DE60105035D1 - 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol und seine therapeutische verwendungen - Google Patents

1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol und seine therapeutische verwendungen

Info

Publication number
DE60105035D1
DE60105035D1 DE60105035T DE60105035T DE60105035D1 DE 60105035 D1 DE60105035 D1 DE 60105035D1 DE 60105035 T DE60105035 T DE 60105035T DE 60105035 T DE60105035 T DE 60105035T DE 60105035 D1 DE60105035 D1 DE 60105035D1
Authority
DE
Germany
Prior art keywords
skin
homopregnacalciferol
1alpha
methylene
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60105035T
Other languages
English (en)
Other versions
DE60105035T2 (de
Inventor
F Deluca
R Sicinski
Sumithra Gowlugari
A Plum
Margaret Clagett-Dame
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE60105035D1 publication Critical patent/DE60105035D1/de
Publication of DE60105035T2 publication Critical patent/DE60105035T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
DE60105035T 2000-09-08 2001-06-11 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol und seine therapeutische verwendungen Expired - Lifetime DE60105035T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65782800A 2000-09-08 2000-09-08
US657828 2000-09-08
PCT/US2001/018710 WO2002020021A1 (en) 2000-09-08 2001-06-11 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications

Publications (2)

Publication Number Publication Date
DE60105035D1 true DE60105035D1 (de) 2004-09-23
DE60105035T2 DE60105035T2 (de) 2005-08-18

Family

ID=24638806

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60105035T Expired - Lifetime DE60105035T2 (de) 2000-09-08 2001-06-11 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol und seine therapeutische verwendungen

Country Status (16)

Country Link
US (2) US6440953B1 (de)
EP (1) EP1315504B1 (de)
JP (1) JP4022144B2 (de)
KR (1) KR100672886B1 (de)
CN (1) CN1473048A (de)
AT (1) ATE273709T1 (de)
AU (2) AU2001275445B2 (de)
BR (1) BR0113703A (de)
CA (1) CA2420026C (de)
DE (1) DE60105035T2 (de)
ES (1) ES2227215T3 (de)
IL (2) IL154699A0 (de)
MX (1) MXPA03001969A (de)
NZ (1) NZ524657A (de)
PT (1) PT1315504E (de)
WO (1) WO2002020021A1 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020183288A1 (en) * 1995-04-03 2002-12-05 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US20040043971A1 (en) * 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US6316642B1 (en) * 1997-03-17 2001-11-13 Wisconsin Alumni Research Foundation 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
US6392071B1 (en) * 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US6358939B1 (en) * 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
NZ533424A (en) * 2001-12-13 2006-08-31 Wisconsin Alumni Res Found Vitamin D derivative, methods of purifying and uses in treating psoriasis, cancer, autoimmune diseases, inflammatory diseases, skin conidtions and renal ostepdystrophy
US6627622B2 (en) 2002-02-18 2003-09-30 Wisconsin Alumni Research Foundation (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses
US6566352B1 (en) * 2002-02-18 2003-05-20 Wisconsin Alumni Research Foudation 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses
DE60310050T2 (de) 2002-03-29 2007-07-05 Wisconsin Alumni Research Foundation, Madison Ein verfahren zur herstellung von 1-alpha-hydroxy-2-methylen-19-nor-homopregnacalciferol
US6846811B2 (en) * 2002-04-22 2005-01-25 Wisconsin Alumni Research Foundation (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses
JP4469794B2 (ja) 2003-02-25 2010-05-26 神戸天然物化学株式会社 ビタミンｄ誘導体を合成するための新規な中間体
EP1656157B1 (de) * 2003-08-20 2011-12-21 Wisconsin Alumni Research Foundation 2-methylen-19-nor-vitamin d2-verbindungen
US7704980B2 (en) * 2003-10-08 2010-04-27 Wisconsin Alumni Research Foundation Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds
WO2005051323A2 (en) * 2003-11-25 2005-06-09 Wisconsin Alumni Research Foundation Vitamin d analogs for obesity prevention and treatment
US7053075B2 (en) * 2003-11-25 2006-05-30 Deluca Hector F Methods for reducing body fat using vitamin D compounds
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
US7915242B2 (en) * 2004-02-17 2011-03-29 Wisconsin Alumni Research Foundation Vitamin D receptor antagonists and their use in treating asthma
US7214671B2 (en) * 2004-02-19 2007-05-08 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases
US7713951B2 (en) * 2004-04-09 2010-05-11 Wisconsin Alumni Research Foundation 2-alkylidene-18,19-dinor-vitamin D compounds
MX2007006094A (es) * 2004-11-22 2007-07-11 Wisconsin Alumni Res Found 2-metilen-19,21-dinor-1a-hidroxi-bishomopregnacalciferol.
WO2006057886A2 (en) * 2004-11-22 2006-06-01 Wisconsin Alumni Research Foundation 2-METHYLENE-19,26,27-TRINOR-(20S)-1α-HYDROXYVITAMIN D3 AND ITS USES
AU2005309819A1 (en) * 2004-11-22 2006-06-01 Wisconsin Alumni Research Foundation 2-methylene-19-nor-(20S)-1alpha-hydroxy-trishomopregnacalciferol
MX2007006090A (es) 2004-11-22 2007-07-11 Wisconsin Alumni Res Found 2-metilen-19-nor-(20r)-1a-hidroxi-bishomopregnacalciferol.
WO2006057932A2 (en) * 2004-11-22 2006-06-01 Wisconsin Alumni Research Foundation 2-METHYLENE-18,19-DINOR-1α-HYDROXY-HOMOPREGNACALCIFEROL AND ITS USES
JP2008520706A (ja) * 2004-11-22 2008-06-19 ウィスコンシン・アルムニ・リサーチ・ファウンデーション ２α−メチル−１９−ノル−１α−ヒドロキシ−ホモプレグナカルシフェロール及びその使用
US7241751B2 (en) * 2004-11-22 2007-07-10 Wisconsin Alumi Research Foundation 2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and its uses
ATE469127T1 (de) * 2004-11-22 2010-06-15 Wisconsin Alumni Res Found 17,20(z)-dehydro-vitamin-d-analoge und deren verwendungen
US20060195353A1 (en) * 2005-02-10 2006-08-31 David Goldberg Lead generation method and system
ATE554774T1 (de) * 2005-02-11 2012-05-15 Wisconsin Alumni Res Found 2-methylen-19-nor-(20s-24epi)-1alpha,25- dihydrovitamin-d2
CA2597624C (en) * 2005-02-11 2012-08-14 Wisconsin Alumni Research Foundation 2-methylene-19-nor-(20s-24s)-1.alpha.,25-dihydroxyvitamin-d2
JP2008538214A (ja) * 2005-03-29 2008-10-16 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１９−ノル−（２３Ｓ）−２５−デヒドロ−１α−ヒドロキシビタミンＤ３−２６，２３−ラクトンおよび２−メチレン−１９−ノル−（２３Ｒ）−２５−デヒドロ−１α−ヒドロキシビタミンＤ３−２６，２３−ラクトン
WO2006119309A2 (en) 2005-05-03 2006-11-09 Wisconsin Alumni Research Foundation 19,26,27-TRINOR-1α,25-DIHYDROXYVITAMIN D3 COMPOUNDS
CA2620354C (en) * 2005-08-30 2013-02-05 Wisconsin Alumni Research Foundation Des-c,d analogs of 1.alpha.,25-dihydroxy-19-norvitamin d3
NZ567438A (en) * 2005-09-22 2010-11-26 Wisconsin Alumni Res Found 19,23,24,25,26,27-Hexanor-1alpha-hydroxyvitamin D3
US7803789B2 (en) 2006-02-02 2010-09-28 Wisconsin Alumni Research Foundation Vitamin D analog—RAK, methods and uses thereof
US7528122B2 (en) * 2006-02-02 2009-05-05 Wisconsin Alumni Research Foundation Vitamin D analog—NEL, methods and uses thereof
US8193169B2 (en) * 2006-04-06 2012-06-05 Wisconsin Alumni Research Foundation (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs
JP2009532458A (ja) * 2006-04-06 2009-09-10 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１α−ヒドロキシ−１９，２１−ジノルビタミンＤ３類縁体およびその使用
MX2008012913A (es) * 2006-04-06 2009-03-06 Wisconsin Alumni Res Found 2-metilen-1a,25-dihidroxi-18,19,21-trinorvitamina d3 y sus usos.
WO2007118198A2 (en) 2006-04-06 2007-10-18 Wisconsin Alumni Research Foundation 2-METHYLENE-1α,25-DIHYDROXY-19,21-DINORVITAMIN D3 ANALOGS AND USES THEREOF
AU2007298673A1 (en) 2006-04-06 2008-03-27 Wisconsin Alumni Research Foundation 2- substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
EP2001841B1 (de) * 2006-04-06 2012-06-13 Wisconsin Alumni Research Foundation 2-methylen-1-alpha-hydroxy-18,19,21-trinorvitamin-d3-analoge und deren verwendungen
US7538098B2 (en) * 2006-04-06 2009-05-26 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 1,2 or 3,2 heterocyclic ring
US7763598B2 (en) * 2006-04-10 2010-07-27 Wisconsin Alumni Research Foundation 1α-hydroxy-2-(3′-hydroxypropylidene)-19-nor-vitamin D compounds with a 1,1-dimethylpropyl side chain
NZ575159A (en) * 2006-09-28 2012-04-27 Wisconsin Alumni Res Found 2-methylene-(20s,25s)-19,27-dinor-(22e)-vitamin d analogs
EP2069297A1 (de) * 2006-09-28 2009-06-17 Wisconsin Alumni Research Foundation 2-methylen-(20r,25s)-19,27-dinor-(22e)-vitamin-d-analoga
AU2008345083B2 (en) * 2007-12-28 2014-05-08 Wisconsin Alumni Research Foundation (20R)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs
AU2008345085A1 (en) * 2007-12-28 2009-07-09 Wisconsin Alumni Research Foundation 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs
MX2010007264A (es) * 2007-12-28 2011-03-15 Wisconsin Alumni Res Foundation Star Análogos de vitamina d 2-metilen-(20s, 25r)-19, 26-dinor.
EP2240439B1 (de) * 2007-12-28 2015-03-18 Wisconsin Alumni Research Foundation (20s)-23,23-difluor-2-methylen-19-norbishomopregnacalciferol-vitamin-d-analoga
AU2008345086B2 (en) * 2007-12-28 2014-02-13 Wisconsin Alumni Research Foundation 2-methylene-20-methyl-19,24,25,26,27-pentanor-vitamin D analogs
WO2009111695A1 (en) * 2008-03-06 2009-09-11 Wisconsin Alumni Research Foundation Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin d compound
US7893043B2 (en) * 2008-07-10 2011-02-22 Wisconsin Alumni Research Foundation 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs
US8222236B2 (en) * 2008-07-10 2012-07-17 Wisconsin Alumni Research Foundation 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs
US8193170B2 (en) * 2008-07-10 2012-06-05 Wisconsin Alumni Research Foundation 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs
US7888339B2 (en) * 2008-07-10 2011-02-15 Wisconsin Alumni Research Foundation 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
US8399439B2 (en) * 2008-07-10 2013-03-19 Wisconsin Alumni Research Foundation 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs
US7648974B1 (en) * 2008-07-10 2010-01-19 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 3,2-dihydrofuran ring
US7713953B2 (en) * 2008-07-10 2010-05-11 Wisconsin Alumni Research Foundation 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs
US7879829B2 (en) * 2008-07-10 2011-02-01 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 1,2-dihydrofuran ring
US8217023B2 (en) 2009-10-02 2012-07-10 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 1,2- or 3,2-cyclopentene ring
MX2012003882A (es) 2009-10-02 2012-06-25 Wisconsin Alumni Res Found Analogos de 1-desoxi-2-metileno-19-nor-vitamina d y sus usos.
AU2010300528B2 (en) 2009-10-02 2016-02-11 Wisconsin Alumni Research Foundation (20S,22E)-2-methylene-19-nor-22-ene-1alpha,25-dihydroxyvitamin D3 analogs
EP2556053B1 (de) * 2010-03-23 2015-07-29 Wisconsin Alumni Research Foundation (20s)-2-methylen-19-nor-22-dimethyl-1alpha,25-dihydroxyvitamin d3 und (20r)-2-methylen-19-nor-22-dimethyl-1alpha,25-hydroxyvitamin d3
US8664206B2 (en) 2010-03-23 2014-03-04 Wisconsin Alumni Research Foundation Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3
EP2556054B1 (de) * 2010-03-23 2017-09-27 Wisconsin Alumni Research Foundation Diastereomere von 2-methylen-19-nor-22-methyl-1alpha,25-dihydroxyvitamin d3
WO2012065050A1 (en) 2010-11-12 2012-05-18 Wisconsin Alumni Research Foundation 22-haloacetoxy-homopregnacalciferol analogs and their uses
US9290447B2 (en) 2011-05-03 2016-03-22 Wisconsin Alumni Research Foundation (20R) and (20S)-24-(p-toluenesulfonyloxy)-25,26,27-trinorvitamin D3 analogs and their uses
WO2012158794A1 (en) 2011-05-17 2012-11-22 Wisconsin Alumni Research Foundation N-cyclopropyl-(20r)-2-methylene-19,26,27-trinor-25-aza-vitamin d analogs and their uses
EP2714656B1 (de) 2011-06-03 2017-05-03 Wisconsin Alumni Research Foundation (22e) -2-methylen-26,27-cyclo-22-dehydro-1alpha-hydroxy-19-norvitamin-d3-derivate
JP6035331B2 (ja) * 2011-06-14 2016-11-30 ウイスコンシン アラムニ リサーチ ファンデーション ３−デスオキシ−２−メチレン−１９−ノル−ビタミンｄ類似体およびそれらの使用
WO2013003307A1 (en) 2011-06-28 2013-01-03 Wisconsin Alumni Research Foundation 2-methylene-(22e)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-vitamin d analogs
WO2013012644A1 (en) 2011-07-18 2013-01-24 Wisconsin Alumni I Research Foundation 2-methylene-20(21)-dehydro-19,24,25,26,27,-pentanor-vitamin d analogs
JP6072811B2 (ja) * 2011-10-21 2017-02-01 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−ビタミンｄ類似体およびそれらの使用
EP2768804B1 (de) * 2011-10-21 2018-02-28 Wisconsin Alumni Research Foundation 2-methylen-vitamin-d-analoge und ihre verwendungen
US8785422B2 (en) 2012-06-06 2014-07-22 Wisconsin Alumni Research Foundation A-ring modified 19-nor-vitamin D analogs and their uses
US9416102B2 (en) 2013-01-23 2016-08-16 Wisconsin Alumni Research Foundation (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539256A (en) * 1982-09-09 1985-09-03 Minnesota Mining And Manufacturing Co. Microporous sheet material, method of making and articles made therewith
US4666634A (en) 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
US4800198A (en) 1985-04-23 1989-01-24 Wisconsin Alumni Research Foundation Method of inducing the differentiation of malignant cells with secosterol
CA1333616C (en) 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US5459136A (en) 1990-08-24 1995-10-17 Wisconsin Alumni Research Foundation Methods using vitamin D compounds for improvement of skin conditions
US5089641A (en) 1991-03-11 1992-02-18 Wisconsin Alumni Research Foundation Synthesis of 1α-hydroxy-secosterol compounds
JP2898882B2 (ja) 1993-04-05 1999-06-02 ウイスコンシン アラムナイ リサーチ フオンデーシヨン ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物
US5877168A (en) 1995-02-10 1999-03-02 Chugai Seiyaku Kabushiki Kaisha Vitamin D derivative with substituent at the 2β-position
IL118156A (en) * 1995-05-09 2001-08-26 Duphar Int Res Vitamin d compounds, their preparation and pharmaceutical compositions containing them
US5840718A (en) * 1997-03-06 1998-11-24 Hoffmann-La Roche Inc. 22-epimeric-1,25-dihydroxy-16,22,23-triene-cholecalciferol
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US5945410A (en) 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds

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CA2420026C (en) 2010-01-19
ATE273709T1 (de) 2004-09-15
DE60105035T2 (de) 2005-08-18
EP1315504B1 (de) 2004-08-18
CN1473048A (zh) 2004-02-04
JP2004512276A (ja) 2004-04-22
AU7544501A (en) 2002-03-22
IL154699A (en) 2010-05-17
US6579861B2 (en) 2003-06-17
EP1315504A1 (de) 2003-06-04
ES2227215T3 (es) 2005-04-01
BR0113703A (pt) 2003-07-22
US20020052350A1 (en) 2002-05-02
JP4022144B2 (ja) 2007-12-12
KR100672886B1 (ko) 2007-01-24
NZ524657A (en) 2004-12-24
US20020183289A1 (en) 2002-12-05
KR20030032015A (ko) 2003-04-23
US6440953B1 (en) 2002-08-27
AU2001275445B2 (en) 2006-07-27
PT1315504E (pt) 2004-12-31

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