JP2003512827A - リガンド活性化転写レギュレータータンパク質 - Google Patents
リガンド活性化転写レギュレータータンパク質Info
- Publication number
- JP2003512827A JP2003512827A JP2001533840A JP2001533840A JP2003512827A JP 2003512827 A JP2003512827 A JP 2003512827A JP 2001533840 A JP2001533840 A JP 2001533840A JP 2001533840 A JP2001533840 A JP 2001533840A JP 2003512827 A JP2003512827 A JP 2003512827A
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- Prior art keywords
- fusion protein
- receptor
- vector
- zinc finger
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Public Health (AREA)
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- High Energy & Nuclear Physics (AREA)
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- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US43304299A | 1999-10-25 | 1999-10-25 | |
| US09/433,042 | 1999-10-25 | ||
| US09/586,625 US7329728B1 (en) | 1999-10-25 | 2000-06-02 | Ligand activated transcriptional regulator proteins |
| US09/586,625 | 2000-06-02 | ||
| PCT/EP2000/010430 WO2001030843A1 (en) | 1999-10-25 | 2000-10-23 | Ligand activated transcriptional regulator proteins |
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| JP2009147520A Division JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
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| JP2009147520A Pending JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
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| JP2009147520A Pending JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
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| US (3) | US7329728B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1226168A1 (cg-RX-API-DMAC7.html) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022536257A (ja) * | 2019-05-28 | 2022-08-15 | オクタント，インク． | 転写リレー系 |
| JP2025062594A (ja) * | 2013-06-05 | 2025-04-14 | デューク ユニバーシティ | Ｒｎａガイド遺伝子編集及び遺伝子調節 |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1181360A1 (en) * | 1999-05-28 | 2002-02-27 | Sangamo Biosciences Inc. | Molecular switches |
| US7329728B1 (en) * | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| AU2001226935B2 (en) * | 2000-01-24 | 2006-06-22 | Gendaq Limited | Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules |
| US7011972B2 (en) | 2000-07-18 | 2006-03-14 | The Scripps Research Institute | Fusion polypeptide comprising two ligand binding domains |
| JP2004504029A (ja) * | 2000-07-18 | 2004-02-12 | ノバルティス アクチエンゲゼルシャフト | 単鎖、一量体、リガンド依存性ポリペプチドスイッチを用いる遺伝子発現の調節 |
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| WO2002026960A2 (en) * | 2000-09-29 | 2002-04-04 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2025062594A (ja) * | 2013-06-05 | 2025-04-14 | デューク ユニバーシティ | Ｒｎａガイド遺伝子編集及び遺伝子調節 |
| JP2022536257A (ja) * | 2019-05-28 | 2022-08-15 | オクタント，インク． | 転写リレー系 |
| JP7545999B2 (ja) | 2019-05-28 | 2024-09-05 | オクタント，インク． | 転写リレー系 |
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