JP2003517294A5 - - Google Patents
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- Publication number
- JP2003517294A5 JP2003517294A5 JP2001511880A JP2001511880A JP2003517294A5 JP 2003517294 A5 JP2003517294 A5 JP 2003517294A5 JP 2001511880 A JP2001511880 A JP 2001511880A JP 2001511880 A JP2001511880 A JP 2001511880A JP 2003517294 A5 JP2003517294 A5 JP 2003517294A5
- Authority
- JP
- Japan
- Prior art keywords
- medicament
- animal
- growth hormone
- vector
- vector according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 description 16
- 239000013598 vector Substances 0.000 description 14
- 102000018997 Growth Hormone Human genes 0.000 description 9
- 108010051696 Growth Hormone Proteins 0.000 description 9
- 239000000122 growth hormone Substances 0.000 description 9
- 108091036066 Three prime untranslated region Proteins 0.000 description 5
- 230000001114 myogenic effect Effects 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 208000027219 Deficiency disease Diseases 0.000 description 3
- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 description 3
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 description 3
- 101710142969 Somatoliberin Proteins 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 230000009001 hormonal pathway Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 239000000203 mixture Substances 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- -1 cationic lipid Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14562499P | 1999-07-26 | 1999-07-26 | |
| US60/145,624 | 1999-07-26 | ||
| PCT/US2000/020127 WO2001006988A2 (en) | 1999-07-26 | 2000-07-24 | Super-active porcine growth hormone releasing hormone analog |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003517294A JP2003517294A (ja) | 2003-05-27 |
| JP2003517294A5 true JP2003517294A5 (https=) | 2007-09-13 |
| JP4644402B2 JP4644402B2 (ja) | 2011-03-02 |
Family
ID=22513900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001511880A Expired - Lifetime JP4644402B2 (ja) | 1999-07-26 | 2000-07-24 | 超高活性ブタ成長ホルモン放出ホルモン類似体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6551996B1 (https=) |
| EP (1) | EP1204321B1 (https=) |
| JP (1) | JP4644402B2 (https=) |
| KR (1) | KR20020047096A (https=) |
| CN (1) | CN1635898A (https=) |
| AT (1) | ATE309358T1 (https=) |
| AU (1) | AU772752B2 (https=) |
| BR (1) | BR0012748A (https=) |
| CA (1) | CA2378943C (https=) |
| DE (1) | DE60023906T2 (https=) |
| MX (1) | MXPA02000938A (https=) |
| PL (1) | PL366132A1 (https=) |
| WO (1) | WO2001006988A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040192593A1 (en) * | 1999-07-26 | 2004-09-30 | Baylor College Of Medicine | Protease resistant ti-growth hormone releasing hormone |
| US20030074679A1 (en) * | 2000-12-12 | 2003-04-17 | Schwartz Robert J. | Administration of nucleic acid sequence to female animal to enhance growth in offspring |
| AR035671A1 (es) * | 2000-12-12 | 2004-06-23 | Advisys Inc | Administracion de secuencia de acido nucleico a un animal hembra, para aumentar el crecimiento de la descendencia |
| AU2002324909A1 (en) * | 2001-09-07 | 2003-03-24 | Baylor College Of Medicine | Linear dna fragments for gene expression |
| AR037038A1 (es) * | 2001-10-26 | 2004-10-20 | Baylor College Medicine | Una composicion y metodo para alterar la masa corporal magra y las propiedades oseas en un sujeto |
| AU2002357143B2 (en) | 2001-12-11 | 2009-07-30 | Advisys, Inc. | Growth hormone releasing hormone supplementation for treating chronically ill subjects |
| US7250405B2 (en) * | 2002-02-07 | 2007-07-31 | Baylor College Of Medicine | Modified pituitary gland development in offspring from expectant mother animals treated with growth hormone releasing hormone therapy |
| CA2485976A1 (en) * | 2002-05-28 | 2003-12-04 | Advisys, Inc. | Increased delivery of a nucleic acid construct in vivo by the poly-l-glutamate (plg) system |
| AU2003249208B2 (en) * | 2002-07-16 | 2010-03-04 | Vgx Pharmaceuticals, Llc | Codon optimized synthetic plasmids |
| KR20050071498A (ko) * | 2002-09-18 | 2005-07-07 | 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 | 성장 호르몬 방출 호르몬 유사체 |
| CA2513743C (en) * | 2003-01-28 | 2013-06-25 | Advisys, Inc. | Reducing culling in herd animals growth hormone releasing hormone (ghrh) |
| CA2575926C (en) * | 2003-08-04 | 2014-02-25 | Advisys, Inc. | Canine specific growth hormone releasing hormone |
| US7442673B2 (en) * | 2003-08-15 | 2008-10-28 | Crompton Corporation | Reaction products of mercaptobenzothiazoles, mercaptothiazolines, and mercaptobenzimidazoles with epoxides as lubricant additives |
| ATE467417T1 (de) * | 2003-12-31 | 2010-05-15 | VGX Pharmaceuticals LLC | Reduzierung von arthritis und lahmheit bei personen unter supllement von wachstumshormon freisetzendem hormon (ghrh) |
| US20090005333A1 (en) * | 2004-01-26 | 2009-01-01 | Vgx Pharmaceuticlas, Inc. | Reducing culling in herd animals growth hormone releasing hormone (ghrh) |
| US7846720B2 (en) * | 2005-01-26 | 2010-12-07 | Vgx Pharmaceuticals, Inc. | Optimized high yield synthetic plasmids |
| DK2118123T3 (en) | 2007-01-31 | 2016-01-25 | Dana Farber Cancer Inst Inc | Stabilized p53 peptides and uses thereof |
| US8592377B2 (en) | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
| US8226468B2 (en) * | 2008-11-13 | 2012-07-24 | Igt | Gaming system and method including points of symbol expansion |
| US20100267635A1 (en) * | 2009-04-20 | 2010-10-21 | Theratechonolgies Inc. | Use of protease inhibitors and grf molecules in combination therapy |
| US20100267636A1 (en) * | 2009-04-20 | 2010-10-21 | Theratechnologies Inc. | Use of cytochrome p450-metabolized drugs and grf molecules in combination therapy |
| ES2711526T3 (es) | 2010-08-13 | 2019-05-06 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| US8993316B2 (en) | 2011-11-16 | 2015-03-31 | Brian P. Hanley | Methods and compositions for gene therapy and GHRH therapy |
| CN102516364B (zh) * | 2011-12-26 | 2013-11-06 | 吉林农业大学 | 一种模拟猪生长激素样的活性肽及制备方法与应用 |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES |
| BR112014020103A2 (pt) | 2012-02-15 | 2018-10-09 | Aileron Therapeutics, Inc. | macrociclos peptidomiméticos |
| WO2013190520A2 (en) | 2012-06-22 | 2013-12-27 | The General Hospital Corporation | Gh-releasing agents in the treatment of vascular stenosis and associated conditions |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| EP3197478A4 (en) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2017181277A1 (en) | 2016-04-19 | 2017-10-26 | Griffon Pharmaceuticals Inc. | Pegylated bioactive peptides and uses thereof |
| CN112724260B (zh) * | 2021-01-15 | 2021-11-30 | 安徽中起生物科技有限公司 | 一种脂质体包封的重组兽用促生长蛋白及其制备方法和应用 |
| CN113582881B (zh) * | 2021-07-29 | 2022-10-11 | 浙江新码生物医药有限公司 | 一种非天然氨基酸及其应用、包含其的重组蛋白以及重组蛋白偶联物 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4410512A (en) | 1981-12-28 | 1983-10-18 | Beckman Instruments, Inc. | Combinations having synergistic pituitary growth hormone releasing activity |
| US5036045A (en) | 1985-09-12 | 1991-07-30 | The University Of Virginia Alumni Patents Foundation | Method for increasing growth hormone secretion |
| US4839344A (en) | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| USRE33699E (en) | 1987-07-09 | 1991-09-24 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
| US5023322A (en) | 1988-08-31 | 1991-06-11 | Mta Kutatas-Es Szervezetelemzo Intezete | Analogs of growth hormone releasing factor (GRF) and a method for the preparation thereof |
| US5084442A (en) | 1988-09-06 | 1992-01-28 | Hoffmann-La Roche Inc. | Cyclic growth hormone releasing factor analogs and method for the manufacture thereof |
| US5137872A (en) | 1989-09-18 | 1992-08-11 | Pitman-Moore, Inc. | Growth hormone-releasing factor analogs |
| WO1991011522A1 (en) | 1990-01-26 | 1991-08-08 | Baylor College Of Medicine | MUTATED PROMOTER REGION FROM CHICKEN SKELETAL α-ACTIN GENE |
| EP0544706A4 (en) | 1990-06-29 | 1993-10-13 | Hoffmann-La Roche Inc. | Histidine substituted growth hormone releasing factor analogs |
| US5486505A (en) | 1990-07-24 | 1996-01-23 | Polygen Holding Corporation | Polypeptide compounds having growth hormone releasing activity |
| CA2084061A1 (en) | 1991-04-09 | 1992-10-10 | Arthur M. Felix | Growth hormone releasing factor analogs |
| US5663146A (en) | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| US5298422A (en) | 1991-11-06 | 1994-03-29 | Baylor College Of Medicine | Myogenic vector systems |
| AU683121B2 (en) | 1993-12-23 | 1997-10-30 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US5792747A (en) | 1995-01-24 | 1998-08-11 | The Administrators Of The Tulane Educational Fund | Highly potent agonists of growth hormone releasing hormone |
| EP0820296A4 (en) | 1995-04-14 | 1999-06-30 | Univ Tulane | ANALOGS OF THE GROWTH HORMONE-RELEASING FACTOR |
| AU7522896A (en) * | 1995-10-27 | 1997-05-15 | Merck & Co., Inc. | Wet granulation formulation of a growth hormone secretagogue |
| US6123964A (en) | 1995-10-27 | 2000-09-26 | Merck & Co., Inc. | Wet granulation formulation of a growth hormone secretagogue |
| TW432073B (en) | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
| US6221617B1 (en) * | 1996-12-06 | 2001-04-24 | Julie Heinrich | Bioassay for growth hormone releasing hormone |
| US6127341A (en) * | 1997-06-20 | 2000-10-03 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| EP1005484A1 (en) * | 1997-06-20 | 2000-06-07 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| AU8589998A (en) * | 1997-07-24 | 1999-02-16 | Valentis, Inc. | Ghrh expression system and methods of use |
| ATE511400T1 (de) * | 2000-03-03 | 2011-06-15 | Genetronics Inc | Nukleinsäure-fomulierungen zur genverabreichung |
-
2000
- 2000-07-24 AU AU66078/00A patent/AU772752B2/en not_active Expired
- 2000-07-24 BR BR0012748-5A patent/BR0012748A/pt not_active IP Right Cessation
- 2000-07-24 DE DE60023906T patent/DE60023906T2/de not_active Expired - Lifetime
- 2000-07-24 EP EP00953666A patent/EP1204321B1/en not_active Expired - Lifetime
- 2000-07-24 WO PCT/US2000/020127 patent/WO2001006988A2/en not_active Ceased
- 2000-07-24 KR KR1020027001095A patent/KR20020047096A/ko not_active Withdrawn
- 2000-07-24 CN CNA008133727A patent/CN1635898A/zh active Pending
- 2000-07-24 JP JP2001511880A patent/JP4644402B2/ja not_active Expired - Lifetime
- 2000-07-24 US US09/624,268 patent/US6551996B1/en not_active Expired - Lifetime
- 2000-07-24 CA CA2378943A patent/CA2378943C/en not_active Expired - Lifetime
- 2000-07-24 AT AT00953666T patent/ATE309358T1/de not_active IP Right Cessation
- 2000-07-24 MX MXPA02000938A patent/MXPA02000938A/es active IP Right Grant
- 2000-07-24 PL PL00366132A patent/PL366132A1/xx not_active Application Discontinuation
-
2002
- 2002-10-01 US US10/262,377 patent/US20030148948A1/en not_active Abandoned
- 2002-10-01 US US10/262,141 patent/US7166461B2/en not_active Expired - Lifetime
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