JP2003510255A5 - - Google Patents
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- Publication number
- JP2003510255A5 JP2003510255A5 JP2001525216A JP2001525216A JP2003510255A5 JP 2003510255 A5 JP2003510255 A5 JP 2003510255A5 JP 2001525216 A JP2001525216 A JP 2001525216A JP 2001525216 A JP2001525216 A JP 2001525216A JP 2003510255 A5 JP2003510255 A5 JP 2003510255A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- benzyl
- substituted
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000001257 hydrogen Substances 0.000 description 23
- 229910052739 hydrogen Inorganic materials 0.000 description 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 23
- 229910052731 fluorine Inorganic materials 0.000 description 20
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 19
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 17
- 229910052801 chlorine Inorganic materials 0.000 description 12
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 9
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 8
- 239000011737 fluorine Substances 0.000 description 8
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 8
- 239000003814 drug Substances 0.000 description 5
- 150000002431 hydrogen Chemical class 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 241000282326 Felis catus Species 0.000 description 3
- 229910001413 alkali metal ion Inorganic materials 0.000 description 3
- 150000001340 alkali metals Chemical class 0.000 description 3
- 229910001420 alkaline earth metal ion Inorganic materials 0.000 description 3
- -1 ammonium ions Chemical class 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- 150000001768 cations Chemical group 0.000 description 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 2
- 0 CC(CCC(I)=O)C1[C@@]2(C)C(C)(*)C[C@@]3[C@@](C)(CCC(C)(*)C4)[C@]4CC(*)(*)[C@]3[C@@]2CC1 Chemical compound CC(CCC(I)=O)C1[C@@]2(C)C(C)(*)C[C@@]3[C@@](C)(CCC(C)(*)C4)[C@]4CC(*)(*)[C@]3[C@@]2CC1 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 201000001883 cholelithiasis Diseases 0.000 description 1
- 208000001130 gallstones Diseases 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19945385.3-43 | 1999-09-22 | ||
| DE1999145385 DE19945385A1 (de) | 1999-09-22 | 1999-09-22 | Substituierte 4-Benzylaminochinoline und ihre Heteroanlagen, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE10028193.1 | 2000-06-09 | ||
| DE2000128193 DE10028193A1 (de) | 2000-06-09 | 2000-06-09 | Substituierte 4-Benzylamminochinoline und ihre Heteroanalogen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika, sowie sie enthaltende Medikamente |
| PCT/EP2000/008691 WO2001021642A1 (de) | 1999-09-22 | 2000-09-06 | 4-benzylaminochinoline konjugaten mit gallensaeure und ihre heteroanalogen, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und deren anwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003510255A JP2003510255A (ja) | 2003-03-18 |
| JP2003510255A5 true JP2003510255A5 (https=) | 2007-10-04 |
| JP4833471B2 JP4833471B2 (ja) | 2011-12-07 |
Family
ID=26005994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001525216A Expired - Fee Related JP4833471B2 (ja) | 1999-09-22 | 2000-09-06 | 胆汁酸との４−ベンジルアミノキノリン抱合体およびそれらのヘテロ類似体、それらの製造法、それらの化合物を含有する薬剤ならびにそれらの使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6339077B1 (https=) |
| EP (1) | EP1218401B1 (https=) |
| JP (1) | JP4833471B2 (https=) |
| KR (1) | KR20030010575A (https=) |
| CN (1) | CN1158299C (https=) |
| AT (1) | ATE269352T1 (https=) |
| AU (1) | AU779412B2 (https=) |
| BR (1) | BR0014233A (https=) |
| CA (1) | CA2385445A1 (https=) |
| CZ (1) | CZ2002992A3 (https=) |
| DE (1) | DE50006842D1 (https=) |
| DK (1) | DK1218401T3 (https=) |
| EE (1) | EE200200143A (https=) |
| ES (1) | ES2218222T3 (https=) |
| HK (1) | HK1049169B (https=) |
| HR (1) | HRP20020238A2 (https=) |
| HU (1) | HUP0203045A3 (https=) |
| IL (1) | IL148739A0 (https=) |
| NO (1) | NO20021337L (https=) |
| NZ (1) | NZ517899A (https=) |
| PL (1) | PL353992A1 (https=) |
| PT (1) | PT1218401E (https=) |
| RU (1) | RU2247125C2 (https=) |
| SK (1) | SK3862002A3 (https=) |
| WO (1) | WO2001021642A1 (https=) |
| YU (1) | YU19302A (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6576644B2 (en) | 2000-09-06 | 2003-06-10 | Bristol-Myers Squibb Co. | Quinoline inhibitors of cGMP phosphodiesterase |
| ITMI20021025A1 (it) * | 2002-05-14 | 2003-11-14 | Nicox Sa | Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale |
| CZ301037B6 (cs) * | 2007-09-06 | 2009-10-21 | Vysoká škola chemicko-technologická v Praze | Amidové konjugáty steroidních a žlucových kyselin s D-glukosaminem a zpusob jejich prípravy |
| NZ594923A (en) * | 2009-03-24 | 2013-11-29 | Abbott Lab | Process for preparing antiviral compound |
| RU2605549C2 (ru) * | 2010-04-02 | 2016-12-20 | Синомикс, Инк. | Производные 3-карбокси-4-аминохинолина, полезные как модификаторы сладкого вкуса |
| AU2012295255B2 (en) | 2011-08-12 | 2016-04-21 | Senomyx, Inc. | Sweet flavor modifier |
| WO2016073251A1 (en) | 2014-11-07 | 2016-05-12 | Senomyx, Inc. | Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers |
| US12186329B2 (en) | 2018-08-23 | 2025-01-07 | President And Fellows Of Harvard College | Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes |
| EP3890745B1 (en) | 2018-12-04 | 2025-11-19 | President and Fellows of Harvard College | Synthetic derivatives of cholic acid 7-sulfate and uses thereof |
| KR20250171471A (ko) | 2019-05-10 | 2025-12-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 장 박테리아 담즙산 대사의 소분자 조정제 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4789678A (en) * | 1986-08-25 | 1988-12-06 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds |
| JPH0667846B2 (ja) * | 1989-04-28 | 1994-08-31 | 一 滝川 | 利胆剤 |
| IT1259419B (it) * | 1991-05-24 | 1996-03-18 | Erba Carlo Spa | Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi |
| TW289021B (https=) * | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
| IT1274000B (it) * | 1994-04-06 | 1997-07-14 | Alfa Wassermann Spa | Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi |
| DE4432708A1 (de) | 1994-09-14 | 1996-03-21 | Hoechst Ag | Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung |
| JPH09315979A (ja) * | 1996-05-24 | 1997-12-09 | Tokyo Tanabe Co Ltd | 利胆剤 |
| AU7552198A (en) * | 1997-06-11 | 1998-12-30 | Sankyo Company Limited | Benzylamine derivatives |
-
2000
- 2000-09-06 SK SK386-2002A patent/SK3862002A3/sk unknown
- 2000-09-06 RU RU2002110440/04A patent/RU2247125C2/ru not_active IP Right Cessation
- 2000-09-06 JP JP2001525216A patent/JP4833471B2/ja not_active Expired - Fee Related
- 2000-09-06 PT PT00964126T patent/PT1218401E/pt unknown
- 2000-09-06 EP EP00964126A patent/EP1218401B1/de not_active Expired - Lifetime
- 2000-09-06 HU HU0203045A patent/HUP0203045A3/hu unknown
- 2000-09-06 CN CNB008131554A patent/CN1158299C/zh not_active Expired - Fee Related
- 2000-09-06 NZ NZ517899A patent/NZ517899A/en unknown
- 2000-09-06 EE EEP200200143A patent/EE200200143A/xx unknown
- 2000-09-06 KR KR1020027003757A patent/KR20030010575A/ko not_active Ceased
- 2000-09-06 AU AU75156/00A patent/AU779412B2/en not_active Ceased
- 2000-09-06 WO PCT/EP2000/008691 patent/WO2001021642A1/de not_active Ceased
- 2000-09-06 DE DE50006842T patent/DE50006842D1/de not_active Expired - Lifetime
- 2000-09-06 CA CA002385445A patent/CA2385445A1/en not_active Abandoned
- 2000-09-06 CZ CZ2002992A patent/CZ2002992A3/cs unknown
- 2000-09-06 IL IL14873900A patent/IL148739A0/xx unknown
- 2000-09-06 HK HK03101156.5A patent/HK1049169B/zh not_active IP Right Cessation
- 2000-09-06 HR HR20020238A patent/HRP20020238A2/xx not_active Application Discontinuation
- 2000-09-06 DK DK00964126T patent/DK1218401T3/da active
- 2000-09-06 BR BR0014233-6A patent/BR0014233A/pt not_active IP Right Cessation
- 2000-09-06 PL PL00353992A patent/PL353992A1/xx not_active Application Discontinuation
- 2000-09-06 ES ES00964126T patent/ES2218222T3/es not_active Expired - Lifetime
- 2000-09-06 YU YU19302A patent/YU19302A/sh unknown
- 2000-09-06 AT AT00964126T patent/ATE269352T1/de not_active IP Right Cessation
- 2000-09-22 US US09/667,668 patent/US6339077B1/en not_active Expired - Lifetime
-
2002
- 2002-03-18 NO NO20021337A patent/NO20021337L/no not_active Application Discontinuation
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