JP2003512827A - リガンド活性化転写レギュレータータンパク質 - Google Patents
リガンド活性化転写レギュレータータンパク質Info
- Publication number
- JP2003512827A JP2003512827A JP2001533840A JP2001533840A JP2003512827A JP 2003512827 A JP2003512827 A JP 2003512827A JP 2001533840 A JP2001533840 A JP 2001533840A JP 2001533840 A JP2001533840 A JP 2001533840A JP 2003512827 A JP2003512827 A JP 2003512827A
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- Prior art keywords
- fusion protein
- receptor
- vector
- zinc finger
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
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| US43304299A | 1999-10-25 | 1999-10-25 | |
| US09/433,042 | 1999-10-25 | ||
| US09/586,625 | 2000-06-02 | ||
| US09/586,625 US7329728B1 (en) | 1999-10-25 | 2000-06-02 | Ligand activated transcriptional regulator proteins |
| PCT/EP2000/010430 WO2001030843A1 (en) | 1999-10-25 | 2000-10-23 | Ligand activated transcriptional regulator proteins |
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| JP2009147520A Division JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
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| JP2003512827A true JP2003512827A (ja) | 2003-04-08 |
| JP2003512827A5 JP2003512827A5 (https=) | 2007-11-22 |
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| JP2009147520A Pending JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
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| JP2009147520A Pending JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
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| Country | Link |
|---|---|
| US (3) | US7329728B1 (https=) |
| EP (1) | EP1226168A1 (https=) |
| JP (2) | JP2003512827A (https=) |
| AU (1) | AU775988B2 (https=) |
| CA (1) | CA2388535A1 (https=) |
| IL (2) | IL149142A0 (https=) |
| NZ (1) | NZ518218A (https=) |
| WO (1) | WO2001030843A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022536257A (ja) * | 2019-05-28 | 2022-08-15 | オクタント，インク． | 転写リレー系 |
| JP2025062594A (ja) * | 2013-06-05 | 2025-04-14 | デューク ユニバーシティ | Ｒｎａガイド遺伝子編集及び遺伝子調節 |
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| WO2001000815A1 (en) * | 1999-05-28 | 2001-01-04 | Sangamo Biosciences, Inc. | Molecular switches |
| US7329728B1 (en) | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| ATE355368T1 (de) * | 2000-01-24 | 2006-03-15 | Gendaq Ltd | Nucleinsäure bindende polypeptide gekennzeichnet durch flexible linker verbundene nucleinsäuredomäne |
| US7011972B2 (en) | 2000-07-18 | 2006-03-14 | The Scripps Research Institute | Fusion polypeptide comprising two ligand binding domains |
| IL153833A0 (en) * | 2000-07-18 | 2003-07-31 | Novartis Ag | Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches |
| US6919204B2 (en) | 2000-09-29 | 2005-07-19 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
| AU2002213431A1 (en) * | 2000-09-29 | 2002-04-08 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
| WO2002057293A2 (en) | 2001-01-22 | 2002-07-25 | Sangamo Biosciences, Inc. | Modified zinc finger binding proteins |
| IL157335A0 (en) | 2001-03-13 | 2004-02-19 | Novartis Ag | Lentiviral packaging constructs |
| EP1397382B1 (en) | 2001-05-31 | 2008-08-06 | Novartis AG | Novel estrogen receptor ligand binding domain variants and novel ligands and pharmaceutical compositions |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025062594A (ja) * | 2013-06-05 | 2025-04-14 | デューク ユニバーシティ | Ｒｎａガイド遺伝子編集及び遺伝子調節 |
| JP7854214B2 (ja) | 2013-06-05 | 2026-05-01 | デューク ユニバーシティ | Ｒｎａガイド遺伝子編集及び遺伝子調節 |
| JP2022536257A (ja) * | 2019-05-28 | 2022-08-15 | オクタント，インク． | 転写リレー系 |
| JP7545999B2 (ja) | 2019-05-28 | 2024-09-05 | オクタント，インク． | 転写リレー系 |
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| US7442784B2 (en) | 2008-10-28 |
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| AU775988B2 (en) | 2004-08-19 |
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