JP2003505383A - 新規ジフェニル−ピペリジン誘導体 - Google Patents

新規ジフェニル−ピペリジン誘導体

Info

Publication number
JP2003505383A
JP2003505383A JP2001511441A JP2001511441A JP2003505383A JP 2003505383 A JP2003505383 A JP 2003505383A JP 2001511441 A JP2001511441 A JP 2001511441A JP 2001511441 A JP2001511441 A JP 2001511441A JP 2003505383 A JP2003505383 A JP 2003505383A
Authority
JP
Japan
Prior art keywords
methyl
piperidinyl
diphenyl
chlorobenzyl
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001511441A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003505383A5 (https=
Inventor
アンドリュー・ジョン・ギルビー・バクスター
スティーブン・ジョン・ブロー
トーマス・マッキナリー
Original Assignee
アストラゼネカ ユーケイ リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アストラゼネカ ユーケイ リミテッド filed Critical アストラゼネカ ユーケイ リミテッド
Publication of JP2003505383A publication Critical patent/JP2003505383A/ja
Publication of JP2003505383A5 publication Critical patent/JP2003505383A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP2001511441A 1999-07-21 2000-07-18 新規ジフェニル−ピペリジン誘導体 Withdrawn JP2003505383A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9902765A SE9902765D0 (sv) 1999-07-21 1999-07-21 Novel compounds
SE9902765-8 1999-07-21
PCT/GB2000/002756 WO2001005782A1 (en) 1999-07-21 2000-07-18 Novel diphenyl-piperidine derivate

Publications (2)

Publication Number Publication Date
JP2003505383A true JP2003505383A (ja) 2003-02-12
JP2003505383A5 JP2003505383A5 (https=) 2007-08-16

Family

ID=20416552

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001511441A Withdrawn JP2003505383A (ja) 1999-07-21 2000-07-18 新規ジフェニル−ピペリジン誘導体

Country Status (17)

Country Link
US (1) US6566376B1 (https=)
EP (1) EP1202984B1 (https=)
JP (1) JP2003505383A (https=)
KR (1) KR20020027498A (https=)
CN (1) CN1152873C (https=)
AT (1) ATE233754T1 (https=)
AU (1) AU771344B2 (https=)
BR (1) BR0012610A (https=)
CA (1) CA2378084A1 (https=)
DE (1) DE60001586T2 (https=)
IL (1) IL147149A0 (https=)
MX (1) MXPA02000671A (https=)
NO (1) NO20020282L (https=)
NZ (1) NZ516606A (https=)
SE (1) SE9902765D0 (https=)
WO (1) WO2001005782A1 (https=)
ZA (1) ZA200110540B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010531835A (ja) * 2007-07-02 2010-09-30 エフ．ホフマン−ラ ロシュ アーゲー Ｃｃｒ２受容体アンタゴニストとしてのイミダゾール誘導体

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200303304A (en) * 2002-02-18 2003-09-01 Astrazeneca Ab Chemical compounds
SE0400208D0 (sv) 2004-02-02 2004-02-02 Astrazeneca Ab Chemical compounds
EP1962605A2 (en) * 2005-12-12 2008-09-03 Merck & Co., Inc. 2-arylthiazole derivatives as cxcr3 receptor modulators
US10344095B2 (en) * 2006-02-16 2019-07-09 University Of Kentucky Research Foundation CCR3 inhibition for ocular angiogenesis and macular degeneration
TW200812582A (en) * 2006-04-06 2008-03-16 Astrazeneca Ab Medicaments
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
WO2010138591A1 (en) 2009-05-26 2010-12-02 University Of Kentucky Research Foundation Ccr3 and its ligands are therapeutic and diagnostic targets for neovascular age-related macular degeneration
US9045455B2 (en) 2013-03-14 2015-06-02 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
EP2970136A1 (en) 2013-03-14 2016-01-20 Epizyme, Inc. Arginine methyl transferase inhibtors and uses thereof
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
WO2014153172A1 (en) 2013-03-14 2014-09-25 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
PL2970132T3 (pl) 2013-03-14 2021-04-06 Epizyme, Inc. Inhibitory metylotransferazy argininy i ich zastosowania
CA2903264A1 (en) 2013-03-14 2014-11-06 Epizyme, Inc. Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof
EP3363434A1 (en) 2013-03-14 2018-08-22 Epizyme Inc Arginine methyltransferase inhibitors and uses thereof
US9023883B2 (en) 2013-03-14 2015-05-05 Epizyme, Inc. PRMT1 inhibitors and uses thereof
US9765035B2 (en) 2013-03-14 2017-09-19 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
EP2970134B1 (en) 2013-03-14 2018-02-28 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
MX368059B (es) 2013-07-18 2019-09-18 Novartis Ag Inhibidores de autotaxina que comprenden un núcleo de anillo heteroaromático de bencil-amida cíclica.
CN108299411B (zh) * 2017-01-13 2021-02-05 中国人民解放军军事医学科学院毒物药物研究所 4,4-二苯基哌啶类化合物或其可药用盐、药物组合物及用途
US12221463B2 (en) 2020-08-07 2025-02-11 The Board Of Regents Of The University Of Oklahoma Method of promoting wound healing by inhibiting CCR3

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2139084C3 (de) * 1971-08-04 1979-03-01 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Verfahren zur Herstellung von 4,4-Diphenyl-piperidinen
IL90858A (en) 1988-07-07 1994-08-26 Rhone Poulenc Sante Derivatives of (AZA) naphthalensultam, their preparation and compositions containing them
US5352684A (en) 1990-04-10 1994-10-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyridines as medicaments
DE4140542A1 (de) * 1991-12-09 1993-06-17 Bayer Ag Piperdylmethyl substituierte chormanderivate
US6339087B1 (en) 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
DE19756235A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
HN1999000149A (es) * 1998-09-09 2000-01-12 Pfizer Prod Inc Derivados de 4,4-biarilpiperidina
US6046331A (en) * 1998-12-17 2000-04-04 Synaptic Pharmaceutical Corporation Imidazolones and their use in treating benign prostatic hyperplasia and other disorders

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010531835A (ja) * 2007-07-02 2010-09-30 エフ．ホフマン−ラ ロシュ アーゲー Ｃｃｒ２受容体アンタゴニストとしてのイミダゾール誘導体

Also Published As

Publication number Publication date
US6566376B1 (en) 2003-05-20
NO20020282L (no) 2002-03-21
NO20020282D0 (no) 2002-01-18
BR0012610A (pt) 2002-04-09
ATE233754T1 (de) 2003-03-15
DE60001586T2 (de) 2004-02-12
AU6001600A (en) 2001-02-05
DE60001586D1 (de) 2003-04-10
IL147149A0 (en) 2002-08-14
AU771344B2 (en) 2004-03-18
WO2001005782A1 (en) 2001-01-25
NZ516606A (en) 2003-09-26
EP1202984B1 (en) 2003-03-05
CA2378084A1 (en) 2001-01-25
EP1202984A1 (en) 2002-05-08
CN1361775A (zh) 2002-07-31
CN1152873C (zh) 2004-06-09
ZA200110540B (en) 2003-03-24
MXPA02000671A (es) 2002-07-02
SE9902765D0 (sv) 1999-07-21
KR20020027498A (ko) 2002-04-13

Similar Documents

Publication Publication Date Title
JP2003505383A (ja) 新規ジフェニル−ピペリジン誘導体
US7238688B2 (en) Piperidine compounds
US20040006081A1 (en) Pharmaceutically active piperidine derivatives, in particular as modulators of chemokine receptor activity
JP2003507456A (ja) ケモカインレセプター活性のモジュレーターとして有用な置換ピペリジン化合物
KR20050052511A (ko) 케모킨 매개된 질병 상태의 치료에서 사용하기 위한 신규피페리딘 유도체
KR20010108394A (ko) 신규 화합물
JP4459622B2 (ja) ピペリジン誘導体およびケモカイン・レセプター（特にｃｃｒ５）活性モジュレーターとしてのその使用
JPH11514634A (ja) １−（１，２−ジ置換ピペリジニル）−４−置換ピペラジン誘導体
EP1363902B1 (en) Chemical compounds
KR20040094876A (ko) 케모킨 수용체 활성 (특히 ｃｃｒ5)의 조절제로서 유용한피페리딘 또는 8-아자-바이시클로[3.2.1]옥트-3-일 유도체
JP2005513017A (ja) ケモカイン受容体（特にｃｃｒ）活性のモジュレーターとしてのピペリジン誘導体とその使用
JP4177895B2 (ja) タキキニンアンタゴニストとしてのｎ―アシル―２―置換―４―（ベンゾイミダゾリル―またはイミダゾピリジニル―置換残基）―ピペリジン
JP2004520423A (ja) Ｃｃｒ５モジュレーターとしてのｎ−ピペリジニル化合物
US6562825B1 (en) Piperazine derivatives as modulators of chemokine receptor activity
JP2005501869A (ja) ケモカインレセプター活性の調節物質としての新規なピペリジニル−モルホリニル誘導体
US20090030039A1 (en) Piperidine Derivatives as Cxcr3 Receptor Antagonists
JP2005501866A (ja) ケモカイン受容体活性のモジュレーターとしての新規ピペリジニル誘導体
EP2200982B1 (en) Piperidine derivatives as nk3 receptor antagonists
JP2007528867A (ja) ケモカイン受容体活性のモジュレーターとして有用なピペリジンもしくは８−アザ−ビシクロ［３．２．１］オクタ−３−イル誘導体
WO2003087063A1 (en) Imidazolidine compounds as chemokine receptor modulators
CN101124203A (zh) 化合物
JPWO2005030722A1 (ja) Ｎ−置換−ｎ−（４−ピペリジニル）アミド誘導体
WO2004032856A2 (en) Compounds
JP2009526016A (ja) Ｃｘｃｒ３受容体拮抗物質としてのピペリジン誘導体

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070620

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070620

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20080501