CY1108686T1 - (20s)-1 α-υδροξυ-2-μεθυλενιο-19-νορ-δις-ομοπρεγνακαλσιφερολη και οι χρησεις της - Google Patents
(20s)-1 α-υδροξυ-2-μεθυλενιο-19-νορ-δις-ομοπρεγνακαλσιφερολη και οι χρησεις τηςInfo
- Publication number
- CY1108686T1 CY1108686T1 CY20091100032T CY091100032T CY1108686T1 CY 1108686 T1 CY1108686 T1 CY 1108686T1 CY 20091100032 T CY20091100032 T CY 20091100032T CY 091100032 T CY091100032 T CY 091100032T CY 1108686 T1 CY1108686 T1 CY 1108686T1
- Authority
- CY
- Cyprus
- Prior art keywords
- skin
- compound
- methylene
- hydroxy
- well
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Abstract
Η παρούσα εφεύρεση αποκαλύπτει την (20S)-1α-υδροξυ-2-μεθυλενιο-19-νορ-δις-ομο-πρεγνακαλσιφερόλη, φαρμακευτικές χρήσεις της και μία μέθοδο καθαρισμού αυτής της ενώσεως για τη λήψη της σε κρυσταλλική μορφή. Η ένωση αυτή εμφανίζει έντονη δράση στην ανακοπή του πολλαπλασιασμού αδιαφοροποίητων κυττάρων και στην επαγωγή της διαφοροποιήσεως τους προς μονοκύτταρα δικαιολογώντας έτσι τη χρήση της ως αντικαρκινικού παράγοντα και για την αγωγή δερματικών νόσων όπως η ψωρίαση καθώς και δερματικών καταστάσεων όπως οι ρυτίδες, το χαλαρό δέρμα, το ξηρό δέρμα και η ανεπαρκής έκκριση σμήγματος. Η ένωση αυτή έχει επίσης μικρή, αν όχι και μηδενική, ασβεσταιμική δράση και συνεπώς μπορεί να χρησιμοποιηθεί για την αγωγή ανοσολογικών διαταραχών σε ανθρώπους καθώς και της νεφρικής οστεοδυστροφίας.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34113801P | 2001-12-13 | 2001-12-13 | |
US10/078,204 US6627622B2 (en) | 2002-02-18 | 2002-02-18 | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
EP02794233A EP1453798B1 (en) | 2001-12-13 | 2002-12-12 | (20s)-1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108686T1 true CY1108686T1 (el) | 2014-04-09 |
Family
ID=26760229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100032T CY1108686T1 (el) | 2001-12-13 | 2009-01-14 | (20s)-1 α-υδροξυ-2-μεθυλενιο-19-νορ-δις-ομοπρεγνακαλσιφερολη και οι χρησεις της |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1453798B1 (el) |
JP (1) | JP4149928B2 (el) |
KR (1) | KR100631457B1 (el) |
CN (1) | CN1308303C (el) |
AT (1) | ATE411283T1 (el) |
AU (1) | AU2002359680B2 (el) |
CA (1) | CA2468833C (el) |
CY (1) | CY1108686T1 (el) |
DE (1) | DE60229430D1 (el) |
DK (1) | DK1453798T3 (el) |
ES (1) | ES2315426T3 (el) |
HK (1) | HK1077804A1 (el) |
MX (1) | MXPA04005652A (el) |
NZ (1) | NZ533424A (el) |
PT (1) | PT1453798E (el) |
SI (1) | SI1453798T1 (el) |
WO (1) | WO2003051828A2 (el) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7704980B2 (en) * | 2003-10-08 | 2010-04-27 | Wisconsin Alumni Research Foundation | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
US8404667B2 (en) * | 2006-12-29 | 2013-03-26 | Wisconsin Alumni Research Foundation | Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog |
EP1828113B1 (en) * | 2004-11-22 | 2010-05-12 | Wisconsin Alumni Research Foundation | 2-methylene-19,26,27-trinor-(20s)-1-alpha-hydroxyvitamin d3 and its uses |
AU2005309818A1 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20R)-1-alpha-hydroxy-bishomopregnacalciferol |
AU2005309820B2 (en) * | 2004-11-22 | 2011-06-23 | Wisconsin Alumni Research Foundation | 2-methylene-19,21-dinor-1alpha-hydroxy-bishomopregnacalciferol |
MX2007013558A (es) | 2005-05-03 | 2008-01-24 | Wisconsin Alumni Res Found | Compuestos de 19,26,27-trinor-1a,25-dihidroxivitamina d3. |
NZ570814A (en) * | 2006-04-06 | 2011-11-25 | Wisconsin Alumni Res Found | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
US7648973B2 (en) * | 2006-04-06 | 2010-01-19 | Wisconsin Alumni Research Foundation | 2-methylene-1α,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
EP2001841B1 (en) * | 2006-04-06 | 2012-06-13 | Wisconsin Alumni Research Foundation | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin d3 analogs and uses thereof |
US20080171728A1 (en) * | 2007-01-12 | 2008-07-17 | Quatrx Pharmaceuticals Co. | Efficient Process for Preparing Steroids and Vitamin D Derivatives With the Unnatural Configuration at C20 (20 Alpha-Methyl) from Pregnenolone |
WO2009111695A1 (en) * | 2008-03-06 | 2009-09-11 | Wisconsin Alumni Research Foundation | Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin d compound |
JP6035331B2 (ja) * | 2011-06-14 | 2016-11-30 | ウイスコンシン アラムニ リサーチ ファンデーション | 3−デスオキシ−2−メチレン−19−ノル−ビタミンd類似体およびそれらの使用 |
WO2013012644A1 (en) * | 2011-07-18 | 2013-01-24 | Wisconsin Alumni I Research Foundation | 2-methylene-20(21)-dehydro-19,24,25,26,27,-pentanor-vitamin d analogs |
JP6114292B2 (ja) * | 2011-10-21 | 2017-04-12 | ウイスコンシン アラムニ リサーチ ファンデーション | 2−メチレン−ビタミンd類似体およびそれらの使用 |
JP6072811B2 (ja) * | 2011-10-21 | 2017-02-01 | ウイスコンシン アラムニ リサーチ ファンデーション | 2−メチレン−ビタミンd類似体およびそれらの使用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE58473B1 (en) * | 1985-04-23 | 1993-09-22 | Wisconsin Alumni Res Found | Seco-sterol compounds effective in inducing the differentiation of malignant cells |
JPH05238937A (ja) * | 1992-03-09 | 1993-09-17 | Wisconsin Alumni Res Found | 細胞分化誘発薬剤 |
US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
BR0113703A (pt) * | 2000-09-08 | 2003-07-22 | Wisconsin Alumni Researcg Foun | Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de pele |
-
2002
- 2002-12-12 NZ NZ533424A patent/NZ533424A/en not_active IP Right Cessation
- 2002-12-12 DK DK02794233T patent/DK1453798T3/da active
- 2002-12-12 ES ES02794233T patent/ES2315426T3/es not_active Expired - Lifetime
- 2002-12-12 SI SI200230786T patent/SI1453798T1/sl unknown
- 2002-12-12 WO PCT/US2002/039715 patent/WO2003051828A2/en active Application Filing
- 2002-12-12 JP JP2003552716A patent/JP4149928B2/ja not_active Expired - Fee Related
- 2002-12-12 CA CA002468833A patent/CA2468833C/en not_active Expired - Fee Related
- 2002-12-12 DE DE60229430T patent/DE60229430D1/de not_active Expired - Lifetime
- 2002-12-12 AU AU2002359680A patent/AU2002359680B2/en not_active Ceased
- 2002-12-12 KR KR1020047009032A patent/KR100631457B1/ko active IP Right Grant
- 2002-12-12 PT PT02794233T patent/PT1453798E/pt unknown
- 2002-12-12 MX MXPA04005652A patent/MXPA04005652A/es active IP Right Grant
- 2002-12-12 CN CNB028281047A patent/CN1308303C/zh not_active Expired - Fee Related
- 2002-12-12 AT AT02794233T patent/ATE411283T1/de active
- 2002-12-12 EP EP02794233A patent/EP1453798B1/en not_active Expired - Lifetime
-
2005
- 2005-11-03 HK HK05109794A patent/HK1077804A1/xx not_active IP Right Cessation
-
2009
- 2009-01-14 CY CY20091100032T patent/CY1108686T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR100631457B1 (ko) | 2006-10-11 |
PT1453798E (pt) | 2009-01-23 |
NZ533424A (en) | 2006-08-31 |
KR20040063949A (ko) | 2004-07-14 |
ATE411283T1 (de) | 2008-10-15 |
EP1453798A2 (en) | 2004-09-08 |
JP4149928B2 (ja) | 2008-09-17 |
CA2468833A1 (en) | 2003-06-26 |
HK1077804A1 (en) | 2006-02-24 |
EP1453798B1 (en) | 2008-10-15 |
WO2003051828A2 (en) | 2003-06-26 |
AU2002359680A1 (en) | 2003-06-30 |
CN1308303C (zh) | 2007-04-04 |
SI1453798T1 (sl) | 2009-04-30 |
ES2315426T3 (es) | 2009-04-01 |
WO2003051828A3 (en) | 2003-09-12 |
CA2468833C (en) | 2009-09-08 |
AU2002359680B2 (en) | 2007-10-18 |
JP2005513066A (ja) | 2005-05-12 |
MXPA04005652A (es) | 2005-03-23 |
DE60229430D1 (de) | 2008-11-27 |
DK1453798T3 (da) | 2009-02-16 |
CN1620431A (zh) | 2005-05-25 |
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