JP2003515323A5 - - Google Patents
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- Publication number
- JP2003515323A5 JP2003515323A5 JP2001538975A JP2001538975A JP2003515323A5 JP 2003515323 A5 JP2003515323 A5 JP 2003515323A5 JP 2001538975 A JP2001538975 A JP 2001538975A JP 2001538975 A JP2001538975 A JP 2001538975A JP 2003515323 A5 JP2003515323 A5 JP 2003515323A5
- Authority
- JP
- Japan
- Prior art keywords
- canine
- polypeptide
- seq
- fragment
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Claims (4)
- 配列番号14に示すアミノ酸配列またはその変異型、ホモログ、断片、または誘導体を有するイヌ5T4ポリペプチド。
- 請求項1に記載のイヌ5T4ポリペプチドをコードすることができるヌクレオチド配列。
- 配列番号15に示す配列またはその変異型、ホモログ、断片、または誘導体を有する請求項2に記載のヌクレオチド配列。
- 請求項1に記載のイヌ5T4ポリペプチドに特異的に結合することができる抗体。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB1999/003859 WO2000029428A2 (en) | 1998-11-18 | 1999-11-18 | 5t4 tumour-associated antigen for use in tumour immunotherapy |
GB99/03859 | 1999-11-18 | ||
GB0003527A GB0003527D0 (en) | 2000-02-15 | 2000-02-15 | Antibodies |
GB0003527.9 | 2000-02-15 | ||
GB0005071A GB0005071D0 (en) | 2000-03-02 | 2000-03-02 | Antibodies |
GB0005071.6 | 2000-03-02 | ||
PCT/GB2000/004317 WO2001036486A2 (en) | 1999-11-18 | 2000-11-13 | Scfv antibodies against disease associated molecules |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2003515323A JP2003515323A (ja) | 2003-05-07 |
JP2003515323A5 true JP2003515323A5 (ja) | 2007-12-20 |
Family
ID=27255534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001538975A Pending JP2003515323A (ja) | 1999-11-18 | 2000-11-13 | 抗 体 |
Country Status (7)
Country | Link |
---|---|
US (4) | US7074909B2 (ja) |
EP (1) | EP1242456B1 (ja) |
JP (1) | JP2003515323A (ja) |
CN (1) | CN1423660A (ja) |
AU (1) | AU1290001A (ja) |
CA (1) | CA2391925A1 (ja) |
WO (1) | WO2001036486A2 (ja) |
Families Citing this family (44)
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ATE411342T1 (de) * | 1999-11-18 | 2008-10-15 | Oxford Biomedica Ltd | Scfv antikörper gegen krankheiten-assoziierte moleküle |
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JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
CA2611726C (en) * | 2005-06-10 | 2017-07-11 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical compositions containing sc(fv)2 |
AU2006256041B2 (en) | 2005-06-10 | 2012-03-29 | Chugai Seiyaku Kabushiki Kaisha | Stabilizer for protein preparation comprising meglumine and use thereof |
KR101360671B1 (ko) | 2005-06-10 | 2014-02-07 | 추가이 세이야쿠 가부시키가이샤 | sc(Fv)2를 함유하는 의약조성물 |
GB0519303D0 (en) * | 2005-09-21 | 2005-11-02 | Oxford Biomedica Ltd | Chemo-immunotherapy method |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
RU2009111138A (ru) | 2006-10-12 | 2010-11-20 | Вайет (Us) | Способы и композиции с уменьшенной опалесценцией |
US8097422B2 (en) | 2007-06-20 | 2012-01-17 | Salk Institute For Biological Studies | Kir channel modulators |
KR100949791B1 (ko) * | 2007-12-18 | 2010-03-30 | 이동기 | 오프-타겟 효과를 최소화하고 RNAi 기구를 포화시키지않는 신규한 siRNA 구조 및 그 용도 |
WO2010007365A1 (en) * | 2008-07-15 | 2010-01-21 | Oxford Biomedica (Uk) Ltd | Immunotherapeutic method |
WO2010087994A2 (en) | 2009-01-30 | 2010-08-05 | Whitehead Institute For Biomedical Research | Methods for ligation and uses thereof |
JP2011026294A (ja) * | 2009-06-26 | 2011-02-10 | Canon Inc | 化合物 |
JP2014533929A (ja) * | 2011-09-23 | 2014-12-18 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハー | 5t4およびcd3に対する二重特異的結合性分子 |
WO2013111054A1 (en) | 2012-01-24 | 2013-08-01 | Pfizer Inc. | Methods for detecting 5t4-positive circulating tumor cells and methods of diagnosis of 5t4-positive cancer in a mammalian subject |
CA2915960A1 (en) | 2013-06-17 | 2014-12-24 | Asana Biosciences, Llc | 5t4-targeted immunofusion molecule and methods |
RU2758952C1 (ru) | 2013-09-27 | 2021-11-03 | Чугаи Сейяку Кабусики Кайся | Способ получения полипептидного гетеромультимера |
WO2015054659A1 (en) | 2013-10-11 | 2015-04-16 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
KR102355745B1 (ko) * | 2013-10-11 | 2022-01-26 | 아사나 바이오사이언시스 엘엘씨 | 단백질-폴리머-약물 접합체 |
WO2015133484A1 (ja) * | 2014-03-04 | 2015-09-11 | 国立大学法人徳島大学 | 腎臓疾患に関するマーカー及びその利用 |
WO2016120331A1 (de) | 2015-01-28 | 2016-08-04 | Karl Sebastian Lang | Agonistische anti-cd66cd66 antikörper für die antiviralen therapie |
KR20180091918A (ko) | 2015-12-28 | 2018-08-16 | 추가이 세이야쿠 가부시키가이샤 | Fc 영역 함유 폴리펩타이드의 정제를 효율화하기 위한 방법 |
CN106749656B (zh) * | 2016-11-11 | 2018-04-13 | 郑州师范学院 | 一种抗小鼠RCN3蛋白单克隆ScFv抗体及其淘选方法 |
US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
AU2018235130B2 (en) | 2017-03-15 | 2023-12-07 | Oxford Biomedica (Uk) Limited | Method |
US10752682B2 (en) | 2017-11-01 | 2020-08-25 | Nantbio, Inc. | Anti-IL8 antibodies |
EP3717021A1 (en) | 2017-11-27 | 2020-10-07 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
WO2019126691A1 (en) | 2017-12-21 | 2019-06-27 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
BR112020018490A2 (pt) | 2018-03-12 | 2020-12-29 | Genmab A/S | Anticorpo, imunoconjugado ou conjugado de anticorpo-fármaco, construção de ácido nucléico, vetor de expressão, célula, composição, composição farmacêutica, anticorpo, método, método para produzir um anticorpo, kit de partes, e, anticorpo anti-idiotípico |
EP3873534A1 (en) | 2018-10-29 | 2021-09-08 | Mersana Therapeutics, Inc. | Cysteine engineered antibody-drug conjugates with peptide-containing linkers |
Family Cites Families (38)
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DE19531346A1 (de) * | 1995-08-25 | 1997-02-27 | Gsf Forschungszentrum Umwelt | Arzneimittel zur Immuntherapie, enthaltend Antikörper, die spezifisch das MHCII-Antigen eines zu behandelnden Patienten erkennen |
WO1997017090A1 (en) | 1995-11-07 | 1997-05-15 | Baylor College Of Medicine | Adenovirus-mediated production of bioactive proteins by mammalian cells and animals |
SE9601245D0 (sv) | 1996-03-29 | 1996-03-29 | Pharmacia Ab | Chimeric superantigens and their use |
TW517061B (en) | 1996-03-29 | 2003-01-11 | Pharmacia & Amp Upjohn Ab | Modified/chimeric superantigens and their use |
NZ331978A (en) * | 1996-05-04 | 2000-05-26 | Zeneca Ltd | Monoclonal antibody to CEA (carcinomembryonic antigen), conjugates comprising said antibody, and their therapeutic use in an adept system |
JP4175678B2 (ja) * | 1996-06-07 | 2008-11-05 | 武田薬品工業株式会社 | 新規ペプチド、その製造法および用途 |
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EP1068338A2 (en) * | 1998-03-06 | 2001-01-17 | Oxford Biomedica (UK) Limited | Enhanced prodrug activation |
ATE293690T1 (de) * | 1998-11-18 | 2005-05-15 | Oxford Biomedica Ltd | Verwendung vom krebs-assoziierten antigen 5t4 zur immuntherapie |
ATE411342T1 (de) * | 1999-11-18 | 2008-10-15 | Oxford Biomedica Ltd | Scfv antikörper gegen krankheiten-assoziierte moleküle |
JP2003515323A (ja) | 1999-11-18 | 2003-05-07 | オックスフォード バイオメディカ(ユーケイ)リミテッド | 抗 体 |
-
2000
- 2000-11-13 JP JP2001538975A patent/JP2003515323A/ja active Pending
- 2000-11-13 CA CA002391925A patent/CA2391925A1/en not_active Abandoned
- 2000-11-13 EP EP00974682A patent/EP1242456B1/en not_active Expired - Lifetime
- 2000-11-13 AU AU12900/01A patent/AU1290001A/en not_active Abandoned
- 2000-11-13 WO PCT/GB2000/004317 patent/WO2001036486A2/en active Application Filing
- 2000-11-13 CN CN00818416A patent/CN1423660A/zh active Pending
-
2001
- 2001-11-02 US US10/016,686 patent/US7074909B2/en not_active Expired - Lifetime
-
2006
- 2006-04-26 US US11/333,859 patent/US7514546B2/en not_active Expired - Lifetime
-
2008
- 2008-05-15 US US12/121,621 patent/US20100040539A1/en not_active Abandoned
-
2010
- 2010-07-28 US US12/845,380 patent/US20110052577A1/en not_active Abandoned
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