JP2003519207A - トルテロジンおよびその類似体の調製方法ならびにこの方法で調製される中間体 - Google Patents

トルテロジンおよびその類似体の調製方法ならびにこの方法で調製される中間体

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Publication number
JP2003519207A
JP2003519207A JP2001550189A JP2001550189A JP2003519207A JP 2003519207 A JP2003519207 A JP 2003519207A JP 2001550189 A JP2001550189 A JP 2001550189A JP 2001550189 A JP2001550189 A JP 2001550189A JP 2003519207 A JP2003519207 A JP 2003519207A
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compound
formula
enantiomers
enriched
defined above
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Japanese (ja)
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JP2003519207A5 (https=
Inventor
アンデシヨン，ペール・ゲー
ヘドベリ，クリステイアン
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フアーマシア・アー・ベー
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2001550189A 1999-12-30 2000-12-22 トルテロジンおよびその類似体の調製方法ならびにこの方法で調製される中間体 Pending JP2003519207A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9904850A SE9904850D0 (sv) 1999-12-30 1999-12-30 Novel process and intermediates
SE9904850-6 1999-12-30
PCT/SE2000/002662 WO2001049649A1 (en) 1999-12-30 2000-12-22 Process of preparing tolterodine and analogues there of as well as intermediates prepared in the process

Publications (2)

Publication Number Publication Date
JP2003519207A true JP2003519207A (ja) 2003-06-17
JP2003519207A5 JP2003519207A5 (https=) 2007-12-06

Family

ID=20418365

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001550189A Pending JP2003519207A (ja) 1999-12-30 2000-12-22 トルテロジンおよびその類似体の調製方法ならびにこの方法で調製される中間体

Country Status (29)

Country Link
US (1) US6310248B2 (https=)
EP (2) EP1242361B1 (https=)
JP (1) JP2003519207A (https=)
KR (1) KR20020062669A (https=)
CN (1) CN1209342C (https=)
AR (1) AR027138A1 (https=)
AT (1) ATE282019T1 (https=)
AU (1) AU782796B2 (https=)
BR (1) BR0016785A (https=)
CA (1) CA2392832A1 (https=)
CZ (1) CZ20022255A3 (https=)
DE (1) DE60015799T2 (https=)
DK (1) DK1242361T3 (https=)
EE (1) EE200200325A (https=)
ES (1) ES2228658T3 (https=)
HU (1) HUP0203816A3 (https=)
IL (1) IL150275A0 (https=)
MX (1) MXPA02006415A (https=)
MY (1) MY118906A (https=)
NO (1) NO20023189L (https=)
NZ (1) NZ519079A (https=)
PE (1) PE20011123A1 (https=)
PL (1) PL355947A1 (https=)
PT (1) PT1242361E (https=)
SE (1) SE9904850D0 (https=)
SK (1) SK9392002A3 (https=)
TW (1) TWI225476B (https=)
WO (1) WO2001049649A1 (https=)
ZA (1) ZA200204066B (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006160622A (ja) * 2004-12-03 2006-06-22 Sumitomo Chemical Co Ltd トルテロジンの製造方法
JP2007515459A (ja) * 2003-12-22 2007-06-14 ラガクティブス，エス．エル． トルテロジンを得るための方法
WO2012063843A1 (ja) * 2010-11-09 2012-05-18 株式会社カネカ ハロゲン化インデノン類及びそれを用いた光学活性インダノン類又は光学活性インダノール類の製造方法
KR20150097511A (ko) * 2012-12-19 2015-08-26 하. 룬드벡 아크티에셀스카브 6-클로로-3-(페닐-ｄ5)-인덴-1-온 및 이의 용도

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EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
US6703504B2 (en) 2002-02-11 2004-03-09 Clarke Slemon Conformationally constrained compounds as dendrimer cores
WO2003064501A1 (en) * 2002-01-31 2003-08-07 Clarke Slemon Conformationally restricted compounds as dendrimer cores
EP1424079A1 (en) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
ITMI20031354A1 (it) * 2003-07-02 2005-01-03 Istituto Di Chimica Biomolecolare D El Cnr Sezione Sintesis enantioselettiva di composti enantiomericamente arricchiti.
ITMI20040616A1 (it) * 2004-03-30 2004-06-30 Dinamite Dipharma S P A In For Processo per la preparazione di tolterodina e suoi intermedi
EP1629834A1 (en) 2004-08-27 2006-03-01 KRKA, D.D., Novo Mesto Sustained release pharmaceutical composition of tolterodine
ITMI20041920A1 (it) * 2004-10-11 2005-01-11 Chemi Spa Processo per la preparazione di n, n-diisopropil-3-2-idrossi-5-metilfenil-3-fenil-propabammina
EP1838659B1 (en) * 2004-12-24 2015-07-15 LEK Pharmaceuticals d.d. Process for preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine
US7528267B2 (en) * 2005-08-01 2009-05-05 Girindus America, Inc. Method for enantioselective hydrogenation of chromenes
ES2268987B1 (es) 2005-08-05 2008-02-01 Ragactives, S.L. Procedimiento para la obtencion de 3,3-difenilpropilaminas.
KR100647068B1 (ko) 2005-09-15 2006-11-23 하나제약 주식회사 라세믹ｎ,ｎ-디이소프로필-3-(2-히드록시-5-메틸페닐)-3-페닐프로판아민의 제조방법
KR100686351B1 (ko) * 2006-01-12 2007-02-22 주식회사 카이로제닉스 톨테로딘 라세미체의 제조방법
DE602007009096D1 (de) 2006-05-24 2010-10-21 Pfizer Ltd Verfahren zur herstellung von benzopyran-2-olderivaten
BRPI0712842A2 (pt) 2006-06-12 2012-07-24 Sanol Arznei Schwarz Gmbh internediÁrio quiral, processo para produÇço do mesmo e seu emprego na fabricaÇço da tolterodina, fesoterodina ou o metabàlito ativo das mesmas.
KR100717361B1 (ko) * 2006-08-07 2007-05-11 주식회사 카이로제닉스 톨테로딘 라세미체 및 이의 중간체의 제조방법
WO2009019599A2 (en) 2007-08-08 2009-02-12 Themis Laboratories Private Limited Extended release compositions comprising tolterodine
HRP20140640T1 (hr) 2008-08-19 2014-11-21 Xenoport, Inc. Prolijekovi monometil estera fumarne kiseline, farmaceutski sastavi iz toga i postupci njihove uporabe
ES2412408T3 (es) 2008-12-24 2013-07-11 Daiichi Sankyo Company, Limited Compuestos de indanilo
CA2748249C (en) 2008-12-24 2013-07-02 Daiichi Sankyo Company, Limited Cyclic amine compounds
KR101275984B1 (ko) * 2010-10-18 2013-06-18 경기대학교 산학협력단 광학활성을 갖는 크로만계 유도체 및 이의 제조방법
WO2012098044A1 (en) 2011-01-17 2012-07-26 Cambrex Profarmaco Milano S.R.L. Process for the preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate
EP2476665A1 (en) 2011-01-17 2012-07-18 Cambrex Profarmaco Milano S.r.l. Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate
PL3135656T3 (pl) 2011-06-20 2019-07-31 H. Lundbeck A/S Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii
CN103159657B (zh) * 2011-12-08 2016-06-29 重庆华邦胜凯制药有限公司 一种定向合成不饱和共轭醇的方法
KR101380982B1 (ko) 2013-04-29 2014-04-10 경기대학교 산학협력단 광학활성을 갖는 크로만-2-올 유도체 및 이의 제조방법
WO2017137955A1 (en) 2016-02-14 2017-08-17 Celestis Pharmaceuticals Pvt. Ltd. Novel (r) and rac 3-(2-(allyloxy)-5-methylphenyl)-n,n-diisopropyl-3- phenylpropan-1-amine and its use for synthesis of (r) and rac-2-(3- (diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol
US20210282443A1 (en) * 2016-07-12 2021-09-16 Chromocell Corporation Compounds, compositions, and methods for modulating sweet taste
EP3891134A1 (en) 2018-12-03 2021-10-13 H. Lundbeck A/S Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine

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JPH03503163A (ja) * 1988-01-22 1991-07-18 フアーマシア・アンド・アツプジヨン・アー・ベー 新規アミン、その使用及び製法
JPH08503208A (ja) * 1992-11-06 1996-04-09 フアーマシア・アー・ベー 新規な３，３−ジフェニルプロピルアミン類、その使用および製造法
JP2001507691A (ja) * 1996-12-31 2001-06-12 ファルマシア・アンド・アップジョン・カンパニー トルテロジンの製法
JP2003519079A (ja) * 1998-05-12 2003-06-17 シュヴァルツ・ファルマ・アクチエンゲゼルシャフト ３，３−ジフェニルプロピルアミンの新規な誘導体

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ZA969363B (en) * 1995-11-08 1997-11-18 Smithkline Beecham Corp An improved process for preparing aromatic ring-fused cyclopentane derivatives.

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Publication number Priority date Publication date Assignee Title
JPH03503163A (ja) * 1988-01-22 1991-07-18 フアーマシア・アンド・アツプジヨン・アー・ベー 新規アミン、その使用及び製法
JPH08503208A (ja) * 1992-11-06 1996-04-09 フアーマシア・アー・ベー 新規な３，３−ジフェニルプロピルアミン類、その使用および製造法
JP2001507691A (ja) * 1996-12-31 2001-06-12 ファルマシア・アンド・アップジョン・カンパニー トルテロジンの製法
JP2003519079A (ja) * 1998-05-12 2003-06-17 シュヴァルツ・ファルマ・アクチエンゲゼルシャフト ３，３−ジフェニルプロピルアミンの新規な誘導体

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007515459A (ja) * 2003-12-22 2007-06-14 ラガクティブス，エス．エル． トルテロジンを得るための方法
JP4874122B2 (ja) * 2003-12-22 2012-02-15 ラガクティブス，エス．エル． トルテロジンを得るための方法
JP2006160622A (ja) * 2004-12-03 2006-06-22 Sumitomo Chemical Co Ltd トルテロジンの製造方法
WO2012063843A1 (ja) * 2010-11-09 2012-05-18 株式会社カネカ ハロゲン化インデノン類及びそれを用いた光学活性インダノン類又は光学活性インダノール類の製造方法
JP2016074712A (ja) * 2010-11-09 2016-05-12 株式会社カネカ エノン化合物
JP5941410B2 (ja) * 2010-11-09 2016-06-29 株式会社カネカ ハロゲン化インデノン類及びそれを用いた光学活性インダノン類又は光学活性インダノール類の製造方法
KR20150097511A (ko) * 2012-12-19 2015-08-26 하. 룬드벡 아크티에셀스카브 6-클로로-3-(페닐-ｄ5)-인덴-1-온 및 이의 용도
JP2016501901A (ja) * 2012-12-19 2016-01-21 ハー・ルンドベック・アクチエゼルスカベット ６−クロロ−３−（フェニル−ｄ５）インデン−１−オンおよびその使用
KR102212096B1 (ko) * 2012-12-19 2021-02-04 하. 룬드벡 아크티에셀스카브 6-클로로-3-(페닐-ｄ5)-인덴-1-온 및 이의 용도

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