BR0113703A - Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de pele - Google Patents
Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de peleInfo
- Publication number
- BR0113703A BR0113703A BR0113703-4A BR0113703A BR0113703A BR 0113703 A BR0113703 A BR 0113703A BR 0113703 A BR0113703 A BR 0113703A BR 0113703 A BR0113703 A BR 0113703A
- Authority
- BR
- Brazil
- Prior art keywords
- psoriasis
- treatment
- skin
- renal osteodystrophy
- autoimmune
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
"COMPOSTOS E MéTODOS DE TRATAMENTO DE PSORìASE, LEUCEMIA, CâNCER DO CóLON, DO SEIO OU DA PRóSTATA, OSTEODISTROFIA RENAL, DE DOENçAS AUTO-IMUNE, INFLAMATóRIA E DE CONDIçãO DE PELE". Esta invenção revela a 1<244>-hidroxi-2-metileno-19-nor-homopregnacalciferol e usos farmacêuticos para a mesma. Este composto exibe pronunciada atividade na interrupção da proliferação de células indiferenciadas e na indução da sua diferenciação no monócito, evidenciando, assim, o uso como agente anticancerígeno e no tratamento de doenças de pele, tais como psoríase, assim como condições dérmicas tais como rugas, lassidão da pele, pele seca e secreção sebácea insuficiente. Este composto tem também pequena, se é que alguma, atividade calcêmica e, portanto, pode ser usado para tratar desordens imuno em pessoas, assim como osteodistrofia renal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65782800A | 2000-09-08 | 2000-09-08 | |
PCT/US2001/018710 WO2002020021A1 (en) | 2000-09-08 | 2001-06-11 | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0113703A true BR0113703A (pt) | 2003-07-22 |
Family
ID=24638806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0113703-4A Pending BR0113703A (pt) | 2000-09-08 | 2001-06-11 | Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de pele |
Country Status (16)
Country | Link |
---|---|
US (2) | US6440953B1 (pt) |
EP (1) | EP1315504B1 (pt) |
JP (1) | JP4022144B2 (pt) |
KR (1) | KR100672886B1 (pt) |
CN (1) | CN1473048A (pt) |
AT (1) | ATE273709T1 (pt) |
AU (2) | AU2001275445B2 (pt) |
BR (1) | BR0113703A (pt) |
CA (1) | CA2420026C (pt) |
DE (1) | DE60105035T2 (pt) |
ES (1) | ES2227215T3 (pt) |
IL (2) | IL154699A0 (pt) |
MX (1) | MXPA03001969A (pt) |
NZ (1) | NZ524657A (pt) |
PT (1) | PT1315504E (pt) |
WO (1) | WO2002020021A1 (pt) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
US6358939B1 (en) * | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
US6627622B2 (en) | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
WO2003051828A2 (en) * | 2001-12-13 | 2003-06-26 | Wisconsin Alumni Research Foundation | (20s)-1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
US6774251B2 (en) | 2002-03-29 | 2004-08-10 | Wisconsin Alumni Research Foundation | Method of synthesizing 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol |
US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
US7598408B2 (en) | 2003-02-25 | 2009-10-06 | Knc Laboratories Co., Ltd. | Intermediates for synthesis of vitamin D derivatives |
JP5009617B2 (ja) * | 2003-08-20 | 2012-08-22 | ウイスコンシン アラムニ リサーチ ファンデーション | 2−メチレン−19−ノル−ビタミンd2化合物 |
US7704980B2 (en) * | 2003-10-08 | 2010-04-27 | Wisconsin Alumni Research Foundation | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
CA2544502A1 (en) * | 2003-11-25 | 2005-06-09 | Wisconsin Alumni Research Foundation | Vitamin d analogs for obesity prevention and treatment |
US7053075B2 (en) * | 2003-11-25 | 2006-05-30 | Deluca Hector F | Methods for reducing body fat using vitamin D compounds |
US8404667B2 (en) * | 2006-12-29 | 2013-03-26 | Wisconsin Alumni Research Foundation | Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog |
WO2005079464A2 (en) * | 2004-02-17 | 2005-09-01 | Wisconsin Alumni Research Foundation | Vitamin d receptor antagonists and their use in treating asthma |
US7214671B2 (en) * | 2004-02-19 | 2007-05-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases |
US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
MX2007006096A (es) * | 2004-11-22 | 2007-07-11 | Wisconsin Alumni Res Found | 2-metilen-19-nor-(20s)-1a-hidroxi-trishomopregnacalciferol. |
CA2588038A1 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20r)-1-.alpha.-hydroxy-bishomopregnacalciferol |
EP1846369A2 (en) * | 2004-11-22 | 2007-10-24 | Wisconsin Alumni Research Foundation | 2alpha-methyl-19-nor-(20s)-1alpha-hydroxy-bishomopregnacalciferol and its uses |
EP1817278B1 (en) * | 2004-11-22 | 2010-06-30 | Wisconsin Alumni Research Foundation | 2-methylene-18,19-dinor-1alfa-hydroxy-homopregnacalciferol and its uses |
WO2006057902A2 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2alpha-methyl-19-nor-1alpha-hydroxy-homopregnacalciferol and its uses |
WO2006057885A2 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 17,20(e)-dehydro vitamin d analogs and their uses |
DE602005021245D1 (de) * | 2004-11-22 | 2010-06-24 | Wisconsin Alumni Res Found | 2-methylen-19,26,27-trinor-(20s)-1-alpha-hydroxyvitamin d3 and dessen verwendungen |
NZ555561A (en) | 2004-11-22 | 2009-02-28 | Wisconsin Alumni Res Found | 2-methylene-19,21-dinor-1alpha-hydroxy-bishomopregnacalciferol (a Vitamin D derivative) |
WO2006086661A2 (en) * | 2005-02-10 | 2006-08-17 | Above Sea Level, Llc | Lead generation method and system |
EP1848442B1 (en) * | 2005-02-11 | 2012-04-25 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20s-24epi)-1alpha,25-dihydroxyvitamine-d2 |
MX2007009726A (es) * | 2005-02-11 | 2007-09-26 | Wisconsin Alumni Res Found | 2-metilen-19-nor-(20s-24s)-1a, 25-dihidroxivitamina-d2. |
US7235680B2 (en) * | 2005-03-29 | 2007-06-26 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(23S)-25-dehydro-1α-hydroxyvitamin D3-26,23-lactone and 2-methylene-19-nor-(23R)-25-dehydro-1α-hydroxyvitamin D3-26,23-lactone |
CA2605727A1 (en) * | 2005-05-03 | 2006-11-09 | Wisconsin Alumni Research Foundation | 19,26,27-trinor-1.alpha.,25-dihydroxyvitamin d3 compounds |
NZ567015A (en) * | 2005-08-30 | 2010-12-24 | Wisconsin Alumni Res Found | Des-C,D analogs of 1alpha,25-dihydroxy-19-norvitamin D3 |
US20070066566A1 (en) * | 2005-09-22 | 2007-03-22 | Wisconsin Alumni Research Foundation | 19,23,24,25,26,27-Hexanor-1alpha-hydroxyvitamin D3 |
US7803789B2 (en) | 2006-02-02 | 2010-09-28 | Wisconsin Alumni Research Foundation | Vitamin D analog—RAK, methods and uses thereof |
US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
EP2001842B1 (en) * | 2006-04-06 | 2012-06-06 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
NZ570815A (en) * | 2006-04-06 | 2012-01-12 | Wisconsin Alumni Res Found | 19-nor-vitamin D analogs with 1,2,or 3,2 heterocyclic ring |
MX2008012672A (es) * | 2006-04-06 | 2008-10-15 | Wisconsin Alumni Res Found | Analogos de 2-metilen-1a-hidroxi-18,19,21-trinor vitamina d3 y sus usos. |
CA2646911A1 (en) | 2006-04-06 | 2008-03-27 | Hector F. Deluca | 2- substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin d analogs and uses thereof |
NZ571773A (en) * | 2006-04-06 | 2011-11-25 | Wisconsin Alumni Res Found | 2-Methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin D3 and uses thereof |
US8193169B2 (en) * | 2006-04-06 | 2012-06-05 | Wisconsin Alumni Research Foundation | (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs |
WO2007118198A2 (en) | 2006-04-06 | 2007-10-18 | Wisconsin Alumni Research Foundation | 2-METHYLENE-1α,25-DIHYDROXY-19,21-DINORVITAMIN D3 ANALOGS AND USES THEREOF |
EP2004597B1 (en) * | 2006-04-10 | 2011-01-26 | Wisconsin Alumni Research Foundation | 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds with a 1,1-dimethylpropyl side chain |
WO2008039751A2 (en) * | 2006-09-28 | 2008-04-03 | Wisconsin Alumni Research Foundation | 2-methylene-(20s,25s)-19,27-dinor-(22e)-vitamin d analogs |
NZ575111A (en) * | 2006-09-28 | 2012-02-24 | Wisconsin Alumni Res Found | 2-methylene-(20r,25s)-19,27-dinor-(22e)-vitamin d analogs |
JP2011507965A (ja) * | 2007-12-28 | 2011-03-10 | ウィスコンシン アラムナイ リサーチ ファンデーション | 2−メチレン−(20s,25s)−19,26−ジノル−ビタミンd類縁体 |
US8609643B2 (en) * | 2007-12-28 | 2013-12-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs |
JP2011507966A (ja) * | 2007-12-28 | 2011-03-10 | ウィスコンシン アラムナイ リサーチ ファンデーション | 2−メチレン−20−メチル−19,24,25,26,27−ペンタノル−ビタミンd類縁体 |
EP2240439B1 (en) * | 2007-12-28 | 2015-03-18 | Wisconsin Alumni Research Foundation | (20s)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin d analogs |
JP2011508744A (ja) * | 2007-12-28 | 2011-03-17 | ウィスコンシン アラムナイ リサーチ ファンデーション | (20r)−23,23−ジフルオロ−2−メチレン−19−ノル−ビスホモプレグナカルシフェロール−ビタミンd類縁体 |
CA2715811A1 (en) * | 2008-03-06 | 2009-09-11 | Wisconsin Alumni Research Foundation | Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin d compound |
US8193170B2 (en) * | 2008-07-10 | 2012-06-05 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs |
US7888339B2 (en) * | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
US7648974B1 (en) * | 2008-07-10 | 2010-01-19 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 3,2-dihydrofuran ring |
US7713953B2 (en) * | 2008-07-10 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs |
US8222236B2 (en) * | 2008-07-10 | 2012-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs |
US8399439B2 (en) * | 2008-07-10 | 2013-03-19 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs |
US7893043B2 (en) * | 2008-07-10 | 2011-02-22 | Wisconsin Alumni Research Foundation | 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs |
US7879829B2 (en) * | 2008-07-10 | 2011-02-01 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2-dihydrofuran ring |
WO2011041590A2 (en) | 2009-10-02 | 2011-04-07 | Wisconsin Alumni Research Foundation | 1-desoxy-2-methylene-19-nor-vitamin d analogs and their uses |
CA2776462C (en) | 2009-10-02 | 2017-04-18 | Wisconsin Alumni Research Foundation | (20s,22e)-2-methylene-19-nor-22-ene-1.alpha.,25-dihydroxyvitamin d3 analogs |
US8217023B2 (en) | 2009-10-02 | 2012-07-10 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2- or 3,2-cyclopentene ring |
US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
WO2011119610A2 (en) * | 2010-03-23 | 2011-09-29 | Wisconsin Alumni Research Foundation | (20S)-2-METHYLENE-19-NOR-22-DIMETHYL-1α,25- DIHYDROXYVITAMIN D3 AND (20R)-2-METHYLENE-19-NOR-22- DIMETHYL-1α,25-HYDROXYVITAMIN D3 |
WO2011119622A1 (en) * | 2010-03-23 | 2011-09-29 | Wisconsin Alumni Research Foundation | DIASTEREOMERS OF 2-METHYLENE-19-NOR-22-METHYL-1α,25- DIHYDROXYVITAMIN D3 |
WO2012065050A1 (en) | 2010-11-12 | 2012-05-18 | Wisconsin Alumni Research Foundation | 22-haloacetoxy-homopregnacalciferol analogs and their uses |
WO2012151058A1 (en) | 2011-05-03 | 2012-11-08 | Wisconsin Alumni Research Foundation | (20s)-24-(p-toluenesulfonyloxy)-25,26,27-trinorvitamin d3 analogs and their uses |
WO2012158794A1 (en) | 2011-05-17 | 2012-11-22 | Wisconsin Alumni Research Foundation | N-cyclopropyl-(20r)-2-methylene-19,26,27-trinor-25-aza-vitamin d analogs and their uses |
CA2837882C (en) | 2011-06-03 | 2019-03-26 | Wisconsin Alumni Research Foundation | (22e)-2-methylene-26,27-cyclo-22-dehydro-1.alpha.-hydroxy-19-norvitamin d3 derivatives |
JP6035331B2 (ja) * | 2011-06-14 | 2016-11-30 | ウイスコンシン アラムニ リサーチ ファンデーション | 3−デスオキシ−2−メチレン−19−ノル−ビタミンd類似体およびそれらの使用 |
WO2013003307A1 (en) | 2011-06-28 | 2013-01-03 | Wisconsin Alumni Research Foundation | 2-methylene-(22e)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-vitamin d analogs |
WO2013012644A1 (en) | 2011-07-18 | 2013-01-24 | Wisconsin Alumni I Research Foundation | 2-methylene-20(21)-dehydro-19,24,25,26,27,-pentanor-vitamin d analogs |
AU2012326485B2 (en) | 2011-10-21 | 2016-12-08 | Wisconson Alumni Research Foundation | 2-methylene-vitamin D analogs and their uses |
AU2012326538B2 (en) | 2011-10-21 | 2016-12-08 | Wisconsin Alumni Research Foundation | 2-methylene-vitamin D analogs and their uses |
US8785422B2 (en) | 2012-06-06 | 2014-07-22 | Wisconsin Alumni Research Foundation | A-ring modified 19-nor-vitamin D analogs and their uses |
US9416102B2 (en) | 2013-01-23 | 2016-08-16 | Wisconsin Alumni Research Foundation | (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4539256A (en) * | 1982-09-09 | 1985-09-03 | Minnesota Mining And Manufacturing Co. | Microporous sheet material, method of making and articles made therewith |
US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
US4800198A (en) | 1985-04-23 | 1989-01-24 | Wisconsin Alumni Research Foundation | Method of inducing the differentiation of malignant cells with secosterol |
CA1333616C (en) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
US5459136A (en) | 1990-08-24 | 1995-10-17 | Wisconsin Alumni Research Foundation | Methods using vitamin D compounds for improvement of skin conditions |
US5089641A (en) | 1991-03-11 | 1992-02-18 | Wisconsin Alumni Research Foundation | Synthesis of 1α-hydroxy-secosterol compounds |
EP0619306B1 (en) | 1993-04-05 | 1996-09-11 | Wisconsin Alumni Research Foundation | 19-Nor-vitamin D3 compounds with substituent at 2-position |
US5877168A (en) | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
CA2175881A1 (en) * | 1995-05-09 | 1996-11-10 | Andrzej Kutner | Vitamin d compounds and methods of preparing these compounds |
US5840718A (en) * | 1997-03-06 | 1998-11-24 | Hoffmann-La Roche Inc. | 22-epimeric-1,25-dihydroxy-16,22,23-triene-cholecalciferol |
US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
US5843928A (en) | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
-
2001
- 2001-06-11 CN CNA018185193A patent/CN1473048A/zh active Pending
- 2001-06-11 US US09/878,438 patent/US6440953B1/en not_active Expired - Fee Related
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- 2001-06-11 BR BR0113703-4A patent/BR0113703A/pt active Pending
- 2001-06-11 AT AT01942154T patent/ATE273709T1/de not_active IP Right Cessation
- 2001-06-11 AU AU7544501A patent/AU7544501A/xx active Pending
- 2001-06-11 PT PT01942154T patent/PT1315504E/pt unknown
- 2001-06-11 MX MXPA03001969A patent/MXPA03001969A/es active IP Right Grant
- 2001-06-11 ES ES01942154T patent/ES2227215T3/es not_active Expired - Lifetime
- 2001-06-11 CA CA002420026A patent/CA2420026C/en not_active Expired - Fee Related
- 2001-06-11 KR KR1020037003435A patent/KR100672886B1/ko not_active IP Right Cessation
- 2001-06-11 EP EP01942154A patent/EP1315504B1/en not_active Expired - Lifetime
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AU2001275445B2 (en) | 2006-07-27 |
DE60105035T2 (de) | 2005-08-18 |
PT1315504E (pt) | 2004-12-31 |
ATE273709T1 (de) | 2004-09-15 |
CN1473048A (zh) | 2004-02-04 |
US6579861B2 (en) | 2003-06-17 |
CA2420026C (en) | 2010-01-19 |
EP1315504A1 (en) | 2003-06-04 |
MXPA03001969A (es) | 2003-06-24 |
JP2004512276A (ja) | 2004-04-22 |
NZ524657A (en) | 2004-12-24 |
US20020183289A1 (en) | 2002-12-05 |
DE60105035D1 (de) | 2004-09-23 |
ES2227215T3 (es) | 2005-04-01 |
IL154699A (en) | 2010-05-17 |
JP4022144B2 (ja) | 2007-12-12 |
EP1315504B1 (en) | 2004-08-18 |
US6440953B1 (en) | 2002-08-27 |
KR20030032015A (ko) | 2003-04-23 |
IL154699A0 (en) | 2003-10-31 |
CA2420026A1 (en) | 2002-03-14 |
US20020052350A1 (en) | 2002-05-02 |
AU7544501A (en) | 2002-03-22 |
WO2002020021A1 (en) | 2002-03-14 |
KR100672886B1 (ko) | 2007-01-24 |
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