JP2003176261A5 - - Google Patents
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- Publication number
- JP2003176261A5 JP2003176261A5 JP2002190861A JP2002190861A JP2003176261A5 JP 2003176261 A5 JP2003176261 A5 JP 2003176261A5 JP 2002190861 A JP2002190861 A JP 2002190861A JP 2002190861 A JP2002190861 A JP 2002190861A JP 2003176261 A5 JP2003176261 A5 JP 2003176261A5
- Authority
- JP
- Japan
- Prior art keywords
- glycine
- alkali metal
- producing
- aqueous solution
- aminoacetonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 claims 34
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 23
- 239000007864 aqueous solution Substances 0.000 claims 20
- 239000004471 Glycine Substances 0.000 claims 18
- 150000001412 amines Chemical class 0.000 claims 15
- -1 glycine alkali metal salt Chemical class 0.000 claims 15
- 150000002332 glycine derivatives Chemical class 0.000 claims 15
- 229910052783 alkali metal Inorganic materials 0.000 claims 14
- DFNYGALUNNFWKJ-UHFFFAOYSA-N aminoacetonitrile Chemical compound NCC#N DFNYGALUNNFWKJ-UHFFFAOYSA-N 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- 229910052936 alkali metal sulfate Inorganic materials 0.000 claims 8
- 238000006243 chemical reaction Methods 0.000 claims 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 5
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 4
- LTYRAPJYLUPLCI-UHFFFAOYSA-N glycolonitrile Chemical compound OCC#N LTYRAPJYLUPLCI-UHFFFAOYSA-N 0.000 claims 4
- JMANVNJQNLATNU-UHFFFAOYSA-N glycolonitrile Natural products N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 239000002002 slurry Substances 0.000 claims 3
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims 3
- FOUZISDNESEYLX-UHFFFAOYSA-N 2-(2-hydroxyethylazaniumyl)acetate Chemical compound OCCNCC(O)=O FOUZISDNESEYLX-UHFFFAOYSA-N 0.000 claims 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 2
- RPMBPYXLPIWSFJ-UHFFFAOYSA-N 2-aminopentanenitrile Chemical compound CCCC(N)C#N RPMBPYXLPIWSFJ-UHFFFAOYSA-N 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical group CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000003472 neutralizing effect Effects 0.000 claims 2
- 239000012266 salt solution Substances 0.000 claims 2
- OTJFQRMIRKXXRS-UHFFFAOYSA-N (hydroxymethylamino)methanol Chemical compound OCNCO OTJFQRMIRKXXRS-UHFFFAOYSA-N 0.000 claims 1
- LVPZSMIBSMMLPI-UHFFFAOYSA-N 2-(diethylamino)acetonitrile Chemical compound CCN(CC)CC#N LVPZSMIBSMMLPI-UHFFFAOYSA-N 0.000 claims 1
- WBTIFBJEYFLFFW-UHFFFAOYSA-N 2-(hydroxymethylazaniumyl)acetate Chemical compound OCNCC(O)=O WBTIFBJEYFLFFW-UHFFFAOYSA-N 0.000 claims 1
- BOYRGCUYTXBPQH-UHFFFAOYSA-N 2-amino-3-hydroxypropanenitrile Chemical compound OCC(N)C#N BOYRGCUYTXBPQH-UHFFFAOYSA-N 0.000 claims 1
- QFPYWIXREIQTOD-UHFFFAOYSA-N 2-amino-4-hydroxybutanenitrile Chemical compound N#CC(N)CCO QFPYWIXREIQTOD-UHFFFAOYSA-N 0.000 claims 1
- VRDBIJCCXDEZJN-UHFFFAOYSA-N 2-piperidin-1-ylacetic acid Chemical compound OC(=O)CN1CCCCC1 VRDBIJCCXDEZJN-UHFFFAOYSA-N 0.000 claims 1
- CLVBVRODHJFTGF-UHFFFAOYSA-N 2-piperidin-1-ylacetonitrile Chemical compound N#CCN1CCCCC1 CLVBVRODHJFTGF-UHFFFAOYSA-N 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- FSVCELGFZIQNCK-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)glycine Chemical compound OCCN(CCO)CC(O)=O FSVCELGFZIQNCK-UHFFFAOYSA-N 0.000 claims 1
- SGXDXUYKISDCAZ-UHFFFAOYSA-N N,N-diethylglycine Chemical compound CCN(CC)CC(O)=O SGXDXUYKISDCAZ-UHFFFAOYSA-N 0.000 claims 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical group [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 239000012295 chemical reaction liquid Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 108700003601 dimethylglycine Proteins 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- XMYQHJDBLRZMLW-UHFFFAOYSA-N methanolamine Chemical group NCO XMYQHJDBLRZMLW-UHFFFAOYSA-N 0.000 claims 1
- 229940087646 methanolamine Drugs 0.000 claims 1
- 229940078490 n,n-dimethylglycine Drugs 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 229910052938 sodium sulfate Inorganic materials 0.000 claims 1
- 235000011152 sodium sulphate Nutrition 0.000 claims 1
- WUWHFEHKUQVYLF-UHFFFAOYSA-M sodium;2-aminoacetate Chemical group [Na+].NCC([O-])=O WUWHFEHKUQVYLF-UHFFFAOYSA-M 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002190861A JP4306192B2 (ja) | 2001-10-05 | 2002-06-28 | グリシン誘導体の製造方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001-310473 | 2001-10-05 | ||
| JP2001310473 | 2001-10-05 | ||
| JP2002190861A JP4306192B2 (ja) | 2001-10-05 | 2002-06-28 | グリシン誘導体の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003176261A JP2003176261A (ja) | 2003-06-24 |
| JP2003176261A5 true JP2003176261A5 (https=) | 2005-08-25 |
| JP4306192B2 JP4306192B2 (ja) | 2009-07-29 |
Family
ID=26623786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002190861A Expired - Fee Related JP4306192B2 (ja) | 2001-10-05 | 2002-06-28 | グリシン誘導体の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4306192B2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003031390A1 (en) * | 2001-10-05 | 2003-04-17 | Showa Denko K.K. | Highly concentrated aqueous solutions of n,n-dialkyl- glycines and process for preparation thereof |
| CN103342652B (zh) * | 2013-07-24 | 2015-02-25 | 重庆紫光化工股份有限公司 | N,n-二甲基氨基乙酸酯的制备方法 |
| CN103351306B (zh) * | 2013-07-24 | 2015-04-15 | 重庆紫光化工股份有限公司 | 一种一锅法制备n,n-二甲基甘氨酸酯的方法 |
| CN103387518B (zh) * | 2013-07-24 | 2016-06-08 | 重庆紫光化工股份有限公司 | 一种n,n-二甲基甘氨酸的制备方法 |
| CN103922952A (zh) * | 2014-05-07 | 2014-07-16 | 宁夏宝马药业有限公司 | 用羟基乙腈制取环丙基甘氨酸的方法 |
| CN104610078B (zh) * | 2014-10-27 | 2017-07-11 | 河北诚信有限责任公司 | 一种制备高纯度n,n‑二甲基甘氨酸的方法 |
| CN107216256B (zh) * | 2017-05-19 | 2019-06-21 | 舞阳威森生物医药有限公司 | 一种n，n-二异丙基乙二胺的合成方法 |
| CN112986423B (zh) * | 2021-02-07 | 2022-09-23 | 山东京博生物科技有限公司 | 一种氨基乙腈盐酸盐的含量分析方法及其应用 |
-
2002
- 2002-06-28 JP JP2002190861A patent/JP4306192B2/ja not_active Expired - Fee Related
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