JP2003520776A - 経口活性ａ１アデノシン受容体作用薬 - Google Patents

経口活性ａ１アデノシン受容体作用薬

Info

Publication number
JP2003520776A
JP2003520776A JP2001511301A JP2001511301A JP2003520776A JP 2003520776 A JP2003520776 A JP 2003520776A JP 2001511301 A JP2001511301 A JP 2001511301A JP 2001511301 A JP2001511301 A JP 2001511301A JP 2003520776 A JP2003520776 A JP 2003520776A
Authority
JP
Japan
Prior art keywords
alkyl
aryl
group
heteroaryl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001511301A
Other languages
English (en)
Japanese (ja)
Inventor
ブレント ケイ． ブラックバーン、
クリス メルヴィル、
ジェフ エイ． ザブロッキー、
ヴェンカタ ピー． パレ、
エルファティー オー． エルザイン、
リサ ワン、
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Palo Alto Inc
Original Assignee
CV Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CV Therapeutics Inc filed Critical CV Therapeutics Inc
Publication of JP2003520776A publication Critical patent/JP2003520776A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2001511301A 1999-05-24 2000-05-19 経口活性ａ１アデノシン受容体作用薬 Pending JP2003520776A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/317,523 US6576619B2 (en) 1999-05-24 1999-05-24 Orally active A1 adenosine receptor agonists
US09/317,523 1999-05-24
PCT/US2000/014036 WO2000071558A1 (fr) 1999-05-24 2000-05-19 Agonistes du recepteur de l'adenosine active a1 administres par voie orale

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006207713A Division JP2006348040A (ja) 1999-05-24 2006-07-31 経口活性ａ１アデノシン受容体作用薬

Publications (1)

Publication Number Publication Date
JP2003520776A true JP2003520776A (ja) 2003-07-08

Family

ID=23234062

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001511301A Pending JP2003520776A (ja) 1999-05-24 2000-05-19 経口活性ａ１アデノシン受容体作用薬
JP2006207713A Pending JP2006348040A (ja) 1999-05-24 2006-07-31 経口活性ａ１アデノシン受容体作用薬

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2006207713A Pending JP2006348040A (ja) 1999-05-24 2006-07-31 経口活性ａ１アデノシン受容体作用薬

Country Status (19)

Country Link
US (1) US6576619B2 (fr)
EP (1) EP1181302B1 (fr)
JP (2) JP2003520776A (fr)
KR (1) KR100537032B1 (fr)
CN (1) CN1183153C (fr)
AR (1) AR035909A1 (fr)
AT (1) ATE250621T1 (fr)
AU (1) AU760658B2 (fr)
BR (1) BR0010882A (fr)
CA (1) CA2375040C (fr)
DE (1) DE60005507T2 (fr)
ES (1) ES2206238T3 (fr)
IL (2) IL146471A0 (fr)
MX (1) MXPA01012038A (fr)
NO (1) NO320854B1 (fr)
NZ (1) NZ515580A (fr)
TW (1) TW593330B (fr)
WO (1) WO2000071558A1 (fr)
ZA (1) ZA200109626B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL127947A0 (en) 1999-01-07 1999-11-30 Can Fite Technologies Ltd Pharmaceutical use of adenosine agonists
US6790839B2 (en) 1999-01-07 2004-09-14 Can-Fite Biopharma Ltd. Pharmaceutical administration of adenosine agonists
AU2003223237C1 (en) * 2002-02-19 2009-03-26 Gilead Palo Alto, Inc. Partial and full agonists of A1 adenosine receptors
WO2004000280A1 (fr) * 2002-04-29 2003-12-31 Shire Laboraties, Inc. Preparations pharmaceutiques aux caracteristiques biologiques de liberation ameliorees
US8709476B2 (en) 2003-11-04 2014-04-29 Supernus Pharmaceuticals, Inc. Compositions of quaternary ammonium compounds containing bioavailability enhancers
JP5610663B2 (ja) 2003-11-04 2014-10-22 スパーナス ファーマシューティカルズ インコーポレイテッド トロスピウムの１日１回剤形
NZ573307A (en) 2006-06-27 2012-02-24 Biovitrum Ab Publ 2-0'-methyladen0sine derivatives and their use as agonists or antagonists of an adenosine receptor
US7731604B2 (en) * 2006-10-31 2010-06-08 Taylor Made Golf Company, Inc. Golf club iron head
CN101712709A (zh) * 2008-10-06 2010-05-26 中国医学科学院药物研究所 三乙酰基-3-羟基苯基腺苷及其调血脂的用途
DE102011005232A1 (de) 2011-03-08 2012-09-13 AristoCon GmbH & Co. KG Adenosin und seine Derivate zur Verwendung in der Schmerztherapie

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460929A1 (de) 1974-12-21 1976-06-24 Boehringer Sohn Ingelheim Neue xanthinderivate, verfahren zu ihrer herstellung und ihre anwendung
US4364922A (en) 1980-10-14 1982-12-21 University Of Virginia Alumni Patents Foundation Adenosine antagonists in the treatment and diagnosis of A-V node conduction disturbances
JPS57171998A (en) * 1981-04-15 1982-10-22 Fujisawa Pharmaceut Co Ltd Adenosine derivative and its salt, preparation thereof and medicinal composition containing the same
DE3138397A1 (de) 1981-09-26 1983-04-07 Hoechst Ag, 6230 Frankfurt "arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen"
US4593019A (en) 1984-10-26 1986-06-03 Warner-Lambert Company N6 -tricyclic adenosines
AU577743B2 (en) 1984-10-26 1988-09-29 Warner-Lambert Company N6-benzopyrano and benzothiopyrano adenosines
WO1988003148A2 (fr) 1986-10-31 1988-05-05 Warner-Lambert Company Derives heteroaromatiques d'adenosine
US4954504A (en) 1986-11-14 1990-09-04 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity
KR890701609A (ko) * 1987-10-28 1989-12-21 원본미기재 아실 데옥시리보뉴클레오시드 유도체 및 그의 사용
US4980379A (en) 1988-06-30 1990-12-25 The University Of Virginia Use of adenosine antagonists in the treatment of bradyarrhythmias and hemodynamic depression associated with cardiopulmonary resucitation and/or cardiovascular collapse
DE3843117A1 (de) 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung
AU626983B2 (en) 1989-01-31 1992-08-13 Whitby Research, Inc. N6-substituted 9-methyladenines
US5017578A (en) 1989-06-09 1991-05-21 Hoechst-Roussel Pharmaceuticals Inc. N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents
JPH06102662B2 (ja) 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
DE4019892A1 (de) 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
US5432164A (en) 1991-10-24 1995-07-11 Novo Nordisk A/S C2,N6 -disubstituted adenosine derivatives
DE4205306B4 (de) 1992-02-21 2005-11-24 Glüsenkamp, Karl-Heinz, Dr. Säureamide, Arzneimittel mit denselben und Verfahren zur Herstellung von Säureamiden
US5288721A (en) 1992-09-22 1994-02-22 Cell Therapeutics, Inc. Substituted epoxyalkyl xanthines
WO1994016702A1 (fr) 1993-01-26 1994-08-04 Kyowa Hakko Kogyo Co., Ltd. Medicament contre l'elimination irreguliere des matieres fecales
WO1995002604A1 (fr) 1993-07-13 1995-01-26 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Agonistes du recepteur de l'adenosine a¿3?
US5446046A (en) 1993-10-28 1995-08-29 University Of Florida Research Foundation A1 adenosine receptor agonists and antagonists as diuretics
US5789416B1 (en) 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
GB9723566D0 (en) * 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
GB9723590D0 (en) * 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
DE60005507T2 (de) 2004-06-24
NO20015662D0 (no) 2001-11-20
IL146471A (en) 2007-06-03
MXPA01012038A (es) 2002-05-06
DE60005507D1 (de) 2003-10-30
NZ515580A (en) 2004-06-25
JP2006348040A (ja) 2006-12-28
ES2206238T3 (es) 2004-05-16
US6576619B2 (en) 2003-06-10
CA2375040C (fr) 2006-02-07
AU5037600A (en) 2000-12-12
NO20015662L (no) 2002-01-23
BR0010882A (pt) 2002-06-11
ATE250621T1 (de) 2003-10-15
EP1181302A1 (fr) 2002-02-27
KR20020092777A (ko) 2002-12-12
ZA200109626B (en) 2004-03-10
EP1181302B1 (fr) 2003-09-24
CA2375040A1 (fr) 2000-11-30
TW593330B (en) 2004-06-21
CN1390228A (zh) 2003-01-08
AU760658B2 (en) 2003-05-22
KR100537032B1 (ko) 2005-12-16
AR035909A1 (es) 2004-07-28
CN1183153C (zh) 2005-01-05
NO320854B1 (no) 2006-02-06
IL146471A0 (en) 2002-07-25
US20020091099A1 (en) 2002-07-11
WO2000071558A1 (fr) 2000-11-30

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