JP2003521500A5 - - Google Patents
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- Publication number
- JP2003521500A5 JP2003521500A5 JP2001556090A JP2001556090A JP2003521500A5 JP 2003521500 A5 JP2003521500 A5 JP 2003521500A5 JP 2001556090 A JP2001556090 A JP 2001556090A JP 2001556090 A JP2001556090 A JP 2001556090A JP 2003521500 A5 JP2003521500 A5 JP 2003521500A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- linear
- halo
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 description 20
- 150000001875 compounds Chemical class 0.000 description 14
- 125000005843 halogen group Chemical group 0.000 description 9
- 125000003118 aryl group Chemical group 0.000 description 7
- 125000003342 alkenyl group Chemical group 0.000 description 5
- 125000004442 acylamino group Chemical group 0.000 description 4
- 125000004423 acyloxy group Chemical group 0.000 description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 4
- 125000001309 chloro group Chemical group Cl* 0.000 description 4
- -1 methylenedioxy Chemical group 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 description 2
- 125000003860 C1-C20 alkoxy group Chemical group 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- YKQBXINMTQAKMQ-UHFFFAOYSA-N 2-(4-acetamidophenyl)-3-(3,5-dimethoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC(OC)=CC(C=C(C(O)=O)C=2C=CC(NC(C)=O)=CC=2)=C1 YKQBXINMTQAKMQ-UHFFFAOYSA-N 0.000 description 1
- WZZNGZPTMKFWNF-UHFFFAOYSA-N 3-(3,4-dimethoxyphenyl)-2-(4-hydroxyphenyl)prop-2-enoic acid Chemical compound C1=C(OC)C(OC)=CC=C1C=C(C(O)=O)C1=CC=C(O)C=C1 WZZNGZPTMKFWNF-UHFFFAOYSA-N 0.000 description 1
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18034000P | 2000-02-04 | 2000-02-04 | |
| US60/180,340 | 2000-02-04 | ||
| US09/642,618 US6624197B1 (en) | 1998-05-08 | 2000-08-17 | Diphenylethylene compounds |
| US09/642,618 | 2000-08-17 | ||
| PCT/US2001/003797 WO2001056382A1 (en) | 2000-02-04 | 2001-02-05 | Novel diphenylethylene compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003521500A JP2003521500A (ja) | 2003-07-15 |
| JP2003521500A5 true JP2003521500A5 (https=) | 2008-04-03 |
Family
ID=40157708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001556090A Withdrawn JP2003521500A (ja) | 2000-02-04 | 2001-02-05 | 新規ジフェニルエチレン化合物 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1251738B1 (https=) |
| JP (1) | JP2003521500A (https=) |
| CN (1) | CN100484400C (https=) |
| AT (1) | ATE417503T1 (https=) |
| AU (1) | AU784974B2 (https=) |
| CA (1) | CA2397076A1 (https=) |
| DE (1) | DE60137020D1 (https=) |
| MX (1) | MXPA02007514A (https=) |
| NZ (1) | NZ520829A (https=) |
| WO (1) | WO2001056382A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA85053C2 (ru) | 2003-04-22 | 2008-12-25 | Эмд Кроп Биосайенс Канада Инк. | Применение липохитоолигосахаридов для инициирования раннего цветения, созревания плодов или бутонизации и способ инициирования |
| DE102004027912A1 (de) * | 2004-06-09 | 2005-12-29 | Grünenthal GmbH | Substituierte Cyclopenten-Verbindungen |
| CN1723884A (zh) * | 2004-07-21 | 2006-01-25 | 中国人民解放军军事医学科学院放射医学研究所 | 顺式－1，2－取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途 |
| ES2627682T3 (es) | 2009-12-29 | 2017-07-31 | Mapi Pharma Limited | Compuestos intermedios y procesos para la preparación de tapentadol y compuestos relacionados |
| CN117736099A (zh) * | 2022-09-22 | 2024-03-22 | 中国科学院上海药物研究所 | 用于防治血管扩张性疾病的化合物及其制法和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2524827A (en) * | 1948-05-13 | 1950-10-10 | Schering Corp | Halogen substituted polycyclic aryl aliphatic acids |
| US5430062A (en) * | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
| EP0640586B1 (en) * | 1993-03-10 | 1999-06-09 | Morinaga Milk Industry Co., Ltd. | Stilbene derivative and stilbene analog derivative, and use thereof |
| US5686478A (en) * | 1993-07-20 | 1997-11-11 | Merck & Co. Inc. | Endothelin antagonists |
| TW325458B (en) * | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
| JPH0959245A (ja) * | 1995-08-25 | 1997-03-04 | Yamanouchi Pharmaceut Co Ltd | Ｎ−（２−プロペノイル）グアニジン誘導体 |
| US5827898A (en) * | 1996-10-07 | 1998-10-27 | Shaman Pharmaceuticals, Inc. | Use of bisphenolic compounds to treat type II diabetes |
| CA2312953A1 (en) * | 1998-03-31 | 1999-10-07 | Warner-Lambert Company | Quinolones as serine protease inhibitors |
| US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| WO2000069430A1 (en) * | 1999-05-18 | 2000-11-23 | Calyx Therapeutics, Inc. | Novel diphenylethylene compounds |
| US6413504B1 (en) * | 2000-06-30 | 2002-07-02 | Calyx Therapeutics, Inc. | Alpha-arylated cinnamic esters and 1,4-bis(alpha-carboxyl-beta-styryl)benzene esters an UV-blocking agents |
-
2001
- 2001-02-05 AT AT01905454T patent/ATE417503T1/de not_active IP Right Cessation
- 2001-02-05 CA CA002397076A patent/CA2397076A1/en not_active Abandoned
- 2001-02-05 NZ NZ520829A patent/NZ520829A/xx unknown
- 2001-02-05 CN CNB018056083A patent/CN100484400C/zh not_active Expired - Fee Related
- 2001-02-05 MX MXPA02007514A patent/MXPA02007514A/es active IP Right Grant
- 2001-02-05 EP EP01905454A patent/EP1251738B1/en not_active Expired - Lifetime
- 2001-02-05 AU AU33332/01A patent/AU784974B2/en not_active Ceased
- 2001-02-05 DE DE60137020T patent/DE60137020D1/de not_active Expired - Fee Related
- 2001-02-05 JP JP2001556090A patent/JP2003521500A/ja not_active Withdrawn
- 2001-02-05 WO PCT/US2001/003797 patent/WO2001056382A1/en not_active Ceased
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