JP2003508513A5 - - Google Patents
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- Publication number
- JP2003508513A5 JP2003508513A5 JP2001521701A JP2001521701A JP2003508513A5 JP 2003508513 A5 JP2003508513 A5 JP 2003508513A5 JP 2001521701 A JP2001521701 A JP 2001521701A JP 2001521701 A JP2001521701 A JP 2001521701A JP 2003508513 A5 JP2003508513 A5 JP 2003508513A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- hydrogen
- substituted
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(CCC(*)=O)C(CCC[C@]([C@@](*)C1)([C@](*)(C[C@@]2*)[C@@](C)(CCC(**)C3)[C@]13I)I)C2(C)I Chemical compound CC(CCC(*)=O)C(CCC[C@]([C@@](*)C1)([C@](*)(C[C@@]2*)[C@@](C)(CCC(**)C3)[C@]13I)I)C2(C)I 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19941764A DE19941764A1 (de) | 1999-09-02 | 1999-09-02 | Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente |
| DE19941764.4 | 1999-09-02 | ||
| PCT/EP2000/008025 WO2001017954A1 (de) | 1999-09-02 | 2000-08-17 | Gallensäure-substituierte phenyl-alkenoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003508513A JP2003508513A (ja) | 2003-03-04 |
| JP2003508513A5 true JP2003508513A5 (https=) | 2007-10-11 |
| JP4768941B2 JP4768941B2 (ja) | 2011-09-07 |
Family
ID=7920512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001521701A Expired - Fee Related JP4768941B2 (ja) | 1999-09-02 | 2000-08-17 | 胆汁酸置換フェニルアルケノイルグアニジン、それらの製造方法、医薬または診断薬としてのそれらの使用、およびそれらを含む医薬 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6451781B1 (https=) |
| EP (1) | EP1248768B1 (https=) |
| JP (1) | JP4768941B2 (https=) |
| AT (1) | ATE309981T1 (https=) |
| AU (1) | AU774083B2 (https=) |
| CA (1) | CA2383729A1 (https=) |
| DE (2) | DE19941764A1 (https=) |
| DK (1) | DK1248768T3 (https=) |
| ES (1) | ES2251403T3 (https=) |
| IL (1) | IL148250A0 (https=) |
| WO (1) | WO2001017954A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ533645A (en) * | 2001-11-29 | 2008-04-30 | Theracos Inc | Compounds for treatment of inflammation, diabetes and related disorders |
| MX381407B (es) | 2008-12-31 | 2025-03-12 | Ardelyx Inc | Compuestos y métodos para inhibir el antiporte mediado por intercambiador de iones de sodio/iones de hidrógeno (nhe) en el tratamiento de trastornos asociados con retención de fluido o sobrecarga de sal y trastornos del tracto gastrointestinal. |
| US10543207B2 (en) | 2008-12-31 | 2020-01-28 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2018129556A1 (en) * | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| CA2880432C (en) | 2012-08-21 | 2023-03-14 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| HRP20191000T1 (hr) | 2013-04-12 | 2019-09-20 | Ardelyx, Inc. | Spojevi za vezanje nhe3 i metode inhibiranja transporta fosfata |
| MX395405B (es) | 2017-01-09 | 2025-03-25 | Ardelyx Inc | Compuestos útiles para tratar trastornos del tracto gastrointestinal. |
| MX2019008171A (es) | 2017-01-09 | 2020-02-05 | Ardelyx Inc | Inhibidores del antiporte mediado por nhe. |
| US12186329B2 (en) | 2018-08-23 | 2025-01-07 | President And Fellows Of Harvard College | Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes |
| EP3890745B1 (en) | 2018-12-04 | 2025-11-19 | President and Fellows of Harvard College | Synthetic derivatives of cholic acid 7-sulfate and uses thereof |
| KR20250171471A (ko) | 2019-05-10 | 2025-12-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 장 박테리아 담즙산 대사의 소분자 조정제 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0667846B2 (ja) * | 1989-04-28 | 1994-08-31 | 一 滝川 | 利胆剤 |
| TW289021B (https=) * | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
| IT1274000B (it) * | 1994-04-06 | 1997-07-14 | Alfa Wassermann Spa | Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi |
| JPH09315979A (ja) * | 1996-05-24 | 1997-12-09 | Tokyo Tanabe Co Ltd | 利胆剤 |
| DE19849722A1 (de) * | 1998-10-28 | 2000-05-04 | Aventis Pharma Gmbh | Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1999
- 1999-09-02 DE DE19941764A patent/DE19941764A1/de not_active Withdrawn
-
2000
- 2000-08-17 AT AT00958461T patent/ATE309981T1/de not_active IP Right Cessation
- 2000-08-17 JP JP2001521701A patent/JP4768941B2/ja not_active Expired - Fee Related
- 2000-08-17 AU AU69965/00A patent/AU774083B2/en not_active Ceased
- 2000-08-17 CA CA002383729A patent/CA2383729A1/en not_active Abandoned
- 2000-08-17 DE DE50011660T patent/DE50011660D1/de not_active Expired - Lifetime
- 2000-08-17 EP EP00958461A patent/EP1248768B1/de not_active Expired - Lifetime
- 2000-08-17 WO PCT/EP2000/008025 patent/WO2001017954A1/de not_active Ceased
- 2000-08-17 IL IL14825000A patent/IL148250A0/xx unknown
- 2000-08-17 DK DK00958461T patent/DK1248768T3/da active
- 2000-08-17 ES ES00958461T patent/ES2251403T3/es not_active Expired - Lifetime
- 2000-09-05 US US09/655,725 patent/US6451781B1/en not_active Expired - Lifetime
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