JP2003512827A5 - - Google Patents
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- JP2003512827A5 JP2003512827A5 JP2001533840A JP2001533840A JP2003512827A5 JP 2003512827 A5 JP2003512827 A5 JP 2003512827A5 JP 2001533840 A JP2001533840 A JP 2001533840A JP 2001533840 A JP2001533840 A JP 2001533840A JP 2003512827 A5 JP2003512827 A5 JP 2003512827A5
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- Prior art keywords
- receptor
- fusion protein
- vector
- nucleic acid
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000037865 fusion proteins Human genes 0.000 description 69
- 108020001507 fusion proteins Proteins 0.000 description 69
- 239000002773 nucleotide Substances 0.000 description 33
- 125000003729 nucleotide group Chemical group 0.000 description 33
- 238000000034 method Methods 0.000 description 27
- 239000013598 vector Substances 0.000 description 27
- 102000039446 nucleic acids Human genes 0.000 description 25
- 108020004707 nucleic acids Proteins 0.000 description 25
- 150000007523 nucleic acids Chemical class 0.000 description 25
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 21
- 239000011701 zinc Substances 0.000 description 21
- 229910052725 zinc Inorganic materials 0.000 description 21
- 210000004027 cell Anatomy 0.000 description 19
- 239000003446 ligand Substances 0.000 description 17
- 230000014509 gene expression Effects 0.000 description 16
- 108020001756 ligand binding domains Proteins 0.000 description 16
- 108090000623 proteins and genes Proteins 0.000 description 16
- 102000005962 receptors Human genes 0.000 description 16
- 108020003175 receptors Proteins 0.000 description 16
- 108090000765 processed proteins & peptides Proteins 0.000 description 13
- 238000013518 transcription Methods 0.000 description 11
- 230000035897 transcription Effects 0.000 description 11
- 102000027411 intracellular receptors Human genes 0.000 description 10
- 108091008582 intracellular receptors Proteins 0.000 description 10
- 230000027455 binding Effects 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 9
- 230000004913 activation Effects 0.000 description 8
- 239000013603 viral vector Substances 0.000 description 7
- 108020004414 DNA Proteins 0.000 description 6
- 102000011252 Krueppel-associated box Human genes 0.000 description 6
- 108050001491 Krueppel-associated box Proteins 0.000 description 6
- 102000007399 Nuclear hormone receptor Human genes 0.000 description 6
- 108020005497 Nuclear hormone receptor Proteins 0.000 description 6
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
- 239000006274 endogenous ligand Substances 0.000 description 4
- 102000015694 estrogen receptors Human genes 0.000 description 4
- 108010038795 estrogen receptors Proteins 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 102000003998 progesterone receptors Human genes 0.000 description 4
- 108090000468 progesterone receptors Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 102000005969 steroid hormone receptors Human genes 0.000 description 4
- 102000004217 thyroid hormone receptors Human genes 0.000 description 4
- 108090000721 thyroid hormone receptors Proteins 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 description 3
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 description 3
- 108091008747 NR2F3 Proteins 0.000 description 3
- 108091007494 Nucleic acid- binding domains Proteins 0.000 description 3
- 102000016978 Orphan receptors Human genes 0.000 description 3
- 108070000031 Orphan receptors Proteins 0.000 description 3
- 108091027981 Response element Proteins 0.000 description 3
- 102000034527 Retinoid X Receptors Human genes 0.000 description 3
- 108010038912 Retinoid X Receptors Proteins 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 108010080146 androgen receptors Proteins 0.000 description 3
- 102000001307 androgen receptors Human genes 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 108010009483 glucocorticoid receptor alpha Proteins 0.000 description 3
- 108010044321 glucocorticoid receptor beta Proteins 0.000 description 3
- 108091008039 hormone receptors Proteins 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 102000009310 vitamin D receptors Human genes 0.000 description 3
- 108050000156 vitamin D receptors Proteins 0.000 description 3
- 241000702421 Dependoparvovirus Species 0.000 description 2
- 108010068250 Herpes Simplex Virus Protein Vmw65 Proteins 0.000 description 2
- 241000713666 Lentivirus Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 2
- 108010085012 Steroid Receptors Proteins 0.000 description 2
- -1 VP64 Proteins 0.000 description 2
- 241000700618 Vaccinia virus Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 2
- 108010057988 ecdysone receptor Proteins 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 239000006277 exogenous ligand Substances 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 229930002330 retinoic acid Natural products 0.000 description 2
- 108020003113 steroid hormone receptors Proteins 0.000 description 2
- 229960001727 tretinoin Drugs 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 241001430294 unidentified retrovirus Species 0.000 description 2
- 230000004568 DNA-binding Effects 0.000 description 1
- 108091029865 Exogenous DNA Proteins 0.000 description 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 description 1
- 102100033417 Glucocorticoid receptor Human genes 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 101001006782 Homo sapiens Kinesin-associated protein 3 Proteins 0.000 description 1
- 101000753286 Homo sapiens Transcription intermediary factor 1-beta Proteins 0.000 description 1
- 101000818735 Homo sapiens Zinc finger protein 10 Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108010034634 Repressor Proteins Proteins 0.000 description 1
- 102000009661 Repressor Proteins Human genes 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102100022012 Transcription intermediary factor 1-beta Human genes 0.000 description 1
- 101710185494 Zinc finger protein Proteins 0.000 description 1
- 102100021112 Zinc finger protein 10 Human genes 0.000 description 1
- 102100023597 Zinc finger protein 816 Human genes 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 230000000937 inactivator Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000001638 lipofection Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000001818 nuclear effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 102000003702 retinoic acid receptors Human genes 0.000 description 1
- 108090000064 retinoic acid receptors Proteins 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000006490 viral transcription Effects 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43304299A | 1999-10-25 | 1999-10-25 | |
| US09/433,042 | 1999-10-25 | ||
| US09/586,625 US7329728B1 (en) | 1999-10-25 | 2000-06-02 | Ligand activated transcriptional regulator proteins |
| US09/586,625 | 2000-06-02 | ||
| PCT/EP2000/010430 WO2001030843A1 (en) | 1999-10-25 | 2000-10-23 | Ligand activated transcriptional regulator proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009147520A Division JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003512827A JP2003512827A (ja) | 2003-04-08 |
| JP2003512827A5 true JP2003512827A5 (cg-RX-API-DMAC7.html) | 2007-11-22 |
Family
ID=27029724
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001533840A Withdrawn JP2003512827A (ja) | 1999-10-25 | 2000-10-23 | リガンド活性化転写レギュレータータンパク質 |
| JP2009147520A Pending JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009147520A Pending JP2009273463A (ja) | 1999-10-25 | 2009-06-22 | リガンド活性化転写レギュレータータンパク質 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7329728B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1226168A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2003512827A (cg-RX-API-DMAC7.html) |
| AU (1) | AU775988B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2388535A1 (cg-RX-API-DMAC7.html) |
| IL (2) | IL149142A0 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ518218A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001030843A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1181360A1 (en) * | 1999-05-28 | 2002-02-27 | Sangamo Biosciences Inc. | Molecular switches |
| US7329728B1 (en) * | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| AU2001226935B2 (en) * | 2000-01-24 | 2006-06-22 | Gendaq Limited | Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules |
| US7011972B2 (en) | 2000-07-18 | 2006-03-14 | The Scripps Research Institute | Fusion polypeptide comprising two ligand binding domains |
| JP2004504029A (ja) * | 2000-07-18 | 2004-02-12 | ノバルティス アクチエンゲゼルシャフト | 単鎖、一量体、リガンド依存性ポリペプチドスイッチを用いる遺伝子発現の調節 |
| US6919204B2 (en) | 2000-09-29 | 2005-07-19 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
| WO2002026960A2 (en) * | 2000-09-29 | 2002-04-04 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
| ES2409080T3 (es) * | 2001-01-22 | 2013-06-24 | Sangamo Biosciences Inc. | Proteínas de unión con dedos de zinc modificadas |
| US7070993B2 (en) | 2001-03-13 | 2006-07-04 | Novartis Ag | Lentiviral packaging constructs |
| DE60228082D1 (de) | 2001-05-31 | 2008-09-18 | Novartis Ag | Nten und neue liganden und pharmazeutische zusammensetzungen |
| DK1531666T3 (da) | 2002-05-29 | 2014-01-13 | Regeneron Pharma | Inducerbart eukaryot-ekspressionssystem |
| US8673589B2 (en) | 2002-05-29 | 2014-03-18 | Regeneron Pharmaceuticals, Inc. | Inducible eukaryotic expression system |
| EP1627046A4 (en) * | 2003-05-06 | 2008-02-13 | Scripps Research Inst | BINDING MOLECULES WITH DOMAIN EXCHANGE, USE METHOD AND METHOD OF MANUFACTURE |
| US20070087346A1 (en) * | 2003-10-24 | 2007-04-19 | Gennaro Ciliberto | Orthogonal gene switches |
| US7829528B2 (en) * | 2004-09-14 | 2010-11-09 | The Rockefeller University | Compositions and methods for treating STAT-6 associated diseases or conditions |
| WO2009018576A1 (en) * | 2007-08-02 | 2009-02-05 | Biodesic | Compositions and methods for analyte detection and quantitation |
| PL2441774T3 (pl) | 2010-10-15 | 2019-05-31 | Fund Centre De Regulacio Genòmica | Peptydy zawierające motywy palców cynkowych i ich zastosowania |
| US8450107B1 (en) | 2011-11-30 | 2013-05-28 | The Broad Institute Inc. | Nucleotide-specific recognition sequences for designer TAL effectors |
| US20130137173A1 (en) * | 2011-11-30 | 2013-05-30 | Feng Zhang | Nucleotide-specific recognition sequences for designer tal effectors |
| US10801017B2 (en) | 2011-11-30 | 2020-10-13 | The Broad Institute, Inc. | Nucleotide-specific recognition sequences for designer TAL effectors |
| TWI666222B (zh) * | 2012-02-02 | 2019-07-21 | 陶氏農業科學公司 | 植物轉錄活化交互作用之模體（ｍｏｔｉｆ）及其用途 |
| BR112014019431A8 (pt) | 2012-02-07 | 2017-07-11 | Global Bio Therapeutics Usa Inc | Método compartimentalizado de distribuição de ácido nucleico e composições e usos desses |
| ES2987399T3 (es) * | 2013-06-05 | 2024-11-14 | Univ Duke | Edición génica guiada por ARN y regulación génica |
| CN105813579B (zh) | 2013-08-08 | 2019-05-07 | 全球生物疗法有限公司 | 用于微创手术过程的夹具装置和其应用 |
| WO2017134137A1 (en) * | 2016-02-05 | 2017-08-10 | Polygene Ag | Glucocorticoid-based gene regulation system |
| WO2017181152A2 (en) | 2016-04-15 | 2017-10-19 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
| SG11201808457PA (en) | 2016-04-15 | 2018-10-30 | Alpine Immune Sciences Inc | Icos ligand variant immunomodulatory proteins and uses thereof |
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| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| WO2018022945A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd112 variant immunomodulatory proteins and uses thereof |
| AU2017345764A1 (en) | 2016-10-20 | 2019-05-02 | Alpine Immune Sciences, Inc. | Secretable variant immunomodulatory proteins and engineered cell therapy |
| LT3596116T (lt) | 2017-03-16 | 2023-11-10 | Alpine Immune Sciences, Inc. | Imunomoduliacinių baltymų pd-l1 variantai ir jų naudojimo būdai |
| CA3053812A1 (en) | 2017-03-16 | 2018-09-20 | Alpine Immune Sciences, Inc. | Pd-l2 variant immunomodulatory proteins and uses thereof |
| WO2018170026A2 (en) | 2017-03-16 | 2018-09-20 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
| EP3694870A1 (en) | 2017-10-10 | 2020-08-19 | Alpine Immune Sciences, Inc. | Ctla-4 variant immunomodulatory proteins and uses thereof |
| MY203416A (en) | 2017-10-18 | 2024-06-27 | Alpine Immune Sciences Inc | Variant icos ligand immunomodulatory proteins and related compositions and methods |
| JP7401432B2 (ja) * | 2017-12-01 | 2023-12-19 | エンコーデッド セラピューティクス， インコーポレイテッド | 操作されたｄｎａ結合タンパク質 |
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| SG11202102644XA (en) | 2018-09-19 | 2021-04-29 | Alpine Immune Sciences Inc | Methods and uses of variant cd80 fusion proteins and related constructs |
| JP2022513113A (ja) | 2018-11-26 | 2022-02-07 | マサチューセッツ インスティテュート オブ テクノロジー | 免疫寛容のための組成物および方法 |
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| US20230174612A1 (en) * | 2020-04-09 | 2023-06-08 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
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| WO2022084748A1 (en) * | 2020-10-23 | 2022-04-28 | Spindle Biotech, Inc. | Compositions and methods for rna synthesis |
| WO2023017494A1 (en) | 2021-08-13 | 2023-02-16 | Triovance Holding Llc | A skin substitute composition and methods of producing and using the same |
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| WO2003066828A2 (en) | 2002-02-07 | 2003-08-14 | The Scripps Research Institute | Zinc finger libraries |
| US20060211846A1 (en) * | 2002-02-13 | 2006-09-21 | Barbas Carlos F Iii | Zinc finger binding domains for nucleotide sequence ANN |
| US20070020627A1 (en) | 2002-06-11 | 2007-01-25 | The Scripps Research Institute | Artificial transcription factors |
| JP2008508221A (ja) * | 2004-07-28 | 2008-03-21 | グラクソ グループ リミテッド | 消化器疾患の治療に有用なピペラジン誘導体 |
| JP2009504156A (ja) * | 2005-08-11 | 2009-02-05 | ザ スクリップス リサーチ インスティテュート | Ｃｎｎに対するジンクフィンガー結合ドメイン |
| CA2631422A1 (en) * | 2005-11-28 | 2007-05-31 | The Scripps Research Institute | Zinc finger binding domains for tnn |
| US20070154989A1 (en) * | 2006-01-03 | 2007-07-05 | The Scripps Research Institute | Zinc finger domains specifically binding agc |
| US8874746B1 (en) | 2010-05-24 | 2014-10-28 | Datacore Software Corporation | Collaboration between discrete systems and a shared system to consolidate shared storage-related services |
-
2000
- 2000-06-02 US US09/586,625 patent/US7329728B1/en not_active Expired - Fee Related
- 2000-10-23 EP EP00972849A patent/EP1226168A1/en not_active Ceased
- 2000-10-23 NZ NZ518218A patent/NZ518218A/en unknown
- 2000-10-23 AU AU11438/01A patent/AU775988B2/en not_active Ceased
- 2000-10-23 WO PCT/EP2000/010430 patent/WO2001030843A1/en not_active Ceased
- 2000-10-23 IL IL14914200A patent/IL149142A0/xx unknown
- 2000-10-23 CA CA002388535A patent/CA2388535A1/en not_active Abandoned
- 2000-10-23 JP JP2001533840A patent/JP2003512827A/ja not_active Withdrawn
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2002
- 2002-04-15 IL IL149142A patent/IL149142A/en not_active IP Right Cessation
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2003
- 2003-04-23 US US10/422,934 patent/US7442784B2/en not_active Expired - Fee Related
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2008
- 2008-07-22 US US12/220,328 patent/US20080318839A1/en not_active Abandoned
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2009
- 2009-06-22 JP JP2009147520A patent/JP2009273463A/ja active Pending
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