JP2004107315A5 - - Google Patents
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- JP2004107315A5 JP2004107315A5 JP2002382584A JP2002382584A JP2004107315A5 JP 2004107315 A5 JP2004107315 A5 JP 2004107315A5 JP 2002382584 A JP2002382584 A JP 2002382584A JP 2002382584 A JP2002382584 A JP 2002382584A JP 2004107315 A5 JP2004107315 A5 JP 2004107315A5
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- formula
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- compound represented
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 description 138
- 238000004519 manufacturing process Methods 0.000 description 15
- 238000010511 deprotection reaction Methods 0.000 description 6
- 238000006359 acetalization reaction Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 238000007363 ring formation reaction Methods 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 238000005907 ketalization reaction Methods 0.000 description 3
- 238000007273 lactonization reaction Methods 0.000 description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
- YZUPZGFPHUVJKC-UHFFFAOYSA-N 1-bromo-2-methoxyethane Chemical compound COCCBr YZUPZGFPHUVJKC-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 239000003729 cation exchange resin Substances 0.000 description 2
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 description 2
- 125000006239 protecting group Chemical group 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000003377 acid catalyst Substances 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000012024 dehydrating agents Substances 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- NXJCBFBQEVOTOW-UHFFFAOYSA-L palladium(2+);dihydroxide Chemical compound O[Pd]O NXJCBFBQEVOTOW-UHFFFAOYSA-L 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002382584A JP2004107315A (ja) | 2002-07-22 | 2002-12-27 | ヘキサヒドロフロフラノール誘導体の製造方法、その中間体およびその製造方法 |
| EP03758920A EP1589018A4 (en) | 2002-12-27 | 2003-10-27 | METHOD OF PREPARING HEXAHYDROFUROFURANOL DERIVATIVES, INTERMEDIATE PRODUCTS AND MANUFACTURING METHOD THEREFOR |
| AU2003275675A AU2003275675A1 (en) | 2002-12-27 | 2003-10-27 | Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same |
| CNB2003801099264A CN100537575C (zh) | 2002-12-27 | 2003-10-27 | 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法 |
| PCT/JP2003/013685 WO2004060895A1 (ja) | 2002-12-27 | 2003-10-27 | ヘキサヒドロフロフラノール誘導体の製造方法、その中間体及びその製造方法 |
| US10/744,733 US6867321B2 (en) | 2002-12-27 | 2003-12-23 | Production method of hexahydrofurofuranol derivative, intermediate therefor and production method thereof |
| US11/064,573 US7468448B2 (en) | 2002-12-27 | 2005-02-24 | Production method of hexahydrofurofuranol derivative, intermediate therefor and production method thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002212680 | 2002-07-22 | ||
| JP2002382584A JP2004107315A (ja) | 2002-07-22 | 2002-12-27 | ヘキサヒドロフロフラノール誘導体の製造方法、その中間体およびその製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004107315A JP2004107315A (ja) | 2004-04-08 |
| JP2004107315A5 true JP2004107315A5 (https=) | 2006-01-12 |
Family
ID=32300422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002382584A Pending JP2004107315A (ja) | 2002-07-22 | 2002-12-27 | ヘキサヒドロフロフラノール誘導体の製造方法、その中間体およびその製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2004107315A (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5127156B2 (ja) * | 2005-06-06 | 2013-01-23 | 住友化学株式会社 | ヘキサヒドロフロフラノール誘導体の製造方法 |
| ES2372417T3 (es) * | 2005-06-06 | 2012-01-19 | Sumitomo Chemical Company Limited | Método para producir un derivado de hexahidrofurofuranol. |
| CN104520262A (zh) * | 2012-08-09 | 2015-04-15 | 住友化学株式会社 | 六氢呋喃并呋喃醇衍生物的制造方法 |
| CN110272398B (zh) | 2018-03-16 | 2022-11-29 | 江苏瑞科医药科技有限公司 | 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法 |
-
2002
- 2002-12-27 JP JP2002382584A patent/JP2004107315A/ja active Pending
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