AU784974B2 - Novel diphenylethylene compounds - Google Patents

Novel diphenylethylene compounds Download PDF

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Publication number
AU784974B2
AU784974B2 AU33332/01A AU3333201A AU784974B2 AU 784974 B2 AU784974 B2 AU 784974B2 AU 33332/01 A AU33332/01 A AU 33332/01A AU 3333201 A AU3333201 A AU 3333201A AU 784974 B2 AU784974 B2 AU 784974B2
Authority
AU
Australia
Prior art keywords
compound
linear
alkyl
branched alkyl
coor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU33332/01A
Other languages
English (en)
Other versions
AU3333201A (en
Inventor
Debendranath Dey
Satyanarayana Medicherla
Bishwajit Nag
Partha Neogi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Theracos Inc
Original Assignee
Theracos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/642,618 external-priority patent/US6624197B1/en
Application filed by Theracos Inc filed Critical Theracos Inc
Publication of AU3333201A publication Critical patent/AU3333201A/en
Assigned to THERACOS, INC. reassignment THERACOS, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: CALYX THERAPEUTICS, INC.
Application granted granted Critical
Publication of AU784974B2 publication Critical patent/AU784974B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU33332/01A 2000-02-04 2001-02-05 Novel diphenylethylene compounds Ceased AU784974B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18034000P 2000-02-04 2000-02-04
US60/180340 2000-02-04
US09/642,618 US6624197B1 (en) 1998-05-08 2000-08-17 Diphenylethylene compounds
US09/642618 2000-08-17
PCT/US2001/003797 WO2001056382A1 (en) 2000-02-04 2001-02-05 Novel diphenylethylene compounds

Publications (2)

Publication Number Publication Date
AU3333201A AU3333201A (en) 2001-08-14
AU784974B2 true AU784974B2 (en) 2006-08-10

Family

ID=40157708

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33332/01A Ceased AU784974B2 (en) 2000-02-04 2001-02-05 Novel diphenylethylene compounds

Country Status (10)

Country Link
EP (1) EP1251738B1 (https=)
JP (1) JP2003521500A (https=)
CN (1) CN100484400C (https=)
AT (1) ATE417503T1 (https=)
AU (1) AU784974B2 (https=)
CA (1) CA2397076A1 (https=)
DE (1) DE60137020D1 (https=)
MX (1) MXPA02007514A (https=)
NZ (1) NZ520829A (https=)
WO (1) WO2001056382A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA85053C2 (ru) 2003-04-22 2008-12-25 Эмд Кроп Биосайенс Канада Инк. Применение липохитоолигосахаридов для инициирования раннего цветения, созревания плодов или бутонизации и способ инициирования
DE102004027912A1 (de) * 2004-06-09 2005-12-29 Grünenthal GmbH Substituierte Cyclopenten-Verbindungen
CN1723884A (zh) * 2004-07-21 2006-01-25 中国人民解放军军事医学科学院放射医学研究所 顺式－1，2－取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途
ES2627682T3 (es) 2009-12-29 2017-07-31 Mapi Pharma Limited Compuestos intermedios y procesos para la preparación de tapentadol y compuestos relacionados
CN117736099A (zh) * 2022-09-22 2024-03-22 中国科学院上海药物研究所 用于防治血管扩张性疾病的化合物及其制法和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430062A (en) * 1992-05-21 1995-07-04 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents
US5525632A (en) * 1993-09-08 1996-06-11 Ajinomoto Co., Ltd. Stilbene derivatives and pharmaceutical compositions containing them
JPH0959245A (ja) * 1995-08-25 1997-03-04 Yamanouchi Pharmaceut Co Ltd Ｎ−（２−プロペノイル）グアニジン誘導体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2524827A (en) * 1948-05-13 1950-10-10 Schering Corp Halogen substituted polycyclic aryl aliphatic acids
EP0640586B1 (en) * 1993-03-10 1999-06-09 Morinaga Milk Industry Co., Ltd. Stilbene derivative and stilbene analog derivative, and use thereof
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
US5827898A (en) * 1996-10-07 1998-10-27 Shaman Pharmaceuticals, Inc. Use of bisphenolic compounds to treat type II diabetes
CA2312953A1 (en) * 1998-03-31 1999-10-07 Warner-Lambert Company Quinolones as serine protease inhibitors
US7105552B2 (en) * 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
WO2000069430A1 (en) * 1999-05-18 2000-11-23 Calyx Therapeutics, Inc. Novel diphenylethylene compounds
US6413504B1 (en) * 2000-06-30 2002-07-02 Calyx Therapeutics, Inc. Alpha-arylated cinnamic esters and 1,4-bis(alpha-carboxyl-beta-styryl)benzene esters an UV-blocking agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430062A (en) * 1992-05-21 1995-07-04 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents
US5525632A (en) * 1993-09-08 1996-06-11 Ajinomoto Co., Ltd. Stilbene derivatives and pharmaceutical compositions containing them
JPH0959245A (ja) * 1995-08-25 1997-03-04 Yamanouchi Pharmaceut Co Ltd Ｎ−（２−プロペノイル）グアニジン誘導体

Also Published As

Publication number Publication date
CN100484400C (zh) 2009-05-06
JP2003521500A (ja) 2003-07-15
MXPA02007514A (es) 2004-02-26
EP1251738A4 (en) 2005-08-10
EP1251738A1 (en) 2002-10-30
DE60137020D1 (de) 2009-01-29
WO2001056382A1 (en) 2001-08-09
AU3333201A (en) 2001-08-14
EP1251738B1 (en) 2008-12-17
NZ520829A (en) 2004-12-24
CA2397076A1 (en) 2001-08-09
ATE417503T1 (de) 2009-01-15
CN1437441A (zh) 2003-08-20

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: THERACOS, INC.

Free format text: THE FORMER OWNER WAS: CALYX THERAPEUTICS, INC.