JP2003523325A - 受容体チロシンキナーゼ阻害剤とα１−酸性糖タンパク質結合性有機化合物との組合せ - Google Patents
受容体チロシンキナーゼ阻害剤とα１−酸性糖タンパク質結合性有機化合物との組合せInfo
- Publication number
- JP2003523325A JP2003523325A JP2001548102A JP2001548102A JP2003523325A JP 2003523325 A JP2003523325 A JP 2003523325A JP 2001548102 A JP2001548102 A JP 2001548102A JP 2001548102 A JP2001548102 A JP 2001548102A JP 2003523325 A JP2003523325 A JP 2003523325A
- Authority
- JP
- Japan
- Prior art keywords
- carbamoyl
- group
- lower alkyl
- abl
- tyrosine kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000002253 acid Substances 0.000 claims abstract description 40
- 239000000203 mixture Substances 0.000 claims abstract description 35
- 238000009472 formulation Methods 0.000 claims abstract description 22
- 229940127361 Receptor Tyrosine Kinase Inhibitors Drugs 0.000 claims abstract description 12
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- 125000000217 alkyl group Chemical group 0.000 claims description 46
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 38
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- 125000001841 imino group Chemical group [H]N=* 0.000 claims description 8
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 8
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| PCT/EP2000/013161 WO2001047507A2 (en) | 1999-12-27 | 2000-12-22 | Combinations of receptor tyrosine kinase inhibitor with an a1-acidic glycoprotein binding compound |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007505859A (ja) * | 2003-09-19 | 2007-03-15 | ノバルティス アクチエンゲゼルシャフト | イマチニブおよびミドスタウリンでの消化管間質腫瘍の処置 |
| JP2009051837A (ja) * | 2002-01-23 | 2009-03-12 | Novartis Ag | Ｎ−フェニル−２−ピリミジン−アミン誘導体のｎ−オキシド |
| JP2010031019A (ja) * | 2002-04-23 | 2010-02-12 | Novartis Ag | 薬物高含量錠剤 |
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| US20040034026A1 (en) * | 2000-11-22 | 2004-02-19 | Wood Jeannette M | Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity |
| WO2003000186A2 (en) | 2001-06-21 | 2003-01-03 | Ariad Pharmaceuticals, Inc. | Novel phenylamino-pyrimidines and uses thereof |
| US7323469B2 (en) | 2001-08-07 | 2008-01-29 | Novartis Ag | 7H-pyrrolo[2,3-d]pyrimidine derivatives |
| GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| DE60224299T2 (de) * | 2001-10-25 | 2008-12-11 | Novartis Ag | Kombinationsmedikationen mit einem selektiven cyclooxygenase-2-inhibitor |
| CA2479257A1 (en) * | 2002-03-21 | 2003-10-02 | Dana-Farber Cancer Institute, Inc. | Inhibition of cell death responses induced by oxidative stress |
| AU2007201830C1 (en) * | 2002-04-23 | 2017-09-07 | Novartis Pharma Ag | High drug load tablet |
| US20060052387A1 (en) * | 2002-06-26 | 2006-03-09 | Marsh Clay B | Organic compounds |
| CA2498982A1 (en) * | 2002-07-24 | 2004-01-29 | Novartis Ag | 4-(4-methylpiperazin-1-ylmethyl)-n-[4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide for treating anaplastic thyroid cancer |
| EP1542989B1 (en) * | 2002-07-31 | 2007-04-18 | Critical Outcome Technologies, Inc. | Protein tyrosine kinase inhibitors |
| GB0222514D0 (en) | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
| EP1551824B1 (en) * | 2002-10-09 | 2007-12-12 | Critical Outcome Technologies, Inc. | Protein tyrosine kinase inhibitors |
| JP2007523827A (ja) | 2003-08-25 | 2007-08-23 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | 混合性白血病遺伝子の再構成を伴う急性リンパ芽球性白血病の処置方法 |
| TW200517114A (en) * | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
| WO2005077933A1 (en) † | 2004-02-11 | 2005-08-25 | Natco Pharma Limited | Novel polymorphic form of imatinib mesylate and a process for its preparation |
| US7358250B2 (en) | 2004-06-29 | 2008-04-15 | Amgen Inc. | Pyrrolo[2,3-d]pyrimidines that modulate ACK1 activity |
| MX2007001399A (es) * | 2004-08-02 | 2007-04-18 | Osi Pharm Inc | Compuestos que inhiben pirrolopirimidina multi-cinasa aril-amino sustituidas. |
| JP5208516B2 (ja) | 2004-12-30 | 2013-06-12 | エグゼリクシス， インコーポレイテッド | キナーゼモジュレーターとしてのピリミジン誘導体および使用方法 |
| US20070059359A1 (en) * | 2005-06-07 | 2007-03-15 | Thomas Backensfeld | Immediate-release and high-drug-load pharmaceutical formulations of non-micronised (4-chlorophenyl)[4-(4-pyridylmethyl)phthalazin-1-yl] and salts thereof |
| US20060275365A1 (en) * | 2005-06-07 | 2006-12-07 | Thomas Backensfeld | Immediate-release and high-drug-load pharmaceutical formulations of micronised (4-chlorophenyl) [4-(4-pyridylmethyl)phthalazin-1-yl] and salts thereof |
| WO2006136391A2 (en) * | 2005-06-23 | 2006-12-28 | Novartis Ag | Treatment of solid tumor disease with combinations comprising imatinib and an efflux pump inhibitor |
| US7910595B2 (en) * | 2005-12-21 | 2011-03-22 | Abbott Laboratories | Anti-viral compounds |
| ES2395386T3 (es) | 2005-12-21 | 2013-02-12 | Abbott Laboratories | Compuestos antivirales |
| ATE475660T1 (de) | 2005-12-21 | 2010-08-15 | Abbott Lab | Antivirale verbindungen |
| SG171592A1 (en) * | 2006-04-20 | 2011-06-29 | Janssen Pharmaceutica Nv | Method of inhibiting c-kit kinase |
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| WO2009079797A1 (en) | 2007-12-26 | 2009-07-02 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
| AP2010005347A0 (en) | 2008-01-11 | 2010-08-31 | Natco Pharma Ltd | Novel pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents |
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| AU2009248923B2 (en) | 2008-05-21 | 2015-01-29 | Takeda Pharmaceutical Company Limited | Phosphorous derivatives as kinase inhibitors |
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| ITRM20090578A1 (it) * | 2009-11-10 | 2011-05-11 | Noi Per Voi Onlus | Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti. |
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| US20120115878A1 (en) | 2010-11-10 | 2012-05-10 | John Vincent Calienni | Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof |
| TR201010618A2 (tr) * | 2010-12-20 | 2012-07-23 | Bi̇lgi̇ç Mahmut | İmatinib içeren bir oral dozaj formu ve bu oral dozaj formunun üretimi |
| PL394169A1 (pl) | 2011-03-09 | 2012-09-10 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Kompozycja farmaceutyczna metanosulfonianu imatinibu do napełniania jednostkowych postaci dawkowania oraz sposób jej wytwarzania |
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| US5587459A (en) * | 1994-08-19 | 1996-12-24 | Regents Of The University Of Minnesota | Immunoconjugates comprising tyrosine kinase inhibitors |
| US5750493A (en) * | 1995-08-30 | 1998-05-12 | Raymond F. Schinazi | Method to improve the biological and antiviral activity of protease inhibitors |
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- 2000-12-22 EP EP00985244A patent/EP1250140B1/en not_active Expired - Lifetime
- 2000-12-22 AU AU21719/01A patent/AU2171901A/en not_active Abandoned
- 2000-12-22 WO PCT/EP2000/013161 patent/WO2001047507A2/en not_active Ceased
- 2000-12-22 HK HK03101801.4A patent/HK1050993A1/zh unknown
- 2000-12-22 AT AT00985244T patent/ATE432069T1/de active
- 2000-12-22 US US10/169,035 patent/US20030125343A1/en not_active Abandoned
- 2000-12-22 PE PE2000001393A patent/PE20010991A1/es not_active Application Discontinuation
- 2000-12-22 DE DE60042283T patent/DE60042283D1/de not_active Expired - Lifetime
- 2000-12-22 CA CA002394944A patent/CA2394944A1/en not_active Abandoned
- 2000-12-22 PT PT00985244T patent/PT1250140E/pt unknown
- 2000-12-22 BR BR0016817-3A patent/BR0016817A/pt not_active Application Discontinuation
- 2000-12-22 CN CNB008178976A patent/CN1304005C/zh not_active Expired - Fee Related
- 2000-12-22 AR ARP000106887A patent/AR030179A1/es not_active Application Discontinuation
- 2000-12-22 CO CO00097404A patent/CO5271710A1/es not_active Application Discontinuation
- 2000-12-22 ES ES00985244T patent/ES2326307T3/es not_active Expired - Lifetime
- 2000-12-22 JP JP2001548102A patent/JP2003523325A/ja active Pending
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009051837A (ja) * | 2002-01-23 | 2009-03-12 | Novartis Ag | Ｎ−フェニル−２−ピリミジン−アミン誘導体のｎ−オキシド |
| JP2010031019A (ja) * | 2002-04-23 | 2010-02-12 | Novartis Ag | 薬物高含量錠剤 |
| JP2013079271A (ja) * | 2002-04-23 | 2013-05-02 | Novartis Ag | 薬物高含量錠剤 |
| JP2015143250A (ja) * | 2002-04-23 | 2015-08-06 | ノバルティス アーゲー | 薬物高含量錠剤 |
| JP2007505859A (ja) * | 2003-09-19 | 2007-03-15 | ノバルティス アクチエンゲゼルシャフト | イマチニブおよびミドスタウリンでの消化管間質腫瘍の処置 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR0016817A (pt) | 2002-10-01 |
| AU2171901A (en) | 2001-07-09 |
| ATE432069T1 (de) | 2009-06-15 |
| TWI246917B (en) | 2006-01-11 |
| EP1250140B1 (en) | 2009-05-27 |
| ITMI992711A0 (it) | 1999-12-27 |
| EP1250140A2 (en) | 2002-10-23 |
| DE60042283D1 (de) | 2009-07-09 |
| HK1050993A1 (zh) | 2003-07-18 |
| US20030125343A1 (en) | 2003-07-03 |
| ITMI992711A1 (it) | 2001-06-27 |
| PT1250140E (pt) | 2009-08-24 |
| CN1304005C (zh) | 2007-03-14 |
| US20090221519A1 (en) | 2009-09-03 |
| AR030179A1 (es) | 2003-08-13 |
| CN1414858A (zh) | 2003-04-30 |
| WO2001047507A3 (en) | 2002-04-04 |
| CA2394944A1 (en) | 2001-07-05 |
| CO5271710A1 (es) | 2003-04-30 |
| ES2326307T3 (es) | 2009-10-07 |
| WO2001047507A2 (en) | 2001-07-05 |
| PE20010991A1 (es) | 2001-10-23 |
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