JP2002542182A - 粘膜上の可溶性ウイルス特異リガンドの半減期を増加させる方法 - Google Patents
粘膜上の可溶性ウイルス特異リガンドの半減期を増加させる方法Info
- Publication number
- JP2002542182A JP2002542182A JP2000611895A JP2000611895A JP2002542182A JP 2002542182 A JP2002542182 A JP 2002542182A JP 2000611895 A JP2000611895 A JP 2000611895A JP 2000611895 A JP2000611895 A JP 2000611895A JP 2002542182 A JP2002542182 A JP 2002542182A
- Authority
- JP
- Japan
- Prior art keywords
- specific ligand
- virus
- bacterial
- bacteria
- chimeric molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12972299P | 1999-04-16 | 1999-04-16 | |
US60/129,722 | 1999-04-16 | ||
PCT/US2000/010079 WO2000062758A1 (en) | 1999-04-16 | 2000-04-14 | A method for improving the half-life of soluble viral-specific ligands on mucosal membranes |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2002542182A true JP2002542182A (ja) | 2002-12-10 |
Family
ID=22441292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000611895A Pending JP2002542182A (ja) | 1999-04-16 | 2000-04-14 | 粘膜上の可溶性ウイルス特異リガンドの半減期を増加させる方法 |
Country Status (7)
Country | Link |
---|---|
US (2) | US6365156B1 (de) |
EP (1) | EP1171098A4 (de) |
JP (1) | JP2002542182A (de) |
CN (1) | CN1355690A (de) |
AU (1) | AU4350400A (de) |
CA (1) | CA2369762A1 (de) |
WO (1) | WO2000062758A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6610293B1 (en) * | 1997-06-16 | 2003-08-26 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine | Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
JP2006514636A (ja) * | 2002-12-02 | 2006-05-11 | バイオシネクサス インコーポレーテッド | 抗ブドウ球菌療法およびワクチンの標的としての壁テイコイン酸 |
US20050244402A1 (en) * | 2004-04-30 | 2005-11-03 | Villanueva Julie M | Absorption of pain-causing agents |
WO2005116071A2 (en) * | 2004-05-28 | 2005-12-08 | University Of Massachusetts | Snares for pathogenic or infectious agents and uses related thereto |
EP1786445B1 (de) | 2004-08-25 | 2011-06-08 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Lebendige mikrobielle mikrobizide |
CN101437532B (zh) | 2006-05-05 | 2013-08-21 | 冈戈根股份有限公司 | 噬菌体衍生的抗微生物活性剂 |
US8962015B2 (en) | 2007-09-28 | 2015-02-24 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
US8846053B2 (en) | 2008-09-26 | 2014-09-30 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
US9145453B2 (en) * | 2007-09-28 | 2015-09-29 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
US20100080773A1 (en) | 2008-09-26 | 2010-04-01 | Sdg, Inc. | Orally Bioavailable Lipid-Based Constructs |
JP2011501958A (ja) | 2007-10-29 | 2011-01-20 | バージニア テック インテレクチュアル プロパティーズ インコーポレーテッド | ブタDC−SIGN、ICAM−3およびLSECtinならびにそれらの使用 |
US20110044968A1 (en) * | 2008-03-10 | 2011-02-24 | Pharmal N Corporation | Compositions for treatment with metallopeptidases, methods of making and using the same |
CN102617738B (zh) * | 2011-01-26 | 2013-07-31 | 中国科学院武汉病毒研究所 | 重组融合蛋白cld的多肽、编码序列及制备方法和应用 |
US10233219B2 (en) | 2013-04-12 | 2019-03-19 | Tufts Medical Center | Methods and systems for designing and/or characterizing soluble lipidated ligand agents |
ES2805037T3 (es) | 2016-01-22 | 2021-02-10 | Tufts Medical Ct Inc | Compuestos y métodos para tratar la inflamación |
JP7071933B2 (ja) * | 2016-02-25 | 2022-05-19 | アプライド バイオロジカル ラボラトリーズ インコーポレイテッド | 浮遊病原体および刺激物に対して防御するための組成物および方法 |
CN106282178B (zh) * | 2016-09-05 | 2019-06-04 | 南京农业大学 | 重组嗜酸乳杆菌s层蛋白在大肠杆菌中的高效表达及其应用 |
US11077173B2 (en) | 2017-03-13 | 2021-08-03 | Sdg, Inc. | Lipid-based nanoparticles and methods using same |
CN110612114A (zh) | 2017-03-13 | 2019-12-24 | Sdg公司 | 具有增强的稳定性的基于脂质的纳米颗粒 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5834589A (en) * | 1990-12-14 | 1998-11-10 | New York University | Chimeric viral receptor polypeptides |
CA2104958A1 (en) | 1991-03-07 | 1992-09-08 | Jean C. Nichols | Use of cell surface receptor targeted molecules for the treatment of viral diseases |
US5348867A (en) | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
HU220420B (hu) | 1992-03-13 | 2002-01-28 | The Rockefeller University | Gram-pozitív baktériumok hibrid sejtfelszíni fehérjéje, eljárás és készlet fertőzés kimutatására |
US5531988A (en) | 1994-10-28 | 1996-07-02 | Metagenics, Inc. | Bacteria and immunoglobulin-containing composition for human gastrointestinal health |
US5733540A (en) * | 1995-03-08 | 1998-03-31 | Lee; Peter Poon-Hang | Protection from viral infection via colonization of mucosal membranes with genetically modified bacteria |
-
2000
- 2000-04-14 EP EP00923364A patent/EP1171098A4/de not_active Withdrawn
- 2000-04-14 CN CN00808771A patent/CN1355690A/zh active Pending
- 2000-04-14 JP JP2000611895A patent/JP2002542182A/ja active Pending
- 2000-04-14 WO PCT/US2000/010079 patent/WO2000062758A1/en not_active Application Discontinuation
- 2000-04-14 CA CA002369762A patent/CA2369762A1/en not_active Abandoned
- 2000-04-14 AU AU43504/00A patent/AU4350400A/en not_active Abandoned
- 2000-04-14 US US09/549,261 patent/US6365156B1/en not_active Expired - Lifetime
-
2002
- 2002-01-10 US US10/043,689 patent/US20020086020A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2000062758A1 (en) | 2000-10-26 |
EP1171098A4 (de) | 2003-04-02 |
CN1355690A (zh) | 2002-06-26 |
EP1171098A1 (de) | 2002-01-16 |
US20020086020A1 (en) | 2002-07-04 |
AU4350400A (en) | 2000-11-02 |
CA2369762A1 (en) | 2000-10-26 |
US6365156B1 (en) | 2002-04-02 |
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