DK1237892T3 - Fremgangsmåde til fremstilling af epinastinhydrochlorid i den højtsmeltende krystalmodifikation - Google Patents
Fremgangsmåde til fremstilling af epinastinhydrochlorid i den højtsmeltende krystalmodifikationInfo
- Publication number
- DK1237892T3 DK1237892T3 DK00985110T DK00985110T DK1237892T3 DK 1237892 T3 DK1237892 T3 DK 1237892T3 DK 00985110 T DK00985110 T DK 00985110T DK 00985110 T DK00985110 T DK 00985110T DK 1237892 T3 DK1237892 T3 DK 1237892T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- crystal modification
- epinastine hydrochloride
- melting crystal
- melting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19958460A DE19958460A1 (de) | 1999-12-03 | 1999-12-03 | Verfahren zur Herstellung von Epinastine-Hydrochlorid in der hochschmelzenden Kristallmodifikation |
| PCT/EP2000/011942 WO2001040229A2 (de) | 1999-12-03 | 2000-11-29 | Verfahren zur herstellung von epinastine-hydrochlorid in der hochschmelzenden kristallmodifikation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1237892T3 true DK1237892T3 (da) | 2003-08-04 |
Family
ID=7931396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00985110T DK1237892T3 (da) | 1999-12-03 | 2000-11-29 | Fremgangsmåde til fremstilling af epinastinhydrochlorid i den højtsmeltende krystalmodifikation |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6403790B1 (da) |
| EP (1) | EP1237892B1 (da) |
| JP (1) | JP4789383B2 (da) |
| KR (1) | KR100737191B1 (da) |
| CN (1) | CN1402728A (da) |
| AR (1) | AR026678A1 (da) |
| AT (1) | ATE238306T1 (da) |
| AU (1) | AU2163501A (da) |
| BR (1) | BR0016052A (da) |
| CA (1) | CA2389170C (da) |
| CO (1) | CO5251470A1 (da) |
| CZ (1) | CZ20021843A3 (da) |
| DE (2) | DE19958460A1 (da) |
| DK (1) | DK1237892T3 (da) |
| EA (1) | EA200200630A1 (da) |
| ES (1) | ES2198368T3 (da) |
| HU (1) | HUP0203501A2 (da) |
| IL (1) | IL149711A0 (da) |
| MX (1) | MXPA02005330A (da) |
| PL (1) | PL355628A1 (da) |
| PT (1) | PT1237892E (da) |
| UY (1) | UY26461A1 (da) |
| WO (1) | WO2001040229A2 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19954516A1 (de) * | 1999-11-12 | 2001-05-17 | Boehringer Ingelheim Int | Epinastin-haltige Lösungen |
| JP4298212B2 (ja) * | 2002-03-29 | 2009-07-15 | 大日本印刷株式会社 | 塩酸エピナスチン高融点型結晶の製造法 |
| EP1531802A1 (en) * | 2002-08-02 | 2005-05-25 | Boehringer Ingelheim International GmbH | Pharmaceutical formulations comprising combinations of epinastine, pseudoephedrine and methylephedrine |
| KR101386530B1 (ko) | 2006-12-29 | 2014-04-18 | 케이피엑스 라이프사이언스 주식회사 | 순도 및 수율이 향상된3-아미노-9,13ｂ디하이드로-1Ｈ-디벤즈-[ｃ,ｆ]이미다조[1,5-ａ]-아제핀 염산염의 제조방법 |
| CN104098575B (zh) * | 2013-04-15 | 2016-06-01 | 四川科瑞德凯华制药有限公司 | 一种盐酸依匹斯汀晶型及其制备方法和用途 |
| CN115448927A (zh) * | 2022-10-20 | 2022-12-09 | 重庆瑞泊莱医药科技有限公司 | 一种氢溴酸依匹斯汀晶型ii及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3008944A1 (de) * | 1980-03-08 | 1981-09-24 | C.H. Boehringer Sohn, 6507 Ingelheim | Dibenzimidazoazepine, ihre herstellung und verwendung |
| DE4102148A1 (de) * | 1991-01-25 | 1992-07-30 | Boehringer Ingelheim Kg | Verfahren zur herstellung von 3-amino-9,13b-dihydro-1h-dibenz-(c,f)imidazol(1,5-a)azepin-hydrochlorid |
| JP3726291B2 (ja) * | 1993-07-05 | 2005-12-14 | 三菱ウェルファーマ株式会社 | 安定な結晶構造を有するベンゾオキサジン化合物およびその製造法 |
| JPH083160A (ja) * | 1994-06-22 | 1996-01-09 | Nippon Kayaku Co Ltd | ６−（１−ｈ−イミダゾール−１−イル）−７−ニトロ−２，３−（１ｈ，４ｈ）−キノキサリンジオン塩酸塩又は硫酸塩の分離精製法 |
| JP3755908B2 (ja) * | 1994-08-17 | 2006-03-15 | 塩野義製薬株式会社 | セファロスポリン化合物の晶析法 |
| JPH0948765A (ja) * | 1995-08-04 | 1997-02-18 | Toyama Chem Co Ltd | 安定な結晶構造を有するトリアゾール誘導体およびその製造法 |
| DE19542281C2 (de) * | 1995-11-14 | 1997-12-04 | Boehringer Ingelheim Kg | Verwendung von Epinastin für die Behandlung der Migräne |
-
1999
- 1999-12-03 DE DE19958460A patent/DE19958460A1/de not_active Withdrawn
-
2000
- 2000-11-20 US US09/716,355 patent/US6403790B1/en not_active Expired - Lifetime
- 2000-11-29 AT AT00985110T patent/ATE238306T1/de active
- 2000-11-29 PT PT00985110T patent/PT1237892E/pt unknown
- 2000-11-29 EA EA200200630A patent/EA200200630A1/ru unknown
- 2000-11-29 BR BR0016052-0A patent/BR0016052A/pt not_active Application Discontinuation
- 2000-11-29 WO PCT/EP2000/011942 patent/WO2001040229A2/de not_active Ceased
- 2000-11-29 HU HU0203501A patent/HUP0203501A2/hu unknown
- 2000-11-29 CN CN00816517A patent/CN1402728A/zh active Pending
- 2000-11-29 KR KR1020027007120A patent/KR100737191B1/ko not_active Expired - Lifetime
- 2000-11-29 AU AU21635/01A patent/AU2163501A/en not_active Abandoned
- 2000-11-29 MX MXPA02005330A patent/MXPA02005330A/es active IP Right Grant
- 2000-11-29 ES ES00985110T patent/ES2198368T3/es not_active Expired - Lifetime
- 2000-11-29 PL PL00355628A patent/PL355628A1/xx not_active Application Discontinuation
- 2000-11-29 JP JP2001540984A patent/JP4789383B2/ja not_active Expired - Lifetime
- 2000-11-29 DE DE50001920T patent/DE50001920D1/de not_active Expired - Lifetime
- 2000-11-29 UY UY26461A patent/UY26461A1/es not_active Application Discontinuation
- 2000-11-29 CZ CZ20021843A patent/CZ20021843A3/cs unknown
- 2000-11-29 CA CA002389170A patent/CA2389170C/en not_active Expired - Lifetime
- 2000-11-29 DK DK00985110T patent/DK1237892T3/da active
- 2000-11-29 EP EP00985110A patent/EP1237892B1/de not_active Expired - Lifetime
- 2000-11-29 IL IL14971100A patent/IL149711A0/xx unknown
- 2000-12-01 CO CO00092015A patent/CO5251470A1/es not_active Application Discontinuation
- 2000-12-01 AR ARP000106338A patent/AR026678A1/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2389170C (en) | 2008-01-08 |
| HUP0203501A2 (hu) | 2003-03-28 |
| AR026678A1 (es) | 2003-02-19 |
| BR0016052A (pt) | 2002-07-23 |
| PL355628A1 (en) | 2004-05-04 |
| WO2001040229A2 (de) | 2001-06-07 |
| KR100737191B1 (ko) | 2007-07-10 |
| EP1237892B1 (de) | 2003-04-23 |
| CZ20021843A3 (cs) | 2002-08-14 |
| EA200200630A1 (ru) | 2002-12-26 |
| ES2198368T3 (es) | 2004-02-01 |
| UY26461A1 (es) | 2001-07-31 |
| US6403790B1 (en) | 2002-06-11 |
| IL149711A0 (en) | 2002-11-10 |
| AU2163501A (en) | 2001-06-12 |
| EP1237892A2 (de) | 2002-09-11 |
| CO5251470A1 (es) | 2003-02-28 |
| ATE238306T1 (de) | 2003-05-15 |
| WO2001040229A3 (de) | 2001-12-06 |
| DE19958460A1 (de) | 2001-06-07 |
| MXPA02005330A (es) | 2003-01-28 |
| JP2003515536A (ja) | 2003-05-07 |
| DE50001920D1 (de) | 2003-05-28 |
| CA2389170A1 (en) | 2001-06-07 |
| CN1402728A (zh) | 2003-03-12 |
| PT1237892E (pt) | 2003-08-29 |
| KR20020058080A (ko) | 2002-07-12 |
| JP4789383B2 (ja) | 2011-10-12 |
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