DE19941764A1 - Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente - Google Patents

Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente

Info

Publication number
DE19941764A1
DE19941764A1 DE19941764A DE19941764A DE19941764A1 DE 19941764 A1 DE19941764 A1 DE 19941764A1 DE 19941764 A DE19941764 A DE 19941764A DE 19941764 A DE19941764 A DE 19941764A DE 19941764 A1 DE19941764 A1 DE 19941764A1
Authority
DE
Germany
Prior art keywords
alkyl
phenyl
hydrogen
substituted
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19941764A
Other languages
German (de)
English (en)
Inventor
Heinz-Werner Kleemann
Armin Hofmeister
Eugen Falk
Hans-Willi Jansen
Hans-Ludwig Schaefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to DE19941764A priority Critical patent/DE19941764A1/de
Priority to CA002383729A priority patent/CA2383729A1/en
Priority to PCT/EP2000/008025 priority patent/WO2001017954A1/de
Priority to JP2001521701A priority patent/JP4768941B2/ja
Priority to IL14825000A priority patent/IL148250A0/xx
Priority to DK00958461T priority patent/DK1248768T3/da
Priority to EP00958461A priority patent/EP1248768B1/de
Priority to DE50011660T priority patent/DE50011660D1/de
Priority to AT00958461T priority patent/ATE309981T1/de
Priority to AU69965/00A priority patent/AU774083B2/en
Priority to ES00958461T priority patent/ES2251403T3/es
Priority to US09/655,725 priority patent/US6451781B1/en
Publication of DE19941764A1 publication Critical patent/DE19941764A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DE19941764A 1999-09-02 1999-09-02 Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente Withdrawn DE19941764A1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE19941764A DE19941764A1 (de) 1999-09-02 1999-09-02 Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente
CA002383729A CA2383729A1 (en) 1999-09-02 2000-08-17 Bile acid-substituted phenyl-alkenoylguanidines, method for producing said phenyl-alkenoylguanidines, use thereof as medicaments or diagnostic reagents and medicaments containing the same
PCT/EP2000/008025 WO2001017954A1 (de) 1999-09-02 2000-08-17 Gallensäure-substituierte phenyl-alkenoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente
JP2001521701A JP4768941B2 (ja) 1999-09-02 2000-08-17 胆汁酸置換フェニルアルケノイルグアニジン、それらの製造方法、医薬または診断薬としてのそれらの使用、およびそれらを含む医薬
IL14825000A IL148250A0 (en) 1999-09-02 2000-08-17 Bile acid-substituted phenyl-alkenoylguanidines, method for producing said phenyl-alkenoylguanidines, use thereof as medicaments or diagnostic reagents and medicaments containing the same
DK00958461T DK1248768T3 (da) 1999-09-02 2000-08-17 Substituerede acylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som medikamenter eller diagnostika samt medikamenter, der indeholder disse
EP00958461A EP1248768B1 (de) 1999-09-02 2000-08-17 Gallensäure-substituierte phenyl-alkenoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente
DE50011660T DE50011660D1 (de) 1999-09-02 2000-08-17 Gallensäure-substituierte phenyl-alkenoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente
AT00958461T ATE309981T1 (de) 1999-09-02 2000-08-17 Gallensäure-substituierte phenyl- alkenoylguanidine, verfahren zu ihrer herstellung,ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente
AU69965/00A AU774083B2 (en) 1999-09-02 2000-08-17 Bile acid-substituted phenyl-alkenoylguanidines, method for producing said phenyl-alkenoylguanidines, use thereof as medicaments or diagnostic reagents and medicaments containing the same
ES00958461T ES2251403T3 (es) 1999-09-02 2000-08-17 Fenil-alquenoilguanidinas sustituidas con acido biliar, procedimiento para su preparacion, su uso como medicamentos o agentes de diagnostico, asi como medicamentos que las contienen.
US09/655,725 US6451781B1 (en) 1999-09-02 2000-09-05 Substituted acylguanidines, process for their preparation, their use as medicaments or diagnostics, and medicaments comprising them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19941764A DE19941764A1 (de) 1999-09-02 1999-09-02 Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente

Publications (1)

Publication Number Publication Date
DE19941764A1 true DE19941764A1 (de) 2001-03-15

Family

ID=7920512

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19941764A Withdrawn DE19941764A1 (de) 1999-09-02 1999-09-02 Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente
DE50011660T Expired - Lifetime DE50011660D1 (de) 1999-09-02 2000-08-17 Gallensäure-substituierte phenyl-alkenoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50011660T Expired - Lifetime DE50011660D1 (de) 1999-09-02 2000-08-17 Gallensäure-substituierte phenyl-alkenoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente

Country Status (11)

Country Link
US (1) US6451781B1 (https=)
EP (1) EP1248768B1 (https=)
JP (1) JP4768941B2 (https=)
AT (1) ATE309981T1 (https=)
AU (1) AU774083B2 (https=)
CA (1) CA2383729A1 (https=)
DE (2) DE19941764A1 (https=)
DK (1) DK1248768T3 (https=)
ES (1) ES2251403T3 (https=)
IL (1) IL148250A0 (https=)
WO (1) WO2001017954A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12186329B2 (en) 2018-08-23 2025-01-07 President And Fellows Of Harvard College Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes
US12419897B2 (en) 2018-12-04 2025-09-23 President And Fellows Of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
US12577273B2 (en) 2019-05-10 2026-03-17 President And Fellows Of Harvard College Small molecule modulators of gut bacterial bile acid metabolism

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ563604A (en) * 2001-11-29 2009-04-30 Theracos Inc Compounds for treatment of inflammation, diabetes and related disorders
SI2384318T1 (en) 2008-12-31 2018-03-30 Ardelyx, Inc. MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT
US10543207B2 (en) 2008-12-31 2020-01-28 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2018129556A1 (en) * 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
BR112015003516A2 (pt) 2012-08-21 2017-07-04 Ardelyx Inc compostos e métodos para inibição de antiporte mediado por nhe no tratamento de transtornos associados à retenção de fluido ou sobrecarga de sal e transtornos do trato gastrintestinal
LT2983667T (lt) 2013-04-12 2019-07-10 Ardelyx, Inc. Nhe3 rišantys junginiai ir fosfato pernešimo slopinimo būdai
CA3049678A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0667846B2 (ja) * 1989-04-28 1994-08-31 一 滝川 利胆剤
TW289021B (https=) * 1993-05-08 1996-10-21 Hoechst Ag
IT1274000B (it) * 1994-04-06 1997-07-14 Alfa Wassermann Spa Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi
JPH09315979A (ja) * 1996-05-24 1997-12-09 Tokyo Tanabe Co Ltd 利胆剤
DE19849722A1 (de) * 1998-10-28 2000-05-04 Aventis Pharma Gmbh Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Chm. Invest. 61, 998-1026 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12186329B2 (en) 2018-08-23 2025-01-07 President And Fellows Of Harvard College Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes
US12419897B2 (en) 2018-12-04 2025-09-23 President And Fellows Of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
US12577273B2 (en) 2019-05-10 2026-03-17 President And Fellows Of Harvard College Small molecule modulators of gut bacterial bile acid metabolism

Also Published As

Publication number Publication date
EP1248768B1 (de) 2005-11-16
AU6996500A (en) 2001-04-10
DE50011660D1 (de) 2005-12-22
JP2003508513A (ja) 2003-03-04
CA2383729A1 (en) 2001-03-15
DK1248768T3 (da) 2006-03-27
AU774083B2 (en) 2004-06-17
US6451781B1 (en) 2002-09-17
WO2001017954A1 (de) 2001-03-15
ES2251403T3 (es) 2006-05-01
IL148250A0 (en) 2002-09-12
ATE309981T1 (de) 2005-12-15
EP1248768A1 (de) 2002-10-16
JP4768941B2 (ja) 2011-09-07

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8130 Withdrawal