JP2003521500A - 新規ジフェニルエチレン化合物 - Google Patents

新規ジフェニルエチレン化合物

Info

Publication number
JP2003521500A
JP2003521500A JP2001556090A JP2001556090A JP2003521500A JP 2003521500 A JP2003521500 A JP 2003521500A JP 2001556090 A JP2001556090 A JP 2001556090A JP 2001556090 A JP2001556090 A JP 2001556090A JP 2003521500 A JP2003521500 A JP 2003521500A
Authority
JP
Japan
Prior art keywords
alkyl
branched
double bond
compound
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001556090A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003521500A5 (https=
Inventor
ネオギ、パーサ
ナグ、ビシュワジット
メディチャーラ、サトヤナラヤナ
デイ、デベンドラナス
Original Assignee
カリックス セラピューティックス インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/642,618 external-priority patent/US6624197B1/en
Application filed by カリックス セラピューティックス インコーポレイテッド filed Critical カリックス セラピューティックス インコーポレイテッド
Publication of JP2003521500A publication Critical patent/JP2003521500A/ja
Publication of JP2003521500A5 publication Critical patent/JP2003521500A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2001556090A 2000-02-04 2001-02-05 新規ジフェニルエチレン化合物 Withdrawn JP2003521500A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18034000P 2000-02-04 2000-02-04
US60/180,340 2000-02-04
US09/642,618 US6624197B1 (en) 1998-05-08 2000-08-17 Diphenylethylene compounds
US09/642,618 2000-08-17
PCT/US2001/003797 WO2001056382A1 (en) 2000-02-04 2001-02-05 Novel diphenylethylene compounds

Publications (2)

Publication Number Publication Date
JP2003521500A true JP2003521500A (ja) 2003-07-15
JP2003521500A5 JP2003521500A5 (https=) 2008-04-03

Family

ID=40157708

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001556090A Withdrawn JP2003521500A (ja) 2000-02-04 2001-02-05 新規ジフェニルエチレン化合物

Country Status (10)

Country Link
EP (1) EP1251738B1 (https=)
JP (1) JP2003521500A (https=)
CN (1) CN100484400C (https=)
AT (1) ATE417503T1 (https=)
AU (1) AU784974B2 (https=)
CA (1) CA2397076A1 (https=)
DE (1) DE60137020D1 (https=)
MX (1) MXPA02007514A (https=)
NZ (1) NZ520829A (https=)
WO (1) WO2001056382A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008506722A (ja) * 2004-07-21 2008-03-06 中国人民解放▲軍▼▲軍▼事医学科学院放射医学研究所 シス−１，２−置換スチルベン誘導体、および糖尿病の治療および／または予防のための薬剤の製造におけるそれらの使用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA85053C2 (ru) 2003-04-22 2008-12-25 Эмд Кроп Биосайенс Канада Инк. Применение липохитоолигосахаридов для инициирования раннего цветения, созревания плодов или бутонизации и способ инициирования
DE102004027912A1 (de) * 2004-06-09 2005-12-29 Grünenthal GmbH Substituierte Cyclopenten-Verbindungen
ES2627682T3 (es) 2009-12-29 2017-07-31 Mapi Pharma Limited Compuestos intermedios y procesos para la preparación de tapentadol y compuestos relacionados
CN117736099A (zh) * 2022-09-22 2024-03-22 中国科学院上海药物研究所 用于防治血管扩张性疾病的化合物及其制法和用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2524827A (en) * 1948-05-13 1950-10-10 Schering Corp Halogen substituted polycyclic aryl aliphatic acids
US5430062A (en) * 1992-05-21 1995-07-04 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents
EP0640586B1 (en) * 1993-03-10 1999-06-09 Morinaga Milk Industry Co., Ltd. Stilbene derivative and stilbene analog derivative, and use thereof
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
TW325458B (en) * 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
JPH0959245A (ja) * 1995-08-25 1997-03-04 Yamanouchi Pharmaceut Co Ltd Ｎ−（２−プロペノイル）グアニジン誘導体
US5827898A (en) * 1996-10-07 1998-10-27 Shaman Pharmaceuticals, Inc. Use of bisphenolic compounds to treat type II diabetes
CA2312953A1 (en) * 1998-03-31 1999-10-07 Warner-Lambert Company Quinolones as serine protease inhibitors
US7105552B2 (en) * 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
WO2000069430A1 (en) * 1999-05-18 2000-11-23 Calyx Therapeutics, Inc. Novel diphenylethylene compounds
US6413504B1 (en) * 2000-06-30 2002-07-02 Calyx Therapeutics, Inc. Alpha-arylated cinnamic esters and 1,4-bis(alpha-carboxyl-beta-styryl)benzene esters an UV-blocking agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008506722A (ja) * 2004-07-21 2008-03-06 中国人民解放▲軍▼▲軍▼事医学科学院放射医学研究所 シス−１，２−置換スチルベン誘導体、および糖尿病の治療および／または予防のための薬剤の製造におけるそれらの使用
US8039513B2 (en) 2004-07-21 2011-10-18 Institute Of Radiation Medicine, Academy Of Military Medical Sciences, Pla Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes

Also Published As

Publication number Publication date
CN100484400C (zh) 2009-05-06
MXPA02007514A (es) 2004-02-26
EP1251738A4 (en) 2005-08-10
EP1251738A1 (en) 2002-10-30
DE60137020D1 (de) 2009-01-29
AU784974B2 (en) 2006-08-10
WO2001056382A1 (en) 2001-08-09
AU3333201A (en) 2001-08-14
EP1251738B1 (en) 2008-12-17
NZ520829A (en) 2004-12-24
CA2397076A1 (en) 2001-08-09
ATE417503T1 (de) 2009-01-15
CN1437441A (zh) 2003-08-20

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