JP2003529563A - ビュープロピオン代謝産物並びにその合成および使用方法 - Google Patents

ビュープロピオン代謝産物並びにその合成および使用方法

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Publication number
JP2003529563A
JP2003529563A JP2001561322A JP2001561322A JP2003529563A JP 2003529563 A JP2003529563 A JP 2003529563A JP 2001561322 A JP2001561322 A JP 2001561322A JP 2001561322 A JP2001561322 A JP 2001561322A JP 2003529563 A JP2003529563 A JP 2003529563A
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JP
Japan
Prior art keywords
chlorophenyl
optically pure
hydroxy
pharmaceutically acceptable
metabolite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001561322A
Other languages
English (en)
Japanese (ja)
Inventor
ファン，クン，ケイ．
セナナヤク，クリサンタ，エイチ．
グローバー，ポール
Original Assignee
セプラコア インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27056838&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2003529563(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/510,241 external-priority patent/US6342496B1/en
Application filed by セプラコア インコーポレーテッド filed Critical セプラコア インコーポレーテッド
Publication of JP2003529563A publication Critical patent/JP2003529563A/ja
Pending legal-status Critical Current

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
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    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
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    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
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    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2001561322A 2000-02-22 2000-08-23 ビュープロピオン代謝産物並びにその合成および使用方法 Pending JP2003529563A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/510,241 US6342496B1 (en) 1999-03-01 2000-02-22 Bupropion metabolites and methods of use
US09/510,241 2000-02-22
US09/640,725 US6337328B1 (en) 1999-03-01 2000-08-18 Bupropion metabolites and methods of use
US09/640,725 2000-08-18
PCT/US2000/023080 WO2001062257A2 (en) 2000-02-22 2000-08-23 Bupropion metabolites and methods of their synthesis and use

Publications (1)

Publication Number Publication Date
JP2003529563A true JP2003529563A (ja) 2003-10-07

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Family Applications (1)

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JP2001561322A Pending JP2003529563A (ja) 2000-02-22 2000-08-23 ビュープロピオン代謝産物並びにその合成および使用方法

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Cited By (10)

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JP2022153638A (ja) * 2018-02-23 2022-10-12 アクスサム セラピューティクス インコーポレイテッド 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形および方法
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EP1602369A3 (en) 2007-02-14
HUP0300030A2 (en) 2003-05-28
CZ20022857A3 (cs) 2004-01-14
DE60029139T2 (de) 2007-05-16
EP1259243A2 (en) 2002-11-27
CY1106160T1 (el) 2011-06-08
WO2001062257A3 (en) 2002-07-04
ATE331520T1 (de) 2006-07-15
CA2400482C (en) 2011-10-11
DK1259243T3 (da) 2006-10-23
KR20020075803A (ko) 2002-10-05
PL357389A1 (en) 2004-07-26
MXPA02008093A (es) 2003-05-23
ES2261234T3 (es) 2006-11-16
CA2400482A1 (en) 2001-08-30
CZ302842B6 (cs) 2011-12-07
PL202736B1 (pl) 2009-07-31
EP1602369A2 (en) 2005-12-07
WO2001062257A2 (en) 2001-08-30
US6337328B1 (en) 2002-01-08
EP1259243B1 (en) 2006-06-28
ES2261234T5 (es) 2010-12-23
DE60029139T3 (de) 2011-02-24
DE60029139D1 (de) 2006-08-10
KR100720290B1 (ko) 2007-05-21
EP1259243B2 (en) 2010-07-21
US20020052341A1 (en) 2002-05-02
AU2000269268B2 (en) 2005-09-08
US20100125070A1 (en) 2010-05-20
ATE463247T1 (de) 2010-04-15

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