JP2003517462A5 - - Google Patents
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- Publication number
- JP2003517462A5 JP2003517462A5 JP2001511958A JP2001511958A JP2003517462A5 JP 2003517462 A5 JP2003517462 A5 JP 2003517462A5 JP 2001511958 A JP2001511958 A JP 2001511958A JP 2001511958 A JP2001511958 A JP 2001511958A JP 2003517462 A5 JP2003517462 A5 JP 2003517462A5
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- benzethonium chloride
- vial
- added
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960001950 benzethonium chloride Drugs 0.000 description 39
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 39
- 238000000034 method Methods 0.000 description 27
- 239000000203 mixture Substances 0.000 description 23
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 18
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 18
- 229960005323 phenoxyethanol Drugs 0.000 description 18
- NDTDVKKGYBULHF-UHFFFAOYSA-N 2-(1-hydroxy-3-phenylnaphthalen-2-yl)-3-phenylnaphthalen-1-ol Chemical compound C=1C2=CC=CC=C2C(O)=C(C=2C(=CC3=CC=CC=C3C=2O)C=2C=CC=CC=2)C=1C1=CC=CC=C1 NDTDVKKGYBULHF-UHFFFAOYSA-N 0.000 description 15
- 229940067107 phenylethyl alcohol Drugs 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 102000003951 Erythropoietin Human genes 0.000 description 4
- 108090000394 Erythropoietin Proteins 0.000 description 4
- 229940105423 erythropoietin Drugs 0.000 description 4
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical group [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19821699P | 1999-07-22 | 1999-07-22 | |
| US60/198,216 | 1999-07-22 | ||
| PCT/US2000/040446 WO2001007075A2 (en) | 1999-07-22 | 2000-07-21 | Multi-dose erythropoietin formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003517462A JP2003517462A (ja) | 2003-05-27 |
| JP2003517462A5 true JP2003517462A5 (https=) | 2007-08-30 |
Family
ID=22732468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001511958A Pending JP2003517462A (ja) | 1999-07-22 | 2000-07-21 | 複数回投与用エリスロポエチン製剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7432360B2 (https=) |
| EP (1) | EP1200115B9 (https=) |
| JP (1) | JP2003517462A (https=) |
| KR (1) | KR100693263B1 (https=) |
| CN (2) | CN101091792A (https=) |
| AT (1) | ATE304863T1 (https=) |
| AU (1) | AU777397B2 (https=) |
| BR (1) | BR0012667A (https=) |
| CA (1) | CA2378945C (https=) |
| CZ (1) | CZ302750B6 (https=) |
| DE (1) | DE60022759T2 (https=) |
| DK (1) | DK1200115T3 (https=) |
| EA (1) | EA006220B1 (https=) |
| EE (1) | EE200200037A (https=) |
| ES (1) | ES2248110T3 (https=) |
| HK (1) | HK1050318A1 (https=) |
| HR (1) | HRP20020159B1 (https=) |
| HU (1) | HUP0202246A3 (https=) |
| IL (2) | IL147755A0 (https=) |
| NO (1) | NO20020303L (https=) |
| NZ (1) | NZ516735A (https=) |
| PL (1) | PL202945B1 (https=) |
| RS (1) | RS50355B (https=) |
| WO (1) | WO2001007075A2 (https=) |
| ZA (1) | ZA200200742B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU4602A (sh) | 1999-07-22 | 2005-06-10 | Aventis Pharmaceuticals Inc. | Farmaceutske formulacije zaštićene od dejstva mikroorganizama |
| PL219131B1 (pl) | 2000-05-15 | 2015-03-31 | Hoffmann La Roche | Ciekła kompozycja farmaceutyczna, sposób jej wytwarzania oraz jej zastosowanie |
| US7148211B2 (en) | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| KR20070015549A (ko) * | 2004-03-26 | 2007-02-05 | 얀센 파마슈티카 엔.브이. | 에리트로포이에틴의 병용 용량요법 |
| US7772182B2 (en) | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| WO2006081969A1 (de) * | 2005-02-03 | 2006-08-10 | Clariant Produkte (Deutschland) Gmbh | Konservierungsmittel |
| JP2011116752A (ja) * | 2009-10-29 | 2011-06-16 | Jcr Pharmaceuticals Co Ltd | エリスロポエチン含有水性液剤 |
| KR101805087B1 (ko) * | 2010-09-16 | 2017-12-05 | 주식회사 엘지화학 | 높은 방부력을 제공하는 오일 주사 제형 |
| EP3364944B1 (en) * | 2015-10-22 | 2024-06-12 | Iltoo Pharma | Pharmaceutical compositions of il-2 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3489837A (en) * | 1968-07-11 | 1970-01-13 | Leroy J Hyman | Synergistic antiseptic composition consisting of 9-aminoacridine hydrochloride and benzethonium chloride |
| JPS6045849B2 (ja) | 1980-08-25 | 1985-10-12 | 林原 健 | ヒトエリトロポエチンの製造方法 |
| US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| JPS6191131A (ja) * | 1984-10-09 | 1986-05-09 | Chugai Pharmaceut Co Ltd | 医薬品の吸着防止方法および組成物 |
| JPS6197229A (ja) | 1984-10-18 | 1986-05-15 | Chugai Pharmaceut Co Ltd | 安定なエリトロポエチン製剤 |
| JPH0651637B2 (ja) * | 1985-03-28 | 1994-07-06 | エーザイ株式会社 | ペプタイドの吸着防止組成物 |
| US5045529A (en) * | 1989-03-27 | 1991-09-03 | Bionostics, Inc. | Tonometric fluid for blood gas and co-oximetry instruments |
| JP3249147B2 (ja) * | 1990-06-01 | 2002-01-21 | キリン−アムジエン・インコーポレーテツド | 生理活性蛋白含有経口製剤 |
| CA2050425A1 (en) * | 1990-09-03 | 1992-03-04 | Yoshiaki Uda | Pharmaceutical composition and its mucous use |
| DE4126983A1 (de) * | 1991-08-15 | 1993-02-18 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke |
| US5661125A (en) | 1992-08-06 | 1997-08-26 | Amgen, Inc. | Stable and preserved erythropoietin compositions |
| JP2532025B2 (ja) * | 1993-07-23 | 1996-09-11 | 株式会社林原生物化学研究所 | 新リンホカインｉｉｉを有効成分とする抗腫瘍作用を有するリンホカインの活性増強剤 |
| WO1995033474A1 (en) * | 1994-06-03 | 1995-12-14 | Tsumura & Co. | Medicinal composition |
| JP2000504319A (ja) * | 1996-01-19 | 2000-04-11 | イーライ・リリー・アンド・カンパニー | 肥満症タンパク質製剤 |
| US6261545B1 (en) * | 1996-09-13 | 2001-07-17 | Advanced Medicine Research Institute | Ophthalmic compositions of neurotrophic factors, remedies for optic nerve function disorders and method for treating optic nerve function disorders |
| JPH1112193A (ja) * | 1997-06-19 | 1999-01-19 | Sankyo Co Ltd | ヒトカルシトニン含有水溶液製剤 |
| GB9726555D0 (en) * | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Vaccine |
-
2000
- 2000-07-21 DK DK00960177T patent/DK1200115T3/da active
- 2000-07-21 PL PL353569A patent/PL202945B1/pl not_active IP Right Cessation
- 2000-07-21 HU HU0202246A patent/HUP0202246A3/hu unknown
- 2000-07-21 AT AT00960177T patent/ATE304863T1/de active
- 2000-07-21 CA CA2378945A patent/CA2378945C/en not_active Expired - Fee Related
- 2000-07-21 WO PCT/US2000/040446 patent/WO2001007075A2/en not_active Ceased
- 2000-07-21 EP EP00960177A patent/EP1200115B9/en not_active Expired - Lifetime
- 2000-07-21 RS YUP-47/02A patent/RS50355B/sr unknown
- 2000-07-21 HK HK03102133.1A patent/HK1050318A1/zh unknown
- 2000-07-21 NZ NZ516735A patent/NZ516735A/en not_active IP Right Cessation
- 2000-07-21 ES ES00960177T patent/ES2248110T3/es not_active Expired - Lifetime
- 2000-07-21 IL IL14775500A patent/IL147755A0/xx unknown
- 2000-07-21 HR HR20020159A patent/HRP20020159B1/xx not_active IP Right Cessation
- 2000-07-21 KR KR1020027000944A patent/KR100693263B1/ko not_active Expired - Fee Related
- 2000-07-21 CZ CZ20020264A patent/CZ302750B6/cs not_active IP Right Cessation
- 2000-07-21 AU AU71374/00A patent/AU777397B2/en not_active Ceased
- 2000-07-21 EE EEP200200037A patent/EE200200037A/xx unknown
- 2000-07-21 DE DE60022759T patent/DE60022759T2/de not_active Expired - Lifetime
- 2000-07-21 BR BR0012667-5A patent/BR0012667A/pt not_active IP Right Cessation
- 2000-07-21 CN CNA2006100710932A patent/CN101091792A/zh active Pending
- 2000-07-21 JP JP2001511958A patent/JP2003517462A/ja active Pending
- 2000-07-21 EA EA200200073A patent/EA006220B1/ru not_active IP Right Cessation
- 2000-07-21 CN CN00812138A patent/CN1371284A/zh active Pending
-
2002
- 2002-01-21 IL IL147755A patent/IL147755A/en not_active IP Right Cessation
- 2002-01-21 NO NO20020303A patent/NO20020303L/no not_active Application Discontinuation
- 2002-01-28 ZA ZA200200742A patent/ZA200200742B/xx unknown
-
2005
- 2005-06-27 US US11/167,818 patent/US7432360B2/en not_active Expired - Fee Related
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