JP2003512827A5 - - Google Patents
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- JP2003512827A5 JP2003512827A5 JP2001533840A JP2001533840A JP2003512827A5 JP 2003512827 A5 JP2003512827 A5 JP 2003512827A5 JP 2001533840 A JP2001533840 A JP 2001533840A JP 2001533840 A JP2001533840 A JP 2001533840A JP 2003512827 A5 JP2003512827 A5 JP 2003512827A5
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- JP
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- Prior art keywords
- receptor
- fusion protein
- vector
- nucleic acid
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000037865 fusion proteins Human genes 0.000 description 69
- 108020001507 fusion proteins Proteins 0.000 description 69
- 239000002773 nucleotide Substances 0.000 description 33
- 125000003729 nucleotide group Chemical group 0.000 description 33
- 238000000034 method Methods 0.000 description 27
- 239000013598 vector Substances 0.000 description 27
- 102000039446 nucleic acids Human genes 0.000 description 25
- 108020004707 nucleic acids Proteins 0.000 description 25
- 150000007523 nucleic acids Chemical class 0.000 description 25
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 21
- 239000011701 zinc Substances 0.000 description 21
- 229910052725 zinc Inorganic materials 0.000 description 21
- 210000004027 cell Anatomy 0.000 description 19
- 239000003446 ligand Substances 0.000 description 17
- 230000014509 gene expression Effects 0.000 description 16
- 108020001756 ligand binding domains Proteins 0.000 description 16
- 108090000623 proteins and genes Proteins 0.000 description 16
- 102000005962 receptors Human genes 0.000 description 16
- 108020003175 receptors Proteins 0.000 description 16
- 108090000765 processed proteins & peptides Proteins 0.000 description 13
- 238000013518 transcription Methods 0.000 description 11
- 230000035897 transcription Effects 0.000 description 11
- 102000027411 intracellular receptors Human genes 0.000 description 10
- 108091008582 intracellular receptors Proteins 0.000 description 10
- 230000027455 binding Effects 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 9
- 230000004913 activation Effects 0.000 description 8
- 239000013603 viral vector Substances 0.000 description 7
- 108020004414 DNA Proteins 0.000 description 6
- 102000011252 Krueppel-associated box Human genes 0.000 description 6
- 108050001491 Krueppel-associated box Proteins 0.000 description 6
- 102000007399 Nuclear hormone receptor Human genes 0.000 description 6
- 108020005497 Nuclear hormone receptor Proteins 0.000 description 6
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
- 239000006274 endogenous ligand Substances 0.000 description 4
- 102000015694 estrogen receptors Human genes 0.000 description 4
- 108010038795 estrogen receptors Proteins 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 102000003998 progesterone receptors Human genes 0.000 description 4
- 108090000468 progesterone receptors Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 102000005969 steroid hormone receptors Human genes 0.000 description 4
- 102000004217 thyroid hormone receptors Human genes 0.000 description 4
- 108090000721 thyroid hormone receptors Proteins 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 description 3
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 description 3
- 108091008747 NR2F3 Proteins 0.000 description 3
- 108091007494 Nucleic acid- binding domains Proteins 0.000 description 3
- 102000016978 Orphan receptors Human genes 0.000 description 3
- 108070000031 Orphan receptors Proteins 0.000 description 3
- 108091027981 Response element Proteins 0.000 description 3
- 102000034527 Retinoid X Receptors Human genes 0.000 description 3
- 108010038912 Retinoid X Receptors Proteins 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 108010080146 androgen receptors Proteins 0.000 description 3
- 102000001307 androgen receptors Human genes 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 108010009483 glucocorticoid receptor alpha Proteins 0.000 description 3
- 108010044321 glucocorticoid receptor beta Proteins 0.000 description 3
- 108091008039 hormone receptors Proteins 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 102000009310 vitamin D receptors Human genes 0.000 description 3
- 108050000156 vitamin D receptors Proteins 0.000 description 3
- 241000702421 Dependoparvovirus Species 0.000 description 2
- 108010068250 Herpes Simplex Virus Protein Vmw65 Proteins 0.000 description 2
- 241000713666 Lentivirus Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 2
- 108010085012 Steroid Receptors Proteins 0.000 description 2
- -1 VP64 Proteins 0.000 description 2
- 241000700618 Vaccinia virus Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 2
- 108010057988 ecdysone receptor Proteins 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 239000006277 exogenous ligand Substances 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 229930002330 retinoic acid Natural products 0.000 description 2
- 108020003113 steroid hormone receptors Proteins 0.000 description 2
- 229960001727 tretinoin Drugs 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 241001430294 unidentified retrovirus Species 0.000 description 2
- 230000004568 DNA-binding Effects 0.000 description 1
- 108091029865 Exogenous DNA Proteins 0.000 description 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 description 1
- 102100033417 Glucocorticoid receptor Human genes 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 101001006782 Homo sapiens Kinesin-associated protein 3 Proteins 0.000 description 1
- 101000753286 Homo sapiens Transcription intermediary factor 1-beta Proteins 0.000 description 1
- 101000818735 Homo sapiens Zinc finger protein 10 Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108010034634 Repressor Proteins Proteins 0.000 description 1
- 102000009661 Repressor Proteins Human genes 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102100022012 Transcription intermediary factor 1-beta Human genes 0.000 description 1
- 101710185494 Zinc finger protein Proteins 0.000 description 1
- 102100021112 Zinc finger protein 10 Human genes 0.000 description 1
- 102100023597 Zinc finger protein 816 Human genes 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 230000000937 inactivator Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000001638 lipofection Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000001818 nuclear effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 102000003702 retinoic acid receptors Human genes 0.000 description 1
- 108090000064 retinoic acid receptors Proteins 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000006490 viral transcription Effects 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43304299A | 1999-10-25 | 1999-10-25 | |
| US09/433,042 | 1999-10-25 | ||
| US09/586,625 | 2000-06-02 | ||
| US09/586,625 US7329728B1 (en) | 1999-10-25 | 2000-06-02 | Ligand activated transcriptional regulator proteins |
| PCT/EP2000/010430 WO2001030843A1 (en) | 1999-10-25 | 2000-10-23 | Ligand activated transcriptional regulator proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009147520A Division JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003512827A JP2003512827A (ja) | 2003-04-08 |
| JP2003512827A5 true JP2003512827A5 (https=) | 2007-11-22 |
Family
ID=27029724
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001533840A Withdrawn JP2003512827A (ja) | 1999-10-25 | 2000-10-23 | リガンド活性化転写レギュレータータンパク質 |
| JP2009147520A Pending JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009147520A Pending JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7329728B1 (https=) |
| EP (1) | EP1226168A1 (https=) |
| JP (2) | JP2003512827A (https=) |
| AU (1) | AU775988B2 (https=) |
| CA (1) | CA2388535A1 (https=) |
| IL (2) | IL149142A0 (https=) |
| NZ (1) | NZ518218A (https=) |
| WO (1) | WO2001030843A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001000815A1 (en) * | 1999-05-28 | 2001-01-04 | Sangamo Biosciences, Inc. | Molecular switches |
| US7329728B1 (en) | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| ATE355368T1 (de) * | 2000-01-24 | 2006-03-15 | Gendaq Ltd | Nucleinsäure bindende polypeptide gekennzeichnet durch flexible linker verbundene nucleinsäuredomäne |
| US7011972B2 (en) | 2000-07-18 | 2006-03-14 | The Scripps Research Institute | Fusion polypeptide comprising two ligand binding domains |
| IL153833A0 (en) * | 2000-07-18 | 2003-07-31 | Novartis Ag | Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches |
| US6919204B2 (en) | 2000-09-29 | 2005-07-19 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
| AU2002213431A1 (en) * | 2000-09-29 | 2002-04-08 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
| WO2002057293A2 (en) | 2001-01-22 | 2002-07-25 | Sangamo Biosciences, Inc. | Modified zinc finger binding proteins |
| IL157335A0 (en) | 2001-03-13 | 2004-02-19 | Novartis Ag | Lentiviral packaging constructs |
| EP1397382B1 (en) | 2001-05-31 | 2008-08-06 | Novartis AG | Novel estrogen receptor ligand binding domain variants and novel ligands and pharmaceutical compositions |
| ES2439874T3 (es) | 2002-05-29 | 2014-01-27 | Regeneron Pharmaceuticals, Inc. | Sistema de expresión en eucariotas inducible |
| US8673589B2 (en) | 2002-05-29 | 2014-03-18 | Regeneron Pharmaceuticals, Inc. | Inducible eukaryotic expression system |
| EP1627046A4 (en) * | 2003-05-06 | 2008-02-13 | Scripps Research Inst | BINDING MOLECULES WITH DOMAIN EXCHANGE, USE METHOD AND METHOD OF MANUFACTURE |
| EP1680447A2 (en) * | 2003-10-24 | 2006-07-19 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Orthogonal gene switches |
| US7829528B2 (en) * | 2004-09-14 | 2010-11-09 | The Rockefeller University | Compositions and methods for treating STAT-6 associated diseases or conditions |
| US20110294135A1 (en) * | 2007-08-02 | 2011-12-01 | BioDesic, LLC | Compositions and methods for analyte detection and quantitation |
| EP2441774B1 (en) | 2010-10-15 | 2018-12-12 | Fundació Centre de Regulació Genòmica | Peptides having zinc finger domains and uses thereof |
| US20130137173A1 (en) * | 2011-11-30 | 2013-05-30 | Feng Zhang | Nucleotide-specific recognition sequences for designer tal effectors |
| US10801017B2 (en) | 2011-11-30 | 2020-10-13 | The Broad Institute, Inc. | Nucleotide-specific recognition sequences for designer TAL effectors |
| US8450107B1 (en) | 2011-11-30 | 2013-05-28 | The Broad Institute Inc. | Nucleotide-specific recognition sequences for designer TAL effectors |
| RU2662672C2 (ru) * | 2012-02-02 | 2018-07-26 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Пестицидные композиции и относящиеся к ним способы |
| JP6188728B2 (ja) | 2012-02-07 | 2017-08-30 | グローバル・バイオ・セラピューティクス・インコーポレイテッドＧｌｏｂａｌ Ｂｉｏ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 核酸送達の区画化方法ならびにその組成物および使用 |
| WO2014197748A2 (en) * | 2013-06-05 | 2014-12-11 | Duke University | Rna-guided gene editing and gene regulation |
| HK1225258B (en) | 2013-08-08 | 2017-09-08 | Global Bio Therapeutics, Inc. | Clamping device for minimally invasive surgery |
| WO2017134137A1 (en) * | 2016-02-05 | 2017-08-10 | Polygene Ag | Glucocorticoid-based gene regulation system |
| WO2017181152A2 (en) | 2016-04-15 | 2017-10-19 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
| MX2018012472A (es) | 2016-04-15 | 2019-08-12 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras variantes de ligando icos y sus usos. |
| WO2018022945A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd112 variant immunomodulatory proteins and uses thereof |
| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| WO2018022946A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd155 variant immunomodulatory proteins and uses thereof |
| WO2018075978A1 (en) | 2016-10-20 | 2018-04-26 | Alpine Immune Sciences, Inc. | Secretable variant immunomodulatory proteins and engineered cell therapy |
| EP3596116B1 (en) | 2017-03-16 | 2023-09-06 | Alpine Immune Sciences, Inc. | Pd-l1 variant immunomodulatory proteins and uses thereof |
| KR20190141146A (ko) | 2017-03-16 | 2019-12-23 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Pd-l2 변이체 면역조절 단백질 및 그의 용도 |
| SG11201907769XA (en) | 2017-03-16 | 2019-09-27 | Alpine Immune Sciences Inc | Cd80 variant immunomodulatory proteins and uses thereof |
| JP7749319B2 (ja) | 2017-10-10 | 2025-10-06 | アルパイン イミューン サイエンシズ インコーポレイテッド | Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用 |
| BR112020007542A2 (pt) | 2017-10-18 | 2020-12-01 | Alpine Immune Sciences, Inc. | proteínas imunomoduladoras ligantes de icos variantes e composições e métodos relacionados |
| EP3717505A4 (en) * | 2017-12-01 | 2021-12-01 | Encoded Therapeutics, Inc. | GENENICALLY MODIFIED DNA-BINDING PROTEINS |
| AU2019205273B2 (en) | 2018-01-03 | 2024-04-04 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| WO2019241758A1 (en) | 2018-06-15 | 2019-12-19 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
| EP3853247A2 (en) | 2018-09-19 | 2021-07-28 | Alpine Immune Sciences, Inc. | Methods and uses of variant cd80 fusion proteins and related constructs |
| SG11202104337PA (en) | 2018-11-26 | 2021-05-28 | Massachusetts Inst Technology | Compositions and methods for immune tolerance |
| CA3120868A1 (en) | 2018-11-30 | 2020-06-04 | Alpine Immune Sciences, Inc. | Cd86 variant immunomodulatory proteins and uses thereof |
| MX2021012607A (es) | 2019-04-17 | 2022-03-11 | Alpine Immune Sciences Inc | Metodos y usos de proteinas de fusion de ligando icos (icosl) variante. |
| KR20220015443A (ko) * | 2019-05-28 | 2022-02-08 | 옥탄트, 인크. | 전사 릴레이 시스템 |
| PL3976798T3 (pl) | 2019-05-29 | 2026-04-07 | Encoded Therapeutics, Inc. | Kompozycje i sposoby selektywnej regulacji genów |
| MX2022002980A (es) | 2019-09-16 | 2022-04-06 | Amgen Inc | Metodo para la esterilizacion externa de un dispositivo de suministro de farmacos. |
| US20230174612A1 (en) * | 2020-04-09 | 2023-06-08 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| EP4146684A2 (en) | 2020-05-08 | 2023-03-15 | Alpine Immune Sciences, Inc. | April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof |
| CN116802267A (zh) * | 2020-10-23 | 2023-09-22 | 斯宾德尔生物科技公司 | 用于rna合成的组合物和方法 |
| US20240366681A1 (en) | 2021-08-13 | 2024-11-07 | Triovance Holding Llc | A skin substitute composition and methods of producing and using the same |
| EP4698662A2 (en) * | 2023-04-17 | 2026-02-25 | AskBio Inc. | Regulatable controlled expression of a transgene in primates |
| CN117756945A (zh) * | 2023-11-14 | 2024-03-26 | 维康平生(北京)生物科技有限公司 | 融合蛋白及其用途 |
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| US20060078880A1 (en) * | 2002-02-07 | 2006-04-13 | The Scripps Research Institute | Zinc finger libraries |
| US20060211846A1 (en) * | 2002-02-13 | 2006-09-21 | Barbas Carlos F Iii | Zinc finger binding domains for nucleotide sequence ANN |
| JP2006513694A (ja) | 2002-06-11 | 2006-04-27 | ザ スクリップス リサーチ インスティテュート | 人工転写因子 |
| PE20060574A1 (es) * | 2004-07-28 | 2006-06-24 | Glaxo Group Ltd | Derivados de arilpiperazina sulfonamida como agonistas de los receptores de secretagogos de la hormona del crecimiento (ghs) |
| EP2130838A3 (en) * | 2005-08-11 | 2010-04-07 | The Scripps Research Institute | Zinc finger binding domains for CNN |
| EP1963499A4 (en) * | 2005-11-28 | 2009-04-08 | Scripps Research Inst | ZINCFINGER BINDING DOMAIN FOR TNN |
| US20070154989A1 (en) * | 2006-01-03 | 2007-07-05 | The Scripps Research Institute | Zinc finger domains specifically binding agc |
| US8874746B1 (en) | 2010-05-24 | 2014-10-28 | Datacore Software Corporation | Collaboration between discrete systems and a shared system to consolidate shared storage-related services |
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2000
- 2000-06-02 US US09/586,625 patent/US7329728B1/en not_active Expired - Fee Related
- 2000-10-23 CA CA002388535A patent/CA2388535A1/en not_active Abandoned
- 2000-10-23 JP JP2001533840A patent/JP2003512827A/ja not_active Withdrawn
- 2000-10-23 NZ NZ518218A patent/NZ518218A/en unknown
- 2000-10-23 AU AU11438/01A patent/AU775988B2/en not_active Ceased
- 2000-10-23 IL IL14914200A patent/IL149142A0/xx unknown
- 2000-10-23 WO PCT/EP2000/010430 patent/WO2001030843A1/en not_active Ceased
- 2000-10-23 EP EP00972849A patent/EP1226168A1/en not_active Ceased
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2002
- 2002-04-15 IL IL149142A patent/IL149142A/en not_active IP Right Cessation
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2003
- 2003-04-23 US US10/422,934 patent/US7442784B2/en not_active Expired - Fee Related
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2008
- 2008-07-22 US US12/220,328 patent/US20080318839A1/en not_active Abandoned
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2009
- 2009-06-22 JP JP2009147520A patent/JP2009273463A/ja active Pending
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