JP2003530126A5 - - Google Patents
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- Publication number
- JP2003530126A5 JP2003530126A5 JP2001575649A JP2001575649A JP2003530126A5 JP 2003530126 A5 JP2003530126 A5 JP 2003530126A5 JP 2001575649 A JP2001575649 A JP 2001575649A JP 2001575649 A JP2001575649 A JP 2001575649A JP 2003530126 A5 JP2003530126 A5 JP 2003530126A5
- Authority
- JP
- Japan
- Prior art keywords
- immunoreactive
- protein
- preparation
- molecules
- immunoreactive protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 description 17
- 108090000623 proteins and genes Proteins 0.000 description 17
- 238000000034 method Methods 0.000 description 15
- 238000002360 preparation method Methods 0.000 description 12
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 4
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 4
- 238000001042 affinity chromatography Methods 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 3
- 238000005227 gel permeation chromatography Methods 0.000 description 3
- 238000011146 sterile filtration Methods 0.000 description 3
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 2
- 108091008605 VEGF receptors Proteins 0.000 description 2
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 description 2
- 238000005571 anion exchange chromatography Methods 0.000 description 2
- 239000006143 cell culture medium Substances 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 description 1
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 1
- 102100025473 Carcinoembryonic antigen-related cell adhesion molecule 6 Human genes 0.000 description 1
- 102100025470 Carcinoembryonic antigen-related cell adhesion molecule 8 Human genes 0.000 description 1
- 101000981093 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 1 Proteins 0.000 description 1
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 description 1
- 101000914326 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 6 Proteins 0.000 description 1
- 101000914320 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 8 Proteins 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000003011 anion exchange membrane Substances 0.000 description 1
- 229910052789 astatine Inorganic materials 0.000 description 1
- RYXHOMYVWAEKHL-UHFFFAOYSA-N astatine atom Chemical compound [At] RYXHOMYVWAEKHL-UHFFFAOYSA-N 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 201000009613 breast lymphoma Diseases 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000013060 ultrafiltration and diafiltration Methods 0.000 description 1
- 238000011100 viral filtration Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10016877A DE10016877A1 (de) | 2000-04-05 | 2000-04-05 | (Glyko-)Proteine mit hoher Immunreaktivität sowie ein Verfahren zu ihrer Herstellung |
| DE10016877.9 | 2000-04-05 | ||
| PCT/EP2001/003867 WO2001077179A1 (de) | 2000-04-05 | 2001-04-04 | Proteine mit hoher immunreaktivität sowie ein verfahren zu ihrer herstellung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003530126A JP2003530126A (ja) | 2003-10-14 |
| JP2003530126A5 true JP2003530126A5 (enExample) | 2008-04-03 |
| JP4880854B2 JP4880854B2 (ja) | 2012-02-22 |
Family
ID=7637638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001575649A Expired - Fee Related JP4880854B2 (ja) | 2000-04-05 | 2001-04-04 | 高い免疫反応性を有するタンパク質及びその製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7264805B2 (enExample) |
| EP (1) | EP1276770B1 (enExample) |
| JP (1) | JP4880854B2 (enExample) |
| AT (1) | ATE376000T1 (enExample) |
| CY (1) | CY1107136T1 (enExample) |
| DE (2) | DE10016877A1 (enExample) |
| DK (1) | DK1276770T3 (enExample) |
| ES (1) | ES2295160T3 (enExample) |
| PT (1) | PT1276770E (enExample) |
| WO (1) | WO2001077179A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10016877A1 (de) * | 2000-04-05 | 2001-10-18 | Scintec Diagnostics Gmbh Zug | (Glyko-)Proteine mit hoher Immunreaktivität sowie ein Verfahren zu ihrer Herstellung |
| RU2016134843A (ru) | 2009-04-30 | 2018-12-11 | Тел Хашомер Медикал Рисерч Инфрастракче Энд Сервисиз Лтд. | Антитела к ceacam1 и способы их использования |
| WO2013054320A1 (en) | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
| KR102452349B1 (ko) | 2014-04-27 | 2022-10-11 | 페임웨이브 리미티드 | Ceacam1에 대한 인간화 항체 |
| US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5452986A (en) * | 1985-02-28 | 1986-09-24 | Verax Corp. | Fluidized bioreactor and cell cultivation process |
| US5164175A (en) * | 1986-12-10 | 1992-11-17 | Hoechst Aktiengesellschaft | Diagnostic aid containing an organ-specific substance labeled with technetium-99m |
| US4939087A (en) * | 1987-05-12 | 1990-07-03 | Washington State University Research Foundation, Inc. | Method for continuous centrifugal bioprocessing |
| US5132405A (en) * | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US4873316A (en) * | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| IL83878A (en) | 1987-09-13 | 1995-07-31 | Yeda Res & Dev | Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it |
| DE4125625C2 (de) * | 1991-08-02 | 1999-12-02 | Octapharma Ag Glarus | Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen |
| AU667530B2 (en) * | 1992-05-28 | 1996-03-28 | New York Blood Center, Inc., The | Removal of antibodies from blood-derived compositions while retaining coagulation factors |
| DE4225853A1 (de) * | 1992-08-05 | 1994-02-10 | Behringwerke Ag | Granulozytenbindende Antikörperfragmente, ihre Herstellung und Verwendung |
| SE9500148D0 (sv) | 1995-01-18 | 1995-01-18 | Bioinvent Internatioal Ab | Antibodies for use in cancer therapy and diagnosis |
| EP0727480A3 (de) | 1995-02-16 | 2000-04-12 | Forschungszentrum Jülich Gmbh | Verfahren zur Bestimmung von Pharmakokinetik bzw. Toxikokinetik von Testsubstanzen mit Hilfe von in-vitro-Zellkultursystemen und dafür geeignete Vorrichtungen |
| DE19521388C2 (de) | 1995-06-13 | 1997-05-22 | Immuno Gmbh | Technik zur Bestimmung einer spezifisch-bindefähigen Substanz |
| DE19621388A1 (de) | 1996-05-28 | 1997-12-11 | Torsten Urban | Das Tapeten- bzw. Rauhfaserset |
| DE19744531A1 (de) | 1997-10-09 | 1999-05-27 | Klaus Dr Rer Nat Bosslet | Bindemoleküle gegen Rezeptor-Ligand-Komplexe |
| DE19911329A1 (de) * | 1998-03-27 | 2000-09-21 | Benes Ivan Friedrich | Humantherapeutisch anwendbares Radioimmunkonjugat und Verfahren zu seiner Herstellung |
| DE10016877A1 (de) * | 2000-04-05 | 2001-10-18 | Scintec Diagnostics Gmbh Zug | (Glyko-)Proteine mit hoher Immunreaktivität sowie ein Verfahren zu ihrer Herstellung |
-
2000
- 2000-04-05 DE DE10016877A patent/DE10016877A1/de not_active Ceased
-
2001
- 2001-04-04 WO PCT/EP2001/003867 patent/WO2001077179A1/de not_active Ceased
- 2001-04-04 ES ES01931566T patent/ES2295160T3/es not_active Expired - Lifetime
- 2001-04-04 DK DK01931566T patent/DK1276770T3/da active
- 2001-04-04 AT AT01931566T patent/ATE376000T1/de active
- 2001-04-04 JP JP2001575649A patent/JP4880854B2/ja not_active Expired - Fee Related
- 2001-04-04 DE DE50113151T patent/DE50113151D1/de not_active Expired - Lifetime
- 2001-04-04 PT PT01931566T patent/PT1276770E/pt unknown
- 2001-04-04 EP EP01931566A patent/EP1276770B1/de not_active Expired - Lifetime
- 2001-04-04 US US10/240,912 patent/US7264805B2/en not_active Expired - Lifetime
-
2007
- 2007-08-01 US US11/888,483 patent/US7820410B2/en not_active Expired - Fee Related
-
2008
- 2008-01-11 CY CY20081100043T patent/CY1107136T1/el unknown
-
2010
- 2010-09-16 US US12/883,620 patent/US9005574B2/en not_active Expired - Fee Related
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