JP2003528617A - ヒト以外の動物を遺伝子修飾するための新規なベクター - Google Patents

ヒト以外の動物を遺伝子修飾するための新規なベクター

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Publication number
JP2003528617A
JP2003528617A JP2001570810A JP2001570810A JP2003528617A JP 2003528617 A JP2003528617 A JP 2003528617A JP 2001570810 A JP2001570810 A JP 2001570810A JP 2001570810 A JP2001570810 A JP 2001570810A JP 2003528617 A JP2003528617 A JP 2003528617A
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JP
Japan
Prior art keywords
linker
human
cell
animal
sperm
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001570810A
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English (en)
Japanese (ja)
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JP2003528617A5 (enExample
Inventor
ワン，カンシェン
Original Assignee
バイオアグリ コーポレーション
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Application filed by バイオアグリ コーポレーション filed Critical バイオアグリ コーポレーション
Publication of JP2003528617A publication Critical patent/JP2003528617A/ja
Publication of JP2003528617A5 publication Critical patent/JP2003528617A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0006—Modification of the membrane of cells, e.g. cell decoration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/061—Sperm cells, spermatogonia
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
JP2001570810A 2000-03-28 2001-03-05 ヒト以外の動物を遺伝子修飾するための新規なベクター Pending JP2003528617A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/537,861 US7067308B1 (en) 2000-03-28 2000-03-28 Vector for genetically modifying non-human animals
US09/537,861 2000-03-28
PCT/US2001/007018 WO2001073094A2 (en) 2000-03-28 2001-03-05 Novel sperm-dna complexes for genetically modifying non-human animals

Publications (2)

Publication Number Publication Date
JP2003528617A true JP2003528617A (ja) 2003-09-30
JP2003528617A5 JP2003528617A5 (enExample) 2008-04-03

Family

ID=24144410

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001570810A Pending JP2003528617A (ja) 2000-03-28 2001-03-05 ヒト以外の動物を遺伝子修飾するための新規なベクター

Country Status (10)

Country Link
US (2) US7067308B1 (enExample)
EP (2) EP1760155A3 (enExample)
JP (1) JP2003528617A (enExample)
CN (1) CN1432067A (enExample)
AR (1) AR028298A1 (enExample)
AT (1) ATE348184T1 (enExample)
AU (1) AU2001245438A1 (enExample)
DE (1) DE60125156T2 (enExample)
PE (1) PE20011214A1 (enExample)
WO (1) WO2001073094A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067308B1 (en) * 2000-03-28 2006-06-27 Bioagri Corporation Vector for genetically modifying non-human animals
US7053187B2 (en) 2000-03-28 2006-05-30 Gioagri Corporation Sperm-specific monoclonal antibody, mAbC
US7527966B2 (en) 2002-06-26 2009-05-05 Transgenrx, Inc. Gene regulation in transgenic animals using a transposon-based vector
WO2008138072A1 (en) * 2007-05-16 2008-11-20 Mat Malta Advanced Technologies Limited Treatment and prevention of influenza
WO2010036976A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of antibodies
WO2010036978A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of growth hormone
WO2010118235A1 (en) * 2009-04-08 2010-10-14 The Regents Of The University Of California Dna-cell conjugates
EP2417263B1 (en) 2009-04-09 2015-09-23 ProteoVec Holding L.L.C. Production of proteins using transposon-based vectors
CN102453720B (zh) * 2010-10-28 2013-01-30 华中农业大学 一种在猪肌肉组织高效表达的融合启动子
RS63220B1 (sr) * 2011-10-28 2022-06-30 Regeneron Pharma Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc)
US20150024497A1 (en) * 2013-07-19 2015-01-22 Elwha Llc Methods and Systems for Utilizing Sperm for Molecular Delivery
JP7493940B2 (ja) 2017-05-31 2024-06-03 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション 鳥類における形質選択
CN120858939A (zh) * 2025-07-01 2025-10-31 内蒙古大学 一种突破山羊-绵羊远缘杂交生殖隔离的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428132A (en) * 1987-10-11 1995-06-27 United States Of America Conjugate and method for integration of foreign DNA into cells
WO1997011597A1 (fr) * 1995-09-29 1997-04-03 Hoechst Marion Roussel Ltd. Obtention d'un animal transgenique

Family Cites Families (14)

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IT1228210B (it) 1989-01-10 1991-06-05 Consiglio Nazionale Ricerche Procedimento per la introduzione di dna esogeno nelle cellule somatiche e germinali di animali.
IL92529A0 (en) 1989-12-03 1990-08-31 Yissum Res Dev Co Generation of transgenic vertebrates by employing transformed sperm cells via artificial insemination
US5521291A (en) 1991-09-30 1996-05-28 Boehringer Ingelheim International, Gmbh Conjugates for introducing nucleic acid into higher eucaryotic cells
US6063630A (en) * 1991-11-05 2000-05-16 Transkaryotic Therapies, Inc. Targeted introduction of DNA into primary or secondary cells and their use for gene therapy
AU2146092A (en) 1992-05-28 1993-12-30 Scientific Dimensions Usa, Inc. Transgenic animal production with biolistically transformed spermatozoa
RU2081914C1 (ru) 1994-07-21 1997-06-20 Андрей Вадимович Кузнецов Способ введения чужеродной днк в сперматозоиды
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
CN1112165C (zh) 1997-08-15 2003-06-25 中国农业大学 精子介dna转移生产转基因动物的方法
CN1289370A (zh) 1998-01-28 2001-03-28 宝酒造株式会社 将基因转移进生殖细胞的方法
NZ506341A (en) 1998-02-09 2003-02-28 Tranxenogen Inc Genetic manipulation of spermatogonia
IL123411A0 (en) 1998-02-22 1998-09-24 Kimron Veterinary Inst High efficiency methods and compositions for integrating exogenous dna into genomic dna of sperm
JP2002524054A (ja) 1998-08-11 2002-08-06 アンソニー・シー・エフ・ペリー 遺伝子転移を行う方法
US7053187B2 (en) * 2000-03-28 2006-05-30 Gioagri Corporation Sperm-specific monoclonal antibody, mAbC
US7067308B1 (en) * 2000-03-28 2006-06-27 Bioagri Corporation Vector for genetically modifying non-human animals

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428132A (en) * 1987-10-11 1995-06-27 United States Of America Conjugate and method for integration of foreign DNA into cells
WO1997011597A1 (fr) * 1995-09-29 1997-04-03 Hoechst Marion Roussel Ltd. Obtention d'un animal transgenique

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6010062545, Ｊ． Ｒｅｐｒｏｄ． Ｆｅｒｔｉｌ．, 1983, ｖｏｌ． ６８, ４９７−５０５ *
JPN6010062546, Ｔｒａｎｓｇｅｎｉｃ Ｒｅｓ．, 1998, ｖｏｌ． ７, １４７−１５５ *
JPN6010062547, Ｈｙｂｒｉｄｏｍａ, 1993, ｖｏｌ． １２, ７０９−７１８ *
JPN6010062548, Ｈｕｍ． Ｒｅｐｒｏｄ．, 1996, ｖｏｌ． １１, ２５９５−２５９９ *
JPN6010062549, Ｊ． Ｒｅｐｒｏｄ． Ｉｍｍｕｎｏｌ．, 1998, ｖｏｌ． １３, ７３−８４ *
JPN6010062550, ＤＮＡ Ｃｅｌｌ Ｂｉｏｌ．, 1997, ｖｏｌ． １６, １０８７−１０９７ *

Also Published As

Publication number Publication date
EP1268836B1 (en) 2006-12-13
WO2001073094A3 (en) 2002-05-30
EP1760155A2 (en) 2007-03-07
DE60125156T2 (de) 2007-09-20
WO2001073094A2 (en) 2001-10-04
CN1432067A (zh) 2003-07-23
AU2001245438A1 (en) 2001-10-08
EP1760155A3 (en) 2007-03-14
DE60125156D1 (de) 2007-01-25
US20070214512A1 (en) 2007-09-13
AR028298A1 (es) 2003-04-30
PE20011214A1 (es) 2001-11-29
EP1268836A2 (en) 2003-01-02
ATE348184T1 (de) 2007-01-15
US7067308B1 (en) 2006-06-27

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