ATE417503T1 - Neue diphenylethylene-verbindungen - Google Patents
Neue diphenylethylene-verbindungenInfo
- Publication number
- ATE417503T1 ATE417503T1 AT01905454T AT01905454T ATE417503T1 AT E417503 T1 ATE417503 T1 AT E417503T1 AT 01905454 T AT01905454 T AT 01905454T AT 01905454 T AT01905454 T AT 01905454T AT E417503 T1 ATE417503 T1 AT E417503T1
- Authority
- AT
- Austria
- Prior art keywords
- new
- compounds
- diphenylethylene compounds
- glucose
- lipid
- Prior art date
Links
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical class C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 title abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- 102000016267 Leptin Human genes 0.000 abstract 1
- 108010092277 Leptin Proteins 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 229940125708 antidiabetic agent Drugs 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000000667 effect on insulin Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004153 glucose metabolism Effects 0.000 abstract 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 abstract 1
- 229940039781 leptin Drugs 0.000 abstract 1
- 230000037356 lipid metabolism Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18034000P | 2000-02-04 | 2000-02-04 | |
| US09/642,618 US6624197B1 (en) | 1998-05-08 | 2000-08-17 | Diphenylethylene compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE417503T1 true ATE417503T1 (de) | 2009-01-15 |
Family
ID=40157708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01905454T ATE417503T1 (de) | 2000-02-04 | 2001-02-05 | Neue diphenylethylene-verbindungen |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1251738B1 (de) |
| JP (1) | JP2003521500A (de) |
| CN (1) | CN100484400C (de) |
| AT (1) | ATE417503T1 (de) |
| AU (1) | AU784974B2 (de) |
| CA (1) | CA2397076A1 (de) |
| DE (1) | DE60137020D1 (de) |
| MX (1) | MXPA02007514A (de) |
| NZ (1) | NZ520829A (de) |
| WO (1) | WO2001056382A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA85053C2 (ru) | 2003-04-22 | 2008-12-25 | Эмд Кроп Биосайенс Канада Инк. | Применение липохитоолигосахаридов для инициирования раннего цветения, созревания плодов или бутонизации и способ инициирования |
| DE102004027912A1 (de) * | 2004-06-09 | 2005-12-29 | Grünenthal GmbH | Substituierte Cyclopenten-Verbindungen |
| CN1723884A (zh) * | 2004-07-21 | 2006-01-25 | 中国人民解放军军事医学科学院放射医学研究所 | 顺式－1，2－取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途 |
| ES2627682T3 (es) | 2009-12-29 | 2017-07-31 | Mapi Pharma Limited | Compuestos intermedios y procesos para la preparación de tapentadol y compuestos relacionados |
| CN117736099A (zh) * | 2022-09-22 | 2024-03-22 | 中国科学院上海药物研究所 | 用于防治血管扩张性疾病的化合物及其制法和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2524827A (en) * | 1948-05-13 | 1950-10-10 | Schering Corp | Halogen substituted polycyclic aryl aliphatic acids |
| US5430062A (en) * | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
| EP0640586B1 (de) * | 1993-03-10 | 1999-06-09 | Morinaga Milk Industry Co., Ltd. | Stilbenderivate und analoga sowie deren anwendung |
| US5686478A (en) * | 1993-07-20 | 1997-11-11 | Merck & Co. Inc. | Endothelin antagonists |
| TW325458B (en) * | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
| JPH0959245A (ja) * | 1995-08-25 | 1997-03-04 | Yamanouchi Pharmaceut Co Ltd | Ｎ−（２−プロペノイル）グアニジン誘導体 |
| US5827898A (en) * | 1996-10-07 | 1998-10-27 | Shaman Pharmaceuticals, Inc. | Use of bisphenolic compounds to treat type II diabetes |
| CA2312953A1 (en) * | 1998-03-31 | 1999-10-07 | Warner-Lambert Company | Quinolones as serine protease inhibitors |
| US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| WO2000069430A1 (en) * | 1999-05-18 | 2000-11-23 | Calyx Therapeutics, Inc. | Novel diphenylethylene compounds |
| US6413504B1 (en) * | 2000-06-30 | 2002-07-02 | Calyx Therapeutics, Inc. | Alpha-arylated cinnamic esters and 1,4-bis(alpha-carboxyl-beta-styryl)benzene esters an UV-blocking agents |
-
2001
- 2001-02-05 AT AT01905454T patent/ATE417503T1/de not_active IP Right Cessation
- 2001-02-05 CA CA002397076A patent/CA2397076A1/en not_active Abandoned
- 2001-02-05 NZ NZ520829A patent/NZ520829A/xx unknown
- 2001-02-05 CN CNB018056083A patent/CN100484400C/zh not_active Expired - Fee Related
- 2001-02-05 MX MXPA02007514A patent/MXPA02007514A/es active IP Right Grant
- 2001-02-05 EP EP01905454A patent/EP1251738B1/de not_active Expired - Lifetime
- 2001-02-05 AU AU33332/01A patent/AU784974B2/en not_active Ceased
- 2001-02-05 DE DE60137020T patent/DE60137020D1/de not_active Expired - Fee Related
- 2001-02-05 JP JP2001556090A patent/JP2003521500A/ja not_active Withdrawn
- 2001-02-05 WO PCT/US2001/003797 patent/WO2001056382A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN100484400C (zh) | 2009-05-06 |
| JP2003521500A (ja) | 2003-07-15 |
| MXPA02007514A (es) | 2004-02-26 |
| EP1251738A4 (de) | 2005-08-10 |
| EP1251738A1 (de) | 2002-10-30 |
| DE60137020D1 (de) | 2009-01-29 |
| AU784974B2 (en) | 2006-08-10 |
| WO2001056382A1 (en) | 2001-08-09 |
| AU3333201A (en) | 2001-08-14 |
| EP1251738B1 (de) | 2008-12-17 |
| NZ520829A (en) | 2004-12-24 |
| CA2397076A1 (en) | 2001-08-09 |
| CN1437441A (zh) | 2003-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |