JP2005525817A - ヒト抗体産生が可能なトランスジェニック有蹄動物 - Google Patents

ヒト抗体産生が可能なトランスジェニック有蹄動物 Download PDF

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Publication number
JP2005525817A
JP2005525817A JP2004506471A JP2004506471A JP2005525817A JP 2005525817 A JP2005525817 A JP 2005525817A JP 2004506471 A JP2004506471 A JP 2004506471A JP 2004506471 A JP2004506471 A JP 2004506471A JP 2005525817 A JP2005525817 A JP 2005525817A
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Prior art keywords
embryo
cell
cells
ungulate
antibody
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JP2004506471A
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English (en)
Japanese (ja)
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JP2005525817A5 (enExample
Inventor
ロブル，ジェイムズ，エム．
コラス，フィリップ
サリヴァン，エディー
カシナサン，ピー．
ゴルヅビー，リチャード，エー．
義巳 黒岩
一磨 富塚
功 石田
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Kirin Brewery Co Ltd
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Kirin Brewery Co Ltd
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Application filed by Kirin Brewery Co Ltd filed Critical Kirin Brewery Co Ltd
Publication of JP2005525817A publication Critical patent/JP2005525817A/ja
Publication of JP2005525817A5 publication Critical patent/JP2005525817A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8773—Ovine embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2004506471A 2002-05-17 2003-05-19 ヒト抗体産生が可能なトランスジェニック有蹄動物 Pending JP2005525817A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38153102P 2002-05-17 2002-05-17
US42505602P 2002-11-08 2002-11-08
PCT/US2003/015937 WO2003097812A2 (en) 2002-05-17 2003-05-19 Transgenic ungulates capable of human antibody production

Publications (2)

Publication Number Publication Date
JP2005525817A true JP2005525817A (ja) 2005-09-02
JP2005525817A5 JP2005525817A5 (enExample) 2006-11-24

Family

ID=29553536

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004506471A Pending JP2005525817A (ja) 2002-05-17 2003-05-19 ヒト抗体産生が可能なトランスジェニック有蹄動物

Country Status (10)

Country Link
EP (1) EP1513397B1 (enExample)
JP (1) JP2005525817A (enExample)
KR (1) KR20050000558A (enExample)
CN (1) CN1668187A (enExample)
AT (1) ATE464389T1 (enExample)
CA (1) CA2484655A1 (enExample)
DE (1) DE60332111D1 (enExample)
IL (1) IL165088A0 (enExample)
NZ (1) NZ536341A (enExample)
WO (1) WO2003097812A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016513105A (ja) * 2013-02-13 2016-05-12 ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ ｅｔ ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ 改変グリコシル化を有するセツキシマブおよびその使用
JP2023515773A (ja) * 2020-02-12 2023-04-14 サブ、エルエルシー． 抗胸腺細胞グロブリン

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0110029D0 (en) 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
WO2005104835A2 (en) * 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Transgenic animals and uses thereof
US8785187B2 (en) * 2004-06-09 2014-07-22 The University Court Of The University Of Edinburgh Neural stem cells
CA2958259C (en) * 2004-10-22 2020-06-30 Revivicor, Inc. Ungulates with genetically modified immune systems
TW200817512A (en) 2006-07-07 2008-04-16 Kirin Pharma Kk Human artificial chromosome (hac) vector, and human cell pharmaceutical comprising human artificial chromosome (hac) vector
DK2348827T3 (en) 2008-10-27 2015-07-20 Revivicor Inc IMMUNICIPLY COMPROMATED PETS
EP3187581A1 (en) 2008-12-23 2017-07-05 BOCO Silicon Valley, Inc. Target populations of oligodendrocyte precursor cells and methods of making and using same
CN102711804B (zh) 2009-11-13 2015-09-16 赛诺菲-安万特德国有限公司 包含glp-1激动剂和甲硫氨酸的药物组合物
CN102803488A (zh) 2009-11-17 2012-11-28 协和发酵麒麟株式会社 人类人工染色体载体
CN104755493B (zh) * 2012-08-03 2020-12-25 Sab有限责任公司 用于在转基因动物中生产人类抗体的复杂的染色体工程
EA038968B1 (ru) * 2013-04-18 2021-11-16 Институт Насьональ Де Ла Сант Эт Де Ла Решерш Медикаль Композиция с пониженной иммуногенностью
CN107001449A (zh) * 2014-10-15 2017-08-01 芝诺锡拉公司 具有降低的免疫原性的组合物
EP4665391A1 (en) * 2023-02-17 2025-12-24 Sab, Llc Ungulate-derived polyclonal immunoglobulin specific for influenza virus and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652373A (en) * 1990-01-15 1997-07-29 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
CA2089661C (en) * 1990-08-29 2007-04-03 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) * 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US5789655A (en) * 1994-05-13 1998-08-04 The Regents Of The University Of California Transgenic animals expressing artificial epitope-tagged proteins
ATE390933T1 (de) 1995-04-27 2008-04-15 Amgen Fremont Inc Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8
AU718138B2 (en) * 1995-08-29 2000-04-06 Kyowa Hakko Kirin Co., Ltd. Chimeric animal and method for constructing the same
EP2314625B1 (en) 1996-12-03 2014-05-07 Amgen Fremont Inc. Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
AU1777301A (en) * 1999-11-19 2001-05-30 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
WO2002070648A2 (en) * 2000-11-17 2002-09-12 Hematech, Llc Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
US20020108132A1 (en) * 2001-02-02 2002-08-08 Avigenics Inc. Production of a monoclonal antibody by a transgenic chicken

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016513105A (ja) * 2013-02-13 2016-05-12 ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ ｅｔ ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ 改変グリコシル化を有するセツキシマブおよびその使用
JP2023515773A (ja) * 2020-02-12 2023-04-14 サブ、エルエルシー． 抗胸腺細胞グロブリン

Also Published As

Publication number Publication date
EP1513397A2 (en) 2005-03-16
KR20050000558A (ko) 2005-01-05
NZ536341A (en) 2008-05-30
WO2003097812A2 (en) 2003-11-27
IL165088A0 (en) 2005-12-18
CN1668187A (zh) 2005-09-14
EP1513397A4 (en) 2007-10-24
AU2003245300A1 (en) 2003-12-02
ATE464389T1 (de) 2010-04-15
EP1513397B1 (en) 2010-04-14
WO2003097812A3 (en) 2004-02-12
DE60332111D1 (de) 2010-05-27
CA2484655A1 (en) 2003-11-27

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