JP2002540137A5 - - Google Patents
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- Publication number
- JP2002540137A5 JP2002540137A5 JP2000607603A JP2000607603A JP2002540137A5 JP 2002540137 A5 JP2002540137 A5 JP 2002540137A5 JP 2000607603 A JP2000607603 A JP 2000607603A JP 2000607603 A JP2000607603 A JP 2000607603A JP 2002540137 A5 JP2002540137 A5 JP 2002540137A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- tumor
- group
- carbon atoms
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims 32
- 239000002246 antineoplastic agent Substances 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 125000004432 carbon atom Chemical group C* 0.000 claims 14
- 229920000642 polymer Polymers 0.000 claims 10
- 125000001931 aliphatic group Chemical group 0.000 claims 9
- 229920002988 biodegradable polymer Polymers 0.000 claims 9
- 239000004621 biodegradable polymer Substances 0.000 claims 9
- 241000124008 Mammalia Species 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 206010006187 Breast cancer Diseases 0.000 claims 6
- 208000026310 Breast neoplasm Diseases 0.000 claims 6
- 229930012538 Paclitaxel Natural products 0.000 claims 6
- 239000000178 monomer Substances 0.000 claims 6
- 229960001592 paclitaxel Drugs 0.000 claims 6
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 6
- 230000002601 intratumoral effect Effects 0.000 claims 5
- 229940123237 Taxane Drugs 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 125000004470 heterocyclooxy group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000002723 alicyclic group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 230000009036 growth inhibition Effects 0.000 claims 2
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 125000004825 2,2-dimethylpropylene group Chemical group [H]C([H])([H])C(C([H])([H])[H])(C([H])([H])[*:1])C([H])([H])[*:2] 0.000 claims 1
- 125000004810 2-methylpropylene group Chemical group [H]C([H])([H])C([H])(C([H])([H])[*:2])C([H])([H])[*:1] 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- -1 and R 3 is H Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 210000000038 chest Anatomy 0.000 claims 1
- 125000004956 cyclohexylene group Chemical group 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/276,866 US6537585B1 (en) | 1999-03-26 | 1999-03-26 | Methods and compositions for treating solid tumors |
| US09/276,866 | 1999-03-26 | ||
| PCT/US2000/007304 WO2000057852A2 (en) | 1999-03-26 | 2000-03-20 | Methods and compositions for treating solid tumors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011132938A Division JP2011219483A (ja) | 1999-03-26 | 2011-06-15 | 固型腫瘍の治療方法及び組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002540137A JP2002540137A (ja) | 2002-11-26 |
| JP2002540137A5 true JP2002540137A5 (https=) | 2007-05-17 |
Family
ID=23058398
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000607603A Pending JP2002540137A (ja) | 1999-03-26 | 2000-03-20 | 固型腫瘍の治療方法及び組成物 |
| JP2011132938A Pending JP2011219483A (ja) | 1999-03-26 | 2011-06-15 | 固型腫瘍の治療方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011132938A Pending JP2011219483A (ja) | 1999-03-26 | 2011-06-15 | 固型腫瘍の治療方法及び組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6537585B1 (https=) |
| EP (1) | EP1185249B1 (https=) |
| JP (2) | JP2002540137A (https=) |
| KR (1) | KR20010111578A (https=) |
| CN (1) | CN1367684A (https=) |
| AT (1) | ATE306251T1 (https=) |
| AU (1) | AU778279B2 (https=) |
| BR (1) | BR0009213A (https=) |
| CA (1) | CA2368621C (https=) |
| CZ (1) | CZ20013260A3 (https=) |
| DE (1) | DE60023138T2 (https=) |
| HU (1) | HUP0201436A3 (https=) |
| IL (1) | IL145492A0 (https=) |
| NO (1) | NO20014662L (https=) |
| PL (1) | PL351280A1 (https=) |
| TR (1) | TR200102801T2 (https=) |
| WO (1) | WO2000057852A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6350464B1 (en) * | 1999-01-11 | 2002-02-26 | Guilford Pharmaceuticals, Inc. | Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same |
| US6537585B1 (en) | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
| AU2001270310A1 (en) * | 2000-07-07 | 2002-01-21 | Guilford Pharmaceuticals Inc. | Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same |
| AU2001280597A1 (en) * | 2000-07-17 | 2002-01-30 | Guilford Pharmaceuticals Inc. | Compositions for sustained release of analgesic agents, and methods of making and using the same |
| US20020198135A1 (en) * | 2000-10-12 | 2002-12-26 | Wenbin Dang | Compositions for release of radiosensitizers, and methods of making and using the same |
| US20020141966A1 (en) * | 2000-11-16 | 2002-10-03 | Wenbin Dang | Compositions for treatment of malignant effusions, and methods of making and using the same |
| US20020081339A1 (en) * | 2000-12-22 | 2002-06-27 | Philippe Menei | Treatment of inoperable tumors by stereotactic injection of microspheres |
| WO2003000776A1 (en) * | 2001-05-14 | 2003-01-03 | Johns Hopkins Singapore Pte Ltd | Biodegradable polyphosphoramidates for controlled release of bioactive substances |
| US7345138B2 (en) * | 2001-05-14 | 2008-03-18 | Johns Hopkins Singapore Pte Ltd. | Biodegradable polyphosphates for controlled release of bioactive substances |
| WO2003007914A2 (en) * | 2001-07-19 | 2003-01-30 | Guilford Pharmaceuticals, Inc. | Biocompatible polymer containing composition for treatment of prostate cancers |
| US20030134892A1 (en) * | 2001-07-19 | 2003-07-17 | Wenbin Dang | Compositions for treatment of head and neck cancers, and methods of making and using the same |
| AU2003202255A1 (en) * | 2002-01-09 | 2003-07-30 | Guilford Pharmaceuticals, Inc. | Compositions for treatment of central nervous system neoplasms, and methods of making and using the same |
| AU2003216424A1 (en) | 2002-02-25 | 2003-10-08 | Guilford Pharmaceuticals, Inc. | Phosphorus-containing compounds with polymeric chains, and methods of making and using the same |
| GB0223379D0 (en) * | 2002-10-09 | 2002-11-13 | Angiogene Pharm Ltd | Combination therapy |
| SI1677828T1 (sl) * | 2003-10-21 | 2013-04-30 | Psimedica Limited | Kompozitni material, ki vsebuje porozen polprevodnik impregniran z organsko substanco |
| US7795205B2 (en) * | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
| WO2006002366A2 (en) * | 2004-06-24 | 2006-01-05 | Surmodics, Inc. | Biodegradable ocular devices, methods and systems |
| WO2006002399A2 (en) * | 2004-06-24 | 2006-01-05 | Surmodics, Inc. | Biodegradable implantable medical devices, methods and systems |
| US20080124400A1 (en) * | 2004-06-24 | 2008-05-29 | Angiotech International Ag | Microparticles With High Loadings Of A Bioactive Agent |
| EP1835931A4 (en) * | 2004-12-06 | 2008-12-17 | Sciclone Pharmaceuticals Inc | ALPHA THYMOSINE PEPTIDES AS CANCER VACCINE ADJUVANTIES |
| SI1853250T1 (sl) | 2005-02-18 | 2012-01-31 | Abraxis Bioscience Llc | Kombinacije in reĹľimi dajanja terapevtskih sredstev in kombinirana terapija |
| US8735394B2 (en) * | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| CA2618807C (en) * | 2005-08-12 | 2015-01-06 | University Health Network | Methods and devices for lymphatic targeting |
| GB0525864D0 (en) * | 2005-12-20 | 2006-02-01 | Novartis Ag | Organic compounds |
| EP3047860B1 (en) | 2006-07-20 | 2024-08-28 | OrbusNeich Medical Pte. Ltd. | Bioabsorbable polymeric composition for a medical device |
| US7959942B2 (en) | 2006-10-20 | 2011-06-14 | Orbusneich Medical, Inc. | Bioabsorbable medical device with coating |
| US8691321B2 (en) | 2006-10-20 | 2014-04-08 | Orbusneich Medical, Inc. | Bioabsorbable polymeric composition and medical device background |
| CN101390828B (zh) * | 2007-02-12 | 2010-06-09 | 济南康泉医药科技有限公司 | 同载抗代谢类药物和增效剂的抗癌组合物 |
| US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
| CA2763365C (en) | 2009-05-29 | 2016-09-13 | Cydex Pharmaceuticals, Inc. | Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same |
| ES2362525B8 (es) | 2009-10-08 | 2013-01-03 | Azurebio, S.L. | Formulación de medicamentos en forma de agujas percutaneas penetrantes. |
| TWI438009B (zh) * | 2010-02-19 | 2014-05-21 | Teikoku Pharma Usa Inc | 紫杉烷前－乳劑調配物及其製造與使用之方法 |
| NZ717490A (en) | 2010-03-29 | 2017-12-22 | Abraxis Bioscience Llc | Methods of treating cancer |
| KR20130028727A (ko) | 2010-03-29 | 2013-03-19 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 약물 전달 및 유효성 향상 방법 |
| EA027666B1 (ru) | 2010-05-03 | 2017-08-31 | ТЕИКОКУ ФАРМА ЮСЭй, ИНК. | Неводные лекарственные средства в форме проэмульсии на основе таксанов и способы их приготовления и использования |
| BR112012030909A2 (pt) | 2010-06-04 | 2020-08-18 | Abraxis Bioscience, Llc | métodos de tratamento de câncer pancreático |
| CN104884065B (zh) | 2012-09-21 | 2019-01-01 | 强烈治疗剂公司 | 治疗癌症的方法 |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| US9545447B2 (en) | 2013-01-04 | 2017-01-17 | The Texas A&M University System | Polymer-drug systems |
| EP3302423B1 (en) | 2015-06-04 | 2022-05-25 | Crititech, Inc. | Particle production system and particle collection device |
| BR112018069628A2 (pt) | 2016-04-04 | 2019-02-12 | Crititech, Inc. | métodos para tratamento de tumor sólido |
| EP3615145B1 (en) | 2017-06-09 | 2024-05-15 | Crititech, Inc. | Compositions for use in the treatment of epithelial cysts by intracystic injection of antineoplastic particles |
| WO2018231908A1 (en) | 2017-06-14 | 2018-12-20 | Crititech, Inc. | Methods for treating lung disorders |
| KR20250057947A (ko) | 2017-10-03 | 2025-04-29 | 크리티테크, 인크. | 암의 치료를 위한 면역치료제의 전신 전달과 조합된 항신생물성 입자의 국소 전달 |
| WO2020072090A1 (en) * | 2018-10-03 | 2020-04-09 | Crititech, Inc. | Use of antineoplastic agents to stimulate the immune system for production of tertiary lymphoid structures (tls) |
| JP2022508807A (ja) | 2018-10-16 | 2022-01-19 | ユーエス・ナノ・フード・アンド・ドラッグ・インコーポレーテッド | 腫瘍内注射製剤 |
| US11752165B2 (en) | 2020-04-13 | 2023-09-12 | US Nano Food & Drug, Inc | Basic chemotherapeutic intratumour injection formulation |
| GB2623319A (en) | 2022-10-11 | 2024-04-17 | Af Chempharm Ltd | Method of synthesis of chloro-oxo-dioxaphospholane oxides and derivates |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3271329A (en) | 1958-09-19 | 1966-09-06 | Eastman Kodak Co | Method for producing polymers derived from phosphites and glycols |
| US3442982A (en) | 1965-10-15 | 1969-05-06 | Weston Chemical Corp | Polyphosphites of 2,2-dimethyl-3-hydroxypropyl - 2 - dimethyl - 3-hydroxypropionate |
| FR2219193B1 (https=) | 1973-02-28 | 1976-05-21 | Rhone Poulenc Sa | |
| US3932566A (en) | 1974-09-16 | 1976-01-13 | Celanese Corporation | Phosphonate polymers |
| US4100354A (en) | 1976-08-05 | 1978-07-11 | Owens-Corning Fiberglass Corporation | Terephthalate ester polyols |
| US4259222A (en) | 1978-08-16 | 1981-03-31 | Basf Wyandotte Corporation | Linear saturated polyesters of phosphoric acid and halogenated diols as flame-retardant additives and coatings |
| DE2925206A1 (de) | 1979-06-22 | 1981-01-29 | Bayer Ag | Aromatische polyesterphosphonate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung thermoplastischer formkoerper |
| FR2498612A1 (fr) | 1981-01-26 | 1982-07-30 | Peters Ligatures | Nouveaux polymeres insolubles a biodegradabilite reglable a volonte, leurs procedes de preparation et leur application en tant que biomateriaux |
| US4757128A (en) | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
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| US5256765A (en) | 1989-03-09 | 1993-10-26 | The Johns Hopkins University School Of Medicine | Biodegradable poly(phosphate esters) |
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| US5162115A (en) | 1989-05-09 | 1992-11-10 | Pietronigro Dennis D | Antineoplastic solution and method for treating neoplasms |
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| NZ240214A (en) | 1990-10-16 | 1993-02-25 | Takeda Chemical Industries Ltd | Polymer compositions comprising a polylactic acid and a copolymer of glycolic acid and a hydroxycarboxylic acid; use as carrier for prolonged release pharmaceutical compositions of water soluble drugs |
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| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| JPH09507233A (ja) | 1993-12-29 | 1997-07-22 | マトリクス ファーマスーティカル，インコーポレイティド | 細胞増殖性疾患に罹る宿主の治療方法及び治療のための組成物 |
| DE4404365A1 (de) | 1994-02-11 | 1995-08-17 | Cassella Ag | Phosphin- und phosphonsäuregruppenhaltige Polykondensate |
| US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
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| ATE279461T1 (de) | 1997-04-03 | 2004-10-15 | Guilford Pharm Inc | Bioabbaubare terephthalat polyester-polyphosphat polymere, zusammensetzungen, gegenstände und verfahren für ihre herstellung und verwendung |
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| NZ501184A (en) | 1997-04-30 | 2002-08-28 | Guilford Pharm Inc | Biodegradable poly (phosphodiester) compositions that degrade in vivo into non-toxic residues |
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| US6028163A (en) | 1997-06-27 | 2000-02-22 | Guilford Pharmaceuticals Inc. | Solution polymerization of high molecular weight poly(phosphoesters) in toluene |
| US6153212A (en) * | 1998-10-02 | 2000-11-28 | Guilford Pharmaceuticals Inc. | Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same |
| WO2000019976A2 (en) | 1998-10-02 | 2000-04-13 | Guilford Pharmaceuticals Inc. | Biodegradable terephthalate polyester-poly(phosphonate) and polyester-poly(phosphite) compositions, articles, and methods of using them |
| US6419709B1 (en) * | 1998-10-02 | 2002-07-16 | Guilford Pharmaceuticals, Inc. | Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same |
| US6350464B1 (en) | 1999-01-11 | 2002-02-26 | Guilford Pharmaceuticals, Inc. | Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same |
| US6537585B1 (en) | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
| CA2369740A1 (en) | 1999-04-22 | 2000-11-02 | American Biosciences, Inc. | Long term administration of pharmacologically active agents |
| AU2001270310A1 (en) | 2000-07-07 | 2002-01-21 | Guilford Pharmaceuticals Inc. | Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same |
| AU2001280597A1 (en) * | 2000-07-17 | 2002-01-30 | Guilford Pharmaceuticals Inc. | Compositions for sustained release of analgesic agents, and methods of making and using the same |
| US20020198135A1 (en) * | 2000-10-12 | 2002-12-26 | Wenbin Dang | Compositions for release of radiosensitizers, and methods of making and using the same |
| WO2003007914A2 (en) * | 2001-07-19 | 2003-01-30 | Guilford Pharmaceuticals, Inc. | Biocompatible polymer containing composition for treatment of prostate cancers |
| US20030134892A1 (en) * | 2001-07-19 | 2003-07-17 | Wenbin Dang | Compositions for treatment of head and neck cancers, and methods of making and using the same |
-
1999
- 1999-03-26 US US09/276,866 patent/US6537585B1/en not_active Expired - Fee Related
-
2000
- 2000-03-20 AU AU37625/00A patent/AU778279B2/en not_active Ceased
- 2000-03-20 CA CA2368621A patent/CA2368621C/en not_active Expired - Fee Related
- 2000-03-20 IL IL14549200A patent/IL145492A0/xx unknown
- 2000-03-20 WO PCT/US2000/007304 patent/WO2000057852A2/en not_active Ceased
- 2000-03-20 CZ CZ20013260A patent/CZ20013260A3/cs unknown
- 2000-03-20 JP JP2000607603A patent/JP2002540137A/ja active Pending
- 2000-03-20 EP EP00916536A patent/EP1185249B1/en not_active Expired - Lifetime
- 2000-03-20 TR TR2001/02801T patent/TR200102801T2/xx unknown
- 2000-03-20 HU HU0201436A patent/HUP0201436A3/hu unknown
- 2000-03-20 CN CN00806972A patent/CN1367684A/zh active Pending
- 2000-03-20 AT AT00916536T patent/ATE306251T1/de not_active IP Right Cessation
- 2000-03-20 BR BR0009213-4A patent/BR0009213A/pt not_active Application Discontinuation
- 2000-03-20 DE DE60023138T patent/DE60023138T2/de not_active Expired - Lifetime
- 2000-03-20 PL PL00351280A patent/PL351280A1/xx not_active Application Discontinuation
- 2000-03-20 KR KR1020017012256A patent/KR20010111578A/ko not_active Withdrawn
-
2001
- 2001-09-25 NO NO20014662A patent/NO20014662L/no not_active Application Discontinuation
-
2003
- 2003-02-03 US US10/357,292 patent/US7101568B2/en not_active Expired - Fee Related
-
2011
- 2011-06-15 JP JP2011132938A patent/JP2011219483A/ja active Pending
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