JP2005525817A5 - - Google Patents
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- Publication number
- JP2005525817A5 JP2005525817A5 JP2004506471A JP2004506471A JP2005525817A5 JP 2005525817 A5 JP2005525817 A5 JP 2005525817A5 JP 2004506471 A JP2004506471 A JP 2004506471A JP 2004506471 A JP2004506471 A JP 2004506471A JP 2005525817 A5 JP2005525817 A5 JP 2005525817A5
- Authority
- JP
- Japan
- Prior art keywords
- embryo
- cell
- ungulate
- oocyte
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 102
- 210000001161 mammalian embryo Anatomy 0.000 claims 101
- 238000000034 method Methods 0.000 claims 75
- 210000000287 oocyte Anatomy 0.000 claims 48
- 108020004707 nucleic acids Proteins 0.000 claims 36
- 102000039446 nucleic acids Human genes 0.000 claims 36
- 150000007523 nucleic acids Chemical class 0.000 claims 36
- 108010077544 Chromatin Proteins 0.000 claims 32
- 210000003483 chromatin Anatomy 0.000 claims 32
- 210000004940 nucleus Anatomy 0.000 claims 29
- 108090000623 proteins and genes Proteins 0.000 claims 23
- 210000003754 fetus Anatomy 0.000 claims 21
- 230000035772 mutation Effects 0.000 claims 20
- 238000004519 manufacturing process Methods 0.000 claims 18
- 102000004169 proteins and genes Human genes 0.000 claims 18
- 210000000349 chromosome Anatomy 0.000 claims 16
- 230000009261 transgenic effect Effects 0.000 claims 16
- 210000004291 uterus Anatomy 0.000 claims 14
- 238000003780 insertion Methods 0.000 claims 12
- 230000037431 insertion Effects 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 10
- 230000008707 rearrangement Effects 0.000 claims 10
- 108060003951 Immunoglobulin Proteins 0.000 claims 9
- 108700005091 Immunoglobulin Genes Proteins 0.000 claims 9
- 102000018358 immunoglobulin Human genes 0.000 claims 9
- 230000005030 transcription termination Effects 0.000 claims 9
- 238000000338 in vitro Methods 0.000 claims 8
- 230000001776 parthenogenetic effect Effects 0.000 claims 8
- 210000002257 embryonic structure Anatomy 0.000 claims 7
- 230000001605 fetal effect Effects 0.000 claims 7
- 210000002950 fibroblast Anatomy 0.000 claims 7
- 230000008672 reprogramming Effects 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 239000012528 membrane Substances 0.000 claims 6
- 210000003719 b-lymphocyte Anatomy 0.000 claims 5
- 108700028369 Alleles Proteins 0.000 claims 4
- 241000283690 Bos taurus Species 0.000 claims 4
- 241000283707 Capra Species 0.000 claims 4
- 230000004543 DNA replication Effects 0.000 claims 4
- 241001494479 Pecora Species 0.000 claims 4
- 241000282898 Sus scrofa Species 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 230000032823 cell division Effects 0.000 claims 4
- 230000002759 chromosomal effect Effects 0.000 claims 4
- 238000011534 incubation Methods 0.000 claims 4
- 210000004080 milk Anatomy 0.000 claims 4
- 239000008267 milk Substances 0.000 claims 4
- 235000013336 milk Nutrition 0.000 claims 4
- 239000012266 salt solution Substances 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- 241000894007 species Species 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- 230000003115 biocidal effect Effects 0.000 claims 3
- 210000004602 germ cell Anatomy 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 210000002826 placenta Anatomy 0.000 claims 3
- 108020004705 Codon Proteins 0.000 claims 2
- 102000001253 Protein Kinase Human genes 0.000 claims 2
- 108700019146 Transgenes Proteins 0.000 claims 2
- 210000000601 blood cell Anatomy 0.000 claims 2
- 210000001612 chondrocyte Anatomy 0.000 claims 2
- 210000002308 embryonic cell Anatomy 0.000 claims 2
- 210000001339 epidermal cell Anatomy 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 210000003743 erythrocyte Anatomy 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 210000002510 keratinocyte Anatomy 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 230000013011 mating Effects 0.000 claims 2
- 210000002752 melanocyte Anatomy 0.000 claims 2
- 230000000394 mitotic effect Effects 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 210000000107 myocyte Anatomy 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 230000003169 placental effect Effects 0.000 claims 2
- 108060006633 protein kinase Proteins 0.000 claims 2
- 102000002322 Egg Proteins Human genes 0.000 claims 1
- 108010000912 Egg Proteins Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 210000003855 cell nucleus Anatomy 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 210000004996 female reproductive system Anatomy 0.000 claims 1
- 210000002980 germ line cell Anatomy 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 210000004681 ovum Anatomy 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 2
- 101000639792 Homo sapiens U2 small nuclear ribonucleoprotein A' Proteins 0.000 description 1
- 102100034465 U2 small nuclear ribonucleoprotein A' Human genes 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38153102P | 2002-05-17 | 2002-05-17 | |
| US42505602P | 2002-11-08 | 2002-11-08 | |
| PCT/US2003/015937 WO2003097812A2 (en) | 2002-05-17 | 2003-05-19 | Transgenic ungulates capable of human antibody production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005525817A JP2005525817A (ja) | 2005-09-02 |
| JP2005525817A5 true JP2005525817A5 (enExample) | 2006-11-24 |
Family
ID=29553536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004506471A Pending JP2005525817A (ja) | 2002-05-17 | 2003-05-19 | ヒト抗体産生が可能なトランスジェニック有蹄動物 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1513397B1 (enExample) |
| JP (1) | JP2005525817A (enExample) |
| KR (1) | KR20050000558A (enExample) |
| CN (1) | CN1668187A (enExample) |
| AT (1) | ATE464389T1 (enExample) |
| CA (1) | CA2484655A1 (enExample) |
| DE (1) | DE60332111D1 (enExample) |
| IL (1) | IL165088A0 (enExample) |
| NZ (1) | NZ536341A (enExample) |
| WO (1) | WO2003097812A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| CA2563064A1 (en) * | 2004-04-22 | 2005-11-10 | Kirin Beer Kabushiki Kaisha | Transgenic animals and uses thereof |
| GB2414995B (en) | 2004-06-09 | 2006-11-15 | Univ Edinburgh | Neural stem cells |
| US20060130157A1 (en) * | 2004-10-22 | 2006-06-15 | Kevin Wells | Ungulates with genetically modified immune systems |
| AU2007277863A1 (en) | 2006-07-07 | 2008-01-31 | Kyowa Hakko Kirin Co., Ltd. | Human artificial chromosome (HAC) vector, and human cell pharmaceutical comprising human artificial chromosome (HAC) vector |
| DK2348827T3 (en) | 2008-10-27 | 2015-07-20 | Revivicor Inc | IMMUNICIPLY COMPROMATED PETS |
| US20100158878A1 (en) | 2008-12-23 | 2010-06-24 | Alexandra Capela | Target populations of oligodendrocyte precursor cells and methods of making and using same |
| CN102711804B (zh) | 2009-11-13 | 2015-09-16 | 赛诺菲-安万特德国有限公司 | 包含glp-1激动剂和甲硫氨酸的药物组合物 |
| WO2011062207A1 (ja) | 2009-11-17 | 2011-05-26 | 協和発酵キリン株式会社 | ヒト人工染色体ベクター |
| EP2880055B1 (en) * | 2012-08-03 | 2017-06-28 | Sab, Llc | Complex chromosome engineering for production of human antibodies in transgenic animals |
| KR20150145225A (ko) * | 2013-02-13 | 2015-12-29 | 라보라토이레 프란카이즈 듀 프락티온네먼트 에트 데스 바이오테크놀로지스 | 변경된 글리코실화를 갖는 세툭시맙 및 이의 용도 |
| ES2894837T3 (es) * | 2013-04-18 | 2022-02-16 | Inst Nat Sante Rech Med | Composición con inmunogenicidad reducida |
| CN107001449A (zh) | 2014-10-15 | 2017-08-01 | 芝诺锡拉公司 | 具有降低的免疫原性的组合物 |
| CA3167191A1 (en) * | 2020-02-12 | 2021-08-19 | Eddie J. Sullivan | Anti-thymocyte globulin |
| EP4665391A1 (en) * | 2023-02-17 | 2025-12-24 | Sab, Llc | Ungulate-derived polyclonal immunoglobulin specific for influenza virus and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5652373A (en) * | 1990-01-15 | 1997-07-29 | Yeda Research And Development Co. Ltd. | Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU8507191A (en) * | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US5789655A (en) * | 1994-05-13 | 1998-08-04 | The Regents Of The University Of California | Transgenic animals expressing artificial epitope-tagged proteins |
| EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
| ATE352613T1 (de) * | 1995-08-29 | 2007-02-15 | Kirin Brewery | Chimäres tier und methode zu dessen herstellung |
| EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
| WO2001035735A1 (en) * | 1999-11-19 | 2001-05-25 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
| ATE503012T1 (de) * | 2000-11-17 | 2011-04-15 | Kyowa Hakko Kirin Co Ltd | Expression von xenogenen (humanen) immunglobulinen in klonierten, transgenen huftieren |
| US20020108132A1 (en) * | 2001-02-02 | 2002-08-08 | Avigenics Inc. | Production of a monoclonal antibody by a transgenic chicken |
-
2003
- 2003-05-19 WO PCT/US2003/015937 patent/WO2003097812A2/en not_active Ceased
- 2003-05-19 NZ NZ536341A patent/NZ536341A/en unknown
- 2003-05-19 CA CA002484655A patent/CA2484655A1/en not_active Abandoned
- 2003-05-19 EP EP03738939A patent/EP1513397B1/en not_active Expired - Lifetime
- 2003-05-19 DE DE60332111T patent/DE60332111D1/de not_active Expired - Lifetime
- 2003-05-19 CN CNA038167425A patent/CN1668187A/zh active Pending
- 2003-05-19 JP JP2004506471A patent/JP2005525817A/ja active Pending
- 2003-05-19 AT AT03738939T patent/ATE464389T1/de not_active IP Right Cessation
- 2003-05-19 KR KR10-2004-7018599A patent/KR20050000558A/ko not_active Ceased
- 2003-05-19 IL IL16508803A patent/IL165088A0/xx unknown
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