CN1668187A - 能够产生人抗体的转基因有蹄动物 - Google Patents

能够产生人抗体的转基因有蹄动物 Download PDF

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Publication number
CN1668187A
CN1668187A CNA038167425A CN03816742A CN1668187A CN 1668187 A CN1668187 A CN 1668187A CN A038167425 A CNA038167425 A CN A038167425A CN 03816742 A CN03816742 A CN 03816742A CN 1668187 A CN1668187 A CN 1668187A
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CN
China
Prior art keywords
cells
embryo
cell
ungulate
oocyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038167425A
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English (en)
Chinese (zh)
Inventor
J·M·罗布尔
P·科拉斯
E·沙利文
P·卡西纳坦
R·A·戈德斯比
义巳黑岩
一磨富塚
功石田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Pharma KK
Original Assignee
Kirin Brewery Co Ltd
Hematech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery Co Ltd, Hematech Inc filed Critical Kirin Brewery Co Ltd
Publication of CN1668187A publication Critical patent/CN1668187A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8773—Ovine embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNA038167425A 2002-05-17 2003-05-19 能够产生人抗体的转基因有蹄动物 Pending CN1668187A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38153102P 2002-05-17 2002-05-17
US60/381,531 2002-05-17
US42505602P 2002-11-08 2002-11-08
US60/425,056 2002-11-08

Publications (1)

Publication Number Publication Date
CN1668187A true CN1668187A (zh) 2005-09-14

Family

ID=29553536

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038167425A Pending CN1668187A (zh) 2002-05-17 2003-05-19 能够产生人抗体的转基因有蹄动物

Country Status (10)

Country Link
EP (1) EP1513397B1 (enExample)
JP (1) JP2005525817A (enExample)
KR (1) KR20050000558A (enExample)
CN (1) CN1668187A (enExample)
AT (1) ATE464389T1 (enExample)
CA (1) CA2484655A1 (enExample)
DE (1) DE60332111D1 (enExample)
IL (1) IL165088A0 (enExample)
NZ (1) NZ536341A (enExample)
WO (1) WO2003097812A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104755493A (zh) * 2012-08-03 2015-07-01 Sab有限责任公司 用于在转基因动物中生产人类抗体的复杂的染色体工程
CN105263960A (zh) * 2013-04-18 2016-01-20 国家医疗保健研究所 具有降低的免疫原性的组合物

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0110029D0 (en) 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
WO2005104835A2 (en) * 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Transgenic animals and uses thereof
US8785187B2 (en) * 2004-06-09 2014-07-22 The University Court Of The University Of Edinburgh Neural stem cells
CA2958259C (en) * 2004-10-22 2020-06-30 Revivicor, Inc. Ungulates with genetically modified immune systems
TW200817512A (en) 2006-07-07 2008-04-16 Kirin Pharma Kk Human artificial chromosome (hac) vector, and human cell pharmaceutical comprising human artificial chromosome (hac) vector
DK2348827T3 (en) 2008-10-27 2015-07-20 Revivicor Inc IMMUNICIPLY COMPROMATED PETS
EP3187581A1 (en) 2008-12-23 2017-07-05 BOCO Silicon Valley, Inc. Target populations of oligodendrocyte precursor cells and methods of making and using same
CN102711804B (zh) 2009-11-13 2015-09-16 赛诺菲-安万特德国有限公司 包含glp-1激动剂和甲硫氨酸的药物组合物
CN102803488A (zh) 2009-11-17 2012-11-28 协和发酵麒麟株式会社 人类人工染色体载体
EP2956484B1 (en) * 2013-02-13 2018-11-14 Laboratoire Français du Fractionnement et des Biotechnologies Cetuximab with modified glycosylation and uses thereof
CN107001449A (zh) * 2014-10-15 2017-08-01 芝诺锡拉公司 具有降低的免疫原性的组合物
EP4103603A4 (en) * 2020-02-12 2024-03-27 Sab, Llc ANTI-THYMOCYTE GLOBULIN
EP4665391A1 (en) * 2023-02-17 2025-12-24 Sab, Llc Ungulate-derived polyclonal immunoglobulin specific for influenza virus and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652373A (en) * 1990-01-15 1997-07-29 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
CA2089661C (en) * 1990-08-29 2007-04-03 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) * 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US5789655A (en) * 1994-05-13 1998-08-04 The Regents Of The University Of California Transgenic animals expressing artificial epitope-tagged proteins
ATE390933T1 (de) 1995-04-27 2008-04-15 Amgen Fremont Inc Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8
AU718138B2 (en) * 1995-08-29 2000-04-06 Kyowa Hakko Kirin Co., Ltd. Chimeric animal and method for constructing the same
EP2314625B1 (en) 1996-12-03 2014-05-07 Amgen Fremont Inc. Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
AU1777301A (en) * 1999-11-19 2001-05-30 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
WO2002070648A2 (en) * 2000-11-17 2002-09-12 Hematech, Llc Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
US20020108132A1 (en) * 2001-02-02 2002-08-08 Avigenics Inc. Production of a monoclonal antibody by a transgenic chicken

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104755493A (zh) * 2012-08-03 2015-07-01 Sab有限责任公司 用于在转基因动物中生产人类抗体的复杂的染色体工程
CN104755493B (zh) * 2012-08-03 2020-12-25 Sab有限责任公司 用于在转基因动物中生产人类抗体的复杂的染色体工程
CN105263960A (zh) * 2013-04-18 2016-01-20 国家医疗保健研究所 具有降低的免疫原性的组合物
CN105263960B (zh) * 2013-04-18 2020-05-22 国家医疗保健研究所 具有降低的免疫原性的组合物

Also Published As

Publication number Publication date
EP1513397A2 (en) 2005-03-16
KR20050000558A (ko) 2005-01-05
NZ536341A (en) 2008-05-30
WO2003097812A2 (en) 2003-11-27
IL165088A0 (en) 2005-12-18
EP1513397A4 (en) 2007-10-24
AU2003245300A1 (en) 2003-12-02
ATE464389T1 (de) 2010-04-15
EP1513397B1 (en) 2010-04-14
WO2003097812A3 (en) 2004-02-12
DE60332111D1 (de) 2010-05-27
CA2484655A1 (en) 2003-11-27
JP2005525817A (ja) 2005-09-02

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: KIRIN BEER K.K.

Free format text: FORMER OWNER: HEMA TECHNOLOGY CO.,LTD.; APPLICANT

Effective date: 20070601

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20070601

Address after: Tokyo, Japan, Japan

Applicant after: Kirin Beer Co., Ltd.

Address before: American Connecticut

Applicant before: Hemr technology company

Co-applicant before: Kirin Beer Co., Ltd.

ASS Succession or assignment of patent right

Owner name: KIRIN MEDICINE CO., LTD.

Free format text: FORMER OWNER: QILIN CO., LTD.

Effective date: 20080418

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20080418

Address after: Tokyo, Japan, Japan

Applicant after: Kirin Pharma Kabushiki Kaisha

Address before: Tokyo, Japan, Japan

Applicant before: Kirin Holdings Kabushiki Kaish (JP)

AD01 Patent right deemed abandoned
C20 Patent right or utility model deemed to be abandoned or is abandoned