JP2004500317A5 - - Google Patents
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- Publication number
- JP2004500317A5 JP2004500317A5 JP2000565858A JP2000565858A JP2004500317A5 JP 2004500317 A5 JP2004500317 A5 JP 2004500317A5 JP 2000565858 A JP2000565858 A JP 2000565858A JP 2000565858 A JP2000565858 A JP 2000565858A JP 2004500317 A5 JP2004500317 A5 JP 2004500317A5
- Authority
- JP
- Japan
- Prior art keywords
- tablets
- amount
- water
- tablet
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003826 tablet Substances 0.000 description 37
- 239000004480 active ingredient Substances 0.000 description 21
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 17
- 239000008101 lactose Substances 0.000 description 17
- 229920002125 Sokalan® Polymers 0.000 description 13
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 12
- 229960001631 carbomer Drugs 0.000 description 12
- 230000003247 decreasing effect Effects 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 9
- 239000008107 starch Substances 0.000 description 9
- 229920003169 water-soluble polymer Polymers 0.000 description 9
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 8
- 229920002472 Starch Polymers 0.000 description 7
- 235000019698 starch Nutrition 0.000 description 7
- 239000002253 acid Substances 0.000 description 6
- 229920002261 Corn starch Polymers 0.000 description 5
- 239000008120 corn starch Substances 0.000 description 5
- 230000036571 hydration Effects 0.000 description 5
- 238000006703 hydration reaction Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000000227 bioadhesive Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000013268 sustained release Methods 0.000 description 4
- 239000012730 sustained-release form Substances 0.000 description 4
- 229960003604 testosterone Drugs 0.000 description 4
- 229920000148 Polycarbophil calcium Polymers 0.000 description 3
- 229940031663 carbomer-974p Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 239000007935 oral tablet Substances 0.000 description 2
- 229950005134 polycarbophil Drugs 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 229940044977 vaginal tablet Drugs 0.000 description 2
- 239000000003 vaginal tablet Substances 0.000 description 2
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000003388 anti-hormonal effect Effects 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229940125388 beta agonist Drugs 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000003401 opiate antagonist Substances 0.000 description 1
- -1 opioid Substances 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9784398P | 1998-08-25 | 1998-08-25 | |
| US60/097,843 | 1998-08-25 | ||
| US09/379,310 | 1999-08-23 | ||
| US09/379,310 US6248358B1 (en) | 1998-08-25 | 1999-08-23 | Bioadhesive progressive hydration tablets and methods of making and using the same |
| PCT/US1999/019260 WO2000010536A1 (en) | 1998-08-25 | 1999-08-24 | Extended release buccal bioadhesive tablet |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010151682A Division JP2010248231A (ja) | 1998-08-25 | 2010-07-02 | 長時間放出性の口腔生物接着性錠剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004500317A JP2004500317A (ja) | 2004-01-08 |
| JP2004500317A5 true JP2004500317A5 (https=) | 2013-03-28 |
| JP5411398B2 JP5411398B2 (ja) | 2014-02-12 |
Family
ID=22265404
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000565858A Expired - Fee Related JP5411398B2 (ja) | 1998-08-25 | 1999-08-24 | 長時間放出性の口腔生物接着性錠剤 |
| JP2010151682A Pending JP2010248231A (ja) | 1998-08-25 | 2010-07-02 | 長時間放出性の口腔生物接着性錠剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010151682A Pending JP2010248231A (ja) | 1998-08-25 | 2010-07-02 | 長時間放出性の口腔生物接着性錠剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6248358B1 (https=) |
| EP (1) | EP1105104B1 (https=) |
| JP (2) | JP5411398B2 (https=) |
| KR (1) | KR100716702B1 (https=) |
| CN (2) | CN1879608A (https=) |
| AR (1) | AR036972A1 (https=) |
| AT (1) | ATE306253T1 (https=) |
| AU (1) | AU754880B2 (https=) |
| BR (1) | BR9913239B1 (https=) |
| CA (1) | CA2341375C (https=) |
| DE (1) | DE69927694T2 (https=) |
| DK (1) | DK1105104T3 (https=) |
| ES (1) | ES2251220T3 (https=) |
| HU (1) | HU226591B1 (https=) |
| IL (1) | IL141445A (https=) |
| MA (1) | MA24964A1 (https=) |
| MX (1) | MXPA01002007A (https=) |
| MY (2) | MY125919A (https=) |
| NO (1) | NO331255B1 (https=) |
| NZ (1) | NZ509963A (https=) |
| PE (1) | PE20001036A1 (https=) |
| RU (1) | RU2227022C2 (https=) |
| UA (1) | UA78967C2 (https=) |
| WO (1) | WO2000010536A1 (https=) |
| ZA (1) | ZA995445B (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6624200B2 (en) * | 1998-08-25 | 2003-09-23 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
| AU2005203703B2 (en) * | 1998-08-25 | 2007-05-24 | Columbia Laboratories (Bermuda) Limited | Bioadhesive progressive hydration tablets |
| US7803392B2 (en) | 2000-12-27 | 2010-09-28 | University Of Kentucky Research Foundation | pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules |
| AU2002257430A1 (en) * | 2001-05-01 | 2002-11-11 | Mcgill University | Androgen-mediated neuroprotection and uses thereof |
| US8425892B2 (en) * | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
| CN101327326A (zh) * | 2001-10-29 | 2008-12-24 | 哥伦比亚实验室(百慕大群岛)有限公司 | 阴道给药治疗骨盆痛和不孕症的抗节律障碍剂 |
| US7709026B2 (en) * | 2001-10-29 | 2010-05-04 | Columbia Laboratories, Inc. | Low concentration of peroxide for treating or preventing vaginal infections |
| US20030114394A1 (en) * | 2001-10-29 | 2003-06-19 | Levine Howard L. | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
| US7005138B2 (en) * | 2001-12-21 | 2006-02-28 | Duramed Pharmaceuticals, Inc. | Method of systematically delivering SSRIs |
| GB0210397D0 (en) * | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| AR040682A1 (es) * | 2002-07-25 | 2005-04-13 | Pharmacia Corp | Forma de dosificacion una vez al dia de pramipexol |
| US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
| EP1545471A1 (en) * | 2002-08-02 | 2005-06-29 | Ranbaxy Laboratories, Ltd. | Storage stable tablets of fosinopril sodium |
| RU2213558C1 (ru) * | 2002-09-30 | 2003-10-10 | Нестерук Владимир Викторович | Антибактериальное средство |
| US20040127476A1 (en) * | 2002-11-14 | 2004-07-01 | Alvin Kershman | Oral testosterone delivery system with improved sustained release |
| EA012306B1 (ru) * | 2003-01-24 | 2009-08-28 | Магле Холдинг Аб | Композиционный материал для доставки через слизистые оболочки |
| SE0302947D0 (sv) | 2003-01-24 | 2003-11-07 | Magle Ab | A composition material for transmucosal delivery |
| ES2282062T1 (es) | 2004-06-04 | 2007-10-16 | Teva Pharmaceutical Industries Ltd. | Composicion farmaceutica que contiene irbesartan. |
| EA200700388A1 (ru) * | 2004-08-13 | 2007-08-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Композиция пеллеты пролонгированного высвобождения, содержащая прамипексол или его фармацевтически приемлемую соль, способ её изготовления и её применение |
| HRP20100682T4 (hr) * | 2004-08-13 | 2014-08-01 | Boehringer Ingelheim International Gmbh | Formulacija tablete produljenog oslobađanja koja sadrži pramipeksol ili njegovu farmaceutski prihvatljivu sol, postupak njezine priprave i uporaba |
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| US20070048369A1 (en) * | 2005-08-26 | 2007-03-01 | National Starch And Chemical Investment Holding Corporation | Mucosal delivery tablet |
| BRPI0619806A2 (pt) | 2005-12-13 | 2011-10-18 | Biodelivery Sciences Int Inc | dispositivo para fornecimento de fármacos transmucosal resistente ao abuso |
| CA2641665A1 (en) * | 2006-02-10 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Modified release formulation |
| US20090098202A1 (en) * | 2006-02-10 | 2009-04-16 | Boehringer Ingelheim International Gmbh | Extended Release Formulation |
| WO2007096906A2 (en) * | 2006-02-27 | 2007-08-30 | Panacea Biotec Ltd. | Novel buccoadhesive compositions and process of preparation thereof |
| EP1837020A1 (en) | 2006-03-24 | 2007-09-26 | Bioalliance Pharma | Mucosal bioadhesive slow release carrier for delivering active principles |
| US20070248655A1 (en) * | 2006-04-21 | 2007-10-25 | Haley Jeffrey T | Lenticular shaped protective mouth sore discs |
| EP1872775A1 (en) | 2006-06-29 | 2008-01-02 | Polichem S.A. | Use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant for the manufacture of a medicament for treating female genital disorders |
| RU2504377C2 (ru) | 2006-07-21 | 2014-01-20 | БайоДеливери Сайенсиз Интэнэшнл, Инк. | Способ трансмукозальной доставки лекарства, средство трансмукозальной доставки лекарства (варианты) и способ лечения боли |
| WO2008091592A1 (en) | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| EP2952522B1 (en) | 2007-01-31 | 2019-10-30 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| US8828981B2 (en) | 2007-02-06 | 2014-09-09 | George Creasy | Progesterone for the treatment or prevention of spontaneous preterm birth |
| AU2008232709C1 (en) | 2007-03-28 | 2015-01-15 | President And Fellows Of Harvard College | Stitched polypeptides |
| EP1987820A1 (en) * | 2007-05-04 | 2008-11-05 | Christian Fiala, Ph. D. | Slow release misoprostol for obstetric and/or gynaecological applications |
| AU2009240586A1 (en) * | 2008-04-24 | 2009-10-29 | Evestra, Inc. | Oral contraceptive dosage forms comprising a progestogen dispersed in an enteric polymer and further comprising an estrogen |
| EP2163240A1 (en) * | 2008-09-12 | 2010-03-17 | Universita' Degli Studi Di Genova | A method for the production of bioadhesive compact matrices |
| RU2015144851A (ru) | 2009-06-18 | 2019-01-10 | Серенити Фармасьютикалз, Элэлси | Безопасное применение десмопрессина |
| KR20170058446A (ko) | 2010-08-13 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| MX352959B (es) | 2011-08-18 | 2017-12-15 | Biodelivery Sciences Int Inc | Dispositivos mucoadhesivos resistentes al abuso para el suministro de buprenorfina. |
| AR088392A1 (es) | 2011-10-18 | 2014-05-28 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos |
| US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
| CA2862038C (en) | 2012-02-15 | 2021-05-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| WO2016049359A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10253067B2 (en) | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| EA202192716A1 (ru) * | 2019-04-05 | 2022-01-17 | Гедеа Байотек Аб | Состав вагинальных таблеток |
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| US5800832A (en) | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
| US5807575A (en) | 1997-02-14 | 1998-09-15 | Rougier Inc. | Manufacture of cross-linked amylose useful as a excipient for control release of active compounds |
-
1999
- 1999-08-23 US US09/379,310 patent/US6248358B1/en not_active Expired - Lifetime
- 1999-08-24 NZ NZ509963A patent/NZ509963A/en not_active IP Right Cessation
- 1999-08-24 RU RU2001107846/15A patent/RU2227022C2/ru not_active IP Right Cessation
- 1999-08-24 JP JP2000565858A patent/JP5411398B2/ja not_active Expired - Fee Related
- 1999-08-24 AT AT99942454T patent/ATE306253T1/de active
- 1999-08-24 MX MXPA01002007A patent/MXPA01002007A/es not_active IP Right Cessation
- 1999-08-24 BR BRPI9913239-7A patent/BR9913239B1/pt not_active IP Right Cessation
- 1999-08-24 IL IL14144599A patent/IL141445A/xx not_active IP Right Cessation
- 1999-08-24 WO PCT/US1999/019260 patent/WO2000010536A1/en not_active Ceased
- 1999-08-24 AU AU55826/99A patent/AU754880B2/en not_active Ceased
- 1999-08-24 DK DK99942454T patent/DK1105104T3/da active
- 1999-08-24 EP EP99942454A patent/EP1105104B1/en not_active Expired - Lifetime
- 1999-08-24 ES ES99942454T patent/ES2251220T3/es not_active Expired - Lifetime
- 1999-08-24 KR KR1020017002347A patent/KR100716702B1/ko not_active Expired - Fee Related
- 1999-08-24 HU HU0103218A patent/HU226591B1/hu not_active IP Right Cessation
- 1999-08-24 CA CA002341375A patent/CA2341375C/en not_active Expired - Fee Related
- 1999-08-24 UA UA2001031967A patent/UA78967C2/uk unknown
- 1999-08-24 CN CNA2005101375941A patent/CN1879608A/zh active Pending
- 1999-08-24 CN CNB998122009A patent/CN1259903C/zh not_active Expired - Fee Related
- 1999-08-24 DE DE69927694T patent/DE69927694T2/de not_active Expired - Lifetime
- 1999-08-25 MY MYPI99003649A patent/MY125919A/en unknown
- 1999-08-25 ZA ZA9905445A patent/ZA995445B/xx unknown
- 1999-08-25 AR ARP990104253A patent/AR036972A1/es active IP Right Grant
- 1999-08-25 PE PE1999000855A patent/PE20001036A1/es not_active Application Discontinuation
- 1999-08-25 MA MA25744A patent/MA24964A1/fr unknown
-
2000
- 2000-06-20 MY MYPI20002772A patent/MY133365A/en unknown
-
2001
- 2001-02-23 NO NO20010919A patent/NO331255B1/no not_active IP Right Cessation
-
2010
- 2010-07-02 JP JP2010151682A patent/JP2010248231A/ja active Pending
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