148557A1 (en) * | 2003-07-29 | 2005-07-07 | Jin Tian | Use of Vitamin Ds to treat kidney disease |
| US20050192255A1 (en) * | 2003-07-30 | 2005-09-01 | Jin Tian | Use of Vitamin Ds or Vitamin D analogs to treat cardiovascular disease |
| US20050209203A1 (en) * | 2003-07-30 | 2005-09-22 | Jin Tian | Use of vitamin Ds or vitamin D analogs to treat cardiovascular disease |
| US20060171983A1 (en) * | 2003-07-30 | 2006-08-03 | Jin Tian | Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease |
| US7704980B2 (en) * | 2003-10-08 | 2010-04-27 | Wisconsin Alumni Research Foundation | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
| GB0513984D0 (en) * | 2005-07-07 | 2005-08-17 | Teva Pharma | Dosage form |
| US10716798B2 (en) | 2007-02-21 | 2020-07-21 | The Regents Of The University Of Michigan | Compositions and methods for tranquilizing heart muscle |
| WO2008121386A2 (en) * | 2007-03-30 | 2008-10-09 | Amgen Inc. | Calcimimetic compounds for use in the treatment of bowel disorders |
| WO2008131267A2 (en) * | 2007-04-18 | 2008-10-30 | Johns Hopkins University | Low calcemic, highly antiproliferative, analogs of calcitriol |
| US8318708B2 (en) * | 2007-11-06 | 2012-11-27 | Salk Institute For Biological Studies | Use of vitamin D receptor agonists, ligands, and precursors to treat pancreatic fibrosis |
| EP2217250A4 (en) | 2007-11-09 | 2011-01-05 | California Inst Of Techn | IMMUNOMODULATING COMPOUNDS AND RELEVANT COMPOSITIONS AND METHODS |
| CR20170434A (es) | 2009-01-27 | 2017-11-21 | Berg Llc | VITAMINA D3 Y ANALOGOS DE LA MISMA PARA ALIVIAR EFECTOS SECUNDARIOS ASOCIADOS CON LA QUIMIOTERAPIA. (Divisional 2011-0445) |
| EA201270226A1 (ru) | 2009-08-14 | 2012-09-28 | БЕРГ БАЙОСИСТЕМЗ, ЭлЭлСи | Витамин d3 и его аналогии для лечения алопеции |
| WO2011063241A1 (en) | 2009-11-20 | 2011-05-26 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds and prodrugs thereof and their uses |
| HRP20181778T1 (hr) | 2010-04-07 | 2019-01-11 | California Institute Of Technology | Prijenosnik za isporuku spoja u membranu sluznice i srodnih pripravaka, postupci i sustavi |
| JP6067550B2 (ja) | 2010-04-13 | 2017-01-25 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ２，４−ピリミジンジアミン化合物およびそのプロドラッグならびにそれらの使用 |
| WO2012103532A1 (en) * | 2011-01-28 | 2012-08-02 | Mazmanian Sarkis K | Combinatorial vitamin d and probiotic therapy for inflammatory bowel disease |
| US9539281B2 (en) | 2011-07-12 | 2017-01-10 | The Brigham And Women's Hospital, Inc. | Lipid-containing PSA compositions, methods of isolation and methods of use thereof |
| ES2547682T3 (es) * | 2011-08-19 | 2015-10-08 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Agente terapéutico de combinación de contiene vasoconstrictor |
| MX2015014701A (es) | 2013-04-24 | 2016-08-08 | Salk Inst For Biological Studi | Circuito genomico del receptor de vitamina d/smad que regula la compuerta de la respuesta fibrotica. |
| JP2016521284A (ja) | 2013-05-10 | 2016-07-21 | カリフォルニア インスティチュート オブ テクノロジー | 大腸ガンのプロバイオティクスによる防止および処置 |
| AU2014274099A1 (en) | 2013-05-29 | 2015-12-24 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin D |
| EP3473299A1 (en) | 2013-06-05 | 2019-04-24 | Salk Institute for Biological Studies | Vitamin d receptor agonists to treat diseases involving cxcl12 activity |
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| KR102343093B1 (ko) | 2015-02-23 | 2021-12-24 | 삼성전자주식회사 | 식기 세척기 및 그 제어방법 |
| WO2016201342A1 (en) | 2015-06-10 | 2016-12-15 | California Institute Of Technology | Sepsis treatment and related compositions methods and systems |
| CN113637040A (zh) | 2015-08-19 | 2021-11-12 | 哈佛学院院长及董事 | 脂化psa组合物和方法 |
| CA3030974A1 (en) | 2016-07-15 | 2018-01-18 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
| WO2019023149A1 (en) | 2017-07-24 | 2019-01-31 | Salk Institute For Biological Studies | USE OF BROMODOMAIN-CONTAINING PROTEIN-9 ANTAGONISTS IN ASSOCIATION WITH VITAMIN D RECEPTOR AGONISTS IN THE TREATMENT OF DIABETES |
| JP2025534350A (ja) | 2022-09-30 | 2025-10-15 | エクステンド バイオサイエンシズ インコーポレーテッド | 長時間作用型副甲状腺ホルモン |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4312806A (en) | 1981-03-02 | 1982-01-26 | G. D. Searle & Co. | Method and compounds for treating inflammatory bowel disease |
| US4638043A (en) | 1984-11-13 | 1987-01-20 | Thermedics, Inc. | Drug release system |
| US5310732A (en) | 1986-02-03 | 1994-05-10 | The Scripps Research Institute | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
| US5518725A (en) | 1989-09-25 | 1996-05-21 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
| US5824313A (en) | 1989-09-25 | 1998-10-20 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
| US5643602A (en) | 1989-11-22 | 1997-07-01 | Astra Aktiebolag | Oral composition for the treatment of inflammatory bowel disease |
| US5216002A (en) | 1989-12-21 | 1993-06-01 | Eli Lilly And Company | Method of treating inflammatory bowel disease |
| JP2811353B2 (ja) | 1990-07-06 | 1998-10-15 | ゼリア新薬工業株式会社 | 炎症性腸疾患予防・治療剤 |
| ZA916555B (en) | 1990-08-27 | 1993-04-28 | Lilly Co Eli | Method of treating inflammatory bowel disease |
| US5391555A (en) | 1991-11-12 | 1995-02-21 | Miles Inc. | Methods for treating inflammatory bowel disease with leukotriene synthesis inhibitors |
| DE4141746A1 (de) | 1991-12-13 | 1993-06-17 | Schering Ag | 20-methyl-substituierte vitamin d-derivate |
| US5932214A (en) | 1994-08-11 | 1999-08-03 | Biogen, Inc. | Treatment for inflammatory bowel disease with VLA-4 blockers |
| DK64592D0 (da) | 1992-05-14 | 1992-05-14 | Carlbiotech Ltd As | Peptider til terapeutisk behandling |
| DE4221961A1 (de) * | 1992-06-30 | 1994-01-05 | Schering Ag | 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel |
| US5294630A (en) | 1992-07-07 | 1994-03-15 | Eli Lilly And Company | Treatment of inflammatory bowel disease |
| US5368854A (en) | 1992-08-20 | 1994-11-29 | Schering Corporation | Use of IL-10 to treat inflammatory bowel disease |
| IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same |
| GB9223061D0 (en) | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
| ATE163262T1 (de) | 1993-04-20 | 1998-03-15 | Hexal Ag | Wirkstoffplaster |
| GB9309422D0 (en) | 1993-05-07 | 1993-06-23 | Res Inst Medicine Chem | Chemical compounds |
| GB9314400D0 (en) | 1993-07-12 | 1993-08-25 | Leo Pharm Prod Ltd | Produktionsaktieselskab) chemical compounds |
| GB9315253D0 (en) | 1993-07-23 | 1993-09-08 | Res Inst Medicine Chem | Chemical compounds |
| US5420109A (en) | 1993-11-12 | 1995-05-30 | Houghten Pharmaceuticals, Inc. | Cytokine restraining agents |
| GB9325415D0 (en) | 1993-12-13 | 1994-02-16 | Res Inst Medicine Chem | Chemical compounds |
| DE4405545A1 (de) * | 1994-02-22 | 1995-08-31 | Dietl Hans | Fettlösliche Vitamine enthaltende Zubereitung zur oralen Applikation |
| GB9405715D0 (en) | 1994-03-23 | 1994-05-11 | Res Inst Medicine Chem | Chemical compounds |
| GB2292079B (en) | 1994-08-12 | 1998-07-15 | Flexpharm Ltd | Coated prednisolone preparation for the treatment of inflamatory bowel disease |
| DE69508895T2 (de) | 1994-12-14 | 1999-10-21 | Duphar International Research B.V., Weesp | Vitamin-D-Derivate und Verfahren zur Herstellung dieser Verbindungen |
| DE69617909T2 (de) | 1995-01-23 | 2002-07-25 | Chugai Seiyaku K.K., Tokio/Tokyo | 2-substituierte vitamin-d3-derivate |
| US5877168A (en) | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
| US5981597A (en) * | 1995-02-13 | 1999-11-09 | Trustees Of The University Of Pennsylvania | Differentiating agents for the treatment of inflammatory intestinal diseases |
| US5569680A (en) | 1995-02-13 | 1996-10-29 | Trustees Of The Univ. Of Penna | Method of treating inflammatory bowel disease with tributyrin |
| GB9509764D0 (en) | 1995-05-15 | 1995-07-05 | Tillotts Pharma Ag | Treatment of inflammatory bowel disease using oral dosage forms of omega-3 polyunsaturated acids |
| US5851548A (en) | 1995-06-07 | 1998-12-22 | Gen-Probe Incorporated | Liposomes containing cationic lipids and vitamin D |
| IL122432A (en) | 1995-06-07 | 2000-07-16 | Cygnus Therapeutic Systems | Transdermal patch for preventing ovulation |
| US5711964A (en) | 1995-06-07 | 1998-01-27 | United States Of America | Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D |
| US5952317A (en) | 1995-09-21 | 1999-09-14 | Wisconsin Alumni Research Foundation | Calcitriol derivatives and their uses |
| ES2144183T3 (es) | 1995-10-30 | 2000-06-01 | Hoffmann La Roche | 1-alfa,26-dihidroxi-d-homo-vitamina d3. |
| US5889028A (en) | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| US5716946A (en) | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
| AU710931B2 (en) | 1996-02-28 | 1999-09-30 | Sumitomo Pharmaceuticals Company, Limited | Crystalline vitamin D derivative |
| GB9607034D0 (en) | 1996-04-03 | 1996-06-05 | Leo Pharm Prod Ltd | Chemical compounds |
| ES2188932T3 (es) | 1996-04-04 | 2003-07-01 | Cilag Ag | Formulacion topica de vitamina d a base de liposomas. |
| US5891865A (en) | 1996-10-04 | 1999-04-06 | Wisconsin Alumni Research Foundation | Treatment of arthritic disease induced by infectious agents |
| AU743514B2 (en) * | 1997-05-16 | 2002-01-24 | Women & Infants Hospital | Cyclic ether vitamin D3 compounds, 1alpha (OH) 3-EPI-vitamin D3 compounds and uses thereof |
| CA2288710A1 (en) * | 1997-05-16 | 1998-11-19 | Women & Infants Hospital | 3-epi vitamin d2 compounds and uses thereof |
| NL1006072C2 (nl) | 1997-05-16 | 1998-11-17 | Jacobs Johannes J | Vergister voor het onder aërobe omstandigheden vergisten van dierlijke mest, inrichting en werkwijze voor het onder aërobe omstandigheden vergisten van dierlijke mest onder toepassing van een dergelijke vergister. |
| US5936105A (en) | 1997-06-13 | 1999-08-10 | Tetrionics, Inc. | 14-EPI-19-nor-vitamin D compounds and methods |
| EP0927721A1 (de) * | 1997-12-17 | 1999-07-07 | Schering Aktiengesellschaft | Neue Vitamin D-Derivate mit Phosphoratomen in den Seitenketten, Zwischenprodukte bei ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| US6214373B1 (en) * | 1999-10-07 | 2001-04-10 | Snowden-Sutton Associates, Inc. | Nutritional composition for treating inflammatory bowel diseases |
| CA2390859A1 (en) * | 1999-12-02 | 2001-06-14 | The Penn State Research Foundation | Treatment of inflammatory bowel disease with vitamin d compounds |
| US20030188756A1 (en) * | 2002-08-19 | 2003-10-09 | Cantorna Margherita T | Treatment of inflammatory bowel disease with vitamin d compounds |
| AU2001275445B2 (en) * | 2000-09-08 | 2006-07-27 | Wisconsin Alumni Research Foundation | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
-
1999
- 1999-12-21 US US09/469,985 patent/US6358939B1/en not_active Expired - Fee Related
-
2000
- 2000-12-21 KR KR1020027008018A patent/KR100660508B1/ko not_active Expired - Fee Related
- 2000-12-21 WO PCT/US2000/034913 patent/WO2001046132A1/en not_active Ceased
- 2000-12-21 CA CA002395200A patent/CA2395200A1/en not_active Abandoned
- 2000-12-21 AU AU22878/01A patent/AU781113B2/en not_active Ceased
- 2000-12-21 JP JP2001547043A patent/JP2004502638A/ja not_active Withdrawn
- 2000-12-21 MX MXPA02006257A patent/MXPA02006257A/es active IP Right Grant
- 2000-12-21 EP EP00986687A patent/EP1240136A4/en not_active Ceased
-
2001
- 2001-12-21 US US10/036,819 patent/US6858595B2/en not_active Expired - Fee Related
-
2002
- 2002-06-20 NO NO20022974A patent/NO326517B1/no not_active IP Right Cessation
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