JP2003515536A5 - - Google Patents
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- Publication number
- JP2003515536A5 JP2003515536A5 JP2001540984A JP2001540984A JP2003515536A5 JP 2003515536 A5 JP2003515536 A5 JP 2003515536A5 JP 2001540984 A JP2001540984 A JP 2001540984A JP 2001540984 A JP2001540984 A JP 2001540984A JP 2003515536 A5 JP2003515536 A5 JP 2003515536A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- hydrochloric acid
- epinastine
- temperature
- extractant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
- WHWZLSFABNNENI-UHFFFAOYSA-N epinastine Chemical compound C1C2=CC=CC=C2C2CN=C(N)N2C2=CC=CC=C21 WHWZLSFABNNENI-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229960003449 epinastine Drugs 0.000 description 2
- 229960002548 epinastine hydrochloride Drugs 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- 238000010533 azeotropic distillation Methods 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19958460A DE19958460A1 (de) | 1999-12-03 | 1999-12-03 | Verfahren zur Herstellung von Epinastine-Hydrochlorid in der hochschmelzenden Kristallmodifikation |
| DE19958460.5 | 1999-12-03 | ||
| PCT/EP2000/011942 WO2001040229A2 (de) | 1999-12-03 | 2000-11-29 | Verfahren zur herstellung von epinastine-hydrochlorid in der hochschmelzenden kristallmodifikation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003515536A JP2003515536A (ja) | 2003-05-07 |
| JP2003515536A5 true JP2003515536A5 (enExample) | 2008-01-24 |
| JP4789383B2 JP4789383B2 (ja) | 2011-10-12 |
Family
ID=7931396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001540984A Expired - Lifetime JP4789383B2 (ja) | 1999-12-03 | 2000-11-29 | 高温融解結晶変態のエピナスチン塩酸塩の生成方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6403790B1 (enExample) |
| EP (1) | EP1237892B1 (enExample) |
| JP (1) | JP4789383B2 (enExample) |
| KR (1) | KR100737191B1 (enExample) |
| CN (1) | CN1402728A (enExample) |
| AR (1) | AR026678A1 (enExample) |
| AT (1) | ATE238306T1 (enExample) |
| AU (1) | AU2163501A (enExample) |
| BR (1) | BR0016052A (enExample) |
| CA (1) | CA2389170C (enExample) |
| CO (1) | CO5251470A1 (enExample) |
| CZ (1) | CZ20021843A3 (enExample) |
| DE (2) | DE19958460A1 (enExample) |
| DK (1) | DK1237892T3 (enExample) |
| EA (1) | EA200200630A1 (enExample) |
| ES (1) | ES2198368T3 (enExample) |
| HU (1) | HUP0203501A2 (enExample) |
| IL (1) | IL149711A0 (enExample) |
| MX (1) | MXPA02005330A (enExample) |
| PL (1) | PL355628A1 (enExample) |
| PT (1) | PT1237892E (enExample) |
| UY (1) | UY26461A1 (enExample) |
| WO (1) | WO2001040229A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19954516A1 (de) * | 1999-11-12 | 2001-05-17 | Boehringer Ingelheim Int | Epinastin-haltige Lösungen |
| JP4298212B2 (ja) * | 2002-03-29 | 2009-07-15 | 大日本印刷株式会社 | 塩酸エピナスチン高融点型結晶の製造法 |
| JP2006501211A (ja) * | 2002-08-02 | 2006-01-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | エピナスチン、プソイドエフェドリン及びメチルエフェドリンの組み合せを含有する医薬組成物 |
| KR101386530B1 (ko) | 2006-12-29 | 2014-04-18 | 케이피엑스 라이프사이언스 주식회사 | 순도 및 수율이 향상된3-아미노-9,13ｂ디하이드로-1Ｈ-디벤즈-[ｃ,ｆ]이미다조[1,5-ａ]-아제핀 염산염의 제조방법 |
| CN104098575B (zh) * | 2013-04-15 | 2016-06-01 | 四川科瑞德凯华制药有限公司 | 一种盐酸依匹斯汀晶型及其制备方法和用途 |
| CN115448927A (zh) * | 2022-10-20 | 2022-12-09 | 重庆瑞泊莱医药科技有限公司 | 一种氢溴酸依匹斯汀晶型ii及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3008944A1 (de) * | 1980-03-08 | 1981-09-24 | C.H. Boehringer Sohn, 6507 Ingelheim | Dibenzimidazoazepine, ihre herstellung und verwendung |
| DE4102148A1 (de) * | 1991-01-25 | 1992-07-30 | Boehringer Ingelheim Kg | Verfahren zur herstellung von 3-amino-9,13b-dihydro-1h-dibenz-(c,f)imidazol(1,5-a)azepin-hydrochlorid |
| JP3726291B2 (ja) * | 1993-07-05 | 2005-12-14 | 三菱ウェルファーマ株式会社 | 安定な結晶構造を有するベンゾオキサジン化合物およびその製造法 |
| JPH083160A (ja) * | 1994-06-22 | 1996-01-09 | Nippon Kayaku Co Ltd | ６−（１−ｈ−イミダゾール−１−イル）−７−ニトロ−２，３−（１ｈ，４ｈ）−キノキサリンジオン塩酸塩又は硫酸塩の分離精製法 |
| JP3755908B2 (ja) * | 1994-08-17 | 2006-03-15 | 塩野義製薬株式会社 | セファロスポリン化合物の晶析法 |
| JPH0948765A (ja) * | 1995-08-04 | 1997-02-18 | Toyama Chem Co Ltd | 安定な結晶構造を有するトリアゾール誘導体およびその製造法 |
| DE19542281C2 (de) * | 1995-11-14 | 1997-12-04 | Boehringer Ingelheim Kg | Verwendung von Epinastin für die Behandlung der Migräne |
-
1999
- 1999-12-03 DE DE19958460A patent/DE19958460A1/de not_active Withdrawn
-
2000
- 2000-11-20 US US09/716,355 patent/US6403790B1/en not_active Expired - Lifetime
- 2000-11-29 DE DE50001920T patent/DE50001920D1/de not_active Expired - Lifetime
- 2000-11-29 IL IL14971100A patent/IL149711A0/xx unknown
- 2000-11-29 CN CN00816517A patent/CN1402728A/zh active Pending
- 2000-11-29 CA CA002389170A patent/CA2389170C/en not_active Expired - Lifetime
- 2000-11-29 AT AT00985110T patent/ATE238306T1/de active
- 2000-11-29 PL PL00355628A patent/PL355628A1/xx not_active Application Discontinuation
- 2000-11-29 MX MXPA02005330A patent/MXPA02005330A/es active IP Right Grant
- 2000-11-29 ES ES00985110T patent/ES2198368T3/es not_active Expired - Lifetime
- 2000-11-29 CZ CZ20021843A patent/CZ20021843A3/cs unknown
- 2000-11-29 HU HU0203501A patent/HUP0203501A2/hu unknown
- 2000-11-29 DK DK00985110T patent/DK1237892T3/da active
- 2000-11-29 EP EP00985110A patent/EP1237892B1/de not_active Expired - Lifetime
- 2000-11-29 JP JP2001540984A patent/JP4789383B2/ja not_active Expired - Lifetime
- 2000-11-29 KR KR1020027007120A patent/KR100737191B1/ko not_active Expired - Lifetime
- 2000-11-29 WO PCT/EP2000/011942 patent/WO2001040229A2/de not_active Ceased
- 2000-11-29 EA EA200200630A patent/EA200200630A1/ru unknown
- 2000-11-29 BR BR0016052-0A patent/BR0016052A/pt not_active Application Discontinuation
- 2000-11-29 UY UY26461A patent/UY26461A1/es not_active Application Discontinuation
- 2000-11-29 AU AU21635/01A patent/AU2163501A/en not_active Abandoned
- 2000-11-29 PT PT00985110T patent/PT1237892E/pt unknown
- 2000-12-01 AR ARP000106338A patent/AR026678A1/es active IP Right Grant
- 2000-12-01 CO CO00092015A patent/CO5251470A1/es not_active Application Discontinuation