JP2003528617A - ヒト以外の動物を遺伝子修飾するための新規なベクター - Google Patents

ヒト以外の動物を遺伝子修飾するための新規なベクター

Info

Publication number
JP2003528617A
JP2003528617A JP2001570810A JP2001570810A JP2003528617A JP 2003528617 A JP2003528617 A JP 2003528617A JP 2001570810 A JP2001570810 A JP 2001570810A JP 2001570810 A JP2001570810 A JP 2001570810A JP 2003528617 A JP2003528617 A JP 2003528617A
Authority
JP
Japan
Prior art keywords
linker
human
cell
animal
sperm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001570810A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003528617A5 (enExample
Inventor
ワン,カンシェン
Original Assignee
バイオアグリ コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイオアグリ コーポレーション filed Critical バイオアグリ コーポレーション
Publication of JP2003528617A publication Critical patent/JP2003528617A/ja
Publication of JP2003528617A5 publication Critical patent/JP2003528617A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0006Modification of the membrane of cells, e.g. cell decoration
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0608Germ cells
    • C12N5/061Sperm cells, spermatogonia
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2001570810A 2000-03-28 2001-03-05 ヒト以外の動物を遺伝子修飾するための新規なベクター Pending JP2003528617A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/537,861 US7067308B1 (en) 2000-03-28 2000-03-28 Vector for genetically modifying non-human animals
US09/537,861 2000-03-28
PCT/US2001/007018 WO2001073094A2 (en) 2000-03-28 2001-03-05 Novel sperm-dna complexes for genetically modifying non-human animals

Publications (2)

Publication Number Publication Date
JP2003528617A true JP2003528617A (ja) 2003-09-30
JP2003528617A5 JP2003528617A5 (enExample) 2008-04-03

Family

ID=24144410

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001570810A Pending JP2003528617A (ja) 2000-03-28 2001-03-05 ヒト以外の動物を遺伝子修飾するための新規なベクター

Country Status (10)

Country Link
US (2) US7067308B1 (enExample)
EP (2) EP1760155A3 (enExample)
JP (1) JP2003528617A (enExample)
CN (1) CN1432067A (enExample)
AR (1) AR028298A1 (enExample)
AT (1) ATE348184T1 (enExample)
AU (1) AU2001245438A1 (enExample)
DE (1) DE60125156T2 (enExample)
PE (1) PE20011214A1 (enExample)
WO (1) WO2001073094A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053187B2 (en) 2000-03-28 2006-05-30 Gioagri Corporation Sperm-specific monoclonal antibody, mAbC
US7067308B1 (en) * 2000-03-28 2006-06-27 Bioagri Corporation Vector for genetically modifying non-human animals
US7527966B2 (en) 2002-06-26 2009-05-05 Transgenrx, Inc. Gene regulation in transgenic animals using a transposon-based vector
NZ597601A (en) 2007-05-16 2013-04-26 Mat Malta Advanced Technologies Ltd Treatment and prevention of influenza
WO2010036976A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of antibodies
WO2010036978A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of growth hormone
EP2417249B1 (en) * 2009-04-08 2022-06-08 The Regents of The University of California Dna-cell conjugates
EP2417263B1 (en) 2009-04-09 2015-09-23 ProteoVec Holding L.L.C. Production of proteins using transposon-based vectors
CN102453720B (zh) * 2010-10-28 2013-01-30 华中农业大学 一种在猪肌肉组织高效表达的融合启动子
SG10201510056SA (en) * 2011-10-28 2016-01-28 Regeneron Pharma Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules
US20150024497A1 (en) * 2013-07-19 2015-01-22 Elwha Llc Methods and Systems for Utilizing Sperm for Molecular Delivery
BR112019025358A2 (pt) 2017-05-31 2020-07-07 Commonwealth Scientific And Industrial Research Organisation ovo aviário transgênico, ave transgênica, ovo ou progênie aviária, método para detectar um ovo aviário macho, método para produzir um ovo aviário, método para replicar um vírus, vírus produzidos pelo uso de ovo aviário, método para produzir uma composição de vacina, composição da vacina produzida pelo uso do método e método para produzir um ovo aviário transgênico ou uma ave produzida pelo ovo

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428132A (en) * 1987-10-11 1995-06-27 United States Of America Conjugate and method for integration of foreign DNA into cells
WO1997011597A1 (fr) * 1995-09-29 1997-04-03 Hoechst Marion Roussel Ltd. Obtention d'un animal transgenique

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1228210B (it) 1989-01-10 1991-06-05 Consiglio Nazionale Ricerche Procedimento per la introduzione di dna esogeno nelle cellule somatiche e germinali di animali.
IL92529A0 (en) 1989-12-03 1990-08-31 Yissum Res Dev Co Generation of transgenic vertebrates by employing transformed sperm cells via artificial insemination
US5521291A (en) 1991-09-30 1996-05-28 Boehringer Ingelheim International, Gmbh Conjugates for introducing nucleic acid into higher eucaryotic cells
US6063630A (en) * 1991-11-05 2000-05-16 Transkaryotic Therapies, Inc. Targeted introduction of DNA into primary or secondary cells and their use for gene therapy
AU2146092A (en) 1992-05-28 1993-12-30 Scientific Dimensions Usa, Inc. Transgenic animal production with biolistically transformed spermatozoa
RU2081914C1 (ru) 1994-07-21 1997-06-20 Андрей Вадимович Кузнецов Способ введения чужеродной днк в сперматозоиды
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
CN1112165C (zh) 1997-08-15 2003-06-25 中国农业大学 精子介dna转移生产转基因动物的方法
WO1999038991A1 (en) 1998-01-28 1999-08-05 Takara Shuzo Co., Ltd. Method for transferring gene into germ cell
NZ506341A (en) 1998-02-09 2003-02-28 Tranxenogen Inc Genetic manipulation of spermatogonia
IL123411A0 (en) 1998-02-22 1998-09-24 Kimron Veterinary Inst High efficiency methods and compositions for integrating exogenous dna into genomic dna of sperm
JP2002524054A (ja) 1998-08-11 2002-08-06 アンソニー・シー・エフ・ペリー 遺伝子転移を行う方法
US7067308B1 (en) * 2000-03-28 2006-06-27 Bioagri Corporation Vector for genetically modifying non-human animals
US7053187B2 (en) * 2000-03-28 2006-05-30 Gioagri Corporation Sperm-specific monoclonal antibody, mAbC

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428132A (en) * 1987-10-11 1995-06-27 United States Of America Conjugate and method for integration of foreign DNA into cells
WO1997011597A1 (fr) * 1995-09-29 1997-04-03 Hoechst Marion Roussel Ltd. Obtention d'un animal transgenique

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6010062545, J. Reprod. Fertil., 1983, vol. 68, 497−505 *
JPN6010062546, Transgenic Res., 1998, vol. 7, 147−155 *
JPN6010062547, Hybridoma, 1993, vol. 12, 709−718 *
JPN6010062548, Hum. Reprod., 1996, vol. 11, 2595−2599 *
JPN6010062549, J. Reprod. Immunol., 1998, vol. 13, 73−84 *
JPN6010062550, DNA Cell Biol., 1997, vol. 16, 1087−1097 *

Also Published As

Publication number Publication date
ATE348184T1 (de) 2007-01-15
EP1268836A2 (en) 2003-01-02
PE20011214A1 (es) 2001-11-29
WO2001073094A3 (en) 2002-05-30
AU2001245438A1 (en) 2001-10-08
US20070214512A1 (en) 2007-09-13
CN1432067A (zh) 2003-07-23
EP1760155A3 (en) 2007-03-14
EP1268836B1 (en) 2006-12-13
EP1760155A2 (en) 2007-03-07
US7067308B1 (en) 2006-06-27
DE60125156T2 (de) 2007-09-20
WO2001073094A2 (en) 2001-10-04
DE60125156D1 (de) 2007-01-25
AR028298A1 (es) 2003-04-30

Similar Documents

Publication Publication Date Title
Chang et al. Effective generation of transgenic pigs and mice by linker based sperm-mediated gene transfer.
US5523222A (en) Polyelectrolyte DNA conjugation and genetic transformation of an animal
JP5087625B2 (ja) 非ヒトトランスジェニック動物におけるヒトまたはヒト化免疫グロブリンの発現強化
JP4102450B2 (ja) 胎仔線維芽細胞による効率的な核移入
Heyman Nuclear transfer: a new tool for reproductive biotechnology in cattle
US20050198698A1 (en) Production of recombinant polypeptides by bovine species and transgenic methods
JP2000508161A (ja) キメラ有蹄類及びトランスジェニック有蹄類の生産のための胚幹細胞
JP2003528617A (ja) ヒト以外の動物を遺伝子修飾するための新規なベクター
JP4095898B2 (ja) 人工染色体を含むトランスジェニック動物のクローニング
RU2005117629A (ru) Трансгенные копытные животные, имеющие пониженную активность прионного белка, и их применения
KR20050000558A (ko) 인간 항체를 제조할 수 있는 트랜스제닉 유제동물
JP2005525817A5 (enExample)
JP2003516134A (ja) 性染色体特異的タンパク質、種特異的および精子特異的タンパク質、ならびにそれらの同定および単離の方法
CN106978416B (zh) 一种基因定位整合表达系统及其应用
EP0258427A1 (en) A method for transferring organic substances to egg cells of animals and compositions for use therein
JP4845073B2 (ja) 再構築受精卵の作製方法及びそれを用いたトランスジェニック胚の作製方法
EP0350052A2 (en) Transgenic animals transformed with autonomously replicating sequence-containing plasmid
RU2402211C2 (ru) Способ получения трансгенных кроликов, продуцирующих белки в молочную железу
US20020194638A1 (en) Vector for genetically modifying non-human animals
CN100526460C (zh) 朊病毒蛋白活性降低的转基因有蹄类动物及其用途
JP7659828B2 (ja) 遺伝子導入ブタの製造方法、体細胞クローニング原料、遺伝子導入ブタ、樹立された体細胞、及び組織ないし臓器
AU747070B2 (en) Efficient nuclear transfer using primordial germ cells
US20030208785A1 (en) Transgenic pig containing heat shock protein 70 transgene
TWI223585B (en) Chimeric animal and method for producing the same
Velander Polyelectrolyte DNA conjugation and genetic transformation of an animal

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080205

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080205

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20100924

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20100924

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101118

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110414