JP2003238445A - 心肥大のための処置としてのヒストンデアセチラーゼの阻害 - Google Patents

心肥大のための処置としてのヒストンデアセチラーゼの阻害

Info

Publication number
JP2003238445A
JP2003238445A JP2002284313A JP2002284313A JP2003238445A JP 2003238445 A JP2003238445 A JP 2003238445A JP 2002284313 A JP2002284313 A JP 2002284313A JP 2002284313 A JP2002284313 A JP 2002284313A JP 2003238445 A JP2003238445 A JP 2003238445A
Authority
JP
Japan
Prior art keywords
histone deacetylase
cardiac hypertrophy
class
inhibitor
hdac
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2002284313A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003238445A5 (cg-RX-API-DMAC7.html
Inventor
Eric N Olson
エヌ． オルソン エリック
Timothy A Mckinsey
エイ． マッキンジー ティモシー
Michael R Bristow
アール． ブリストウ マイケル
Carlin Long
ロング カーリン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Colorado Boulder
University of Texas at Austin
University of Colorado System
Original Assignee
University of Colorado Boulder
University of Texas at Austin
University of Colorado System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Colorado Boulder, University of Texas at Austin, University of Colorado System filed Critical University of Colorado Boulder
Publication of JP2003238445A publication Critical patent/JP2003238445A/ja
Publication of JP2003238445A5 publication Critical patent/JP2003238445A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2002284313A 2001-09-27 2002-09-27 心肥大のための処置としてのヒストンデアセチラーゼの阻害 Withdrawn JP2003238445A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32531101P 2001-09-27 2001-09-27
US60/325,311 2001-09-27
US33404101P 2001-10-31 2001-10-31
US60/334,041 2001-10-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009221681A Division JP2010001311A (ja) 2001-09-27 2009-09-25 心肥大のための処置としてのヒストンデアセチラーゼの阻害

Publications (2)

Publication Number Publication Date
JP2003238445A true JP2003238445A (ja) 2003-08-27
JP2003238445A5 JP2003238445A5 (cg-RX-API-DMAC7.html) 2005-11-10

Family

ID=26984878

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002284313A Withdrawn JP2003238445A (ja) 2001-09-27 2002-09-27 心肥大のための処置としてのヒストンデアセチラーゼの阻害
JP2009221681A Pending JP2010001311A (ja) 2001-09-27 2009-09-25 心肥大のための処置としてのヒストンデアセチラーゼの阻害

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009221681A Pending JP2010001311A (ja) 2001-09-27 2009-09-25 心肥大のための処置としてのヒストンデアセチラーゼの阻害

Country Status (8)

Country Link
US (4) US6706686B2 (cg-RX-API-DMAC7.html)
EP (1) EP1297851B1 (cg-RX-API-DMAC7.html)
JP (2) JP2003238445A (cg-RX-API-DMAC7.html)
AT (1) ATE287731T1 (cg-RX-API-DMAC7.html)
DE (1) DE60202727T2 (cg-RX-API-DMAC7.html)
DK (1) DK1297851T3 (cg-RX-API-DMAC7.html)
ES (1) ES2236415T3 (cg-RX-API-DMAC7.html)
PT (1) PT1297851E (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022550576A (ja) * 2019-10-03 2022-12-02 テナヤ セラピューティクス， インコーポレイテッド ５－フルオロニコチンアミド誘導体およびその使用
US12312345B2 (en) 2019-12-20 2025-05-27 Tenaya Therapeutics, Inc. Fluoroalkyl-oxadiazoles and uses thereof

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US6706686B2 (en) * 2001-09-27 2004-03-16 The Regents Of The University Of Colorado Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
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EP4333841A1 (en) 2021-05-04 2024-03-13 Tenaya Therapeutics, Inc. 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef
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Publication number Priority date Publication date Assignee Title
JP2022550576A (ja) * 2019-10-03 2022-12-02 テナヤ セラピューティクス， インコーポレイテッド ５－フルオロニコチンアミド誘導体およびその使用
JP7744024B2 (ja) 2019-10-03 2025-09-25 テナヤ セラピューティクス， インコーポレイテッド ５－フルオロニコチンアミド誘導体およびその使用
US12312345B2 (en) 2019-12-20 2025-05-27 Tenaya Therapeutics, Inc. Fluoroalkyl-oxadiazoles and uses thereof

Also Published As

Publication number Publication date
PT1297851E (pt) 2005-06-30
US6946441B2 (en) 2005-09-20
US20040186049A1 (en) 2004-09-23
US20060025333A1 (en) 2006-02-02
JP2010001311A (ja) 2010-01-07
US6706686B2 (en) 2004-03-16
DK1297851T3 (da) 2005-05-30
EP1297851A1 (en) 2003-04-02
ATE287731T1 (de) 2005-02-15
DE60202727D1 (de) 2005-03-03
US20030144340A1 (en) 2003-07-31
EP1297851B1 (en) 2005-01-26
US20060069014A1 (en) 2006-03-30
DE60202727T2 (de) 2005-12-29
ES2236415T3 (es) 2005-07-16

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