ATE309981T1 - Gallensäure-substituierte phenyl- alkenoylguanidine, verfahren zu ihrer herstellung,ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente - Google Patents
Gallensäure-substituierte phenyl- alkenoylguanidine, verfahren zu ihrer herstellung,ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamenteInfo
- Publication number
- ATE309981T1 ATE309981T1 AT00958461T AT00958461T ATE309981T1 AT E309981 T1 ATE309981 T1 AT E309981T1 AT 00958461 T AT00958461 T AT 00958461T AT 00958461 T AT00958461 T AT 00958461T AT E309981 T1 ATE309981 T1 AT E309981T1
- Authority
- AT
- Austria
- Prior art keywords
- medications
- alkenoylguanidines
- bale
- diagnostics
- acid
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 201000001883 cholelithiasis Diseases 0.000 abstract 1
- 208000001130 gallstones Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19941764A DE19941764A1 (de) | 1999-09-02 | 1999-09-02 | Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente |
| PCT/EP2000/008025 WO2001017954A1 (de) | 1999-09-02 | 2000-08-17 | Gallensäure-substituierte phenyl-alkenoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE309981T1 true ATE309981T1 (de) | 2005-12-15 |
Family
ID=7920512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00958461T ATE309981T1 (de) | 1999-09-02 | 2000-08-17 | Gallensäure-substituierte phenyl- alkenoylguanidine, verfahren zu ihrer herstellung,ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6451781B1 (https=) |
| EP (1) | EP1248768B1 (https=) |
| JP (1) | JP4768941B2 (https=) |
| AT (1) | ATE309981T1 (https=) |
| AU (1) | AU774083B2 (https=) |
| CA (1) | CA2383729A1 (https=) |
| DE (2) | DE19941764A1 (https=) |
| DK (1) | DK1248768T3 (https=) |
| ES (1) | ES2251403T3 (https=) |
| IL (1) | IL148250A0 (https=) |
| WO (1) | WO2001017954A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ563604A (en) * | 2001-11-29 | 2009-04-30 | Theracos Inc | Compounds for treatment of inflammation, diabetes and related disorders |
| SI2384318T1 (en) | 2008-12-31 | 2018-03-30 | Ardelyx, Inc. | MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT |
| US10543207B2 (en) | 2008-12-31 | 2020-01-28 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2018129556A1 (en) * | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| BR112015003516A2 (pt) | 2012-08-21 | 2017-07-04 | Ardelyx Inc | compostos e métodos para inibição de antiporte mediado por nhe no tratamento de transtornos associados à retenção de fluido ou sobrecarga de sal e transtornos do trato gastrintestinal |
| LT2983667T (lt) | 2013-04-12 | 2019-07-10 | Ardelyx, Inc. | Nhe3 rišantys junginiai ir fosfato pernešimo slopinimo būdai |
| CA3049678A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
| EA201991676A1 (ru) | 2017-01-09 | 2020-01-30 | Арделикс, Инк. | Ингибиторы nhe-опосредованного антипорта |
| US12186329B2 (en) | 2018-08-23 | 2025-01-07 | President And Fellows Of Harvard College | Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes |
| WO2020117945A1 (en) | 2018-12-04 | 2020-06-11 | President And Fellows Of Harvard College | Synthetic derivatives of cholic acid 7-sulfate and uses thereof |
| AU2020274319B2 (en) | 2019-05-10 | 2026-02-12 | President And Fellows Of Harvard College | Small molecule modulators of gut bacterial bile acid metabolism |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0667846B2 (ja) * | 1989-04-28 | 1994-08-31 | 一 滝川 | 利胆剤 |
| TW289021B (https=) * | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
| IT1274000B (it) * | 1994-04-06 | 1997-07-14 | Alfa Wassermann Spa | Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi |
| JPH09315979A (ja) * | 1996-05-24 | 1997-12-09 | Tokyo Tanabe Co Ltd | 利胆剤 |
| DE19849722A1 (de) * | 1998-10-28 | 2000-05-04 | Aventis Pharma Gmbh | Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1999
- 1999-09-02 DE DE19941764A patent/DE19941764A1/de not_active Withdrawn
-
2000
- 2000-08-17 DE DE50011660T patent/DE50011660D1/de not_active Expired - Lifetime
- 2000-08-17 DK DK00958461T patent/DK1248768T3/da active
- 2000-08-17 ES ES00958461T patent/ES2251403T3/es not_active Expired - Lifetime
- 2000-08-17 IL IL14825000A patent/IL148250A0/xx unknown
- 2000-08-17 EP EP00958461A patent/EP1248768B1/de not_active Expired - Lifetime
- 2000-08-17 CA CA002383729A patent/CA2383729A1/en not_active Abandoned
- 2000-08-17 WO PCT/EP2000/008025 patent/WO2001017954A1/de not_active Ceased
- 2000-08-17 AT AT00958461T patent/ATE309981T1/de not_active IP Right Cessation
- 2000-08-17 AU AU69965/00A patent/AU774083B2/en not_active Ceased
- 2000-08-17 JP JP2001521701A patent/JP4768941B2/ja not_active Expired - Fee Related
- 2000-09-05 US US09/655,725 patent/US6451781B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1248768B1 (de) | 2005-11-16 |
| AU6996500A (en) | 2001-04-10 |
| DE50011660D1 (de) | 2005-12-22 |
| JP2003508513A (ja) | 2003-03-04 |
| CA2383729A1 (en) | 2001-03-15 |
| DK1248768T3 (da) | 2006-03-27 |
| AU774083B2 (en) | 2004-06-17 |
| US6451781B1 (en) | 2002-09-17 |
| DE19941764A1 (de) | 2001-03-15 |
| WO2001017954A1 (de) | 2001-03-15 |
| ES2251403T3 (es) | 2006-05-01 |
| IL148250A0 (en) | 2002-09-12 |
| EP1248768A1 (de) | 2002-10-16 |
| JP4768941B2 (ja) | 2011-09-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE236191T1 (de) | Substituierte phenyl-alkenoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente | |
| MXPA02011458A (es) | Derivados de acilfenilurea, metodos para su produccion y uso de los mismos como farmacos. | |
| WO2003084922A8 (de) | Acyl-4-carboxy-phenyl-harnstoffderivate, verfahren zu deren herstellung und deren verwendung | |
| DE59406637D1 (de) | nor-Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel | |
| JO2353B1 (en) | New derivatives of mixed-ring fluoroglycosides and drugs containing these compounds and their use | |
| FI942075A0 (fi) | Sappihappojohdannaisten tetratsolijohdannaisia, menetelmä niiden valmistamiseksi ja näiden yhdisteiden käyttö lääkeaineina | |
| BRPI0512974A (pt) | novos derivados de hidantoìna para o tratamento de doenças obstrutivas das vias aéreas | |
| BR0316690A (pt) | Composto, prodroga, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto, composição farmacêutica, e processo para a preparação de um composto | |
| ATE137762T1 (de) | 11-beta-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel | |
| ATE309981T1 (de) | Gallensäure-substituierte phenyl- alkenoylguanidine, verfahren zu ihrer herstellung,ihre verwendung als medikamente oder diagnostika sowie sie enthaltende medikamente | |
| ATE136298T1 (de) | Chinoloncarbonsäurederivate, verfahren zu ihrer herstellung sowie ihre verwendung als antivirale mittel | |
| ATE425968T1 (de) | Substituierte 4-phenyltetrahydroisochinoline, verfahren zu ihrer herstellung, ihre verwendung als medikament, sowie sie enthaltendes medikament | |
| ATE338022T1 (de) | Substituierte norbornylamino-derivate, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament | |
| ATE198320T1 (de) | Substituierte 2-naphthoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament | |
| ATE252383T1 (de) | Verwendung von 2-methyl-thiazolidin-2,4- dicarbonsäure und / oder ihrer physiologisch verträglichen salze zur herstellung eines medikaments zur behandlung von krebserkrankungen | |
| ATE260901T1 (de) | Imidazolderivate mit biphenylsulfonylsubstitution,verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament | |
| DE69120699D1 (de) | N-Monosubstituierte Cyclopentenylamine, ein Verfahren zu ihrer Herstellung, und ihre Verwendung als Medikament | |
| ATE214051T1 (de) | Substituierte tetrahydropyridinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel | |
| ATE389654T1 (de) | Cycloalkyl substituierte 7-amino-4-chinolon-3- carbonsäure-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
| ATE141264T1 (de) | Substituierte 2-pyrimidinyl- und 2- triazinylessigsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider, fungizider und pflanzenwachstumsregulierender wirkung | |
| ATE200076T1 (de) | Substituierte 1-naphthoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament | |
| ATE112276T1 (de) | Aryl-chinolyl-substituierte 1,4-dihydropyridin- dicarbonsäurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln. | |
| DE502004005522D1 (de) | Substituierte thienoimidazole, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltende medikamente | |
| ATE368029T1 (de) | Pentafluorsulfanyl-benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament | |
| DE60100166D1 (de) | 6-Amino oder 6-Hydrazinosulfonyl-3-quinolylphosphonsäurederivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |