JP2003515323A5 - - Google Patents
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- Publication number
- JP2003515323A5 JP2003515323A5 JP2001538975A JP2001538975A JP2003515323A5 JP 2003515323 A5 JP2003515323 A5 JP 2003515323A5 JP 2001538975 A JP2001538975 A JP 2001538975A JP 2001538975 A JP2001538975 A JP 2001538975A JP 2003515323 A5 JP2003515323 A5 JP 2003515323A5
- Authority
- JP
- Japan
- Prior art keywords
- canine
- polypeptide
- seq
- fragment
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000282465 Canis Species 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB99/03859 | 1999-11-18 | ||
| PCT/GB1999/003859 WO2000029428A2 (en) | 1998-11-18 | 1999-11-18 | 5t4 tumour-associated antigen for use in tumour immunotherapy |
| GB0003527A GB0003527D0 (en) | 2000-02-15 | 2000-02-15 | Antibodies |
| GB0003527.9 | 2000-02-15 | ||
| GB0005071A GB0005071D0 (en) | 2000-03-02 | 2000-03-02 | Antibodies |
| GB0005071.6 | 2000-03-02 | ||
| PCT/GB2000/004317 WO2001036486A2 (en) | 1999-11-18 | 2000-11-13 | Scfv antibodies against disease associated molecules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003515323A JP2003515323A (ja) | 2003-05-07 |
| JP2003515323A5 true JP2003515323A5 (enExample) | 2007-12-20 |
Family
ID=27255534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001538975A Pending JP2003515323A (ja) | 1999-11-18 | 2000-11-13 | 抗 体 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7074909B2 (enExample) |
| EP (1) | EP1242456B1 (enExample) |
| JP (1) | JP2003515323A (enExample) |
| CN (1) | CN1423660A (enExample) |
| AU (1) | AU1290001A (enExample) |
| CA (1) | CA2391925A1 (enExample) |
| WO (1) | WO2001036486A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU747602B2 (en) | 1997-06-04 | 2002-05-16 | Oxford Biomedica (Uk) Limited | Vector |
| US7635687B2 (en) * | 1997-06-04 | 2009-12-22 | Oxford Biomedica (Uk) Limited | Vector system |
| US7276488B2 (en) | 1997-06-04 | 2007-10-02 | Oxford Biomedica (Uk) Limited | Vector system |
| CN1423660A (zh) * | 1999-11-18 | 2003-06-11 | 牛津生物医学(英国)有限公司 | 抗体 |
| KR20020049054A (ko) * | 1999-11-18 | 2002-06-24 | 찰스 굿맨 | 항체 |
| EP1347994A2 (en) * | 2000-11-13 | 2003-10-01 | Oxford Biomedica (UK) Limited | Canine and feline tumour-associated antigen 5t4 |
| SE0102327D0 (sv) | 2001-06-28 | 2001-06-28 | Active Biotech Ab | A novel engineered superantigen for human therapy |
| GB0126378D0 (en) * | 2001-11-02 | 2002-01-02 | Oxford Biomedica Ltd | Antigen |
| AU2003259913A1 (en) * | 2002-08-19 | 2004-03-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US6987270B2 (en) | 2003-05-07 | 2006-01-17 | General Electric Company | Method to account for event losses due to positron range in positron emission tomography and assay of positron-emitting isotopes |
| WO2004111233A1 (ja) | 2003-06-11 | 2004-12-23 | Chugai Seiyaku Kabushiki Kaisha | 抗体の製造方法 |
| TW200530269A (en) | 2003-12-12 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Anti-Mpl antibodies |
| EP1765846A4 (en) * | 2004-07-13 | 2010-02-17 | Cell Genesys Inc | AAV VECTOR COMPOSITIONS AND ITS USE IN PROCESSES FOR INCREASING IMMUNOGLOBULIN EXPRESSION |
| US20060088522A1 (en) * | 2004-09-10 | 2006-04-27 | Wyeth | Humanized anti-5T4 antibodies and anti-5T4/calicheamicin conjugates |
| CN101198698B (zh) | 2005-03-31 | 2014-03-19 | 中外制药株式会社 | 通过调节多肽缔合制备多肽的方法 |
| EP1870458B1 (en) | 2005-03-31 | 2018-05-09 | Chugai Seiyaku Kabushiki Kaisha | sc(Fv)2 STRUCTURAL ISOMERS |
| AU2006256030B2 (en) | 2005-06-10 | 2012-06-21 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical compositions containing sc(Fv)2 |
| CN101237890A (zh) | 2005-06-10 | 2008-08-06 | 中外制药株式会社 | 含有葡甲胺的蛋白质制剂的稳定剂及其利用 |
| WO2006132352A1 (ja) * | 2005-06-10 | 2006-12-14 | Chugai Seiyaku Kabushiki Kaisha | sc(Fv)2を含有する医薬組成物 |
| GB0519303D0 (en) | 2005-09-21 | 2005-11-02 | Oxford Biomedica Ltd | Chemo-immunotherapy method |
| EP2009101B1 (en) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| MX2009003542A (es) | 2006-10-12 | 2009-04-15 | Wyeth Corp | Metodos y composiciones con opalescencia reducida. |
| US8097422B2 (en) | 2007-06-20 | 2012-01-17 | Salk Institute For Biological Studies | Kir channel modulators |
| KR100949791B1 (ko) * | 2007-12-18 | 2010-03-30 | 이동기 | 오프-타겟 효과를 최소화하고 RNAi 기구를 포화시키지않는 신규한 siRNA 구조 및 그 용도 |
| WO2010007365A1 (en) * | 2008-07-15 | 2010-01-21 | Oxford Biomedica (Uk) Ltd | Immunotherapeutic method |
| WO2010087994A2 (en) | 2009-01-30 | 2010-08-05 | Whitehead Institute For Biomedical Research | Methods for ligation and uses thereof |
| JP2011026294A (ja) * | 2009-06-26 | 2011-02-10 | Canon Inc | 化合物 |
| WO2013041687A1 (en) * | 2011-09-23 | 2013-03-28 | Amgen Research (Munich) Gmbh | Bispecific binding molecules for 5t4 and cd3 |
| RU2646498C2 (ru) | 2012-01-24 | 2018-03-05 | Пфайзер Инк. | Способы детектирования 5Т4-положительных циркулирующих опухолевых клеток и способы диагностики 5Т4-положительного рака у млекопитающего |
| JP2016531088A (ja) | 2013-06-17 | 2016-10-06 | アサナ・バイオサイエンシズ,リミテッド・ライアビリティ・カンパニー | 5t4標的化免疫融合分子および方法 |
| CN105764922B (zh) | 2013-09-27 | 2020-07-17 | 中外制药株式会社 | 多肽异源多聚体的制备方法 |
| KR102572149B1 (ko) * | 2013-10-11 | 2023-08-30 | 아사나 바이오사이언시스 엘엘씨 | 단백질-폴리머-약물 접합체 |
| KR102087850B1 (ko) | 2013-10-11 | 2020-03-12 | 메르사나 테라퓨틱스, 인코포레이티드 | 단백질-고분자-약물 접합체 |
| JPWO2015133484A1 (ja) * | 2014-03-04 | 2017-04-06 | 国立大学法人徳島大学 | 腎臓疾患に関するマーカー及びその利用 |
| WO2016120331A1 (de) | 2015-01-28 | 2016-08-04 | Karl Sebastian Lang | Agonistische anti-cd66cd66 antikörper für die antiviralen therapie |
| SG11201803989WA (en) | 2015-12-28 | 2018-06-28 | Chugai Pharmaceutical Co Ltd | Method for promoting efficiency of purification of fc region-containing polypeptide |
| CN106749656B (zh) * | 2016-11-11 | 2018-04-13 | 郑州师范学院 | 一种抗小鼠RCN3蛋白单克隆ScFv抗体及其淘选方法 |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| AU2018235130B2 (en) | 2017-03-15 | 2023-12-07 | Oxford Biomedica (Uk) Limited | Method |
| EP3717021A1 (en) | 2017-11-27 | 2020-10-07 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| JP2021506883A (ja) | 2017-12-21 | 2021-02-22 | メルサナ セラピューティクス インコーポレイテッド | ピロロベンゾジアゼピン抗体結合体 |
| CR20250347A (es) | 2018-03-12 | 2025-09-23 | Genmab As | ANTICUERPOS QUE SE UNEN A 5T4 (Divisional 2020-0463) |
| MX2021004906A (es) | 2018-10-29 | 2021-09-10 | Mersana Therapeutics Inc | Conjugados de anticuerpo modificado con cisteína-fármaco con enlazadores que contienen péptidos. |
| TW202500193A (zh) | 2023-03-22 | 2025-01-01 | 美商信立泰生物醫藥公司 | 抗5t4抗原結合結構域、抗體-藥物共軛體及彼等之使用方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3481051A (en) * | 1969-02-06 | 1969-12-02 | Paramount Packaging Corp | Heating apparatus |
| US4009778A (en) * | 1975-11-04 | 1977-03-01 | The Kartridg Pak Co. | Dual compartment package and method for making same |
| US4267768A (en) * | 1976-09-20 | 1981-05-19 | David M. Cieslak | Process for fabricating a reclosable bag |
| US4997913A (en) * | 1986-06-30 | 1991-03-05 | Oncogen | pH-sensitive immunoconjugates and methods for their use in tumor therapy |
| DE68923027D1 (de) * | 1988-03-04 | 1995-07-20 | Cancer Res Campaign Tech | Antigene. |
| US5591624A (en) * | 1988-03-21 | 1997-01-07 | Chiron Viagene, Inc. | Retroviral packaging cell lines |
| US5060146A (en) | 1988-04-08 | 1991-10-22 | International Business Machines Corporation | Multilingual indexing system for alphabetical lysorting by comparing character weights and ascii codes |
| JPH04500308A (ja) | 1989-05-17 | 1992-01-23 | リサーチ・コーポレーション・テクノロジーズ・インコーポレーテッド | 組換え型生成物のレトロウィルス媒介分泌 |
| GB9109645D0 (en) | 1991-05-03 | 1991-06-26 | Celltech Ltd | Recombinant antibodies |
| ATE255131T1 (de) | 1991-06-14 | 2003-12-15 | Genentech Inc | Humanisierter heregulin antikörper |
| US5776427A (en) * | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
| GB9223816D0 (en) | 1992-11-13 | 1993-01-06 | Medical Res Council | Heat shock proteins and the treatment of tumours |
| EP0621338A3 (en) * | 1993-04-21 | 1997-10-29 | Ajinomoto Kk | The interleukin-2 response blocking immunosuppressor. |
| AU6912294A (en) * | 1993-05-12 | 1994-12-12 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
| GB9324807D0 (en) * | 1993-12-03 | 1994-01-19 | Cancer Res Campaign Tech | Tumour antibody |
| US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| ES2167391T3 (es) * | 1994-09-16 | 2002-05-16 | Merck Patent Gmbh | Inmunoconjugados ii. |
| GB9423085D0 (en) | 1994-11-16 | 1995-01-04 | Stringer Bradley M J | Targeted T lymphocytes |
| US5824762A (en) * | 1994-11-28 | 1998-10-20 | Dow Corning Toray Silicone Co., Ltd. | Organopolysiloxane and method for the preparation of the same |
| WO1996030504A1 (en) | 1995-03-24 | 1996-10-03 | Genetic Therapy, Inc. | Modified viral envelope polypeptide |
| FR2732348B1 (fr) | 1995-03-31 | 1997-04-30 | Rhone Poulenc Rorer Sa | Systeme d'expression conditionnel |
| US5637462A (en) * | 1995-04-19 | 1997-06-10 | Incyte Pharmaceuticals, Inc. | Cathepsin C homolog |
| US20030026789A1 (en) | 1995-05-03 | 2003-02-06 | Richard J. Gregory | Gene therapy using replication competent targeted adenoviral vectors |
| CA2221795A1 (en) * | 1995-06-06 | 1996-12-12 | Human Genome Sciences, Inc. | Colon specific gene and protein |
| WO1997017090A1 (en) | 1995-11-07 | 1997-05-15 | Baylor College Of Medicine | Adenovirus-mediated production of bioactive proteins by mammalian cells and animals |
| SE9601245D0 (sv) * | 1996-03-29 | 1996-03-29 | Pharmacia Ab | Chimeric superantigens and their use |
| TW517061B (en) | 1996-03-29 | 2003-01-11 | Pharmacia & Amp Upjohn Ab | Modified/chimeric superantigens and their use |
| WO1997042329A1 (en) * | 1996-05-04 | 1997-11-13 | Zeneca Limited | Monoclonal antibody to cea, conjugates comprising said antibody, and their therapeutic use in an adept system |
| JP4175678B2 (ja) * | 1996-06-07 | 2008-11-05 | 武田薬品工業株式会社 | 新規ペプチド、その製造法および用途 |
| WO1998012227A1 (en) * | 1996-09-19 | 1998-03-26 | Diagnocure Inc. | Recombinant single chain antibodies directed against the gp54 cancer marker, composition comprising same and use thereof |
| US6348584B1 (en) * | 1996-10-17 | 2002-02-19 | John Edward Hodgson | Fibronectin binding protein compounds |
| AU747602B2 (en) * | 1997-06-04 | 2002-05-16 | Oxford Biomedica (Uk) Limited | Vector |
| JPH1156368A (ja) * | 1997-08-27 | 1999-03-02 | Nippon Seibutsu Kagaku Kenkyusho | 猫トロンボポエチンの活性を有する因子 |
| JP2002505341A (ja) * | 1998-03-06 | 2002-02-19 | オックスフォード バイオメディカ(ユーケイ)リミテッド | プロドラッグの活性化の増強 |
| CN1298851C (zh) * | 1998-11-18 | 2007-02-07 | 牛津生物医学(英国)有限公司 | 多肽 |
| KR20020049054A (ko) * | 1999-11-18 | 2002-06-24 | 찰스 굿맨 | 항체 |
| CN1423660A (zh) | 1999-11-18 | 2003-06-11 | 牛津生物医学(英国)有限公司 | 抗体 |
-
2000
- 2000-11-13 CN CN00818416A patent/CN1423660A/zh active Pending
- 2000-11-13 EP EP00974682A patent/EP1242456B1/en not_active Expired - Lifetime
- 2000-11-13 WO PCT/GB2000/004317 patent/WO2001036486A2/en not_active Ceased
- 2000-11-13 CA CA002391925A patent/CA2391925A1/en not_active Abandoned
- 2000-11-13 AU AU12900/01A patent/AU1290001A/en not_active Abandoned
- 2000-11-13 JP JP2001538975A patent/JP2003515323A/ja active Pending
-
2001
- 2001-11-02 US US10/016,686 patent/US7074909B2/en not_active Expired - Lifetime
-
2006
- 2006-04-26 US US11/333,859 patent/US7514546B2/en not_active Expired - Lifetime
-
2008
- 2008-05-15 US US12/121,621 patent/US20100040539A1/en not_active Abandoned
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